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2017年7月5日星期三

Biggest supplier BAY-1895344 1876467-74-1

BAY-1895344 is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.

 We have more than 15g in stock.
Web: www.eosmedchem.com
Email: info@eosmedchem.com; eosmedchem@gmail.com
EOS Med Chem produce BAY-1895344  1876467-74-1 to be China biggest.
BAY-1895344  1876467-74-1  99%, NMR, MS, COA is OK.
BAY-1895344  1876467-74-1  Size batch could be 100kg.

COA, MSDS, HPLC MORE THAN 98%, NMR, MS is ok
Name: BAY-1895344 
CAS#: 1876467-74-1 
Chemical Formula: C20H21N7O 
Exact Mass: 375.1808 
Molecular Weight: 375.436 
Elemental Analysis: C, 63.98; H, 5.64; N, 26.12; O, 4.26
Synonym: BAY-1895344; BAY 1895344; BAY1895344.
IUPAC/Chemical Name: (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine
InChi Key: YBXRSCXGRPSTMW-CYBMUJFWSA-N
InChi Code: InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1
SMILES Code: CN1N=CC=C1C2=C(C=CN=C3C4=CC=NN4)C3=NC(N5[C@H](C)COCC5)=C2

TECHNICAL DATA

Appearance:
Solid powder
Purity:
>98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:
Soluble in DMSO
Shelf Life:
>2 years if stored properly
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code:
293490
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2017年7月3日星期一

Biggest Supplier Lorlatinib; PF 06463922; PF06463922

EOS Med Chem produce Lorlatinib; PF 06463922; PF06463922 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
Lorlatinib; PF 06463922; PF06463922 Intermediates, EOS Med Chem have 8; Lorlatinib; PF 06463922; PF06463922 Impurity we have 10, all from GMP, FDA plant.


Web: www.eosmedchem.com
Email: info@eosmedchem.com; eosmedchem@gmail.com



Lorlatinib; PF 06463922; PF064639221454846-35-5
Lorlatinib Intermediate, N-11454850-15-7
Lorlatinib Intermediate, N-21454850-13-5
Lorlatinib Intermediate, N-31454850-11-3
Lorlatinib Intermediate, N-41454848-00-0
Lorlatinib Intermediate, N-51454847-99-4
Lorlatinib Intermediate, N-61454847-98-3
Lorlatinib Intermediate, N-71454847-97-2
Lorlatinib Intermediate, N-81454847-96-1
Lorlatinib Intermediate, N-9914225-70-0
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Stock list July 4th


