Selonsertib free base , CAS#: 1448428-04-3

Name:

Selonsertib free base

CAS#: 1448428-04-3 (free base)

Chemical Formula: C24H24FN7O

Exact Mass: 445.20264

Molecular Weight: 445.5

Elemental Analysis: C, 64.71; H, 5.43; F, 4.26; N, 22.01; O, 3.59

Selonsertib free base , CAS#: 1448428-04-3 (free base), until 2016 end, we have produced more than 1000g, to be world biggest supplier.

HPLC 99,%, NMR, MS is ok.

Related CAS #: 1448428-04-3 (free base); 1448428-05-4 (HCl)  

Synonym: GS-4997; GS4997; GS 4997; Selonsertib free base.

IUPAC/Chemical Name: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide

InChi Key: YIDDLAAKOYYGJG-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33)

SMILES Code: O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F

Description: Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.

1: Nelson CH, Wang L, Fang L, Weng W, Cheng F, Hepner M, Lin J, Garnett C, Ramanathan S. A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study. Clin Pharmacol Ther. 2015 Dec;98(6):630-8. doi: 10.1002/cpt.204. Epub 2015 Sep 29. PubMed PMID: 26259519.

2: Lin JH, Zhang JJ, Lin SL, Chertow GM. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. doi: 10.1159/000369152. Epub 2014 Dec 17. PubMed PMID: 25531162.

EOS Med Chem produce NLG919 (GDC-0919) 1402836-58-1 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok

Name: NLG919 (GDC-0919)

CAS#: 1402836-58-1

Chemical Formula: C18H22N2O

Exact Mass: 282.17321

Molecular Weight: 282.38

Elemental Analysis: C, 76.56; H, 7.85; N, 9.92; O, 5.67

EOS Med Chem produce NLG919 (GDC-0919) 1402836-58-1 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

NLG919 (GDC-0919) 1402836-58-1 Intermediates, EOS Med Chem have 8; NLG919 (GDC-0919) 1402836-58-1 Impurity we have 10, all from GMP, FDA plant.

Now NLG919 (GDC-0919) 1402836-58-1 DMF document is preparing.

Until 2016, Aug, NLG919 (GDC-0919) 1402836-58-1 more than produced 25kg API, 120kg Intermediates

NLG-919 API and  intermediates 96797-15-8 ≥98.0% 4-Iodo-1-tritylimidazole

NLG-920 API and  intermediates 40138-16-7 ≥98.0% 2-Formylbenzeneboronic acid

NLG-921 API and  intermediates 1402838-08-7 ≥98.0% 2-(1-trityl-1H-imidazol-4-yl)benzaldehyde

Synonym: GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078.

IUPAC/Chemical Name: 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

SMILES Code: OC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4

Description: GDC-0919, also known as NLG919 and RG6078, is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, NLG919 targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells.

1: Li M, Bolduc AR, Hoda MN, Gamble DN, Dolisca SB, Bolduc AK, Hoang K, Ashley C, McCall D, Rojiani AM, Maria BL, Rixe O, MacDonald TJ, Heeger PS, Mellor AL, Munn  DH, Johnson TS. The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. J Immunother Cancer. 2014 Jul 7;2:21. doi: 10.1186/2051-1426-2-21.  eCollection 2014. PubMed PMID: 25054064; PubMed Central PMCID: PMC4105871.

EOS Med Chem produce Carfilzomib in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok

EOS Med Chem produce Carfilzomib in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Carfilzomib Intermediates, EOS Med Chem have 8; Carfilzomib Impurity we have 10, all from GMP, FDA plant.

Now Carfilzomib DMF document is preparing.

Until 2016, Aug, Carfilzomib more than produced 25kg API, 120kg Intermediates

Carfilzomib API and  intermediates 247068-85-5 ≥99.0% (2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone trifluoroacetate

Carfilzomib API and  intermediates 868540-16-3 ≥99.0% (alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-L-phenylalanine

Name: Carfilzomib (PR171)

CAS#: 868540-17-4

Chemical Formula: C40H57N5O7

Exact Mass: 719.4258

Molecular Weight: 719.91

Elemental Analysis: C, 66.73; H, 7.98; N, 9.73; O, 15.56

Synonym: PR171; PR-171; PR 171; Carflizomib. brand name: Kyprolis

IUPAC/Chemical Name: (S)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

SMILES Code: CC(C)C[C@H](NC([C@@H](NC(CN1CCOCC1)=O)CCC2=CC=CC=C2)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C([C@]4(C)OC4)=O)=O)=O.

Description: Carfilzomib, also known as PR-171, is a tetrapeptide epoxyketone and an epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. Carfilzomib was approved by the FDA for use in patients with relapsed and refractory multiple myeloma on 20 July 2012.

According to Wikipedia, Carfilzomib is derived from epoxomicin, a natural product that was shown by the laboratory of Craig Crews at Yale University to inhibit the proteasome.  The Crews laboratory subsequently invented a more specific derivative of epoxomicin named YU101, which was licensed to Proteolix, Inc.. Scientists at Proteolix modified YU101 to create carfilzomib, which they advanced to multiple Phase 1 and 2 clinical trials, including a pivotal Phase 2 clinical trial designed to seek accelerated approval. Clinical trials for carfilzomib continue under Onyx Pharmaceuticals, which acquired Proteolix in 2009. In January 2011, the U.S. FDA granted carfilzomib fast-track status, allowing Onyx to initiate a rolling submission of its new drug application for carfilzomib. In December 2011, the FDA granted Onyx standard review designation,  for its new drug application submission based on the 003-A1 study, an open-label, single-arm Phase 2b trial. The trial evaluated 266 heavily-pretreated patients with relapsed and refractory multiple myeloma who had received at least two prior therapies, including bortezomib and either thalidomide or lenalidomide. Carfilzomib was approved by the FDA for use in patients with relapsed and refractory multiple myeloma on 20 July 2012.  Onyx expects to launch the drug in the U.S. on 1 August 2012. When it launches, it will cost $10,000 per 28-day cycle, making it the most expensive FDA-approved drug for multiple myeloma.  (source: http://en.wikipedia.org/wiki/Carfilzomib).

  

Carfilzomib is a next generation proteasome inhibitor that selectively targets the proteasome with minimal affinity for off-target proteases. To date, carfilzomib has generated a positive signal in multiple early-stage studies with an encouraging safety profile, including low rates of neuropathy, a known side effect of some approved multiple myeloma therapies. Carfilzomib primarily targets the chymotrypsin-like (CT-L) subunits in both the constitutive proteasome (c20S) and the immunoproteasome (i20S).

  

About epoxomicin : Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. It was originally discovered in 1992. (source: http://en.wikipedia.org/wiki/Epoxomicin).  Epoxomicin  has the following chemical name: (2S,3S)-N-((2S,3R)-3-hydroxy-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxobutan-2-yl)-3-methyl-2-((2S,3S)-3-methyl-2-(N-methylacetamido)pentanamido)pentanamide.

  

epoxomicin :

  

  

Chemical Formula: C28H50N4O7

Exact Mass: 554.36795

Molecular Weight: 554.72

Elemental Analysis: C, 60.63; H, 9.09; N, 10.10; O, 20.19

  

Carfilzomib is an epoxomicin derivative. Structurally, carfilzomib possesses the molecular backbone of epoxomicin with 5 different substituted group (see the following graphic A, B, C, D, and E).

  

  

  

REFERENCES

1: Kim KB, Crews CM. From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes. Nat Prod Rep. 2013 May;30(5):600-4. doi: 10.1039/c3np20126k. Review. PubMed PMID: 23575525; PubMed Central PMCID: PMC3815659.

2: Kortuem KM, Stewart AK. Carfilzomib. Blood. 2013 Feb 7;121(6):893-7. doi: 10.1182/blood-2012-10-459883. Review. PubMed PMID: 23393020.

3: Thompson JL. Carfilzomib: a second-generation proteasome inhibitor for the treatment of relapsed and refractory multiple myeloma. Ann Pharmacother. 2013 Jan;47(1):56-62. doi: 10.1345/aph.1R561. Epub 2013 Jan 8. Review. PubMed PMID: 23300152.

4: Carfilzomib (Kryprolis) for multiple myeloma. Med Lett Drugs Ther. 2012 Dec 24;54(1406):103-4. Review. PubMed PMID: 23282792.

5: McCormack PL. Carfilzomib: in relapsed, or relapsed and refractory, multiple myeloma. Drugs. 2012 Oct 22;72(15):2023-32. doi: 10.2165/11209010-000000000-00000. Review. PubMed PMID: 22994535.

6: Kuhn DJ, Orlowski RZ, Bjorklund CC. Second generation proteasome inhibitors: carfilzomib and immunoproteasome-specific inhibitors (IPSIs). Curr Cancer Drug Targets. 2011 Mar;11(3):285-95. Review. PubMed PMID: 21247387.

EOS Med Chem produce Afatinib in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok

EOS Med Chem produce Afatinib in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Afatinib Intermediates, EOS Med Chem have 8; Afatinib Impurity we have 10, all from GMP, FDA plant.

Now Afatinib DMF document is preparing.

Until 2016, Aug, Afatinib more than produced 25kg API, 120kg Intermediates

Afatinib API and   intermediates 848133-35-7 ≥98.0% trans-4-Dimethylaminocrotonic acid hydrochloride

Afatinib API and   intermediates 13991-36-1 ≥98.0% 4-Bromocrotonic Acid

Afatinib API and   intermediates 162012-69-3 ≥98.0% 7-Fluoro-6-nitro-4-hydroxyquinazoline

Afatinib API and   intermediates 162012-67-1 ≥98.0% 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

Afatinib API and   intermediates 179552-73-9 ≥98.0% 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

Name: Afatinib free base

CAS#: 439081-18-2 (free base)

Chemical Formula: C24H25ClFN5O3

Exact Mass: 485.163

Molecular Weight: 485.94

Elemental Analysis: C, 59.32; H, 5.19; Cl, 7.30; F, 3.91; N, 14.41; O, 9.88

Description: Afatinib, also know as BIBW 2992, is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. EGFR/HER2 tyrosine kinase inhibitor BIBW 2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. Afatinib is approved in much of the world (including the United States, Canada, the United Kingdom and Australia) for the treatment of metastatic non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an angiokinase inhibitor.

Synonym: BIBW-2992; BIBW 2992; BIBW2992. Afatinib free base; trade name: Gilotrif, Tomtovok and Tovok.

IUPAC/Chemical Name: (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide.

SMILES Code: O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/CN(C)C

Related:

439081-18-2(Afatinib free base);

850140-73-7 (Afatinib dimaleate)

As of July 2012, it is undergoing Phase III clinical trials for this indication and breast cancer, as well as Phase II trials for prostate  and head and neck cancer,  and a Phase I glioma trial.  Afatinib is not a first-line treatment; it is only used after other therapies have failed. In October 2010 a Phase III trial in NSCLC patients called Lux-Lung 5 began with this drug. Fall 2010 interim results suggested the drug extended progression-free survival threefold compared to placebo, but did not extend overall survival.  In May 2012, the Phase IIb/III trial Lux-Lung 1 came to the same conclusion. Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib. Double-blind Phase III trials are under way to confirm or refute this finding. Her2-negative breast cancers showed limited or no response to the drug.

  

  

REFERENCES

 1: Belani CP. The role of irreversible EGFR inhibitors in the treatment of non-small cell lung cancer: overcoming resistance to reversible EGFR inhibitors. Cancer Invest. 2010 May;28(4):413-23. Review. PubMed PMID: 20307200.

2: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Dec;31(10):661-700. PubMed PMID: 20140276.

3: Gazdar AF. Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev. 2010 Mar;29(1):37-48. Review. PubMed PMID: 20127143.

4: Sos ML, Rode HB, Heynck S, Peifer M, Fischer F, Klüter S, Pawar VG, Reuter C, Heuckmann JM, Weiss J, Ruddigkeit L, Rabiller M, Koker M, Simard JR, Getlik M, Yuza Y, Chen TH, Greulich H, Thomas RK, Rauh D. Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation. Cancer Res. 2010 Feb 1;70(3):868-74. Epub 2010 Jan 26. PubMed PMID: 20103621.

5: Doebele RC, Oton AB, Peled N, Camidge DR, Bunn PA Jr. New strategies to overcome limitations of reversible EGFR tyrosine kinase inhibitor therapy in non-small cell lung cancer. Lung Cancer. 2010 Jan 19. [Epub ahead of print] PubMed PMID: 20092908.

6: Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009 Oct;119(10):3000-10. doi: 10.1172/JCI38746. Epub 2009 Sep 14. PubMed PMID: 19759520; PubMed Central PMCID: PMC2752070.

7: Ocaña A, Amir E. Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions. Cancer Treat Rev. 2009 Dec;35(8):685-91. Epub 2009 Sep 4. Review. PubMed PMID: 19733440.

8: Nguyen KS, Kobayashi S, Costa DB. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer. 2009 Jul;10(4):281-9. Review. PubMed PMID: 19632948; PubMed Central PMCID: PMC2758558.

9: Perera SA, Li D, Shimamura T, Raso MG, Ji H, Chen L, Borgman CL, Zaghlul S, Brandstetter KA, Kubo S, Takahashi M, Chirieac LR, Padera RF, Bronson RT, Shapiro GI, Greulich H, Meyerson M, Guertler U, Chesa PG, Solca F, Wistuba II, Wong KK. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):474-9. Epub 2009 Jan 2. PubMed PMID: 19122144; PubMed Central PMCID: PMC2626727.

10: Minkovsky N, Berezov A. BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors. Curr Opin Investig Drugs. 2008 Dec;9(12):1336-46. Review. PubMed PMID: 19037840.

EOS Med Chem produce Crizotinib 877399-52-5 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok

EOS Med Chem produce Crizotinib 877399-52-5 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Crizotinib 877399-52-5 Intermediates, EOS Med Chem have 8; Crizotinib 877399-52-5 Impurity we have 10, all from GMP, FDA plant.

Now Crizotinib 877399-52-5 DMF document is preparing.

Until 2016, Aug, Crizotinib 877399-52-5 more than produced 25kg API, 120kg Intermediates

Crizotinib API and  intermediates 877397-65-4 ≥98.0% (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Crizotinib API and  intermediates 330156-50-8 ≥98.0% (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Crizotinib API and  intermediates 756520-66-8 ≥98.0% Benzenemethanol,2,6-dichloro-3-fluoro-a-methyl-

Crizotinib API and  intermediates 877399-00-3 ≥98.0% [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine

Name: Crizotinib

CAS#: 877399-52-5

Chemical Formula: C21H22Cl2FN5O

Exact Mass: 449.11854

Molecular Weight: 450.34

Elemental Analysis: C, 56.01; H, 4.92; Cl, 15.74; F, 4.22; N, 15.55; O, 3.55

Description: Crizotinib, also known as PF-02341066, is an orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. Crizotinib was approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and childre. Crizotinib inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations. Crizotinib was approved in 2011.

Synonym: PF02341066; PF-02341066; PF 02341066; PF2341066; PF-2341066; PF 2341066; Crizotinib; US brand name: Xalkori;

IUPAC/Chemical Name: (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

SMILES Code: NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@@H](C4=C(Cl)C=CC(F)=C4Cl)C

1.  Crizotinib's phyisical and chemical properties:

Crizotinib is a white to pale-yellow powder with a pKa of 9.4 (piperidinium cation) and 5.6 (pyridinium cation).

    

2 . The solubility of crizotinib:

The solubility of crizotinib in aqueous media decreases over the range pH 1.6 to pH 8.2 from greater than 10 mg/mL to less than 0.1 mg/mL. The log of the distribution coefficient (octanol/water) at pH 7.4 is 1.65.

  

3. Mechanism of action:

Crizotinib is an inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), and Recepteur d'Origine Nantais (RON). Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases . Crizotinib demonstrated concentration-dependent inhibition of ALK and c-Met phosphorylation in cell-based assays using tumor cell lines and demonstrated antitumor activity in mice bearing tumor xenografts that expressed EML4- or NPM-ALK fusion proteins or c-Met.

  

Crizotinib also inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms. Crizotinib is currently thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells. Other studies suggest that crizotinib may also act via inhibition of angiogenesis in malignant tumors.(source: http://en.wikipedia.org/wiki/Crizotinib).

On August 26, 2011, the U.S. Food and Drug Administration approved crizotinib (Xalkori) to treat certain late-stage (locally advanced or metastatic) non-small cell lung cancers that express the abnormal anaplastic lymphoma kinase (ALK) gene.

      

REFERENCES

1: Ou SH, Tong WP, Azada M, Siwak-Tapp C, Dy J, Stiber JA. Heart rate decrease during crizotinib treatment and potential correlation to clinical response. Cancer. 2013 Mar 15. doi: 10.1002/cncr.28040. [Epub ahead of print] PubMed PMID: 23505007.

