Paclitaxel impurity World original Source

EOS Med Chem cooperated with Shanghai Institute of Materia Medica, produce Paclitaxel impurity, to be World biggest supplier.

Email: info@eosmedchem.com; eosmedchem@gmail.com

ADD: Diaozhen Chemical Industrial Park, Jinan City, China

Until 2016, EP, USP, JP, BP all we have more than 100mg in stock.

Some un-known impurity, we are world first.

2017, Harvard Discovery in the United States, Yale University together with us, custom synthesis some new Paclitaxel impurity.

WELCOME TO OUR YOUTUBE

USP41	USP41 巴卡亭Ⅲ, ACETYLBACCATIN III	32981-90-1	HPLC 98%+, white powder, stock more than 1.5g
USP41	10-去乙酰基紫杉醇, Deacetyltaxol	78432-77-6	HPLC 98%+, white powder, stock more than 1.9g
USP41	7-木糖基紫杉醇, XYLOTAXOL, 7-(RG)	90332-66-4	HPLC 98%+, white powder, stock more than 1.4g
USP41	2，3-二羟基三尖杉宁碱, DIHYDROCEPHALOMANNINE, 2",3"-(P)	159001-25-9	HPLC 98%+, white powder, stock more than 1.6g
USP41	3’’,4’’-脱氢紫杉醇C	/	HPLC 98%+, white powder, stock more than 1.88g
USP41	苯基类似物	/	HPLC 98%+, white powder, stock more than 1.88g
USP41	7-表三尖杉宁碱  7-EPI-CEPHALOMANNINE	150547-36-7	HPLC 98%+, white powder, stock more than 1.5g

BELOW IS EP9.5

EP9.5	paclitaxel natural for peak identification（包含杂质A/B/C/D/E/F/H/O/P/Q/R）			√
	Paclitaxel impurity EP 9.5A	173101-54-7		HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5B		同USP三尖杉宁碱	HPLC 98%+, white powder, stock more than 1.4g
	Paclitaxel impurity EP 9.5C	153415-45-3	同进口标准紫杉醇C	HPLC 98%+, white powder, stock more than 1.1g
	Paclitaxel impurity EP 9.5D		同USP 7-表三尖杉宁碱	HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5E		同USP 7-表紫杉醇	HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5F		同进口标准N-甲基紫杉醇C	HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5H		同USP 7-表-10-去乙酰基紫杉醇	HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5O	219783-77-4		HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5P			HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5Q		同USP3’’,4’’-脱氢紫杉醇C	HPLC 98%+, white powder, stock more than 1.5g
	Paclitaxel impurity EP 9.5R			√HPLC 98%+, white powder, stock more than 1.5g

The impurity details are as follows:

Email: info@eosmedchem.com; eosmedchem@gmail.com

ADD: Diaozhen Chemical Industrial Park, Jinan City, China

巴卡亭III  Paclitaxel impurity ACETYLBACCATIN III, 7-(P) 32981-90-1, HPLC 98%+, white powder, stock more than 1.5g

Paclitaxel impurity-Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate 32981-85-4, HPLC 98%+, white powder, stock more than 2.5g

Paclitaxel impurity-(2R,3S)-3-PHENYLISOSERINE ETHYLESTER 153433-80-8, HPLC 98%+, white powder, stock more than 2.8g

Paclitaxel impurity-Deacetyltaxol 78432-77-6, HPLC 98%+, white powder, stock more than 2.8g

Paclitaxel impurity-7-Table-10-Deacetyl Paclitaxel, HPLC 98%+, white powder, stock more than 2.8g, the same with USP 10-Deacetyl-7-epipaclitaxel EPimpurity H

Paclitaxel impurity-Taxane 1605-68-1,  HPLC 98%+, white powder, stock more than 2.8g, 

Paclitaxel impurity-Cephalomannine 71610-00-9,HPLC 98%+, white powder, stock more than 2.8g, the same with USP Cephalomannine EPimpurity B

Paclitaxel impurity-7-epi-Cephalomannine 150547-36-7,HPLC 98%+, white powder, stock more than 2.8g,  the same with USP 7-Epicephalomannine EPimpurity D

Paclitaxel impurity-7-Epipaclitaxel 105454-04-4,HPLC 98%+, white powder, stock more than 2.8g,  the same with USP 7-Epipaclitaxel EPimpurity E

Paclitaxel impurity-Taxol C 153415-45-3,HPLC 98%+, white powder, stock more than 2.8g,  the same with  EPimpurity C

Paclitaxel impurity-N-methyl paclitaxel C 153083-53-5 ,HPLC 98%+, white powder, stock more than 2.8g,  the same with  EPimpurity F

Paclitaxel impurity-7-Xylosylpaclitaxel  90332-66-4,  HPLC 98%+, white powder, stock more than 2.8g, 

Paclitaxel impurity-2’’,3’’-Dihydrocephalomannine 159001-25-9,  HPLC 98%+, white powder, stock more than 2.8g, 

Paclitaxel impurity-3”,4”-Dehydropaclitaxel C ,  HPLC 98%+, white powder, stock more than 2.8g, the same with  EPimpurity Q

Paclitaxel impurity-Benzyl analog：Baccatin III 13-ester with (2R,3S)-2-hydroxy-3-phenyl-3-(2-phenyl-acetylamino)propanoic acid,  HPLC 98%+, white powder, stock more than 2.8g

Paclitaxel impurity-Iso Cephalomannine 173101-54-7,  HPLC 98%+, white powder, stock more than 2.8g, 