Web: www.eosmedchem.com
Email: info@eosmedchem.com; eosmedchem@gmail.com

NameWeightCAS
2,4-Dibromo-3-chloro-pyridine11g861024-77-3
2,6-Dichloro-4,5-dimethyl-nicotinonitrile16g56704-30-4  
5-Amino-2-methoxy-isonicotinic acid12g183741-91-5
2,6-Dihydroxy-4,5-dimethyl-nicotinonitrile28g 56704-29-1
6-Amino-3,5-dinitro-pyridin-2-ol7.3g
2-Ethoxy-6-methyl-nicotinonitrile2g54957-81-2  
6-Methyl-4-nitro-pyridin-2-ylamine3g
6-Bromo-pyridine-2-sulfonic acid amide22856013-04-2  
4-Iodo-6-trifluoromethyl-pyridin-2-ylamine3g1227581-86-3  
2-Chloro-4-methoxy-6-methyl-pyridine201227578-45-1  
2-Amino-6-methyl-nicotinonitrile5.584647-20-1  
2-Chloro-6-methyl-pyridin-4-ylamine4.679055-63-3  
4-Amino-2,6-dihydroxy-nicotinonitrile15g
6-Fluoro-3-nitro-pyridin-2-ylamine3g
2-Chloro-5-formyl-4-hydroxy-nicotinonitrile23g
3-Chloro-5-nitro-pyridin-2-ylamine2g
5-Bromo-3,4-dimethyl-pyridin-2-ol12g
5-Bromo-2,4-dichloro-3-nitro-pyridine38g
5-Chloro-4-methoxy-pyridin-2-ylamine2g662117-63-7  
3-Trifluoromethyl-pyridin-2-ol30g
3,5-Dimethyl-isonicotinic acid15g544703-96-0  
2-Bromo-5-chloro-pyridin-3-ol3.2g127561-70-0  
6-Chloro-2-methyl-pyridine-3-carbaldehyde2.5g884495-36-7
2-Fluoro-4-iodo-nicotinonitrile4g898854-59-6  
2-Bromo-4-chloro-pyridin-3-ylamine5g357263-45-7  
2-Methoxy-5-nitro-pyridin-4-ylamine2.5g
5-Chloro-2-methoxy-4-nitro-pyridine4.6g
5-Bromo-6-methoxy-3-nitro-pyridin-2-ylamine8.3
2-Chloro-3-iodo-4-methoxy-pyridine3g 1163693-01-3
2-Bromo-5-chloro-pyridin-4-ylamine3g        1060815-72-6
2-Amino-6-chloro-nicotinonitrile1g52471-07-5  
5-Cyano-2-methyl-isonicotinic acid ethyl ester6g
2,4-Dibromo-3-methyl-pyridine14g128071-93-2  
6-Methoxy-2,4-dimethyl-3-nitro-pyridine23g
5-Fluoro-pyridin-3-ylamine7g210169-05-4  
2,4-Dibromo-6-trifluoromethyl-pyridine24.71211539-45-5
6-Trifluoromethyl-pyridin-2-ylamine10g34486-24-3  
2,6-Diethoxy-pyridin-4-ylamine6.617325-39-2  
5-Iodo-4-methyl-pyridin-2-ylamine3.1356561-08-5  
6-Amino-2-chloro-nicotinonitrile153554-20-4  
4-Chloro-5-fluoro-nicotinic acid2g860296-20-4  
2,3,5-Trichloro-pyridine2g16063-70-0  
6-Chloro-3-methoxy-pyridin-2-ylamine4.7g175965-93-2  
2-Amino-4-methyl-nicotinonitrile1071493-76-0  
4,6-Dimethyl-pyridine-3-carbaldehyde4.5116785-23-0
2,5-Dichloro-4-trifluoromethyl-pyridine1.9g89719-92-6  
3-Trifluoromethyl-pyridine 1-oxide15.5g
4-Chloro-2,6-dimethyl-3-nitro-pyridine5g
4-Bromo-6-trifluoromethyl-pyridin-2-ylamine1g 1196147-49-5
4,6-Dimethyl-5-nitro-pyridin-2-ol1g
2,6-Dichloro-5-methoxy-pyridin-3-ylamine6.2g720666-44-4  
2-Chloro-6-methyl-3-nitro-pyridin-4-ylamine30g
6-Chloro-2,4-dimethyl-3-nitro-pyridine55
4-Chloro-2,5-dimethyl-pyridine522282-80-0
2-Chloro-4,6-dimethyl-nicotinonitrile36g14237-71-9
3-Chloro-2,6-dimethyl-pyridin-4-ylamine10g54754-85-7
2-Chloro-3,5-dimethyl-pyridine27g 72093-12-0
4-Bromo-5-ethyl-2-methyl-pyridine13.5g98488-99-4  
1-(2-Bromo-5-fluoro-pyridin-4-yl)-ethanone5.91114523-56-6
6-Chloro-4-trifluoromethyl-pyridin-2-ylamine1g34486-23-2  
2-Bromo-6-trimethylsilanyl-pyridine4g59409-80-2  
6-Chloro-3-nitro-5-trifluoromethyl-pyridin-2-ylamine6.3g
4-Bromo-2-fluoro-3-methyl-pyridine4g128071-79-4  
2-Ethoxy-6-methyl-nicotinonitrile554957-81-2  
2,4-Dichloro-6-methyl-pyridin-3-ylamine4g
2-Chloro-5-formyl-4-hydroxy-nicotinonitrile23
6-Chloro-4-iodo-nicotinonitrile1001061357-83-2
5-Chloro-4-methoxy-pyridin-2-ylamine2.3662117-63-7  
2,5-Dibromo-4-fluoro-phenol5g1155354-15-6  
45503309-10-2
5-Bromo-1,3-di-tert-butyl-2-methoxy-benzene25g1516-96-7  
2-Bromo-4,5-dichloro-phenol52316-56-5  
2-Chloro-5-methyl-4-nitro-phenol10g
6-Chloro-3-methyl-2,4-dinitro-phenol1.2g
1-Bromo-2-bromomethyl-3-methyl-benzene5.575366-10-8  
4-Chloro-1-chloromethyl-2-methoxy-benzene17.4101079-84-9  
2,3,6-Tribromo-4-nitro-phenylamine8g
2,3,6-Trichloro-phenylamine3.6g88963-39-7  
(2-Amino-5-chloro-phenyl)-pyridin-4-yl-methanone8g105192-42-5
2,4-Dichloro-pyrido[3,2-d]pyrimidine5.5g39551-54-7
3H-Imidazo[4,5-c]pyridine2.5g272-97-9
6-Trifluoromethyl-5H-cyclopentapyrimidin-4-ylamine1.7
4-Chloro-3-nitro-1H-pyrrolo[2,3-b]pyridine100
10914606-88-5  
Thieno[3,2-b]pyridine-6-carboxylic acid1.4g117390-39-3  
Quinazoline-2,4,6-triol8
8-Methyl-7H-purin-6-ylamine4.2g22387-37-7
1H-Indole-2-carboxylic acid2g1477-50-5
6-Methoxy-pyrido[3,4-d]pyrimidine-2,4-diol5.5g
2.7g153035-56-4
5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-ylamine3g507462-51-3  
3-(1-Hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-acrylic acid330
C21 H15 F4 N3
Benzenamine, N,​N'-​(2,​6-​pyridinediyldiethyli​dyne)​bis[2,​4-​difluoro- (9CI)
Molecular Weight
385.36
Boiling Point (Predicted)
Value: 465.6±45.0 °C | Condition: Press: 760 Torr
Density (Predicted)
Value: 1.24±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
pKa (Predicted)
Value: 2.19±0.50 | Condition: Most Basic Temp: 25 °C
Other Names
2,6-Diacetylpyridinebis(2,4-difluoroanil)
100508168-08-9  
7-Bromo-3H-isobenzofuran-1-one2g105694-44-8  
Furo[3,2-c]pyridin-4-ylamine3.5g33007-09-9
6-Chloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine2.6871254-63-6
6-Chloro-1H-pyrazolo[3,4-d]pyrimidine3g23002-51-9
2,6-Dichloro-3,5-dimethyl-pyrazine5g199983-44-3  
2-Bromo-4-methyl-pyrimidine18g130645-48-6  
7-Fluoro-pyrido[4,3-d]pyrimidin-4-ol5.6g
5,6-Dichloro-pyrazine-2,3-diamine2.5g13484-57-6  
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