2: Kaneda H, Okamoto I, Nakagawa K. Rapid Response of Brain Metastasis to Crizotinib in a Patient with ALK Rearrangement-Positive Non-Small-Cell Lung Cancer. J Thorac Oncol. 2013 Apr;8(4):e32-3. doi: 10.1097/JTO.0b013e3182843771. PubMed PMID: 23486271.

3: Maillet D, Martel-Lafay I, Arpin D, Pérol M. Ineffectiveness of Crizotinib on Brain Metastases in Two Cases of Lung Adenocarcinoma with EML4-ALK Rearrangement. J Thorac Oncol. 2013 Apr;8(4):e30-1. doi: 10.1097/JTO.0b013e318288dc2d. PubMed PMID: 23486270.

4: Pilotto S, Peretti U, Novello S, Rossi G, Milella M, Giaj Levra M, Ciuffreda L, Massari F, Brunelli M, Tortora G, Bria E. PROFILing non-small-cell lung cancer patients for treatment with crizotinib according to anaplastic lymphoma kinase abnormalities: translating science into medicine. Expert Opin Pharmacother. 2013 Apr;14(5):597-608. doi: 10.1517/14656566.2013.778828. Epub 2013 Mar 9. PubMed PMID: 23472711.

5: Sun Y, Nowak KA, Zaorsky NG, Winchester CL, Dalal K, Giacalone NJ, Liu N, Werner-Wasik M, Wasik MA, Dicker AP, Lu B. ALK inhibitor PF02341066 (crizotinib) increases sensitivity to radiation in non-small cell lung cancer expressing EML4-ALK. Mol Cancer Ther. 2013 Feb 26. [Epub ahead of print] PubMed PMID: 23443800.

6: Huang D, Kim DW, Kotsakis A, Deng S, Lira P, Ho SN, Lee NV, Vizcarra P, Cao JQ, Christensen JG, Kim TM, Sun JM, Ahn JS, Ahn MJ, Park K, Mao M. Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment. Genomics. 2013 Feb 20. doi:pii: S0888-7543(13)00034-7. 10.1016/j.ygeno.2013.02.006. [Epub ahead of print] PubMed PMID: 23434628.

7: Zheng X, He K, Zhang L, Yu J. Crizotinib induces PUMA-dependent apoptosis in colon cancer cells. Mol Cancer Ther. 2013 Feb 20. [Epub ahead of print] PubMed PMID: 23427294.

8: Srivastava N, VanderLaan PA, Kelly CP, Costa DB. Esophagitis: a novel adverse event of crizotinib in a patient with ALK-positive non-small-cell lung cancer. J Thorac Oncol. 2013 Mar;8(3):e23-4. doi: 10.1097/JTO.0b013e31827e2451. PubMed PMID: 23407563.

9: Browning ET, Weickhardt AJ, Camidge DR. Response to crizotinib rechallenge after initial progression and intervening chemotherapy in ALK lung cancer. J Thorac Oncol. 2013 Mar;8(3):e21. doi: 10.1097/JTO.0b013e31827a892c. PubMed PMID: 23407562.

10: Nonaka S, Yamaguchi S, Nagasawa T, Tahara M. [Pharmacology profile of crizotinib (Xalkori(®)Capsules) and clinical findings on this drug]. Nihon Yakurigaku Zasshi. 2013 Feb;141(2):106-13. Japanese. PubMed PMID: 23391552.

EOS Med Chem produce 60410-16-4 to be China biggest

CBNumber: CB3434428
Chemical Name: (1R,3S)-4-CYCLOPENTENE-1,3-DIOL 1-ACETATE
Molecular Formula: C7H10O3
Formula Weight: 142.15
CAS No.: 60410-16-4

EOS Med Chem produce 60410-16-4 to be China biggest.
60410-16-4 HPLC 99%, NMR, MS, COA is OK.
60410-16-4 Size batch could be 100kg.

EOS Med Chem produce 64248-60-8 2,6-Difluorobenzotrifluoride to be China biggest

EOS Med Chem produce 64248-60-8 2,6-Difluorobenzotrifluoride to be China biggest.

64248-60-8 2,6-Difluorobenzotrifluoride HPLC 99%, NMR, MS, COA is OK.

64248-60-8 2,6-Difluorobenzotrifluoride Size batch could be 1000kg.

331-25-9 3-Fluorophenylacetic acid Assay more than 99%, NMR, HPLC, MS is ok

Since 2008, we start to produce 331-25-9 3-Fluorophenylacetic acid, until 2016, we could be 331-25-9 3-Fluorophenylacetic acid one of world biggest supplier.

Each year, we exported more than 10T to all the world.

My standard could be Japan stand.

331-25-9 3-Fluorophenylacetic acid Assay more than 99%, NMR, HPLC, MS is ok.

Glad to serve you.

HBTU biggest supplier

HBTU 94790-37-1 is a commonly used coupling reagent, and can be used in solid phase peptide synthesis. It is reported to convert carboxylic acids into azides efficiently and practically. This process may be used with a wide range of carboxylic acids including N-protected amino acids. It has also been reported to be useful in one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from acids.

1. Sureshbabu, V.V., et al. 2010. Org. Biomol. Chem. 8: 835-840. PMID: 20135041

EOS Med Chem produce HBTU 94790-37-1 to be China biggest.

HBTU 94790-37-1 HPLC 99%, NMR, MS, COA is OK.

HBTU 94790-37-1 Size batch could be 100kg.

HATU biggest

Name: HATU

CAS#: 148893-10-1

Chemical Formula: C10H15F6N6OP

Exact Mass:

Molecular Weight: 380.24

Elemental Analysis: C, 31.59; H, 3.98; F, 29.98; N, 22.10; O, 4.21; P, 8.15

Synonym: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide

IUPAC/Chemical Name: [dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium;hexafluorophosphate

SMILES Code: C/[N+](C)=C(N(C)C)\ON1N=NC2=CC=CN=C21.F[P-](F)(F)(F)(F)F

Description: HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds. Generally DMF is used as solvent, although other polar organic solvents can also be used. (Source: https://en.wikipedia.org/wiki/HATU).

1: Aaronson JG, Klein LJ, Momose AA, O'Brien AM, Shaw AW, Tucker TJ, Yuan Y, Tellers DM. Rapid HATU-mediated solution phase siRNA conjugation. Bioconjug Chem. 2011 Aug 17;22(8):1723-8. doi: 10.1021/bc2001227. Epub 2011 Jul 11. PubMed PMID: 21744777.

2: Hołyńska M, Kubiak M. Supramolecular motifs in the first structures of organic carboxylate salts of 1-(diaminomethylene)thiourea (HATU). Acta Crystallogr C. 2009 Aug;65(Pt 8):o410-3. doi: 10.1107/S0108270109026390. Epub 2009 Jul 15. PubMed PMID: 19652326.

3: Xiao Z, Yang MG, Li P, Carter PH. Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines. Org Lett. 2009 Mar 19;11(6):1421-4. doi: 10.1021/ol802946p. PubMed PMID: 19243133.

4: Yung A, Papworth-Smith J, Wilkinson SM. Occupational contact urticaria from the solid-phase peptide synthesis coupling agents HATU and HBTU. Contact Dermatitis. 2003 Aug;49(2):108-9. PubMed PMID: 14641366.

