EOS Med Chem, Medicinal Chemical is Big

2017年11月29日星期三

MK3118 (1207753-03-4), more than 20g in stock, biggest Manufacturer

MK3118 (1207753-03-4), NMR, HPLC99%, LCMS, COA, ROS is ok, stock more than 20g.

Name: MK 3118

CAS#: 1207753-03-4

Chemical Formula: C44H67N5O4

Exact Mass: 729.5193

Molecular Weight: 730.05

Elemental Analysis: C, 72.39; H, 9.25; N, 9.59; O, 8.77

Synonym: MK-3118; SCY-078; MK3118; SCY078; MK 3118; SCY 078

IUPAC/Chemical Name: 2-(2-amino-2,3,3-trimethylbutoxy)-1,6a,8,10a-tetramethyl-8-(3-methylbutan-2-yl)-3-(5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid

InChi Key: BODYFEUFKHPRCK-UHFFFAOYSA-N

InChi Code: InChI=1S/C44H67N5O4/c1-27(2)28(3)39(7)18-19-41(9)30-12-13-33-40(8)23-52-25-44(33,31(30)14-17-42(41,10)34(39)37(50)51)22-32(35(40)53-24-43(11,45)38(4,5)6)49-36(47-26-48-49)29-15-20-46-21-16-29/h14-16,20-21,26-28,30,32-35H,12-13,17-19,22-25,45H2,1-11H3,(H,50,51)

SMILES Code: CC(C(C1(C)CCC2(C)C3CCC4C5(C)COCC4(CC(N6C(C7=CC=NC=C7)=NC=N6)C5OCC(C(C)(C)C)(N)C)C3=CCC2(C)C1C(O)=O)C)C

TECHNICAL DATA

Appearance: Solid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term

Description: MK 3118 is a glucan synthase inhibitor potentially for the treatment of candida infection and aspergillosis.

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com

2018. 4.18 Janpan CPHI, Attend

2018. 5.15 Israel Biomed, Attend

2018. 6. 20 China CPHI, W4E82

2018. 8. 28 Korea CPHI, Attend

2018. 10. 9 Spain World CPHI, Attend

郵箱: info@eosmedchem.com ; eosmedchem@gmail.com

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp & Wechat: +8618653174435

住所: Diaozhen Chemical Industrial Park, Jinan City, China

Skype: willgutian

QQ: 2393923585

REFERENCES

1: Lepak AJ, Marchillo K, Andes DR. Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Antimicrob Agents Chemother. 2015 Feb;59(2):1265-72. doi: 10.1128/AAC.04445-14. PubMed PMID: 25512406; PubMed Central PMCID: PMC4335824.

2: Jiménez-Ortigosa C, Paderu P, Motyl MR, Perlin DS. Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates. Antimicrob Agents Chemother. 2014;58(2):1248-51. doi: 10.1128/AAC.02145-13. PubMed PMID: 24323472; PubMed Central PMCID: PMC3910825.

3: Pfaller MA, Messer SA, Motyl MR, Jones RN, Castanheira M. Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST). J Antimicrob Chemother. 2013 Apr;68(4):858-63. doi: 10.1093/jac/dks466. PubMed PMID: 23190764.

4: Pfaller MA, Messer SA, Motyl MR, Jones RN, Castanheira M. In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods. Antimicrob Agents Chemother. 2013 Feb;57(2):1065-8. doi: 10.1128/AAC.01588-12. PubMed PMID: 23229479; PubMed Central PMCID: PMC3553681.

5: Lamoth F, Alexander BD. Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Antimicrob Agents Chemother. 2015 Jul;59(7):4308-11. doi: 10.1128/AAC.00234-15. PubMed PMID: 25896696; PubMed Central PMCID: PMC4468689.

6: Hector RF, Bierer DE. New β-glucan inhibitors as antifungal drugs. Expert Opin Ther Pat. 2011 Oct;21(10):1597-610. doi: 10.1517/13543776.2011.603899. Review. PubMed PMID: 21787240.

7: Wring SA, Randolph R, Park S, Abruzzo G, Chen Q, Flattery A, Garrett G, Peel M, Outcalt R, Powell K, Trucksis M, Angulo D, Borroto-Esoda K. SCY-078 A First in Class Orally Active Antifungal Glucan Synthesis Inhibitor: Pre-Clinical Pharmacokinetics and Pharmacodynamic Target in Murine Models of Disseminated Candidiasis. Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.02068-16. doi: 10.1128/AAC.02068-16. [Epub ahead of print] PubMed PMID: 28137806.

2017年11月28日星期二

Biggest Manufacturer Baloxavir marboxil (CAS: 1985606-14-1 ) and Intermediates

Baloxavir marboxil(CAS:1985606-14-1)and intermediates, NMR, HPLC 99%+, LCMS, COA and ROS is ok.

