Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons
Larotrectinib (LOXO-101) , HPLC 99.3%, Stock 12kg, Intermediates in stock
Name: Larotrectinib free base
CAS#: 1223403-58-4 (free base)
Chemical Formula: C21H22F2N6O2
Exact Mass: 428.17723
Molecular Weight: 428.44
Elemental Analysis: C, 58.87; H, 5.18; F, 8.87; N, 19.62; O, 7.47
Related CAS #: 1223403-58-4 (free base) 1223405-08-0 (sulfate)
Synonym: LOXO 101; LOXO-101; LOXO101; ARRY-470; ARRY470; ARRY 470; Larotrectinib
IUPAC/Chemical Name: (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
InChi Key: NYNZQNWKBKUAII-KBXCAEBGSA-N
InChi Code: InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
SMILES Code: O=C(N1CC[C@@H](C1)O)NC2=C3N=C(N4CCC[C@@H]4C5=CC(F)=CC=C5F)C=CN3N=C2
Larotrectinib (LOXO-101) , HPLC 99.3%, Stock 12kg, Intermediates in stock
| 29274-22-4 | Larotrectinib intermediate |
| 29274-24-6 | Larotrectinib intermediate |
| 1218935-58-0 | Larotrectinib intermediate |
| 1218935-59-1 | Larotrectinib intermediate |
| 1223404-89-4 | Larotrectinib intermediate |
| 1223404-90-7 | Larotrectinib intermediate |
| 1223404-88-3 | Larotrectinib intermediate |
| 1218935-60-4 | Larotrectinib intermediate |
| 1363380-51-1 | Larotrectinib intermediate |
FDA New, GMP Do
Clinical Phase II, III Intermediates
GMP Custom synthesis, Full Document
R&D Center: 8000 sq, More than 100 hoods
Pilot Plant: 20000sq, 40 reactors from 5-200L
Manufacturing Site: 800000sq, 40 reactors from 100-5000L
Name: Larotrectinib free base
CAS#: 1223403-58-4 (free base)
Chemical Formula: C21H22F2N6O2
Exact Mass: 428.17723
Molecular Weight: 428.44
Elemental Analysis: C, 58.87; H, 5.18; F, 8.87; N, 19.62; O, 7.47
Related CAS #: 1223403-58-4 (free base) 1223405-08-0 (sulfate)
Synonym: LOXO 101; LOXO-101; LOXO101; ARRY-470; ARRY470; ARRY 470; Larotrectinib
IUPAC/Chemical Name: (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
InChi Key: NYNZQNWKBKUAII-KBXCAEBGSA-N
InChi Code: InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
SMILES Code: O=C(N1CC[C@@H](C1)O)NC2=C3N=C(N4CCC[C@@H]4C5=CC(F)=CC=C5F)C=CN3N=C2