EOS Med Chem Feb New list

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EOS Med Chem, Medicinal Chemical is Big NUTLIN 3B 675576-97-3
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EOS Med Chem, Medicinal Chemical is Big （+）-JQ1 1268524-70-4
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EOS Med Chem, Medicinal Chemical is Big LY2784544 1229236-86-5
EOS Med Chem, Medicinal Chemical is Big MK-0752 471905-41-6
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EOS Med Chem, Medicinal Chemical is Big TAK875 1374598-80-7
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EOS Med Chem, Medicinal Chemical is Big LY2109761 700874-71-1
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EOS Med Chem, Medicinal Chemical is Big PD153035 183322-45-4
EOS Med Chem, Medicinal Chemical is Big WZ4002 1213269-23-8
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EOS Med Chem, Medicinal Chemical is Big Rociletinib (CO-1686, AVL-301) 1374640-70-6
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EOS Med Chem, Medicinal Chemical is Big Danoprevir (ITMN-191) 850876-88-9
EOS Med Chem, Medicinal Chemical is Big Tivozanib (AV-951) 475108-18-0
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EOS Med Chem, Medicinal Chemical is Big TAK901 934541-31-8
EOS Med Chem, Medicinal Chemical is Big PNU282987 123464-89-1
EOS Med Chem, Medicinal Chemical is Big CX-4945 (Silmitasertib) 1009820-21-6
EOS Med Chem, Medicinal Chemical is Big OTX-015 202590-98-5
EOS Med Chem, Medicinal Chemical is Big PF-3758309 898044-15-0
EOS Med Chem, Medicinal Chemical is Big CGK733 905973-89-9 
EOS Med Chem, Medicinal Chemical is Big SB202190 152121-30-7
EOS Med Chem, Medicinal Chemical is Big BMS-833923 1059734-66-5
EOS Med Chem, Medicinal Chemical is Big Tenovin-6 1011557-82-6
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EOS Med Chem, Medicinal Chemical is Big Icotinib (Hydrochloride) 1204313-51-8
EOS Med Chem, Medicinal Chemical is Big MBX-2982 1037792-44-1
EOS Med Chem, Medicinal Chemical is Big BX-795 702675-74-9
EOS Med Chem, Medicinal Chemical is Big BX-912 702674-56-4
EOS Med Chem, Medicinal Chemical is Big UNC1215 1415800-43-9
EOS Med Chem, Medicinal Chemical is Big TGR5 1197300-24-5
EOS Med Chem, Medicinal Chemical is Big NSI189 1270138-40-3
EOS Med Chem, Medicinal Chemical is Big AGI-6780 1432660-47-3
EOS Med Chem, Medicinal Chemical is Big S1RA 878141-96-9
EOS Med Chem, Medicinal Chemical is Big AR-A014418 487021-52-3
EOS Med Chem, Medicinal Chemical is Big SKLB610 1125780-41-7
EOS Med Chem, Medicinal Chemical is Big JNJ26854165 881202-45-5
EOS Med Chem, Medicinal Chemical is Big XL019 945755-56-6
EOS Med Chem, Medicinal Chemical is Big Fulvestrant 129453-61-8
EOS Med Chem, Medicinal Chemical is Big BMS754807 1001350-96-4
EOS Med Chem, Medicinal Chemical is Big IOWH032 1191252-49-9
EOS Med Chem, Medicinal Chemical is Big CNX-774 1202759-32-7
EOS Med Chem, Medicinal Chemical is Big PF03716556 928774-43-0
EOS Med Chem, Medicinal Chemical is Big Avagacestat(BMS-708163) 1146699-66-2
EOS Med Chem, Medicinal Chemical is Big Wnt-c59 1243243-89-1
EOS Med Chem, Medicinal Chemical is Big Capmatinib (INCB28060) 1029712-80-8
EOS Med Chem, Medicinal Chemical is Big Flumatinib mesylate 895519-91-2
EOS Med Chem, Medicinal Chemical is Big ZCL278 587841-73-4
EOS Med Chem, Medicinal Chemical is Big Atglistatin 1469924-27-3
EOS Med Chem, Medicinal Chemical is Big VU0364439 1246086-78-1
EOS Med Chem, Medicinal Chemical is Big GS9620 1228585-88-3
EOS Med Chem, Medicinal Chemical is Big Tirasemtiv(CK-2017357) 1005491-05-3
EOS Med Chem, Medicinal Chemical is Big SYR472 1029877-94-8
EOS Med Chem, Medicinal Chemical is Big MK8745 885325-71-3
EOS Med Chem, Medicinal Chemical is Big AZD5438 602306-29-6
EOS Med Chem, Medicinal Chemical is Big Glasdegib (PF-04449913) 1095173-27-5
EOS Med Chem, Medicinal Chemical is Big KN-93 Phosphate 1188890-41-6
EOS Med Chem, Medicinal Chemical is Big SCH772984 942183-80-4
EOS Med Chem, Medicinal Chemical is Big P 22077 1247819-59-5
EOS Med Chem, Medicinal Chemical is Big P005091 882257-11-6
EOS Med Chem, Medicinal Chemical is Big KY02111 1118807-13-8
EOS Med Chem, Medicinal Chemical is Big IU1 314245-33-5
EOS Med Chem, Medicinal Chemical is Big Scriptaid 287383-59-9
EOS Med Chem, Medicinal Chemical is Big HBX 41108 924296-39-9
EOS Med Chem, Medicinal Chemical is Big Epothilone B 152044-54-7
EOS Med Chem, Medicinal Chemical is Big Epothilone A 152044-53-6
EOS Med Chem, Medicinal Chemical is Big Oligomycin A 579-13-5
EOS Med Chem, Medicinal Chemical is Big Tubacin 537049-40-4
EOS Med Chem, Medicinal Chemical is Big IWP-L6 1427782-89-5
EOS Med Chem, Medicinal Chemical is Big SAL003 1164470-53-4
EOS Med Chem, Medicinal Chemical is Big N6022 1208315-24-5
EOS Med Chem, Medicinal Chemical is Big Plinabulin (NPI-2358) 714272-27-2
EOS Med Chem, Medicinal Chemical is Big PTC-209 315704-66-6
EOS Med Chem, Medicinal Chemical is Big 4EGI-1 315706-13-9
EOS Med Chem, Medicinal Chemical is Big Monomethyl auristatin E (MMAE) 474645-27-7
EOS Med Chem, Medicinal Chemical is Big AN2728 906673-24-3
EOS Med Chem, Medicinal Chemical is Big R788 (Fostamatinib) Disodium 1025687-58-4
EOS Med Chem, Medicinal Chemical is Big GNF-5 778277-15-9
EOS Med Chem, Medicinal Chemical is Big RO5126766（CH5126766） 946128-88-7
EOS Med Chem, Medicinal Chemical is Big Tubastatin A HCL 1310693-92-5
EOS Med Chem, Medicinal Chemical is Big PF-562271 HCl
EOS Med Chem, Medicinal Chemical is Big LY2811376 1194044-20-6
EOS Med Chem, Medicinal Chemical is Big GNE7915 1351761-44-8
EOS Med Chem, Medicinal Chemical is Big BMY7378 21102-95-4
EOS Med Chem, Medicinal Chemical is Big VS-5584 1246560-33-7
EOS Med Chem, Medicinal Chemical is Big TUG-770 1402601-82-4
EOS Med Chem, Medicinal Chemical is Big Rucaparib(AG-014699) 459868-92-9
EOS Med Chem, Medicinal Chemical is Big XMD8-92 1234480-50-2
EOS Med Chem, Medicinal Chemical is Big OG-L002 1357302-64-7
EOS Med Chem, Medicinal Chemical is Big ABT-346 1226895-20-0
EOS Med Chem, Medicinal Chemical is Big PPQ-102 931706-15-9
EOS Med Chem, Medicinal Chemical is Big AG-490(Tyrphostin B42) 133550-30-8
EOS Med Chem, Medicinal Chemical is Big RN486 1242156-23-5
EOS Med Chem, Medicinal Chemical is Big CID755673 521937-07-5
EOS Med Chem, Medicinal Chemical is Big ML167 1285702-20-6
EOS Med Chem, Medicinal Chemical is Big Cediranib (AZD2171) 288383-20-0
EOS Med Chem, Medicinal Chemical is Big ENMD-2076 934353-76-1
EOS Med Chem, Medicinal Chemical is Big Necrostatin-1 4311-88-0
EOS Med Chem, Medicinal Chemical is Big LH-846 639052-78-1
EOS Med Chem, Medicinal Chemical is Big ML323 1572414-83-5
EOS Med Chem, Medicinal Chemical is Big Alectinib (CH5424802) 1256580-46-7
EOS Med Chem, Medicinal Chemical is Big AGI-5198 1355326-35-0
EOS Med Chem, Medicinal Chemical is Big WHI-P154 211555-04-3
EOS Med Chem, Medicinal Chemical is Big Tariquidar 206873-63-4
EOS Med Chem, Medicinal Chemical is Big LY2835219 1231930-82-7
EOS Med Chem, Medicinal Chemical is Big CP640186 591778-68-6
EOS Med Chem, Medicinal Chemical is Big CX-6258 1202916-90-2
EOS Med Chem, Medicinal Chemical is Big TPT-260 769856-81-7
EOS Med Chem, Medicinal Chemical is Big Y320 288250-47-5
EOS Med Chem, Medicinal Chemical is Big Walrycin B 878419-78-4
EOS Med Chem, Medicinal Chemical is Big Balicatib(AAE-581) 354813-19-7
EOS Med Chem, Medicinal Chemical is Big Inauhzin(INZ) 309271-94-1
EOS Med Chem, Medicinal Chemical is Big Betrixaban 330942-05-7
EOS Med Chem, Medicinal Chemical is Big Dapivirine（TMC-120) 244767-67-7
EOS Med Chem, Medicinal Chemical is Big WZ811 55778-02-4
EOS Med Chem, Medicinal Chemical is Big PXD101(Beliomstat） 414864-00-9
EOS Med Chem, Medicinal Chemical is Big KPT-276 1421919-75-6
EOS Med Chem, Medicinal Chemical is Big CP-673451 343787-29-1
EOS Med Chem, Medicinal Chemical is Big KX1-004 518058-84-9
EOS Med Chem, Medicinal Chemical is Big INCB024360 914471-09-3
EOS Med Chem, Medicinal Chemical is Big PD-173955 260415-63-2
EOS Med Chem, Medicinal Chemical is Big SB334867 792173-99-0
EOS Med Chem, Medicinal Chemical is Big GNE-0877 1374828-69-9
EOS Med Chem, Medicinal Chemical is Big LY2979165 1311385-32-6
EOS Med Chem, Medicinal Chemical is Big SL327 305350-87-2
EOS Med Chem, Medicinal Chemical is Big Raltegravir（MK0518) 518048-05-0
EOS Med Chem, Medicinal Chemical is Big PD151746 179461-52-0
EOS Med Chem, Medicinal Chemical is Big Filgotinib (GLPG0634) 1206161-97-8
EOS Med Chem, Medicinal Chemical is Big GLPG0634 analogue 1206101-20-3
EOS Med Chem, Medicinal Chemical is Big CNX1351 1276105-89-5
EOS Med Chem, Medicinal Chemical is Big Perampanel 380917-97-5
EOS Med Chem, Medicinal Chemical is Big Macitentan 441798-33-0
EOS Med Chem, Medicinal Chemical is Big Bortezomib (PS-341) 179324-69-7
EOS Med Chem, Medicinal Chemical is Big UNC0631 1320288-19-4
EOS Med Chem, Medicinal Chemical is Big CTX0294885 1439934-41-4
EOS Med Chem, Medicinal Chemical is Big Axitinib 319460-85-0
EOS Med Chem, Medicinal Chemical is Big BEZ235(NVP-BEZ235) 915019-65-7
EOS Med Chem, Medicinal Chemical is Big XL388 1251156-08-7
EOS Med Chem, Medicinal Chemical is Big GNE-477 1032754-81-6
EOS Med Chem, Medicinal Chemical is Big KRN633 286370-15-8
EOS Med Chem, Medicinal Chemical is Big CGI-1746 910232-84-7
EOS Med Chem, Medicinal Chemical is Big Dorsomorphin 2HCl 1219168-18-9
EOS Med Chem, Medicinal Chemical is Big JSH-23 749886-87-1
EOS Med Chem, Medicinal Chemical is Big UNC2250 1493694-70-4
EOS Med Chem, Medicinal Chemical is Big AZ20 1233339-22-4
EOS Med Chem, Medicinal Chemical is Big PYR41 418805-02-4
EOS Med Chem, Medicinal Chemical is Big MS436 1395084-25-9
EOS Med Chem, Medicinal Chemical is Big SRPIN340 218156-96-8
EOS Med Chem, Medicinal Chemical is Big XCT790 725247-18-7
EOS Med Chem, Medicinal Chemical is Big BTB06584 219793-45-0
EOS Med Chem, Medicinal Chemical is Big DMH1 1206711-16-1
EOS Med Chem, Medicinal Chemical is Big LDN193189 1062368-24-4
EOS Med Chem, Medicinal Chemical is Big LDN-212854 1432597-26-6
EOS Med Chem, Medicinal Chemical is Big ML-347（LDN-193719） 1062368-49-3
EOS Med Chem, Medicinal Chemical is Big HJC-0350 885434-70-8
EOS Med Chem, Medicinal Chemical is Big MG149 1243583-85-8
EOS Med Chem, Medicinal Chemical is Big K02288 1431985-92-0
EOS Med Chem, Medicinal Chemical is Big BAY11-7085 196309-76-9
EOS Med Chem, Medicinal Chemical is Big RKI-1447 1342278-01-6
EOS Med Chem, Medicinal Chemical is Big JIB-04(NSC 693627) 199596-05-9
EOS Med Chem, Medicinal Chemical is Big SGI-1027 1020149-73-8
EOS Med Chem, Medicinal Chemical is Big CZC24832 1159824-67-5
EOS Med Chem, Medicinal Chemical is Big Dabrafenib（GSK2118436) 1195765-45-7
EOS Med Chem, Medicinal Chemical is Big FR180204 865362-74-9
EOS Med Chem, Medicinal Chemical is Big TP-808 852821-06-8
EOS Med Chem, Medicinal Chemical is Big YH239-EE 1364488-67-4
EOS Med Chem, Medicinal Chemical is Big Regadenoson 313348-27-5
EOS Med Chem, Medicinal Chemical is Big GSK2334470 1227911-45-6
EOS Med Chem, Medicinal Chemical is Big Empagliflozin 864070-44-0
EOS Med Chem, Medicinal Chemical is Big AZD1208 1204144-28-4
EOS Med Chem, Medicinal Chemical is Big GANT61 500579-04-4
EOS Med Chem, Medicinal Chemical is Big RGFP966 1396841-57-8
EOS Med Chem, Medicinal Chemical is Big Lenvatinib（E7080) 417716-92-8
EOS Med Chem, Medicinal Chemical is Big GNF-2 778270-11-4
EOS Med Chem, Medicinal Chemical is Big NLG919 1402836-58-1
EOS Med Chem, Medicinal Chemical is Big XEN445 1515856-92-4
EOS Med Chem, Medicinal Chemical is Big ABT-263 (Navitoclax) 923564-51-6
EOS Med Chem, Medicinal Chemical is Big ABT-199 (GDC-0199) 1257044-40-8
EOS Med Chem, Medicinal Chemical is Big ABT737 852808-04-9
EOS Med Chem, Medicinal Chemical is Big SB271046 209481-20-9
EOS Med Chem, Medicinal Chemical is Big Vicriviroc Malate 599179-03-0
EOS Med Chem, Medicinal Chemical is Big I-BET-762 1260907-17-2
EOS Med Chem, Medicinal Chemical is Big GSK126 1346574-57-9
EOS Med Chem, Medicinal Chemical is Big AUY922 (NVP-AUY922) 747412-49-3
EOS Med Chem, Medicinal Chemical is Big Zosuquidar (LY335979) 3HCl 167465-36-3
EOS Med Chem, Medicinal Chemical is Big VX661 1152311-62-0
EOS Med Chem, Medicinal Chemical is Big VE-821 1232410-49-9
EOS Med Chem, Medicinal Chemical is Big DCC-2036 (Rebastinib) 1020172-07-9
EOS Med Chem, Medicinal Chemical is Big AZD1480 935666-88-9
EOS Med Chem, Medicinal Chemical is Big BTZ043 Racemate 957217-65-1
EOS Med Chem, Medicinal Chemical is Big MG132 133407-82-6
EOS Med Chem, Medicinal Chemical is Big Nintedanib (BIBF 1120) 656247-17-5
EOS Med Chem, Medicinal Chemical is Big Linifanib (ABT-869) 796967-16-3
EOS Med Chem, Medicinal Chemical is Big Veliparib (ABT-888) 912444-00-9
EOS Med Chem, Medicinal Chemical is Big AG1024 65678-07-1
EOS Med Chem, Medicinal Chemical is Big Anacetrapib (MK-0859) 875446-37-0
EOS Med Chem, Medicinal Chemical is Big AP26113   1197958-12-5
EOS Med Chem, Medicinal Chemical is Big Apatinib 811803-05-1
EOS Med Chem, Medicinal Chemical is Big Apremilast (CC-10004) 608141-41-9
EOS Med Chem, Medicinal Chemical is Big AR-A014418 487021-52-3
EOS Med Chem, Medicinal Chemical is Big AT13387 912999-49-6
EOS Med Chem, Medicinal Chemical is Big AT-7867 857531-00-1
EOS Med Chem, Medicinal Chemical is Big AVL292 1202757-89-8
EOS Med Chem, Medicinal Chemical is Big AZ3146 1124329-14-1
EOS Med Chem, Medicinal Chemical is Big PF-05212384 (PKI-587) 1197160-78-3
EOS Med Chem, Medicinal Chemical is Big TG100-115 677297-51-7
EOS Med Chem, Medicinal Chemical is Big Belinostat (PXD101) 414864-00-9
EOS Med Chem, Medicinal Chemical is Big Avelestat (AZD9668) 848141-11-7
EOS Med Chem, Medicinal Chemical is Big Dabigatran (BIBR 953) 211914-51-1
EOS Med Chem, Medicinal Chemical is Big BIRB 796 (Doramapimod) 285983-48-4
EOS Med Chem, Medicinal Chemical is Big Birinapant 1260251-31-7
EOS Med Chem, Medicinal Chemical is Big Bosutinib (SKI-606) 380843-75-4
EOS Med Chem, Medicinal Chemical is Big Masitinib (AB1010) 790299-79-5
EOS Med Chem, Medicinal Chemical is Big BYL719 1217486-61-7
EOS Med Chem, Medicinal Chemical is Big Otenabant (CP-945598) HCl 686347-12-6
EOS Med Chem, Medicinal Chemical is Big CPI-613 95809-78-2