1. Baloxavir marboxil(CAS: 1985606-14-1), NMR, HPLC 99%+, LCMS, COA and ROS, more than 100G in stock, pls check:

Name: Baloxavir marboxil
CAS#: 1985606-14-1
Chemical Formula: C27H23F2N3O7S
Exact Mass: 571.1225
Molecular Weight: 571.5518
Elemental Analysis: C, 56.74; H, 4.06; F, 6.65; N, 7.35; O, 19.59; S, 5.61

Baloxavir marboxil(CAS: 1985606-14-1) intermediates:

Baloxavir marboxil intermediate 1985605-59-1, we have more than 100g in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Baloxavir marboxil intermediate, we have more than 100g in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

CAS No.: 1985605-59-1 (Baloxavir) 1985606-14-1
Synonym: Baloxavir marboxil
IUPAC/Chemical Name: ({(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-6,8-dioxo-3,4,6,8,12,12ahexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl}oxy)methyl methyl carbonate
InChi Key: RZVPBGBYGMDSBG-GGAORHGYSA-N
InChi Code: InChI=1S/C27H23F2N3O7S/c1-36-27(35)39-14-38-25-19(33)8-9-31-24(25)26(34)30-10-11-37-12-21(30)32(31)23-15-6-7-18(28)22(29)17(15)13-40-20-5-3-2-4-16(20)23/h2-9,21,23H,10-14H2,1H3/t21-,23+/m1/s1
SMILES Code: O=C(OCOC(C(C=C1)=O)=C(N1N([C@@H]2C3=CC=CC=C3SCC4=C(F)C(F)=CC=C24)[C@@]5([H])N6CCOC5)C6=O)OC

TECHNICAL DATA
Appearance: Solid powder
Purity: >98%
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term.
Harmonized System Code: 293490

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com

2018. 4.18 Janpan CPHI, Attend

2018. 5.15 Israel Biomed, Attend

2018. 6. 20 China CPHI, W4E82

2018. 8. 28 Korea CPHI, Attend

2018. 10. 9 Spain World CPHI, Attend

郵箱: info@eosmedchem.com ; eosmedchem@gmail.com

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp & Wechat: +8618653174435

住所: Diaozhen Chemical Industrial Park, Jinan City, China

Skype: willgutian

QQ: 2393923585

Biggest Manufacturer Selonsertib(GS-4997) CAS# 1448428-04-3 and Intermediates

Selonsertib(GS-4997), CAS NO.: 1448428-04-3 and intermediates, NMR, HPLC 99%+, LCMS, COA and ROS is ok.

1. Selonsertib(CAS: 1448428-04-3), GS-4997, NMR, HPLC 99%+, LCMS, COA and ROS, more than 500G in stock, pls check:

Name: Selonsertib free base
CAS#: 1448428-04-3 (free base)
Chemical Formula: C24H24FN7O
Exact Mass: 445.20264
Molecular Weight: 445.5
Elemental Analysis: C, 64.71; H, 5.43; F, 4.26; N, 22.01; O, 3.59

Selonsertib(GS-4997)intermediates:

Selonsertib(GS-4997)intermediate 1448508-47-1, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Selonsertib(GS-4997)intermediate 1448427-99-3, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Selonsertib(GS-4997)intermediate, [1448508-47-1 intermediate] 1357942-79-0, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Selonsertib(GS-4997)intermediate, [1448427-99-3 intermediate] 5584-18-9, we have more than 25kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com

2018. 4.18 Janpan CPHI, Attend

2018. 5.15 Israel Biomed, Attend

2018. 6. 20 China CPHI, W4E82

2018. 8. 28 Korea CPHI, Attend

2018. 10. 9 Spain World CPHI, Attend

郵箱: info@eosmedchem.com ; eosmedchem@gmail.com

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp & Wechat: +8618653174435

住所: Diaozhen Chemical Industrial Park, Jinan City, China

Skype: willgutian

QQ: 2393923585

Description: Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.

Related CAS #: 1448428-04-3 (free base); 1448428-05-4 (HCl)

Synonym: GS-4997; GS4997; GS 4997; Selonsertib free base.

IUPAC/Chemical Name: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide

InChi Key: YIDDLAAKOYYGJG-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33)

SMILES Code: O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F

REFERENCES

1: Nelson CH, Wang L, Fang L, Weng W, Cheng F, Hepner M, Lin J, Garnett C, Ramanathan S. A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study. Clin Pharmacol Ther. 2015 Dec;98(6):630-8. doi: 10.1002/cpt.204. Epub 2015 Sep 29. PubMed PMID: 26259519.

2: Lin JH, Zhang JJ, Lin SL, Chertow GM. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. doi: 10.1159/000369152. Epub 2014 Dec 17. PubMed PMID: 25531162.