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2016年10月28日星期五

Best GMP : Brilanestrant | GDC-0810 | ARN-810 | CAS#1365888-06-7

FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big
 
2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

Name: GDC-0810 (ARN-810) 
CAS#: 1365888-06-7 
Chemical Formula: C26H20ClFN2O2 
Exact Mass: 446.11973 
Molecular Weight: 446.9064 
Elemental Analysis: C, 69.88; H, 4.51; Cl, 7.93; F, 4.25; N, 6.27; O, 7.16

Now we have produced 500g. And all Intermediates we have.

Description: Brilanestrant, also known as GDC-0810, ARN-810 and RG6046, an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. GDC-0810 functions by binding to the estrogen receptor, inducing a conformational change resulting in the degradation of the receptor. GDC-0810 or ARN-810 demonstrates robust activity in models of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer. 
Synonym: GDC0810; GDC 0810; GDC-0810; ARN810; ARN 810; ARN-810; RG6046; RG-6046; RG 6046; Brilanestrant
IUPAC/Chemical Name: (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid
SMILES Code: O=C(O)/C=C/C1=CC=C(C=C1)/C(C2=CC3=C(NN=C3)C=C2)=C(CC)\C4=CC=C(C=C4Cl)F


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FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big
 
2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian



2016 Oct New API and Intermediates
Below API and Intermediates, all from GMP system plant, audit is
ok




NAME STRUC CAS
LY2835219 Intermediates1 1118-69-0
LY2835219 Intermediates2 1231930-33-8
LY2835219 Intermediates3 1231930-37-2
LY2835219 Intermediates4 1231930-42-9
LY2835219 Intermediates5 1180132-17-5
LY2835219 1231929-97-7
LY2835219 1231930-82-7
AZD3759 Intermediates1 230955-75-6
AZD3759 Intermediates2 740081-22-5
AZD3759 Intermediates3 612501-52-7

AZD3759 Intermediates4 /
AZD3759 Intermediates5 /
AZD3759 1626387-80-1
CO1686 Intermediates1 68621-88-5
CO1686 Intermediates2 1021426-42-5
CO1686 Intermediates3 1374507-23-9
CO1686 Intermediates4 /
CO1686 1374640-70-6
LEE011 Intermediates1 1374639-77-6
LEE011 Intermediates2 1211443-58-1
LEE011 Intermediates3 1211443-61-6

LEE011 Intermediates4 1374639-78-7
LEE011 1211441-98-3
LEE011 1211443-80-9
Tipiracil Intermediates1 18592-13-7
Tipiracil Intermediates2 73742-45-7
Tipiracil 183204-72-0
HM61713 Intermediates1 16234-14-3
HM61713 Intermediates2 1353553-07-7
HM61713 Intermediates3 /
HM61713 Intermediates4 /
HM61713 1802181-20-9
AZD9291 Intermediates1 1032452-86-0

AZD9291 Intermediates2 1421372-94-2
AZD9291 Intermediates3 1421372-67-9
AZD9291 Intermediates4 1421372-66-8
AZD9291 Intermediates5 1421373-65-0
AP26113 Intermediates1 1089279-91-3
AP26113 Intermediates2 761440-75-9
AP26113 1197958-12-5
AP26113 /
E7050 Intermediates1 53617-36-0
E7050 Intermediates2 864245-57-8
E7050 928037-13-2


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2016年9月6日星期二

Obeticholic Acid List

Obeticholic Acid , produced in my GMP plant.

Each Intermediates could supply you more than 100kg now.

Until now, all Intermediaes, we have produced in GMP plant.

Approved by some big pharma Site Audit.

Each Intermediates, Assay more than 99%, Single Impurity less than 0.1%.

Impurity, Working Standard, Document now is full, DMF we are preparing.

Thanks.

Gu



6-Ethylchenodeoxycholic acid
编号
结构
CAS号
价格
OB7
 
4651-67-6

OB6
 
10538-59-7

OB2
 
1516887-33-4

OB1
 
915038-26-5

OB
459789-99-2
Single impurity less than 0.1%

2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年9月2日星期五

New compounds

Below is my new products, custom synthesis from GMP-LIKE plant.
CAS#859826-41-8
Name:5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one



CAS#1187830-71-2
Name:7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride 

 Glad to serve you.


2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian


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2016年9月1日星期四

GMP-Vorapaxar sulfate 705260-08-8

Vorapaxar sulfate 705260-08-8

 As one of China biggest supplier, Vorapaxar sulfate 705260-08-8, we could produce 1kg now.

 All from C GMP plant.

 Attaching COA.