EOS Med Chem, Medicinal Chemical is Big CUDC-101 1012054-59-9
EOS Med Chem, Medicinal Chemical is Big CUDC-907 1339928-25-4
EOS Med Chem, Medicinal Chemical is Big DAPT (GSI-IX) 208255-80-5
EOS Med Chem, Medicinal Chemical is Big EX-527 49843-98-3
EOS Med Chem, Medicinal Chemical is Big Roxadustat (FG-4592) 808118-40-3
EOS Med Chem, Medicinal Chemical is Big Foretinib (GSK1363089) 849217-64-7
EOS Med Chem, Medicinal Chemical is Big Fingolimod (FTY720) HCl 162359-56-0
EOS Med Chem, Medicinal Chemical is Big Ipatasertib (GDC-0068) 1001264-89-6
EOS Med Chem, Medicinal Chemical is Big Gefitinib 184475-35-2
EOS Med Chem, Medicinal Chemical is Big Panobinostat (LBH589) 404950-80-7
EOS Med Chem, Medicinal Chemical is Big IC-87114 371242-69-2
EOS Med Chem, Medicinal Chemical is Big JNJ38877605 943540-75-8
EOS Med Chem, Medicinal Chemical is Big SGX-523 1022150-57-7
EOS Med Chem, Medicinal Chemical is Big JNJ7706621 443797-96-4
EOS Med Chem, Medicinal Chemical is Big JZL184 1101854-58-3
EOS Med Chem, Medicinal Chemical is Big KU-55933 (ATM Kinase Inhibitor) 587871-26-9
EOS Med Chem, Medicinal Chemical is Big Lapatinib 231277-92-2
EOS Med Chem, Medicinal Chemical is Big LY294002 154447-36-6
EOS Med Chem, Medicinal Chemical is Big LY2608204 1234703-40-2
EOS Med Chem, Medicinal Chemical is Big LY2874455 1254473-64-7
EOS Med Chem, Medicinal Chemical is Big LY404039 635318-11-5
EOS Med Chem, Medicinal Chemical is Big MC1568 852475-26-4
EOS Med Chem, Medicinal Chemical is Big Nepicastat (SYN-117) HCl 170151-24-3
EOS Med Chem, Medicinal Chemical is Big Nilotinib (AMN-107) 641571-10-0
EOS Med Chem, Medicinal Chemical is Big NU-7441 503468-95-9
EOS Med Chem, Medicinal Chemical is Big BKM120 (NVP-BKM120, Buparlisib) 944396-07-0
EOS Med Chem, Medicinal Chemical is Big IWR-1-endo 1127442-82-3
EOS Med Chem, Medicinal Chemical is Big Palomid 529 (P529) 914913-88-5
EOS Med Chem, Medicinal Chemical is Big Pazopanib 444731-52-6
EOS Med Chem, Medicinal Chemical is Big PCI-24781 783355-60-2
EOS Med Chem, Medicinal Chemical is Big PD0325901 391210-10-9 
EOS Med Chem, Medicinal Chemical is Big PD98059 167869-21-8
EOS Med Chem, Medicinal Chemical is Big Danusertib (PHA-739358) 827318-97-8
EOS Med Chem, Medicinal Chemical is Big PHA-665752 477575-56-7
EOS Med Chem, Medicinal Chemical is Big SB431542 301836-41-9
EOS Med Chem, Medicinal Chemical is Big SNS-314 Mesylate 1146618-41-8
EOS Med Chem, Medicinal Chemical is Big SU11274 658084-23-2
EOS Med Chem, Medicinal Chemical is Big Sunitinib Malate 341031-54-7
EOS Med Chem, Medicinal Chemical is Big Telaprevir(VX950) 402957-28-2
EOS Med Chem, Medicinal Chemical is Big Telatinib(BAY57-9352) 332012-40-5
EOS Med Chem, Medicinal Chemical is Big TW-37 877877-35-5
EOS Med Chem, Medicinal Chemical is Big MLN0905 1228960-69-7
EOS Med Chem, Medicinal Chemical is Big Eltrombopag 496775-61-2
EOS Med Chem, Medicinal Chemical is Big GSK1292263 1032823-75-8
EOS Med Chem, Medicinal Chemical is Big Dalcetrapib (JTT-705, RO4607381) 211513-37-0
EOS Med Chem, Medicinal Chemical is Big A-674563 552325-73-2
EOS Med Chem, Medicinal Chemical is Big Dacomitinib (PF299804, PF299) 1110813-31-4
EOS Med Chem, Medicinal Chemical is Big AZD2014 1009298-59-2
EOS Med Chem, Medicinal Chemical is Big ARN-509 956104-40-8
EOS Med Chem, Medicinal Chemical is Big TAK438 1260141-27-2
EOS Med Chem, Medicinal Chemical is Big LX4211 1018899-04-1
EOS Med Chem, Medicinal Chemical is Big RAF265 (CHIR-265) 927880-90-8
EOS Med Chem, Medicinal Chemical is Big CPI-203 1446144-04-2
EOS Med Chem, Medicinal Chemical is Big AT9283 896466-04-9
EOS Med Chem, Medicinal Chemical is Big Rolapitant 552292-08-7
EOS Med Chem, Medicinal Chemical is Big VX809 936727-05-8
EOS Med Chem, Medicinal Chemical is Big LY341495 201943-63-7
EOS Med Chem, Medicinal Chemical is Big SB1317（TG02） 1204918-72-8
EOS Med Chem, Medicinal Chemical is Big AT406 1071992-99-8
EOS Med Chem, Medicinal Chemical is Big Lomeguatrib（PaTrin-2） 192441-08-0
EOS Med Chem, Medicinal Chemical is Big KI8751 228559-41-9
EOS Med Chem, Medicinal Chemical is Big SAR245409 (XL765) 1349796-36-6
EOS Med Chem, Medicinal Chemical is Big Aprepitant（mk-0869 ） 170729-80-3
EOS Med Chem, Medicinal Chemical is Big PA-824 187235-37-6
EOS Med Chem, Medicinal Chemical is Big PQ401 196868-63-0
EOS Med Chem, Medicinal Chemical is Big LY303511 154447-38-8
EOS Med Chem, Medicinal Chemical is Big OSU-03012 742112-33-0
EOS Med Chem, Medicinal Chemical is Big IKK-16 (IKK Inhibitor VII) 873225-46-8
EOS Med Chem, Medicinal Chemical is Big P005672 HCl 1035979-44-2
EOS Med Chem, Medicinal Chemical is Big ZM39923 58753-54-1
EOS Med Chem, Medicinal Chemical is Big A-966492 934162-61-5
EOS Med Chem, Medicinal Chemical is Big DCC-2618 1225278-16-9
EOS Med Chem, Medicinal Chemical is Big Entinostat (MS-275, SNDX-275) 209783-80-2
EOS Med Chem, Medicinal Chemical is Big SRT1720 1001645-58-4
EOS Med Chem, Medicinal Chemical is Big AZ960 905586-69-8
EOS Med Chem, Medicinal Chemical is Big WZ8040 1214265-57-2
EOS Med Chem, Medicinal Chemical is Big Celocoxib 169590-42-5
EOS Med Chem, Medicinal Chemical is Big AS-605240 648450-29-7
EOS Med Chem, Medicinal Chemical is Big TCS1102 916141-36-1
EOS Med Chem, Medicinal Chemical is Big Vandetanib (ZD6474) 443913-73-3
EOS Med Chem, Medicinal Chemical is Big Roscovitine 186692-46-6
EOS Med Chem, Medicinal Chemical is Big Dovitinib (TKI-258, CHIR-258) 405169-16-6
EOS Med Chem, Medicinal Chemical is Big Nesbuvir 691852-58-1
EOS Med Chem, Medicinal Chemical is Big Talampanel（LY300164） 161832-65-1
EOS Med Chem, Medicinal Chemical is Big NVP-AAM077 459836-30-7
EOS Med Chem, Medicinal Chemical is Big SCH-420814 377727-87-2
EOS Med Chem, Medicinal Chemical is Big NMS-873 1418013-75-8
EOS Med Chem, Medicinal Chemical is Big AZD7545 252017-04-2
EOS Med Chem, Medicinal Chemical is Big Genz-123346 491833-30-8
EOS Med Chem, Medicinal Chemical is Big VE-822 1232416-25-9
EOS Med Chem, Medicinal Chemical is Big Reversine 656820-32-5
EOS Med Chem, Medicinal Chemical is Big Rigosertib (ON-01910) 1225497-78-8
EOS Med Chem, Medicinal Chemical is Big GDC-0994 1453848-26-4
EOS Med Chem, Medicinal Chemical is Big YM201636 371942-69-7
EOS Med Chem, Medicinal Chemical is Big VX-702 745833-23-2
EOS Med Chem, Medicinal Chemical is Big (-)-Huperzine A (HupA) 102518-79-6
EOS Med Chem, Medicinal Chemical is Big BAY57-1293 348086-71-5
EOS Med Chem, Medicinal Chemical is Big TMP269 1314890-29-3
EOS Med Chem, Medicinal Chemical is Big Everolimus (RAD001) 159351-69-6
EOS Med Chem, Medicinal Chemical is Big Tasisulam（LY573636） 519055-62-0
EOS Med Chem, Medicinal Chemical is Big SNS-032(BMS-387032) 345627-80-7
EOS Med Chem, Medicinal Chemical is Big Semaxanib (SU5416) 194413-58-6
EOS Med Chem, Medicinal Chemical is Big CCT007093 176957-55-4
EOS Med Chem, Medicinal Chemical is Big TMC647055 1204416-97-6
EOS Med Chem, Medicinal Chemical is Big LB42708 226929-39-1
EOS Med Chem, Medicinal Chemical is Big FH535 108409-83-2
EOS Med Chem, Medicinal Chemical is Big FLI-06 313967-18-9
EOS Med Chem, Medicinal Chemical is Big HA14-1 65673-63-4
EOS Med Chem, Medicinal Chemical is Big RITA (NSC 652287) 213261-59-7
EOS Med Chem, Medicinal Chemical is Big Tenovin-1 380315-80-0
EOS Med Chem, Medicinal Chemical is Big PR-619 2645-32-1
EOS Med Chem, Medicinal Chemical is Big PluriSln 1 91396-88-2
EOS Med Chem, Medicinal Chemical is Big UNC699 1314241-44-5
EOS Med Chem, Medicinal Chemical is Big NSC405020 7497=07=6
EOS Med Chem, Medicinal Chemical is Big TDZD-8 327036-89-5
EOS Med Chem, Medicinal Chemical is Big Mps1-in-2 1228817-38-6
EOS Med Chem, Medicinal Chemical is Big LXR623 875787-07-8
EOS Med Chem, Medicinal Chemical is Big OC000459 851723-84-7
EOS Med Chem, Medicinal Chemical is Big OSI027 936890-98-1
EOS Med Chem, Medicinal Chemical is Big AVP-AEW541 475489-16-8
EOS Med Chem, Medicinal Chemical is Big GSK1838705A 1116235-97-2
EOS Med Chem, Medicinal Chemical is Big E-3810（Lucitanib） 1058137-23-7
EOS Med Chem, Medicinal Chemical is Big Pimecrolimus 137071-32-0
EOS Med Chem, Medicinal Chemical is Big Talabostat mesilate 150080-09-4
EOS Med Chem, Medicinal Chemical is Big Ximelagatran 192939-46-1
EOS Med Chem, Medicinal Chemical is Big Vilanterol 503068-34-6
EOS Med Chem, Medicinal Chemical is Big Nolatrexed (AG-337) 152946-68-4
EOS Med Chem, Medicinal Chemical is Big MK-0524 571170-77-9
EOS Med Chem, Medicinal Chemical is Big Temsirolimus 162635-04-3
EOS Med Chem, Medicinal Chemical is Big PAC-1 315183-21-2
EOS Med Chem, Medicinal Chemical is Big MGCD265 875337-44-3
EOS Med Chem, Medicinal Chemical is Big OTSSP167 hcl 1431697-89-0
EOS Med Chem, Medicinal Chemical is Big GNE9605 1536200-31-3
EOS Med Chem, Medicinal Chemical is Big UNC-0379 1620401-82-2
EOS Med Chem, Medicinal Chemical is Big UNC2025 1429881-91-3
EOS Med Chem, Medicinal Chemical is Big XMD-17-51
EOS Med Chem, Medicinal Chemical is Big NVP-BEP800 847559-80-2
EOS Med Chem, Medicinal Chemical is Big SB743921 940929-33-9
EOS Med Chem, Medicinal Chemical is Big Ixazomib (MLN2238) 1072833-77-2
EOS Med Chem, Medicinal Chemical is Big MLN9708 1201902-80-8
EOS Med Chem, Medicinal Chemical is Big Ispinesib(SB-715992) 336113-53-2
EOS Med Chem, Medicinal Chemical is Big PHA-793887 718630-59-2
EOS Med Chem, Medicinal Chemical is Big PSI-6206 863329-66-2
EOS Med Chem, Medicinal Chemical is Big GSK923295 1088965-37-0
EOS Med Chem, Medicinal Chemical is Big NVP-ADW742 475488-23-4
EOS Med Chem, Medicinal Chemical is Big SC-514 354812-17-2
EOS Med Chem, Medicinal Chemical is Big AM281 202463-68-1
EOS Med Chem, Medicinal Chemical is Big A-205804 251992-66-2
EOS Med Chem, Medicinal Chemical is Big PD318088 391210-00-7 
EOS Med Chem, Medicinal Chemical is Big BIX01294 1392399-03-9
EOS Med Chem, Medicinal Chemical is Big Tacrolimus (FK506） 104987-11-3
EOS Med Chem, Medicinal Chemical is Big HPOB 1429651-50-2
EOS Med Chem, Medicinal Chemical is Big KOBE0065 436133-68-5
EOS Med Chem, Medicinal Chemical is Big RO61-8048 199666-03-0
EOS Med Chem, Medicinal Chemical is Big WH-4-023 837422-57-8
EOS Med Chem, Medicinal Chemical is Big PIK-75 372196-77-5
EOS Med Chem, Medicinal Chemical is Big PIK-90 677338-12-4
EOS Med Chem, Medicinal Chemical is Big VX-680 (Tozasertib, MK-0457） 639089-54-6
EOS Med Chem, Medicinal Chemical is Big Torezolid (TR-701; tedizolid) 856866-72-3
EOS Med Chem, Medicinal Chemical is Big BMS626529 701213-36-7
EOS Med Chem, Medicinal Chemical is Big GSK429286a 864082-47-3 
EOS Med Chem, Medicinal Chemical is Big AZ191 1594092-37-1
EOS Med Chem, Medicinal Chemical is Big WAY-262611 1123231-07-1
EOS Med Chem, Medicinal Chemical is Big ZK-811752(BX471) 288262-96-4
EOS Med Chem, Medicinal Chemical is Big Cerdulatinib(PRT-062070; PRT2070) 1198300-79-6
EOS Med Chem, Medicinal Chemical is Big NMS-P715 1202055-34-2
EOS Med Chem, Medicinal Chemical is Big AMG837 865231-46-5
EOS Med Chem, Medicinal Chemical is Big Rimonabant 158681-13-1
EOS Med Chem, Medicinal Chemical is Big LMK-235 1418033-25-6
EOS Med Chem, Medicinal Chemical is Big AMG706 857876-30-3
EOS Med Chem, Medicinal Chemical is Big IM-12 1129669-05-1
EOS Med Chem, Medicinal Chemical is Big Losmapimod (GW856553X) 585543-15-3
EOS Med Chem, Medicinal Chemical is Big BMS303141 943962-47-8
EOS Med Chem, Medicinal Chemical is Big FidaxoMicin 873857-62-6
EOS Med Chem, Medicinal Chemical is Big Ascomycin 104987-12-4
EOS Med Chem, Medicinal Chemical is Big 6H05 1469338-01-9
EOS Med Chem, Medicinal Chemical is Big AZD1283 919351-41-0
EOS Med Chem, Medicinal Chemical is Big Binimetinib (MEK162, ARRY-162, ARRY-438162) 606143-89-9
EOS Med Chem, Medicinal Chemical is Big z-vad-fmk 187389-52-2
EOS Med Chem, Medicinal Chemical is Big GlyH-101 328541-79-3
EOS Med Chem, Medicinal Chemical is Big Amuvatinib（MP470 ） 850879-09-3
EOS Med Chem, Medicinal Chemical is Big Purmorphamine 483367-10-8
EOS Med Chem, Medicinal Chemical is Big PF-4708671 1255517-76-0
EOS Med Chem, Medicinal Chemical is Big Oprozomib（ONX-0912） 935888-69-0
EOS Med Chem, Medicinal Chemical is Big RVX-208 1044870-39-4
EOS Med Chem, Medicinal Chemical is Big Omarigliptin(MK-3102) 1226781-44-7
EOS Med Chem, Medicinal Chemical is Big BRD4770 1374601-40-7
EOS Med Chem, Medicinal Chemical is Big CB-839 1439399-58-2
EOS Med Chem, Medicinal Chemical is Big G-749 1457983-28-6
EOS Med Chem, Medicinal Chemical is Big WS6 1421227-53-3
EOS Med Chem, Medicinal Chemical is Big LY-364947 396129-53-6
EOS Med Chem, Medicinal Chemical is Big MI-2 1271738-62-5
EOS Med Chem, Medicinal Chemical is Big MI-3 1271738-59-0
EOS Med Chem, Medicinal Chemical is Big PFI-2 1627676-59-8
EOS Med Chem, Medicinal Chemical is Big Enocitabine 55726-47-1 
EOS Med Chem, Medicinal Chemical is Big AMG-47A 882663-88-9
EOS Med Chem, Medicinal Chemical is Big ABT-751 (E7010) 141430-65-1
EOS Med Chem, Medicinal Chemical is Big APD668 832714-46-2
EOS Med Chem, Medicinal Chemical is Big ELN441958 913064-47-8
EOS Med Chem, Medicinal Chemical is Big OSI930 728033-96-3
EOS Med Chem, Medicinal Chemical is Big PFI-3
EOS Med Chem, Medicinal Chemical is Big AC55541 916170-19-9
EOS Med Chem, Medicinal Chemical is Big ZK811752 (BX471) 217645-70-0
EOS Med Chem, Medicinal Chemical is Big IKKε-IN-1 1292310-49-6
EOS Med Chem, Medicinal Chemical is Big WS3 1421227-52-2
EOS Med Chem, Medicinal Chemical is Big UMI-77 518303-20-3
EOS Med Chem, Medicinal Chemical is Big Verdinexor（KPT-335） 1392136-43-4
EOS Med Chem, Medicinal Chemical is Big D4476 301836-43-1
EOS Med Chem, Medicinal Chemical is Big GW4064 278779-30-9
EOS Med Chem, Medicinal Chemical is Big UNC2881 1493764-08-1
EOS Med Chem, Medicinal Chemical is Big PI-3065 955977-50-1
EOS Med Chem, Medicinal Chemical is Big CHIR98014 252935-94-7
EOS Med Chem, Medicinal Chemical is Big Rostafuroxin (PST2238) 156722-18-8
EOS Med Chem, Medicinal Chemical is Big Defactinib（PF-04554878） 1073154-85-4 
EOS Med Chem, Medicinal Chemical is Big GKT137831 1218942-37-0
EOS Med Chem, Medicinal Chemical is Big Ellipticine 519-23-3
EOS Med Chem, Medicinal Chemical is Big U73122 112648-68-7
EOS Med Chem, Medicinal Chemical is Big AZD2932 883986-34-3