Email: info@eosmedchem.com; eosmedchem@gmail.com

ADD: Diaozhen Chemical Industrial Park, Jinan City, China

Paclitaxel impurity-Paclitaxel Impurity O  219783-77-4,  HPLC 98%+, white powder, stock more than 2.8g, 

Paclitaxel impurity-Paclitaxel Impurity P ,  HPLC 98%+, white powder, stock more than 2.8g, 

Paclitaxel impurity-Paclitaxel Impurity R ,  HPLC 98%+, white powder, stock more than 2.8g, 

Email: info@eosmedchem.com; eosmedchem@gmail.com

ADD: Diaozhen Chemical Industrial Park, Jinan City, China

Biggest Manufacturer，Osimertinib AZD-9291 （1421373-66-1） and Intermediates.

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.

2018 Korea CPHI, C30

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.

1.

Osimertinib AZD-9291, CAS#1421373-66-1, HNMR, HPLC 99%+, LCMS, COA, MSDS and ROS, more than 25KG in stock, pls check:

Name:Osimertinib AZD-9291

CAS#: 1421373-66-1

Chemical Formula: C29H37N7O5S 

Exact Mass: 

Molecular Weight: 595.72 

Elemental Analysis: C, 58.47; H, 6.26; N, 16.46; O, 13.43; S, 5.38

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

2. 

Osimertinib AZD-9291  Intermediates:

1. Osimertinib AZD-9291 Intermediate:N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methylindol-3-yl)pyrimidin-2-amine

Cas#1421372-94-2,

We have more than 33kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

2. Osimertinib AZD-9291 Intermediate:N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine

Cas#1421372-67-9,

We have more than43kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

3. Osimertinib AZD-9291 Intermediate:N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine

Cas#1421372-66-8

We have more than 54kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Reference：

1: Lung cancer: Diverse EGFR mutations explain AZD9291 resistance. Nat Rev Clin Oncol. 2015 May 19. doi: 10.1038/nrclinonc.2015.97. [Epub ahead of print] PubMed PMID: 25985937.
2: Thress KS, Paweletz CP, Felip E, Cho BC, Stetson D, Dougherty B, Lai Z, Markovets A, Vivancos A, Kuang Y, Ercan D, Matthews SE, Cantarini M, Barrett JC, Jänne PA, Oxnard GR. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat Med. 2015 Jun;21(6):560-2. doi: 10.1038/nm.3854. Epub 2015 May 4. PubMed PMID: 25939061.
3: Jänne PA, Yang JC, Kim DW, Planchard D, Ohe Y, Ramalingam SS, Ahn MJ, Kim SW, Su WC, Horn L, Haggstrom D, Felip E, Kim JH, Frewer P, Cantarini M, Brown KH, Dickinson PA, Ghiorghiu S, Ranson M. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med. 2015 Apr 30;372(18):1689-99. doi: 10.1056/NEJMoa1411817. PubMed PMID: 25923549.
4: Eberlein CA, Stetson D, Markovets AA, Al-Kadhimi KJ, Lai Z, Fisher PR, Meador CB, Spitzler P, Ichihara E, Ross SJ, Ahdesmaki MJ, Ahmed A, Ratcliffe LE, O'Brien EL, Barnes CH, Brown H, Smith PD, Dry JR, Beran G, Thress KS, Dougherty B, Pao W, Cross DA. Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models. Cancer Res. 2015 Jun 15;75(12):2489-500. doi: 10.1158/0008-5472.CAN-14-3167. Epub 2015 Apr 13. PubMed PMID: 25870145.
5: Jiang T, Zhou C. Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients with EGFR inhibitor-resistant non-small cell lung cancer. Transl Lung Cancer Res. 2014 Dec;3(6):370-2. doi: 10.3978/j.issn.2218-6751.2014.08.02. PubMed PMID: 25806323; PubMed Central PMCID: PMC4367669.
6: Finlay MR, Anderton M, Ashton S, Ballard P, Bethel PA, Box MR, Bradbury RH, Brown SJ, Butterworth S, Campbell A, Chorley C, Colclough N, Cross DA, Currie GS, Grist M, Hassall L, Hill GB, James D, James M, Kemmitt P, Klinowska T, Lamont G, Lamont SG, Martin N, McFarland HL, Mellor MJ, Orme JP, Perkins D, Perkins P, Richmond G, Smith P, Ward RA, Waring MJ, Whittaker D, Wells S, Wrigley GL. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67. doi: 10.1021/jm500973a. Epub 2014 Oct 1. PubMed PMID: 25271963.
7: AZD9291 could be an option for NSCLC. Cancer Discov. 2014 Aug;4(8):OF10. doi: 10.1158/2159-8290.CD-NB2014-077. Epub 2014 May 22. PubMed PMID: 25092747.

8: Cross DA, Ashton SE, Ghiorghiu S, Eberlein C, Nebhan CA, Spitzler PJ, Orme JP, Finlay MR, Ward RA, Mellor MJ, Hughes G, Rahi A, Jacobs VN, Red Brewer M, Ichihara E, Sun J, Jin H, Ballard P, Al-Kadhimi K, Rowlinson R, Klinowska T, Richmond GH, Cantarini M, Kim DW, Ranson MR, Pao W. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61. doi: 10.1158/2159-8290.CD-14-0337. Epub 2014 Jun 3. PubMed PMID: 24893891; PubMed Central PMCID: PMC4315625.