EOS Med Chem, Medchem is big
Web: www.eosmedchem.com 
Email: gutian@eosmedchem.com; eosmedchem@gmail.com 
Office line: 0086-531-69905422-806
MOB & WhatsApp: +8618653174435
Skype: willgutian
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2016年8月30日星期二

Only we have produced: 136564-83-5 and 136564-87-9

Aug 20th, we finished 2 new compound for a new API.

 136564-83-5 and 136564-87-9

 Until now, we are world first commercial production supplier.

 In my GMP plant.

EOS Med Chem, Medchem is big
Web: www.eosmedchem.com 
Email: gutian@eosmedchem.com; eosmedchem@gmail.com 
Office line: 0086-531-69905422-806
MOB & WhatsApp: +8618653174435
Skype: willgutian


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2016年8月19日星期五

Aug worked new compounds

Below list is EOS Med Chem, Aug worked new compounds.

 Until now, each one, we could supply about 1-50kg.

 Most is used in New Drug Discovery.

 Thanks.
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian
1245514-96-8
917772-69-1
1231934-45-4
40472-88-6
67500-19-0
1235305-63-1
1260403-56-2
619-26-1
528882-15-7
528882-16-8
1418272-86-2
292170-96-8
908864-98-2
89284-05-9
1214358-61-8
131674-39-0
55676-21-6
116834-96-9
885223-65-4
916325-85-4
1186115-39-8
57830-14-5
104901-43-1
78946-25-5
1333400-84-2
1333400-85-3
1077-94-7
866327-70-0
342013-82-5
26892-90-0
54535-22-7
40851-95-4
1350925-20-0
1350925-21-1
1350925-22-2
1431872-99-9
1431873-03-8
1103234-56-5
1186223-50-6
84832-02-0
84832-01-9
83141-10-0
6946-10-7
1258234-18-2
1007882-59-8
1240893-76-8
1007882-58-7
1292836-05-5
1261118-01-7
1261118-02-8
1261118-03-9
1374414-03-5
1310455-86-7
1261118-05-1
1261117-66-1
138229-59-1
68109-89-7
207855-12-7
36792-88-8
36792-88-8
1083057-14-0
1083057-12-8
1047630-61-4
29481-26-3
1369594-41-1
1260846-67-0
1370468-13-5
1620450-59-0
1620454-30-9
1620454-31-0
1620454-32-1
1258234-18-2
1292836-05-5
74798-63-3
61019-05-4
1387445-50-2
402-61-9
4027-57-0
862248-40-6
131110-76-4
794518-57-3
794518-59-5
1620136-60-8
1620136-61-9
1620136-62-0
1620136-70-0
31839-20-0
215659-03-3
50413-44-0
179688-52-9
179688-53-0
179688-54-1
1185019-82-2
1185019-85-5
3937-49-3
7133-05-3
2587-03-3
2897-43-0
1313726-52-1
1616434-23-1
1658500-48-1
1658500-49-2
146351-72-6
1387561-09-2
3182-79-4
288-16-4
944716-73-8
1401305-30-3
1100752-71-3
1421252-92-7
1421252-90-5
1421252-91-6
847926-38-9
958488-76-1
571188-59-5
1423018-14-7
108499-32-7
19432-69-0
6837-14-5
79289-48-8
924962-08-3
924898-11-3
443956-09-0
443956-08-9
34604-60-9
72111-81-0
115619-00-6
115619-01-7
65766-32-7
1369594-41-1
1370468-13-5
1620450-59-0
1190865-44-1
872041-85-5
3937-49-3
7133-05-3
2587-03-3
2897-43-0
96797-15-8
1402838-09-8 
1206126-39-7
152279-17-9
1452-16-0
212558-27-5
247037-77-0
1579251-94-7
1351520-15-4
145349-62-8
136496-72-5
577967-89-6
1371587-51-7
95656-86-3
170384-29-9
916326-10-8
29086-41-7
1480-91-7
898044-50-3
7051-13-0
60154-05-4
21900-52-7
461432-22-4
461432-23-5
73852-17-2
1050392-15-8
1020717-99-0
1374208-42-0
164356-18-6
57830-14-5
1455091-04-9
1455091-10-7
2645-02-5
93247-79-1
138229-59-1
1194506-26-7
1033805-26-3
1125828-26-3
1125828-30-9
54535-22-7
52980-28-6
1182822-31-6
873054-44-5
72768-97-9
476473-97-9
68119-31-3
15295-77-9
1247119-35-2
124078-94-0
76028-96-1
689293-69-4
571189-16-7
571189-59-5
183288-43-9
1187595-85-2
1103234-56-5
330792-70-6
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