EOS Med Chem, Medicinal Chemical is Big GDC-0623 1168091-68-6
EOS Med Chem, Medicinal Chemical is Big PF-431396 717906-29-1
EOS Med Chem, Medicinal Chemical is Big GSK2578215A 1285515-21-0
EOS Med Chem, Medicinal Chemical is Big AT13148 1056901-62-2
EOS Med Chem, Medicinal Chemical is Big TRV-130 1401028-24-7
EOS Med Chem, Medicinal Chemical is Big LED209 245342-14-7
EOS Med Chem, Medicinal Chemical is Big Poziotinib 1092364-38-9
EOS Med Chem, Medicinal Chemical is Big Mc-Val-Cit-PABC-PNP 159857-81-5
EOS Med Chem, Medicinal Chemical is Big BAY87-2243 1227158-85-1
EOS Med Chem, Medicinal Chemical is Big YK-4-279 1037184-44-3
EOS Med Chem, Medicinal Chemical is Big SU9516 377090-84-1
EOS Med Chem, Medicinal Chemical is Big XMD17-109 1435488-37-1
EOS Med Chem, Medicinal Chemical is Big AS602801(Bentamapimod) 848344-36-5
EOS Med Chem, Medicinal Chemical is Big VRT752271 869886-67-9
EOS Med Chem, Medicinal Chemical is Big PF670462 950912-80-8
EOS Med Chem, Medicinal Chemical is Big GNE-493 1033735-94-2
EOS Med Chem, Medicinal Chemical is Big SBC110，736
EOS Med Chem, Medicinal Chemical is Big TBA-354 1257426-19-9
EOS Med Chem, Medicinal Chemical is Big BRL54443 57477-39-1
EOS Med Chem, Medicinal Chemical is Big Preladenant 377727-87-2
EOS Med Chem, Medicinal Chemical is Big LY2606368 1234015-52-1
EOS Med Chem, Medicinal Chemical is Big CK636 442632-72-6
EOS Med Chem, Medicinal Chemical is Big Vidofludimus(4SC-101; SC12267) 717824-30-1
EOS Med Chem, Medicinal Chemical is Big TCS JNK 5a(JNK Inhibitor IX) 312917-14-9
EOS Med Chem, Medicinal Chemical is Big GENZ-644282 529488-28-6
EOS Med Chem, Medicinal Chemical is Big Elvitegravir (GS-9137, JTK-303) 697761-98-1
EOS Med Chem, Medicinal Chemical is Big FK3311 116686-15-8
EOS Med Chem, Medicinal Chemical is Big PND-1186 (VS-4718) 1061353-68-1
EOS Med Chem, Medicinal Chemical is Big CYT997 (Lexibulin) 917111-44-5
EOS Med Chem, Medicinal Chemical is Big Mutant IDH1-IN-1 1355326-21-4
EOS Med Chem, Medicinal Chemical is Big FLLL32 1226895-15-3
EOS Med Chem, Medicinal Chemical is Big BRD73954 1440209-96-0
EOS Med Chem, Medicinal Chemical is Big Batimastat 130370-60-4
EOS Med Chem, Medicinal Chemical is Big TAPI-1 171235-71-5
EOS Med Chem, Medicinal Chemical is Big Ilomastat (GM6001, Galardin) 142880-36-2
EOS Med Chem, Medicinal Chemical is Big URMC-099 1229582-33-5
EOS Med Chem, Medicinal Chemical is Big AZD5363 1143532-39-1
EOS Med Chem, Medicinal Chemical is Big A 77-01 607737-87-1
EOS Med Chem, Medicinal Chemical is Big FRAX597 1286739-19-2
EOS Med Chem, Medicinal Chemical is Big IMD0354 978-62-1
EOS Med Chem, Medicinal Chemical is Big PD184352 212631-79-3
EOS Med Chem, Medicinal Chemical is Big Tandutinib(MLN518) 387867-13-2
EOS Med Chem, Medicinal Chemical is Big Retigabine 150812-12-7
EOS Med Chem, Medicinal Chemical is Big SH-4-54 1456632-40-8
EOS Med Chem, Medicinal Chemical is Big UNC0638 1255580-76-7
EOS Med Chem, Medicinal Chemical is Big JNK-IN-8 1410880-22-6
EOS Med Chem, Medicinal Chemical is Big Pifithrin-α 63208-82-2
EOS Med Chem, Medicinal Chemical is Big Pifithrin-β 511296-88-1
EOS Med Chem, Medicinal Chemical is Big ZSTK-474 475110-96-4
EOS Med Chem, Medicinal Chemical is Big Pemetrexed 150399-23-8
EOS Med Chem, Medicinal Chemical is Big LP533401 hcl 1040526-12-2
EOS Med Chem, Medicinal Chemical is Big CCG-1423 285986-88-1
EOS Med Chem, Medicinal Chemical is Big ISRIB(trans-isomer) 1597403-47-8
EOS Med Chem, Medicinal Chemical is Big TCS PIM-1 1 491871-58-0
EOS Med Chem, Medicinal Chemical is Big UNC0379 1620401-82-2
EOS Med Chem, Medicinal Chemical is Big THZ1 1604810-83-4
EOS Med Chem, Medicinal Chemical is Big S0859 1019331-10-2
EOS Med Chem, Medicinal Chemical is Big RG108 48208-26-0
EOS Med Chem, Medicinal Chemical is Big ELR510444 1233948-35-0
EOS Med Chem, Medicinal Chemical is Big GZD824 Dimesylate 1421783-64-3
EOS Med Chem, Medicinal Chemical is Big Chidamide 743420-02-2
EOS Med Chem, Medicinal Chemical is Big Mdivi-1 338967-87-6
EOS Med Chem, Medicinal Chemical is Big Clemizole hcl 1163-36-6
EOS Med Chem, Medicinal Chemical is Big LB-100 1026680-07-8
EOS Med Chem, Medicinal Chemical is Big BML-277 516480-79-8
EOS Med Chem, Medicinal Chemical is Big ACY-241 1316215-12-9
EOS Med Chem, Medicinal Chemical is Big CL-387785 194423-06-8
EOS Med Chem, Medicinal Chemical is Big LCZ696 936623-90-4
EOS Med Chem, Medicinal Chemical is Big UNBS-5162 956590-23-1
EOS Med Chem, Medicinal Chemical is Big Acalisib (GS-9820) 870281-34-8
EOS Med Chem, Medicinal Chemical is Big FTI 277 HCl 180977-34-8
EOS Med Chem, Medicinal Chemical is Big E3330 136164-66-4
EOS Med Chem, Medicinal Chemical is Big Erastin 571203-78-6
EOS Med Chem, Medicinal Chemical is Big SP2509 1423715-09-6 
EOS Med Chem, Medicinal Chemical is Big SAR191801 1234708-04-3
EOS Med Chem, Medicinal Chemical is Big BAF312 (Siponimod) 1230487-00-9
EOS Med Chem, Medicinal Chemical is Big LY2584702 1082949-67-4
EOS Med Chem, Medicinal Chemical is Big LY2090314 603288-22-8
EOS Med Chem, Medicinal Chemical is Big Remodelin 1622921-15-6
EOS Med Chem, Medicinal Chemical is Big Ro48-8071 189197-69-1
EOS Med Chem, Medicinal Chemical is Big BMH-21 896705-16-1
EOS Med Chem, Medicinal Chemical is Big SR1078 1246525-60-9
EOS Med Chem, Medicinal Chemical is Big Zotarolimus(ABT-578) 221877-54-9
EOS Med Chem, Medicinal Chemical is Big Topiroxostat 577778-58-6
EOS Med Chem, Medicinal Chemical is Big CPI-169 1450655-76-1
EOS Med Chem, Medicinal Chemical is Big CPI-360 1802175-06-9
EOS Med Chem, Medicinal Chemical is Big calpeptin 117591-20-5
EOS Med Chem, Medicinal Chemical is Big JNJ1661010 681136-29-8
EOS Med Chem, Medicinal Chemical is Big KPT-9274 1643913-93-2
EOS Med Chem, Medicinal Chemical is Big A83-01 909910-43-6
EOS Med Chem, Medicinal Chemical is Big JNJ31020028 1094873-14-9
EOS Med Chem, Medicinal Chemical is Big SAR405838 (MI-773) 1303607-60-4
EOS Med Chem, Medicinal Chemical is Big 4E1RCat 328998-25-0
EOS Med Chem, Medicinal Chemical is Big Salirasib 162520-00-5
EOS Med Chem, Medicinal Chemical is Big ML141 71203-35-5
EOS Med Chem, Medicinal Chemical is Big GS967 1262618-39-2
EOS Med Chem, Medicinal Chemical is Big Cyclosporin H 83602-39-5
EOS Med Chem, Medicinal Chemical is Big Cyclosporin D 63775-96-2
EOS Med Chem, Medicinal Chemical is Big Deforolimus 572924-54-0
EOS Med Chem, Medicinal Chemical is Big TMC-207(Bedaquiline) 843663-66-1
EOS Med Chem, Medicinal Chemical is Big WEHI539 1431866-33-9
EOS Med Chem, Medicinal Chemical is Big BMS-794833 1174046-72-0
EOS Med Chem, Medicinal Chemical is Big MHY1485 326914-06-1
EOS Med Chem, Medicinal Chemical is Big GSK1324726A (I-BET726) 1300031-52-0
EOS Med Chem, Medicinal Chemical is Big BLZ945 953769-46-5
EOS Med Chem, Medicinal Chemical is Big PF-06447475 1527473-33-1
EOS Med Chem, Medicinal Chemical is Big Bardoxolone Methyl 218600-53-4
EOS Med Chem, Medicinal Chemical is Big SCR7 1533426-72-0
EOS Med Chem, Medicinal Chemical is Big ANA-12 219766-25-3
EOS Med Chem, Medicinal Chemical is Big ITD 1 1099644-42-4
EOS Med Chem, Medicinal Chemical is Big RO-3306 872573-93-8
EOS Med Chem, Medicinal Chemical is Big GSK-LSD1 2HCl 1431368-48-7
EOS Med Chem, Medicinal Chemical is Big CZC-54252 1191911-27-9
EOS Med Chem, Medicinal Chemical is Big Tiplaxtinin（PAI-039） 393105-53-8
EOS Med Chem, Medicinal Chemical is Big Afuresertib (GSK2110183) 1047634-63-8
EOS Med Chem, Medicinal Chemical is Big Molidustat (BAY85-3934) 1154028-82-6
EOS Med Chem, Medicinal Chemical is Big OTX964
EOS Med Chem, Medicinal Chemical is Big PF-06463922 1454846-35-5
EOS Med Chem, Medicinal Chemical is Big GSK1059615 958852-01-2
EOS Med Chem, Medicinal Chemical is Big TAK960 1137868-52-0
EOS Med Chem, Medicinal Chemical is Big GS7340 79270-37-8
EOS Med Chem, Medicinal Chemical is Big MRS2578 711019-86-2
EOS Med Chem, Medicinal Chemical is Big ORG27569 868273-06-7
EOS Med Chem, Medicinal Chemical is Big Noopept（GVS-111） 157115-85-0
EOS Med Chem, Medicinal Chemical is Big NVP-231 362003-83-6
EOS Med Chem, Medicinal Chemical is Big RG120 1448347-49-6
EOS Med Chem, Medicinal Chemical is Big LAQ824 (Dacinostat) 404951-53-7
EOS Med Chem, Medicinal Chemical is Big A-803467 944261-79-4
EOS Med Chem, Medicinal Chemical is Big X-396       1365267-27-1
EOS Med Chem, Medicinal Chemical is Big Chlorotrianisene 569-57-3
EOS Med Chem, Medicinal Chemical is Big b-AP15 1009817-63-3
EOS Med Chem, Medicinal Chemical is Big PF-03394197（Oclacitinib) 1208319-26-9
EOS Med Chem, Medicinal Chemical is Big FL118 151636-76-9
EOS Med Chem, Medicinal Chemical is Big Elacridar (GF120918) 143664-11-3
EOS Med Chem, Medicinal Chemical is Big GNE-317 1394076-92-6
EOS Med Chem, Medicinal Chemical is Big Perifosine (KRX-0401) 157716-52-4
EOS Med Chem, Medicinal Chemical is Big Elesclomol (STA-4783) 488832-69-5
EOS Med Chem, Medicinal Chemical is Big Simeprevir(TMC 435350) 923604-59-5
EOS Med Chem, Medicinal Chemical is Big YO-01027 (Dibenzazepine) 209984-56-5
EOS Med Chem, Medicinal Chemical is Big Evacetrapib（LY2484595) 1186486-62-3
EOS Med Chem, Medicinal Chemical is Big GSK1014802（CNV1014802) 934240-30-9
EOS Med Chem, Medicinal Chemical is Big KRCA-008 1472795-20-2
EOS Med Chem, Medicinal Chemical is Big UNC0642 1481677-78-4
EOS Med Chem, Medicinal Chemical is Big RGB-286638 784210-87-3 
EOS Med Chem, Medicinal Chemical is Big Radotinib（IY-5511) 926037-48-1
EOS Med Chem, Medicinal Chemical is Big SKF-86002 72873-74-6
EOS Med Chem, Medicinal Chemical is Big Irbinitinib（ARRY380) 937263-43-9
EOS Med Chem, Medicinal Chemical is Big AZ5104 1421373-98-9
EOS Med Chem, Medicinal Chemical is Big BIO-32546 1548743-66-3
EOS Med Chem, Medicinal Chemical is Big VRT-1353385 1616113-45-1
EOS Med Chem, Medicinal Chemical is Big SEP-0372814 1516895-53-6
EOS Med Chem, Medicinal Chemical is Big MDL28170 88191-84-8
EOS Med Chem, Medicinal Chemical is Big GSK650394 890842-28-1
EOS Med Chem, Medicinal Chemical is Big TG003 300801-52-9
EOS Med Chem, Medicinal Chemical is Big INCB032304 941685-27-4
EOS Med Chem, Medicinal Chemical is Big CAY10683 (Santacruzamate A) 1477949-42-0
EOS Med Chem, Medicinal Chemical is Big SEA0400 223104-29-8
EOS Med Chem, Medicinal Chemical is Big TH588 1609960-31-7
EOS Med Chem, Medicinal Chemical is Big Avasimibe 166518-60-1
EOS Med Chem, Medicinal Chemical is Big Thiamet G 1009816-48-1
EOS Med Chem, Medicinal Chemical is Big Cathepsin S inhibitor 1373215-15-6
EOS Med Chem, Medicinal Chemical is Big J147 1146963-51-0
EOS Med Chem, Medicinal Chemical is Big Valspodar  PSC-833 121584-18-7
EOS Med Chem, Medicinal Chemical is Big z-devd-fmk 210344-95-9
EOS Med Chem, Medicinal Chemical is Big BLU-9931 1538604-68-0
EOS Med Chem, Medicinal Chemical is Big Cyclopamine 4449-51-8
EOS Med Chem, Medicinal Chemical is Big GSK503 1346572-63-1
EOS Med Chem, Medicinal Chemical is Big L-779450 303727-31-3
EOS Med Chem, Medicinal Chemical is Big PLX647 873786-09-5
EOS Med Chem, Medicinal Chemical is Big Pexidartinib  PLX3397 1029044-16-3
EOS Med Chem, Medicinal Chemical is Big TAE226  NVP-TAE226 761437-28-9
EOS Med Chem, Medicinal Chemical is Big BX517 850717-64-5
EOS Med Chem, Medicinal Chemical is Big CARIPORIDE 159138-80-4
EOS Med Chem, Medicinal Chemical is Big Vilazodone 163521-12-8
EOS Med Chem, Medicinal Chemical is Big fexaramine 574013-66-4 
EOS Med Chem, Medicinal Chemical is Big Altiratinib  DCC-2701 1345847-93-9
EOS Med Chem, Medicinal Chemical is Big PU-WS13 1454619-14-7
EOS Med Chem, Medicinal Chemical is Big PRT-060318  PRT318 1194961-19-7
EOS Med Chem, Medicinal Chemical is Big FG2216 223387-75-5
EOS Med Chem, Medicinal Chemical is Big SB239063 193551-21-2
EOS Med Chem, Medicinal Chemical is Big Darapladib (SB-480848) 356057-34-6
EOS Med Chem, Medicinal Chemical is Big SANT-1 304909-07-7
EOS Med Chem, Medicinal Chemical is Big Tipiracil 183204-72-0
EOS Med Chem, Medicinal Chemical is Big CEP-32496 1188910-76-0
EOS Med Chem, Medicinal Chemical is Big Pixantrone 144510-96-3
EOS Med Chem, Medicinal Chemical is Big Ledipasvir (GS5885) 1256388-51-8
EOS Med Chem, Medicinal Chemical is Big KN-92 HCL 1431698-47-3
EOS Med Chem, Medicinal Chemical is Big Moclobemide 71320-77-9
EOS Med Chem, Medicinal Chemical is Big ADX-47273 851881-60-2
EOS Med Chem, Medicinal Chemical is Big Caspofungin Acetate 179463-17-3
EOS Med Chem, Medicinal Chemical is Big KI16425 355025-24-0
EOS Med Chem, Medicinal Chemical is Big BIBX1382 196612-93-8
EOS Med Chem, Medicinal Chemical is Big GSK2838232 1443461-21-9
EOS Med Chem, Medicinal Chemical is Big KNK437 218924-25-5
EOS Med Chem, Medicinal Chemical is Big PF-3274167 900510-03-4
EOS Med Chem, Medicinal Chemical is Big Cevipabulin 849550-05-6
EOS Med Chem, Medicinal Chemical is Big GDC-0349 1207360-89-1
EOS Med Chem, Medicinal Chemical is Big Semagacestat (LY450139) 425386-60-3
EOS Med Chem, Medicinal Chemical is Big Brexpiprazole 913611-97-9
EOS Med Chem, Medicinal Chemical is Big Taladegib (LY2940680) 1258861-20-9
EOS Med Chem, Medicinal Chemical is Big Mibefradil(Ro 40-5967) 116666-63-8
EOS Med Chem, Medicinal Chemical is Big R428 (BGB324) 1037624-75-1
EOS Med Chem, Medicinal Chemical is Big RX-3117 865838-26-2
EOS Med Chem, Medicinal Chemical is Big Plerixafor (AMD3100) 110078-46-1
EOS Med Chem, Medicinal Chemical is Big K-Ras(G12C) inhibitor 12 1469337-95-8
EOS Med Chem, Medicinal Chemical is Big RI-2 1417162-36-7
EOS Med Chem, Medicinal Chemical is Big Valrubicin 56124-62-0
EOS Med Chem, Medicinal Chemical is Big Carminomycin 39472-31-6
EOS Med Chem, Medicinal Chemical is Big Idarubicin HCl 57852-57-0
EOS Med Chem, Medicinal Chemical is Big KU60019 925701-49-1
EOS Med Chem, Medicinal Chemical is Big SU6656 330161-87-0
EOS Med Chem, Medicinal Chemical is Big TH287 1609960-30-6
EOS Med Chem, Medicinal Chemical is Big Pilaralisib (XL147) 934526-89-3
EOS Med Chem, Medicinal Chemical is Big MK5172 1350514-68-9
EOS Med Chem, Medicinal Chemical is Big BMS-663068 864953-29-7
EOS Med Chem, Medicinal Chemical is Big BMS-626529 701213-36-7
EOS Med Chem, Medicinal Chemical is Big GSK J4 1373423-53-0
EOS Med Chem, Medicinal Chemical is Big WY-14643 (Pirinixic Acid) 50892-23-4
EOS Med Chem, Medicinal Chemical is Big Capadenoson (BAY 68-4986) 544417-40-5
EOS Med Chem, Medicinal Chemical is Big Almorexant hcl 871224-64-5
EOS Med Chem, Medicinal Chemical is Big Tideglusib 865854-05-3
EOS Med Chem, Medicinal Chemical is Big Monomethylauristatin F(MMAF) 745017-94-1
EOS Med Chem, Medicinal Chemical is Big AT7519 844442-38-2
EOS Med Chem, Medicinal Chemical is Big MPI-0479605 1246529-32-7
EOS Med Chem, Medicinal Chemical is Big Vorapaxar 618385-01-6
EOS Med Chem, Medicinal Chemical is Big MK8245 1030612-90-8
EOS Med Chem, Medicinal Chemical is Big ML352 1649450-12-3
EOS Med Chem, Medicinal Chemical is Big mavatrep 956274-94-5
EOS Med Chem, Medicinal Chemical is Big JN-II-127
EOS Med Chem, Medicinal Chemical is Big G007-LK 1380672-07-0
EOS Med Chem, Medicinal Chemical is Big Bikinin 188011-69-0
EOS Med Chem, Medicinal Chemical is Big EPZ015666 1616391-65-1
EOS Med Chem, Medicinal Chemical is Big Liproxstatin-1 950455-15-9
EOS Med Chem, Medicinal Chemical is Big SAG 912545-86-9
EOS Med Chem, Medicinal Chemical is Big GW627368X 439288-66-1
EOS Med Chem, Medicinal Chemical is Big ZM447439 331771-20-1 
EOS Med Chem, Medicinal Chemical is Big U-104 178606-66-1
EOS Med Chem, Medicinal Chemical is Big Solithromycin 760981-83-7
EOS Med Chem, Medicinal Chemical is Big TCS5861528 332117-28-9
EOS Med Chem, Medicinal Chemical is Big Cobimetinib (GDC-0973, RG7420) 934660-93-2
EOS Med Chem, Medicinal Chemical is Big GSK269962A(GSK269962) 850664-21-0
EOS Med Chem, Medicinal Chemical is Big Decernotinib（VX-509） 944842-54-0 
EOS Med Chem, Medicinal Chemical is Big Voreloxin (SNS-595) 175414-77-4
EOS Med Chem, Medicinal Chemical is Big Spautin-1 1262888-28-7
EOS Med Chem, Medicinal Chemical is Big NS6180 353262-04-1
EOS Med Chem, Medicinal Chemical is Big VER155008 1134156-31-2
EOS Med Chem, Medicinal Chemical is Big BAY11-7082 19542-67-7
EOS Med Chem, Medicinal Chemical is Big EGF816 1508250-71-2
EOS Med Chem, Medicinal Chemical is Big Entrectinib 1108743-60-7
EOS Med Chem, Medicinal Chemical is Big SR9243 1613028-81-1
EOS Med Chem, Medicinal Chemical is Big Kenpaullone 142273-20-9
EOS Med Chem, Medicinal Chemical is Big GSK0660 1014691-61-2
EOS Med Chem, Medicinal Chemical is Big AG-120 1448346-63-1
EOS Med Chem, Medicinal Chemical is Big SB-242084 181632-25-7
EOS Med Chem, Medicinal Chemical is Big Fruquintinib(HMPL-013) 1194506-26-7
EOS Med Chem, Medicinal Chemical is Big RQ-00203078 1254205-52-1
EOS Med Chem, Medicinal Chemical is Big TP-0903 1341200-45-0
EOS Med Chem, Medicinal Chemical is Big LDC1267 136030-48-9
EOS Med Chem, Medicinal Chemical is Big AEE788 (NVP-AEE788) 497839-62-0
EOS Med Chem, Medicinal Chemical is Big GLYX13 117928-94-6
EOS Med Chem, Medicinal Chemical is Big BMS-817378 1174161-69-3
EOS Med Chem, Medicinal Chemical is Big SBC-115076 489415-96-5
EOS Med Chem, Medicinal Chemical is Big CH5183284 (Debio-1347) 1265229-25-1
EOS Med Chem, Medicinal Chemical is Big T-5224 530141-72-1
EOS Med Chem, Medicinal Chemical is Big GSK5959 901245-65-6
EOS Med Chem, Medicinal Chemical is Big UNC0224 1197196-48-7
EOS Med Chem, Medicinal Chemical is Big OF-1 919973-83-4
EOS Med Chem, Medicinal Chemical is Big DDR1-IN-1 1449685-96-4
EOS Med Chem, Medicinal Chemical is Big IWP-2 686770-61-6
EOS Med Chem, Medicinal Chemical is Big Endoxifen HCl 1032008-74-4
EOS Med Chem, Medicinal Chemical is Big SBE 13 HCl 1052532-15-6
EOS Med Chem, Medicinal Chemical is Big PURVALANOL A 212844-53-6
EOS Med Chem, Medicinal Chemical is Big CL-387785 (EKI-785） 194423-06-8
EOS Med Chem, Medicinal Chemical is Big ONO-4059 1351635-67-0
EOS Med Chem, Medicinal Chemical is Big GSK-LSD1 2HCl 1431368-48-7
EOS Med Chem, Medicinal Chemical is Big Marimastat(BB2516) 154039-60-8
EOS Med Chem, Medicinal Chemical is Big Epoxomicin 134381-21-8
EOS Med Chem, Medicinal Chemical is Big CCT244747 1404095-34-6
EOS Med Chem, Medicinal Chemical is Big ABT450 1221573-85-8
EOS Med Chem, Medicinal Chemical is Big AM-095 1228690-36-5
EOS Med Chem, Medicinal Chemical is Big E-64 66701-25-5
EOS Med Chem, Medicinal Chemical is Big Aloxistatin 88321-09-9
EOS Med Chem, Medicinal Chemical is Big ORY-1001 1431326-61-2
EOS Med Chem, Medicinal Chemical is Big GSK2879552 1401966-69-5
EOS Med Chem, Medicinal Chemical is Big BET bromodomain inhibitor 1505453-59-7
EOS Med Chem, Medicinal Chemical is Big LY2409881 946518-60-1
EOS Med Chem, Medicinal Chemical is Big B-Raf inhibitor 1021950-26-4
EOS Med Chem, Medicinal Chemical is Big MK-5108 (VX-689) 1010085-13-8
EOS Med Chem, Medicinal Chemical is Big BRD7552 1137359047-7
EOS Med Chem, Medicinal Chemical is Big AS601245.2TFA 345987-15-7
EOS Med Chem, Medicinal Chemical is Big AZD-5597 924641-59-8
EOS Med Chem, Medicinal Chemical is Big FIIN-2 1633044-56-0
EOS Med Chem, Medicinal Chemical is Big Ixabepilone (Azaepothilone B; BMS 247550) 219989-84-1
EOS Med Chem, Medicinal Chemical is Big Pirarubicin 72496-41-4
EOS Med Chem, Medicinal Chemical is Big Pentostatin(Deoxycoformycin) 53910-25-1
EOS Med Chem, Medicinal Chemical is Big Epacadostat 1204669-58-8
EOS Med Chem, Medicinal Chemical is Big LY3009120 1454682-72-4
EOS Med Chem, Medicinal Chemical is Big LY2228820 862507-23-1
EOS Med Chem, Medicinal Chemical is Big CAY10415 146062-49-9
EOS Med Chem, Medicinal Chemical is Big PP1 172889-26-8
EOS Med Chem, Medicinal Chemical is Big SB-3CT 292605-14-2
EOS Med Chem, Medicinal Chemical is Big Enasidenib 1446502-11-9
EOS Med Chem, Medicinal Chemical is Big GDC-0032 1282512-48-4
EOS Med Chem, Medicinal Chemical is Big Omaveloxolone (RTA-408) 1474034-05-3
EOS Med Chem, Medicinal Chemical is Big Voreloxin(SNS-595; AG 7352) 175414-77-4
EOS Med Chem, Medicinal Chemical is Big Favipiravir(T-705) 259793-96-9
EOS Med Chem, Medicinal Chemical is Big Pyroxamide 382180-17-8
EOS Med Chem, Medicinal Chemical is Big Cardiogenol C HCl 671225-39-1
EOS Med Chem, Medicinal Chemical is Big SB-590885 405554-55-4
EOS Med Chem, Medicinal Chemical is Big VX-11e 896720-20-0
EOS Med Chem, Medicinal Chemical is Big Volasertib(BI6727) 755038-65-4
EOS Med Chem, Medicinal Chemical is Big BIO-acetoxime 667463-85-6
EOS Med Chem, Medicinal Chemical is Big J147 1146963-51-0
EOS Med Chem, Medicinal Chemical is Big SB525334 356559-20-1
EOS Med Chem, Medicinal Chemical is Big SB-399885 HCl 402713-80-8
EOS Med Chem, Medicinal Chemical is Big EPZ011989 1598383-40-4
EOS Med Chem, Medicinal Chemical is Big PD123319 130663-39-7
EOS Med Chem, Medicinal Chemical is Big PHA767491 845714-00-3
EOS Med Chem, Medicinal Chemical is Big SW-033291 459147-39-8
EOS Med Chem, Medicinal Chemical is Big GSK2801 1619994-68-1
EOS Med Chem, Medicinal Chemical is Big HA130 1229652-21-4
EOS Med Chem, Medicinal Chemical is Big CEP28122 1022958-60-6
EOS Med Chem, Medicinal Chemical is Big AVN944 297730-17-7
EOS Med Chem, Medicinal Chemical is Big CEP-37440 1391712-60-9
EOS Med Chem, Medicinal Chemical is Big Entospletinib (GS-9973) 1229208-44-9
EOS Med Chem, Medicinal Chemical is Big AZD6738 1352226-88-0
EOS Med Chem, Medicinal Chemical is Big NPS2143 284035-33-2
EOS Med Chem, Medicinal Chemical is Big Givinostat (ITF2357) 732302-99-7
EOS Med Chem, Medicinal Chemical is Big AZD2461 1174043-16-3
EOS Med Chem, Medicinal Chemical is Big PCI-27483 871266-63-6
EOS Med Chem, Medicinal Chemical is Big Febuxostat 144060-53-7
EOS Med Chem, Medicinal Chemical is Big Edoxaban 1229194-11-9
EOS Med Chem, Medicinal Chemical is Big AZD3759 1626387-80-1
EOS Med Chem, Medicinal Chemical is Big Pomalidomide 19171-19-8
EOS Med Chem, Medicinal Chemical is Big AKT inhibitor VIII 612847-09-3
EOS Med Chem, Medicinal Chemical is Big AMG925 1401033-86-0
EOS Med Chem, Medicinal Chemical is Big AMG319 1608125-21-8
EOS Med Chem, Medicinal Chemical is Big AZD8835 1620576-64-8
EOS Med Chem, Medicinal Chemical is Big Ki20227 623142-96-1
EOS Med Chem, Medicinal Chemical is Big Cebranopadol(GRT-6005) 863513-91-1
EOS Med Chem, Medicinal Chemical is Big DBPR-108 1186426-66-3
EOS Med Chem, Medicinal Chemical is Big Enasidenib（AG-221） 1446502-11-9
EOS Med Chem, Medicinal Chemical is Big Firategrast（SB683699） 402567-16-2
EOS Med Chem, Medicinal Chemical is Big GNE-617 1362154-70-8
EOS Med Chem, Medicinal Chemical is Big JZL-195 1210004-12-8
EOS Med Chem, Medicinal Chemical is Big Pyridone6 457081-03-7
EOS Med Chem, Medicinal Chemical is Big ML224(NCGC00242364; ANTAG3) 1338824-21-7
EOS Med Chem, Medicinal Chemical is Big R1530 882531-87-5
EOS Med Chem, Medicinal Chemical is Big RO4987655(CH-4987655) 874101-00-5
EOS Med Chem, Medicinal Chemical is Big Combretastatin A4 117048-59-6
EOS Med Chem, Medicinal Chemical is Big ZM306416 690206-97-4
EOS Med Chem, Medicinal Chemical is Big ETC-159 1638250-96-0
EOS Med Chem, Medicinal Chemical is Big NIBR189 1599432-08-2
EOS Med Chem, Medicinal Chemical is Big Isoxazole 9 (ISX-9) 832115-62-5
EOS Med Chem, Medicinal Chemical is Big SBI-0206965 1538604-68-0
EOS Med Chem, Medicinal Chemical is Big Selinexor (KPT-330) 1393477-72-9
EOS Med Chem, Medicinal Chemical is Big Ipragliflozin 761423-87-4
EOS Med Chem, Medicinal Chemical is Big VR23 1624602-30-7
EOS Med Chem, Medicinal Chemical is Big canagliflozin 842133-18-0
EOS Med Chem, Medicinal Chemical is Big Ruboxistaurin（LY333531) 169939-94-0
EOS Med Chem, Medicinal Chemical is Big JNJ-42041935 1193383-09-3
EOS Med Chem, Medicinal Chemical is Big WAY-362450 (XL335; Turofexorate isopropyl) 629664-81-9
EOS Med Chem, Medicinal Chemical is Big AZD8186 1627494-13-6
EOS Med Chem, Medicinal Chemical is Big Brefeldin A 20350-15-6
EOS Med Chem, Medicinal Chemical is Big STF-31 724741-75-7
EOS Med Chem, Medicinal Chemical is Big TRAM-34 289905-88-0
EOS Med Chem, Medicinal Chemical is Big CFTRinh 172 307510-92-5
EOS Med Chem, Medicinal Chemical is Big Alda-1 349438-38-6
EOS Med Chem, Medicinal Chemical is Big Avibactam sodium(NXL-104) 1192491-61-4
EOS Med Chem, Medicinal Chemical is Big TH-302 918633-87-1
EOS Med Chem, Medicinal Chemical is Big AST-1306 1050500-29-2
EOS Med Chem, Medicinal Chemical is Big AN-2690(Tavaborole) 174671-46-6
EOS Med Chem, Medicinal Chemical is Big Tozadenant (SYN-115) 870070-55-6
EOS Med Chem, Medicinal Chemical is Big SRT3109 1204707-71-0
EOS Med Chem, Medicinal Chemical is Big RepSox(E-616452; SJN 2511) 446859-33-2
EOS Med Chem, Medicinal Chemical is Big Fasudil hydrochloride 105628-07-7
EOS Med Chem, Medicinal Chemical is Big TG101209 936091-14-4
EOS Med Chem, Medicinal Chemical is Big NVP-BSK805 1092499-93-8
EOS Med Chem, Medicinal Chemical is Big Indiplon 325715-02-4
EOS Med Chem, Medicinal Chemical is Big Vinpocetine 42971-09-5
EOS Med Chem, Medicinal Chemical is Big Trelagliptin 865759-25-7
EOS Med Chem, Medicinal Chemical is Big NKTR-118 1354744-91-4
EOS Med Chem, Medicinal Chemical is Big Gemcitabine elaidate(CP-4126; CO-101) 210829-30-4
EOS Med Chem, Medicinal Chemical is Big GW2580 870483-87-7
EOS Med Chem, Medicinal Chemical is Big Sipoglitazar 342026-92-0
EOS Med Chem, Medicinal Chemical is Big SB415286 264218-23-7
EOS Med Chem, Medicinal Chemical is Big NQDI1 175026-96-7
EOS Med Chem, Medicinal Chemical is Big NSC66389 5142-23-4
EOS Med Chem, Medicinal Chemical is Big TAK715 303162-79-0
EOS Med Chem, Medicinal Chemical is Big ODM-201 1297538-32-9
EOS Med Chem, Medicinal Chemical is Big K-115 223645-67-8
EOS Med Chem, Medicinal Chemical is Big DASA-58 1203494-49-8
EOS Med Chem, Medicinal Chemical is Big Umeclidinium(GSK573719A) 869113-09-7
EOS Med Chem, Medicinal Chemical is Big GSK1070916 942918-07-2
EOS Med Chem, Medicinal Chemical is Big ML216 1430213-30-1
EOS Med Chem, Medicinal Chemical is Big AMG337 1173699-31-4
EOS Med Chem, Medicinal Chemical is Big ACP-196 1420477-60-6
EOS Med Chem, Medicinal Chemical is Big PKC412 120685-11-2
EOS Med Chem, Medicinal Chemical is Big APD597 897732-93-3
EOS Med Chem, Medicinal Chemical is Big CJ-023423 415903-37-6
EOS Med Chem, Medicinal Chemical is Big slx-2119 911417-87-3
EOS Med Chem, Medicinal Chemical is Big UPF1069 1048371-03-4
EOS Med Chem, Medicinal Chemical is Big KW2449 1000669-72-6
EOS Med Chem, Medicinal Chemical is Big Azoramide 932986-18-0
EOS Med Chem, Medicinal Chemical is Big CB5083 1542705-92-9
EOS Med Chem, Medicinal Chemical is Big SU5614 1055412-47-9
EOS Med Chem, Medicinal Chemical is Big SU-5607 186611-52-9
EOS Med Chem, Medicinal Chemical is Big PF-03274167 900510-03-4
EOS Med Chem, Medicinal Chemical is Big BMS599626 714971-09-2
EOS Med Chem, Medicinal Chemical is Big NVP-BHG712 940310-85-0
EOS Med Chem, Medicinal Chemical is Big PF-04457845 1020315-31-4
EOS Med Chem, Medicinal Chemical is Big Ciproxidine 903576-44-3
EOS Med Chem, Medicinal Chemical is Big PF-4989216 1276553-09-3
EOS Med Chem, Medicinal Chemical is Big AZD3264 1609281-86-8
EOS Med Chem, Medicinal Chemical is Big AM630 164178-33-0
EOS Med Chem, Medicinal Chemical is Big ETC-1002 738606-46-7
EOS Med Chem, Medicinal Chemical is Big TAS301 193620-69-8
EOS Med Chem, Medicinal Chemical is Big BPTES 314045-39-1
EOS Med Chem, Medicinal Chemical is Big GW5074 220904-83-6
EOS Med Chem, Medicinal Chemical is Big GSK1278863 960539-70-2
EOS Med Chem, Medicinal Chemical is Big ELIGLUSTAT 491833-29-5
EOS Med Chem, Medicinal Chemical is Big APY29 1216665-49-4
EOS Med Chem, Medicinal Chemical is Big LDN-214117 1627503-67-6
EOS Med Chem, Medicinal Chemical is Big Conduritol B epoxide 6090-95-5
EOS Med Chem, Medicinal Chemical is Big DprE1-IN-1 1494675-86-3
EOS Med Chem, Medicinal Chemical is Big Vortioxetine hydrobromide 960203-27-4 
EOS Med Chem, Medicinal Chemical is Big Motolimod(VTX-2337) 926927-61-9
EOS Med Chem, Medicinal Chemical is Big LDC000067 1073485-20-7
EOS Med Chem, Medicinal Chemical is Big PCI-34051 950762-95-5
EOS Med Chem, Medicinal Chemical is Big TAK-063 1238697-26-1
EOS Med Chem, Medicinal Chemical is Big BMS-687453 1000998-59-3
EOS Med Chem, Medicinal Chemical is Big IDO-IN-1 914638-30-5
EOS Med Chem, Medicinal Chemical is Big AZ-037 832123-21-1
EOS Med Chem, Medicinal Chemical is Big ORY-1001 (RG-6016) 1431326-61-2
EOS Med Chem, Medicinal Chemical is Big MK2048 869901-69-9
EOS Med Chem, Medicinal Chemical is Big PF-04929113 (SNX-5422) 908115-27-5
EOS Med Chem, Medicinal Chemical is Big RQ-00203078 1254205-52-1
EOS Med Chem, Medicinal Chemical is Big RO31-8220 138489-18-6
EOS Med Chem, Medicinal Chemical is Big Staurosporine 62996-74-1
EOS Med Chem, Medicinal Chemical is Big Obatoclax Mesylate (GX15-070) 803712-79-0
EOS Med Chem, Medicinal Chemical is Big PS48 1180676-32-7
EOS Med Chem, Medicinal Chemical is Big UNC0646 1320288-17-2
EOS Med Chem, Medicinal Chemical is Big HO-3867 1172133-28-6
EOS Med Chem, Medicinal Chemical is Big velpatasvir（GS-5816） 1377049-84-7
EOS Med Chem, Medicinal Chemical is Big HM61713 1802181-20-9
EOS Med Chem, Medicinal Chemical is Big Olmutinib 1353550-13-6
EOS Med Chem, Medicinal Chemical is Big PFI-4 900305-37-5
EOS Med Chem, Medicinal Chemical is Big A-1210477 1668553-26-1
EOS Med Chem, Medicinal Chemical is Big AZD3965 1448671-31-5
EOS Med Chem, Medicinal Chemical is Big MLN1117 (INK1117) 1268454-23-4
EOS Med Chem, Medicinal Chemical is Big ON123300 1357470-29-1
EOS Med Chem, Medicinal Chemical is Big Brigatinib 1197953-54-0
EOS Med Chem, Medicinal Chemical is Big ML324 1222800-79-4
EOS Med Chem, Medicinal Chemical is Big Cabotegravir (GSK744, GSK1265744) 1051375-10-0
EOS Med Chem, Medicinal Chemical is Big LLY-507 1793053-37-8
EOS Med Chem, Medicinal Chemical is Big Quisinostat (JNJ-26481585) 875320-29-9
EOS Med Chem, Medicinal Chemical is Big Nanchangmycin 65101-87-3
EOS Med Chem, Medicinal Chemical is Big RG7388 1229705-06-9
EOS Med Chem, Medicinal Chemical is Big SGC707 1687736-54-4
EOS Med Chem, Medicinal Chemical is Big BMS-3 1338247-30-5
EOS Med Chem, Medicinal Chemical is Big BMS-5 1338247-35-0
EOS Med Chem, Medicinal Chemical is Big GNF-7 839706-07-9
EOS Med Chem, Medicinal Chemical is Big Lemborexant 1369764-02-2
EOS Med Chem, Medicinal Chemical is Big MLN2480 1096708-71-2
EOS Med Chem, Medicinal Chemical is Big SCH58261 160098-96-4
EOS Med Chem, Medicinal Chemical is Big GSK481 1622849-58-4
EOS Med Chem, Medicinal Chemical is Big vacquinol-1 5428-80-8
EOS Med Chem, Medicinal Chemical is Big ns11021 956014-19-0
EOS Med Chem, Medicinal Chemical is Big mk-571钠盐 115104-28-4
EOS Med Chem, Medicinal Chemical is Big TCS359 301305-73-7
EOS Med Chem, Medicinal Chemical is Big LJH685 1627710-50-2
EOS Med Chem, Medicinal Chemical is Big LJI308 1627709-94-7
EOS Med Chem, Medicinal Chemical is Big UNC1079 1418741-86-2
EOS Med Chem, Medicinal Chemical is Big GSK591 1616391-87-7
EOS Med Chem, Medicinal Chemical is Big ISX9 832115-62-5
EOS Med Chem, Medicinal Chemical is Big Solcitinib 1206163-45-2
EOS Med Chem, Medicinal Chemical is Big Uprosertib，GSK2141795 1047634-65-0
EOS Med Chem, Medicinal Chemical is Big sc79 305834-79-1
EOS Med Chem, Medicinal Chemical is Big BML-275 866405-64-3
EOS Med Chem, Medicinal Chemical is Big DY-131 95167-41-2
EOS Med Chem, Medicinal Chemical is Big ML264 1550008-55-3
EOS Med Chem, Medicinal Chemical is Big RBC8 361185-42-4
EOS Med Chem, Medicinal Chemical is Big AS703026 1236699-92-5
EOS Med Chem, Medicinal Chemical is Big Pralatrexat 146464-95-1
EOS Med Chem, Medicinal Chemical is Big DEL-22379 181223-80-3
EOS Med Chem, Medicinal Chemical is Big SKF96365 hcl 130495-35-1
EOS Med Chem, Medicinal Chemical is Big Skepinone-L 1221485-83-1
EOS Med Chem, Medicinal Chemical is Big R1487 449808-64-4
EOS Med Chem, Medicinal Chemical is Big NSC348884 81624-55-7
EOS Med Chem, Medicinal Chemical is Big Scriptaid (GCK1026) 287383-59-9
EOS Med Chem, Medicinal Chemical is Big ML281 1404437-62-2
EOS Med Chem, Medicinal Chemical is Big EGT1442 1118567-05-7
EOS Med Chem, Medicinal Chemical is Big RG7112 939981-39-2
EOS Med Chem, Medicinal Chemical is Big Brivanib(BMS540215) 649735-46-6
EOS Med Chem, Medicinal Chemical is Big PH797804 586379-66-0
EOS Med Chem, Medicinal Chemical is Big CC-223 1228013-30-6
EOS Med Chem, Medicinal Chemical is Big PIK-293 900185-01-5
EOS Med Chem, Medicinal Chemical is Big MI-136 1628316-74-4
EOS Med Chem, Medicinal Chemical is Big NSC12
EOS Med Chem, Medicinal Chemical is Big SC1 (Pluripotin) 839707-37-8
EOS Med Chem, Medicinal Chemical is Big GSK-2881078 1539314-06-1
EOS Med Chem, Medicinal Chemical is Big Delafloxacin 189279-58-1
EOS Med Chem, Medicinal Chemical is Big Ezutromid 945531-77-1
EOS Med Chem, Medicinal Chemical is Big Naloxegol Oxalate 1354744-91-4
EOS Med Chem, Medicinal Chemical is Big SGI-7079 1239875-86-5
EOS Med Chem, Medicinal Chemical is Big AZ6102 1645286-75-4
EOS Med Chem, Medicinal Chemical is Big FIIN-3 1637735-84-2
EOS Med Chem, Medicinal Chemical is Big Tipifarnib (IND 58359; R115777) 192185-72-1
EOS Med Chem, Medicinal Chemical is Big Glutaminase C-IN-1 (968) 311795-38-7
EOS Med Chem, Medicinal Chemical is Big LHW090-A7 1308256-94-1
EOS Med Chem, Medicinal Chemical is Big MK866 118414-82-7
EOS Med Chem, Medicinal Chemical is Big Eluxadolin 864821-90-9
EOS Med Chem, Medicinal Chemical is Big A-366 1527503-11-2
EOS Med Chem, Medicinal Chemical is Big I-BRD9 1714146-59-4
EOS Med Chem, Medicinal Chemical is Big BI-7273 1883429-21-9
EOS Med Chem, Medicinal Chemical is Big Cambendazol 26097-80-3
EOS Med Chem, Medicinal Chemical is Big GDC-0879 905281-76-7
EOS Med Chem, Medicinal Chemical is Big CP533536 223488-57-1
EOS Med Chem, Medicinal Chemical is Big RO41-1049 HCL 127500-84-9
EOS Med Chem, Medicinal Chemical is Big PRX08066 866206-55-5
EOS Med Chem, Medicinal Chemical is Big LOXO-101 1223403-58-4
EOS Med Chem, Medicinal Chemical is Big Enzastaurin(LY317615) 170364-57-5
EOS Med Chem, Medicinal Chemical is Big BAY80-6946 (Copanlisib) 1032568-63-0
EOS Med Chem, Medicinal Chemical is Big AZD8330 869357-68-6
EOS Med Chem, Medicinal Chemical is Big ZM241385 139180-30-6
EOS Med Chem, Medicinal Chemical is Big SB216763 280744-09-4
EOS Med Chem, Medicinal Chemical is Big CP21R7 (CP21) 125314-13-8
EOS Med Chem, Medicinal Chemical is Big ONO-4059 1351636-18-4
EOS Med Chem, Medicinal Chemical is Big ONO-4059 analog 1351635-67-0
EOS Med Chem, Medicinal Chemical is Big ClozapineN-Oxide 34233-69-7
EOS Med Chem, Medicinal Chemical is Big 10058-F4 403811-55-2
EOS Med Chem, Medicinal Chemical is Big AZD1981 802904-66-1
EOS Med Chem, Medicinal Chemical is Big STF-118804 894187-61-2
EOS Med Chem, Medicinal Chemical is Big FIPI 939055-18-2
EOS Med Chem, Medicinal Chemical is Big Optovin 348575-88-2
EOS Med Chem, Medicinal Chemical is Big GW9662 22978-25-2
EOS Med Chem, Medicinal Chemical is Big RG2833 1215493-56-3
EOS Med Chem, Medicinal Chemical is Big VU0357017 1135242-13-5
EOS Med Chem, Medicinal Chemical is Big KS176 1253452-78-6
EOS Med Chem, Medicinal Chemical is Big VU0361737 1161205-04-4
EOS Med Chem, Medicinal Chemical is Big NSC59984 803647-40-7
EOS Med Chem, Medicinal Chemical is Big PD168393 194423-15-9
EOS Med Chem, Medicinal Chemical is Big AAL-993 269390-77-4
EOS Med Chem, Medicinal Chemical is Big Tenovin-3 1011301-27-1
EOS Med Chem, Medicinal Chemical is Big T0070907 313516-66-4
EOS Med Chem, Medicinal Chemical is Big YYA-021 144217-65-2
EOS Med Chem, Medicinal Chemical is Big RS1 312756-74-4
EOS Med Chem, Medicinal Chemical is Big C-DIM12 178946-89-9
EOS Med Chem, Medicinal Chemical is Big BTZ043 1161233-85-7
EOS Med Chem, Medicinal Chemical is Big PBTZ169 1377239-83-2
EOS Med Chem, Medicinal Chemical is Big JWH-133 259869-55-1
EOS Med Chem, Medicinal Chemical is Big TMS 24144-92-1
EOS Med Chem, Medicinal Chemical is Big Compound 401 168425-64-7
EOS Med Chem, Medicinal Chemical is Big SMER28 307538-42-7
EOS Med Chem, Medicinal Chemical is Big AV412 451492-95-8
EOS Med Chem, Medicinal Chemical is Big BI2536 755038-02-9
EOS Med Chem, Medicinal Chemical is Big CP-724714 383432-38-0
EOS Med Chem, Medicinal Chemical is Big MK-2461 917879-39-1
EOS Med Chem, Medicinal Chemical is Big TAK-285 871026-44-7
EOS Med Chem, Medicinal Chemical is Big GSK-J1 1373422-53-7
EOS Med Chem, Medicinal Chemical is Big PF8380 1144035-53-9
EOS Med Chem, Medicinal Chemical is Big LY2801653 1206799-15-6
EOS Med Chem, Medicinal Chemical is Big FPS-ZM1 945714-67-0
EOS Med Chem, Medicinal Chemical is Big DB07268 929007-72-7
EOS Med Chem, Medicinal Chemical is Big SW-044248 522650-83-5
EOS Med Chem, Medicinal Chemical is Big RBC8 361185-42-4
EOS Med Chem, Medicinal Chemical is Big TETRABENAZINE 718635-93-9
EOS Med Chem, Medicinal Chemical is Big BML-210 537034-17-6
EOS Med Chem, Medicinal Chemical is Big BQU57 1637739-82-2
EOS Med Chem, Medicinal Chemical is Big BPR1J-097 1327167-19-0
EOS Med Chem, Medicinal Chemical is Big Vatalanib 212141-51-0
EOS Med Chem, Medicinal Chemical is Big MK4827 (Niraparib) 1038915-60-4
EOS Med Chem, Medicinal Chemical is Big CEP33779 1257704-57-6
EOS Med Chem, Medicinal Chemical is Big GSK163090 844903-58-8
EOS Med Chem, Medicinal Chemical is Big Coelenterazine 55779-48-1
EOS Med Chem, Medicinal Chemical is Big HTH-01-015 1613724-42-7
EOS Med Chem, Medicinal Chemical is Big SD208 627536-09-8
EOS Med Chem, Medicinal Chemical is Big Galeterone (TOK001) 851983-85-2
EOS Med Chem, Medicinal Chemical is Big Vipadenant（BIIB-014） 442908-10-3
EOS Med Chem, Medicinal Chemical is Big SRT2104 1093403-33-8 
EOS Med Chem, Medicinal Chemical is Big MCC-950 210826-40-7
EOS Med Chem, Medicinal Chemical is Big BDA-366 1821496-27-8
EOS Med Chem, Medicinal Chemical is Big GDC0084 1382979-44-3
EOS Med Chem, Medicinal Chemical is Big CWHM12 1564286-55-0
EOS Med Chem, Medicinal Chemical is Big MK4101 935273-79-3
EOS Med Chem, Medicinal Chemical is Big EW-7197 1352608-82-2
EOS Med Chem, Medicinal Chemical is Big ABT639 1235560-28-7
EOS Med Chem, Medicinal Chemical is Big chir-090 728865-23-4
EOS Med Chem, Medicinal Chemical is Big ms023 1831110-54-3
EOS Med Chem, Medicinal Chemical is Big FLT3-IN-2 923562-23-6
EOS Med Chem, Medicinal Chemical is Big BI-78D3 883065-90-5
EOS Med Chem, Medicinal Chemical is Big NT157 1384426-12-3 
EOS Med Chem, Medicinal Chemical is Big DMXAA 117570-53-3
EOS Med Chem, Medicinal Chemical is Big Tyrphostin（AG528） 133550-49-9
EOS Med Chem, Medicinal Chemical is Big SNG-1153 1446712-19-1
EOS Med Chem, Medicinal Chemical is Big MK-1439(Doravirine) 1338225-97-0
EOS Med Chem, Medicinal Chemical is Big ACT-678689 1783256-96-1
EOS Med Chem, Medicinal Chemical is Big BAY59-3074 406205-74-1
EOS Med Chem, Medicinal Chemical is Big DM1 139504-50-0
EOS Med Chem, Medicinal Chemical is Big EMD534085 858668-07-2
EOS Med Chem, Medicinal Chemical is Big Pristinamycin 270076-60-3
EOS Med Chem, Medicinal Chemical is Big Brincidofovir(CMX001) 444805-28-1
EOS Med Chem, Medicinal Chemical is Big Oritavancin（LY-333328） 171099-57-3
EOS Med Chem, Medicinal Chemical is Big Dactinomycin D 50-76-0
EOS Med Chem, Medicinal Chemical is Big Anidulafungin 166663-25-8
EOS Med Chem, Medicinal Chemical is Big PF-2545920 898562-94-2
EOS Med Chem, Medicinal Chemical is Big FRAX1036 1432908-05-8
EOS Med Chem, Medicinal Chemical is Big Retigabine 150812-13-8
EOS Med Chem, Medicinal Chemical is Big AC710 1351522-04-7
EOS Med Chem, Medicinal Chemical is Big JI-101 900573-88-8
EOS Med Chem, Medicinal Chemical is Big AZD9496 1639042-08-2
EOS Med Chem, Medicinal Chemical is Big INCB039110 1334298-90-6
EOS Med Chem, Medicinal Chemical is Big Capromorelin 193273-66-4
EOS Med Chem, Medicinal Chemical is Big SNX-2112 (PF-04928473) 908112-43-6
EOS Med Chem, Medicinal Chemical is Big SHP099 1801747-11-4
EOS Med Chem, Medicinal Chemical is Big RPI-1 269730-03-2 
EOS Med Chem, Medicinal Chemical is Big GSK484 1652591-81-5
EOS Med Chem, Medicinal Chemical is Big NXY-059 168021-79-2
EOS Med Chem, Medicinal Chemical is Big RO8994 1309684-94-3
EOS Med Chem, Medicinal Chemical is Big Leupeptin Hemisulfate 103476-89-7
EOS Med Chem, Medicinal Chemical is Big EPZ020411 1700663-41-7
EOS Med Chem, Medicinal Chemical is Big YC-1 170632-47-0
EOS Med Chem, Medicinal Chemical is Big NCT-501 1802088-50-1
EOS Med Chem, Medicinal Chemical is Big EPI-001 227947-06-0
EOS Med Chem, Medicinal Chemical is Big THZ2 1604810-84-5
EOS Med Chem, Medicinal Chemical is Big CDKI-73 1421693-22-2
EOS Med Chem, Medicinal Chemical is Big L755507 159182-43-1
EOS Med Chem, Medicinal Chemical is Big Bevirimat（PA-457） 174022-42-5
EOS Med Chem, Medicinal Chemical is Big GSK2565363
EOS Med Chem, Medicinal Chemical is Big GSK2578999A
EOS Med Chem, Medicinal Chemical is Big Delamanid (OPC-67683) 681492-22-8
EOS Med Chem, Medicinal Chemical is Big GSK6853 1910124-24-1
EOS Med Chem, Medicinal Chemical is Big CPI-637 1884712-47-3
EOS Med Chem, Medicinal Chemical is Big NSC23766 733767-34-5
EOS Med Chem, Medicinal Chemical is Big LGK974 1243244-14-5
EOS Med Chem, Medicinal Chemical is Big AZ505 1035227-43-0
EOS Med Chem, Medicinal Chemical is Big ARV-825 1818885-28-7
EOS Med Chem, Medicinal Chemical is Big Maraviroc 376348-65-1
EOS Med Chem, Medicinal Chemical is Big SIS3 521984-48-5  
EOS Med Chem, Medicinal Chemical is Big A804598 1125758-85-1
EOS Med Chem, Medicinal Chemical is Big Madrasin 374913-63-0
EOS Med Chem, Medicinal Chemical is Big MK3697 1224846-01-8
EOS Med Chem, Medicinal Chemical is Big HC-030031 349085-38-7
EOS Med Chem, Medicinal Chemical is Big Stattic 19983-44-9
EOS Med Chem, Medicinal Chemical is Big SCH-530348 705260-08-8
EOS Med Chem, Medicinal Chemical is Big Dalbavancin HCL 171500-79-1
EOS Med Chem, Medicinal Chemical is Big ITSA-1(ITSA1) 200626-61-5
EOS Med Chem, Medicinal Chemical is Big TG6-10-1 1415716-58-3
EOS Med Chem, Medicinal Chemical is Big BMS-707035 729607-74-3
EOS Med Chem, Medicinal Chemical is Big AGK2 304896-28-4
EOS Med Chem, Medicinal Chemical is Big GSK2981278
EOS Med Chem, Medicinal Chemical is Big GDC0152 873652-48-3
EOS Med Chem, Medicinal Chemical is Big SA-4503 165377-44-6
EOS Med Chem, Medicinal Chemical is Big T-1095
EOS Med Chem, Medicinal Chemical is Big ACY738 1375465-91-0
EOS Med Chem, Medicinal Chemical is Big KN62 127191-97-3
EOS Med Chem, Medicinal Chemical is Big GSK6853 1910124-24-1
EOS Med Chem, Medicinal Chemical is Big AM-2394 1442684-77-6
EOS Med Chem, Medicinal Chemical is Big Nexturastat A 1403783-31-2
EOS Med Chem, Medicinal Chemical is Big AG14361 328543-09-5
EOS Med Chem, Medicinal Chemical is Big GDC0853 1434048-34-6
EOS Med Chem, Medicinal Chemical is Big YM17690
EOS Med Chem, Medicinal Chemical is Big "HMN-176 

" 173529-10-7  
EOS Med Chem, Medicinal Chemical is Big BAW2881 (NVP-BAW2881)     "861875-60-7 
"
EOS Med Chem, Medicinal Chemical is Big "Leukadherin-1
" 344897-95-6
EOS Med Chem, Medicinal Chemical is Big "SIS3 HCl  
" 521984-48-5  
EOS Med Chem, Medicinal Chemical is Big "U93631
" 152273-12-6 
EOS Med Chem, Medicinal Chemical is Big A804598 1125758-85-1
EOS Med Chem, Medicinal Chemical is Big Itacitinib 1334298-90-6
EOS Med Chem, Medicinal Chemical is Big EHT1864 754240-09-0
EOS Med Chem, Medicinal Chemical is Big Elagolix 834153-87-6
EOS Med Chem, Medicinal Chemical is Big Elagolix sodium 832720-36-2
EOS Med Chem, Medicinal Chemical is Big Cangrelor (AR-C69931) 163706-36-3
EOS Med Chem, Medicinal Chemical is Big NS-398 123653-11-2
EOS Med Chem, Medicinal Chemical is Big IQ-1S 23146-22-7
EOS Med Chem, Medicinal Chemical is Big LGH447 1210416-52-6
EOS Med Chem, Medicinal Chemical is Big GGTI298 1217457-86-7
EOS Med Chem, Medicinal Chemical is Big Bisantrene 78186-34-2
EOS Med Chem, Medicinal Chemical is Big VLX1570 1431280-51-1
EOS Med Chem, Medicinal Chemical is Big PI3K-IN-2 1225037-39-7
EOS Med Chem, Medicinal Chemical is Big A-740003 861393-28-4
EOS Med Chem, Medicinal Chemical is Big BMS911543 1271022-90-2
EOS Med Chem, Medicinal Chemical is Big Apoptozole 1054543-47-3
EOS Med Chem, Medicinal Chemical is Big CXD101
EOS Med Chem, Medicinal Chemical is Big JNJ63533054 1802326-66-4
EOS Med Chem, Medicinal Chemical is Big Pamapimod 449811-01-2 
EOS Med Chem, Medicinal Chemical is Big T0901317 293754-55-9
EOS Med Chem, Medicinal Chemical is Big A-769662 844499-71-4
EOS Med Chem, Medicinal Chemical is Big MK1064 1207253-08-4
EOS Med Chem, Medicinal Chemical is Big ABT-472 943650-25-7
EOS Med Chem, Medicinal Chemical is Big ZK756326 874911-96-3
EOS Med Chem, Medicinal Chemical is Big AZD0156 1821428-35-6
EOS Med Chem, Medicinal Chemical is Big Selonsertib 1448428-04-3
EOS Med Chem, Medicinal Chemical is Big GSK583 1346547-00-9
EOS Med Chem, Medicinal Chemical is Big Lu AF21934 1445605-23-1
EOS Med Chem, Medicinal Chemical is Big Amiselimod 942398-84-7
EOS Med Chem, Medicinal Chemical is Big Mivebresib 1445993-26-9
EOS Med Chem, Medicinal Chemical is Big PF-4840154 1332708-14-1
EOS Med Chem, Medicinal Chemical is Big Ponesimod 854107-55-4
EOS Med Chem, Medicinal Chemical is Big azd3293 1383982-64-6
EOS Med Chem, Medicinal Chemical is Big CPI-1205 1621862-70-1
EOS Med Chem, Medicinal Chemical is Big BAY1217389 1554458-53-5
EOS Med Chem, Medicinal Chemical is Big OICR-9429 1801787-56-3
EOS Med Chem, Medicinal Chemical is Big STF-62247 315702-99-9
EOS Med Chem, Medicinal Chemical is Big SAR407899 hcl 923262-96-8
EOS Med Chem, Medicinal Chemical is Big P7C3-A20 1235481-90-9
EOS Med Chem, Medicinal Chemical is Big PD150606 179528-45-1
EOS Med Chem, Medicinal Chemical is Big Afatinib (BIBW2992) 439081-18-2
EOS Med Chem, Medicinal Chemical is Big L-685,458 292632-98-5 
EOS Med Chem, Medicinal Chemical is Big VU0364770 61350-00-3
EOS Med Chem, Medicinal Chemical is Big VU0357121 433967-28-3
EOS Med Chem, Medicinal Chemical is Big JK184 315703-52-7
EOS Med Chem, Medicinal Chemical is Big ML348 899713-86-1
EOS Med Chem, Medicinal Chemical is Big VU0364770 61350-00-3
EOS Med Chem, Medicinal Chemical is Big NP118809 41332-24-5
EOS Med Chem, Medicinal Chemical is Big LYS05 1391426-22-4
EOS Med Chem, Medicinal Chemical is Big GSK369796 1010411-21-8
EOS Med Chem, Medicinal Chemical is Big GPR39-C3 1621175-65-2 
EOS Med Chem, Medicinal Chemical is Big Liraglutide 204656-20-2
EOS Med Chem, Medicinal Chemical is Big Sermaglutide 910463-68-2
EOS Med Chem, Medicinal Chemical is Big VCMMAE 646502-53-6
EOS Med Chem, Medicinal Chemical is Big AN3365 1093643-37-8
EOS Med Chem, Medicinal Chemical is Big SF1670 345630-40-2
EOS Med Chem, Medicinal Chemical is Big BML-284 853220-52-7
EOS Med Chem, Medicinal Chemical is Big Vps34-IN-1 1383716-33-3
EOS Med Chem, Medicinal Chemical is Big EAI045 1942114-09-1
EOS Med Chem, Medicinal Chemical is Big EI1 1418308-27-6
EOS Med Chem, Medicinal Chemical is Big SecinH3 853625-60-2
EOS Med Chem, Medicinal Chemical is Big ECBN HCL 1029890-89-8
EOS Med Chem, Medicinal Chemical is Big Basmisanil 1159600-41-5
EOS Med Chem, Medicinal Chemical is Big lasmiditan 439239-90-4
EOS Med Chem, Medicinal Chemical is Big Alvespimycin 467214-20-6
EOS Med Chem, Medicinal Chemical is Big Anlotinib 1058156-90-3
EOS Med Chem, Medicinal Chemical is Big PX-12 141400-58-0
EOS Med Chem, Medicinal Chemical is Big H-89 hcl 127243-85-0
EOS Med Chem, Medicinal Chemical is Big ozanimod 1306760-87-1
EOS Med Chem, Medicinal Chemical is Big MT-1303 942399-20-4
EOS Med Chem, Medicinal Chemical is Big KX2-391 897016-82-9
EOS Med Chem, Medicinal Chemical is Big FGFR4-IN-1 1708971-72-5
EOS Med Chem, Medicinal Chemical is Big BGB-283，GDC-0810 1446090-77-2
EOS Med Chem, Medicinal Chemical is Big SBE13 HCl 1052532-15-6
EOS Med Chem, Medicinal Chemical is Big SKI II 312636-16-1
EOS Med Chem, Medicinal Chemical is Big KPT-8602 1642300-52-4
EOS Med Chem, Medicinal Chemical is Big GDC-0810 1446090-77-2
EOS Med Chem, Medicinal Chemical is Big SAR348830
EOS Med Chem, Medicinal Chemical is Big ACT-703328
EOS Med Chem, Medicinal Chemical is Big AMBIEN 103188-50-7
EOS Med Chem, Medicinal Chemical is Big DBPR-114
EOS Med Chem, Medicinal Chemical is Big SR3029 1454585-06-8
EOS Med Chem, Medicinal Chemical is Big Calicheamicin 108212-75-5
EOS Med Chem, Medicinal Chemical is Big MLN-120B 783348-36-7
EOS Med Chem, Medicinal Chemical is Big MK6096 1088991-73-4
EOS Med Chem, Medicinal Chemical is Big CZ415 1429639-50-8
EOS Med Chem, Medicinal Chemical is Big LY315920 172732-68-2
EOS Med Chem, Medicinal Chemical is Big ML-7 hydrochloride 110448-33-4
EOS Med Chem, Medicinal Chemical is Big Vemakalant 794466-70-9
EOS Med Chem, Medicinal Chemical is Big IWP-4 686772-17-8
EOS Med Chem, Medicinal Chemical is Big Repertaxin 266359-83-5
EOS Med Chem, Medicinal Chemical is Big IWP-3 687561-60-0
EOS Med Chem, Medicinal Chemical is Big KML-29 1380424-42-9
EOS Med Chem, Medicinal Chemical is Big IM-12 1129669-05-1
EOS Med Chem, Medicinal Chemical is Big Melinamide 14417-88-0
EOS Med Chem, Medicinal Chemical is Big Crinobulin 1000852-17-4
EOS Med Chem, Medicinal Chemical is Big UNC569 1350547-65-7
EOS Med Chem, Medicinal Chemical is Big U-73122 112648-68-7
EOS Med Chem, Medicinal Chemical is Big CP724714 537705-08-1
EOS Med Chem, Medicinal Chemical is Big AMG-458 913376-83-7
EOS Med Chem, Medicinal Chemical is Big A943931 1227675-50-4
EOS Med Chem, Medicinal Chemical is Big A484954 142557-61-7
EOS Med Chem, Medicinal Chemical is Big TH1338 1258494-60-8
EOS Med Chem, Medicinal Chemical is Big AR-13324 mesylate 1422144-42-0
EOS Med Chem, Medicinal Chemical is Big AR-13324 hydrochloride 1253952-02-1 
EOS Med Chem, Medicinal Chemical is Big SB203580 152121-47-6
EOS Med Chem, Medicinal Chemical is Big MX-69 1005264-47-0
EOS Med Chem, Medicinal Chemical is Big KRIBB11 342639-96-7
EOS Med Chem, Medicinal Chemical is Big YM-58483 223499-30-7
EOS Med Chem, Medicinal Chemical is Big STO-609 acetate 1173022-21-3
EOS Med Chem, Medicinal Chemical is Big BGP-15 66611-37-8
EOS Med Chem, Medicinal Chemical is Big YL0919 1339058-04-6
EOS Med Chem, Medicinal Chemical is Big HTHQ 148081-72-5
EOS Med Chem, Medicinal Chemical is Big RSL3 1219810-16-8
EOS Med Chem, Medicinal Chemical is Big GW4869 6823-69-4
EOS Med Chem, Medicinal Chemical is Big Elafibranor (GFT505) 923978-27-2
EOS Med Chem, Medicinal Chemical is Big ARQ-092 1313881-70-7 
EOS Med Chem, Medicinal Chemical is Big BFH-772 890128-81-1
EOS Med Chem, Medicinal Chemical is Big GF109203X 133052-90-1
EOS Med Chem, Medicinal Chemical is Big PD1-PDL1 inhibitor 1 1675201-83-8
EOS Med Chem, Medicinal Chemical is Big IPI-549 1693758-51-8
EOS Med Chem, Medicinal Chemical is Big U0126-EtOH 1173097-76-1
EOS Med Chem, Medicinal Chemical is Big PD-L1 inhibitor 1 1675203-84-5
EOS Med Chem, Medicinal Chemical is Big Tebanicline 198283-73-7
EOS Med Chem, Medicinal Chemical is Big NVP-LDE225 956697-53-3
EOS Med Chem, Medicinal Chemical is Big JNK-IN-7 1408064-71-0
EOS Med Chem, Medicinal Chemical is Big Reparixin 266359-83-5
EOS Med Chem, Medicinal Chemical is Big TAS-102 733030-01-8
EOS Med Chem, Medicinal Chemical is Big WEHI-345 1354825-58-3
EOS Med Chem, Medicinal Chemical is Big Epetraborole hydrochloride 1234563-16-6
EOS Med Chem, Medicinal Chemical is Big I-CBP112
EOS Med Chem, Medicinal Chemical is Big BI-9564 1883429-22-8
EOS Med Chem, Medicinal Chemical is Big BAY-1082439 1375469-38-7
EOS Med Chem, Medicinal Chemical is Big NVP-CGM097 1313363-54-0
EOS Med Chem, Medicinal Chemical is Big GSK2256098 1224887-10-8
EOS Med Chem, Medicinal Chemical is Big MK-6892 917910-45-3
EOS Med Chem, Medicinal Chemical is Big Importazole 662163-81-7
EOS Med Chem, Medicinal Chemical is Big Bioymifi 1420071-30-2
EOS Med Chem, Medicinal Chemical is Big UF010 537672-41-6
EOS Med Chem, Medicinal Chemical is Big CC122 1015474-32-4
EOS Med Chem, Medicinal Chemical is Big NMS-P118 1262417-51-5
EOS Med Chem, Medicinal Chemical is Big MGL-3196
EOS Med Chem, Medicinal Chemical is Big MSX122 897657-95-3
EOS Med Chem, Medicinal Chemical is Big XY1 1624117-53-8
EOS Med Chem, Medicinal Chemical is Big Monastrol 254753-54-3
EOS Med Chem, Medicinal Chemical is Big CGS21680 HCL 124431-80-7
EOS Med Chem, Medicinal Chemical is Big Debio0932(CUDC-305 ) 1061318-81-7

EOS Med Chem, Medicinal Chemical is Big Refametinib（RDEA119) 923032-37-5