Open route of synthesis Acalabrutinib (ACP-196) Intermeidtes List /EOS Med Chem, Medicinal Chemical is Big

GMP produce Acalabrutinib & Intermediate

Acalabrutinib & Intermediate, HPLC more than 98%, NMR, LCMS, stock more than 50kg.

COA, MSDS like below.

Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

Name: Acalabrutinib (ACP-196) 
CAS#: 1420477-60-6 
Chemical Formula: C26H23N7O2 
Exact Mass: 465.19132 
Molecular Weight: 465.52 
Elemental Analysis: C, 67.08; H, 4.98; N, 21.06; O, 6.87

Synonym: ACP-196; ACP196; ACP 196; Acalabrutinib
IUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N
InChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1

SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2


Acalabrutinib (ACP-196) CAS:1420477-60-6 , As the world first commercial supplier.

Now we have supply each Intermediates in the step.

OPEN of the ROS for your reference.

Pls fell free ask me any need.

Below Acalabrutinib (ACP-196) Intermeidtes List, Assay more than 98%


Acalabrutinib (ACP-196) Intermediate: 1420478-90-5,(S)-4-(8-amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Acalabrutinib (ACP-196) Intermediate: 1420478-89-2,(S)-benzyl 2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1420478-88-1, (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1420478-87-0, (S)-benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1418307-18-2, (S)-benzyl 2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate 
Acalabrutinib (ACP-196) Intermediate: 1418307-17-1, (S)-benzyl 2-((3-chloropyrazin-2-yl)methylcarbamoyl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 771581-15-8,  2-Aminomethyl-3-chloropyrazine
Acalabrutinib (ACP-196) Intermediate: 55557-52-3, 3-Chloropyrazine-2-carbonitrile

Acalabrutinib (ACP-196) Intermediate: 1383385-64-5, No Name


Acalabrutinib (ACP-196) Intermediate: 180516-87-4, 4-Carboxylphenylboronic acid pinacol ester

2017 China CPHI: E1M35

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2-Azaadamantane HCl [3015-17-6] EOS Med Chem, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

Product Name: 2-AzaadaMantane hydrochloride

Synonyms: 2-AzaadaMantane hydrochloride

CAS: 3015-17-6

MF: C9H16ClN

MW: 173.68304

We finish it in 2015 Sep, now we have 100g in stock, assay more than 96%

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1-(4,5-dichloro-1H-indol-3-yl)-ethanone [1482735-76-1] / 大象藥物化學, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.

1-(4,5-dichloro-1H-indol-3-yl)-ethanone  [1482735-76-1] , as the China sole supplier, we could finish it assay more than 98%, HPLC, NMR, MS is ok.

Thanks.

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Icatibant Intermediates List

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

Sl.No	Name	Structure	CAS No
1	Fmoc-Arg(Pbf)-OH		154445-77-9
2	Fmoc-Oic-OH		130309-37-4
3	Fmoc-D-Tic-OH		130309-33-0
4	Fmoc-Ser(tBu)-OH		71989-33-8
5	Fmoc-Thi-OH		130309-35-2
6	Fmoc-Gly-OH		29022-11-5
7	Fmoc-Hyp(tBu)-OH		122996-47-8
8	Fmoc-Pro-OH		71989-31-6
9	Fmoc-D-Arg(Pbf)-OH		187618-60-6

Best Supplier of 60410-17-5 (1R,4R)-4-hydroxycyclopent-2-en-1-yl acetate

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.

EOS Med Chem, use my own route, finish the 60410-17-5 (1R,4R)-4-hydroxycyclopent-2-en-1-yl acetate.

Now cost is the world half.

 100g in stock. Assay more than 99%, EE more than 99%.

We are glad to provide you HPLC, NMR, LC-MS.

Thanks.

CAS No.:	60410-17-5
Synonyms:	(1R,4R)-4-hydroxycyclopent-2-en-1-yl acetate;
Formula:	C7H10O3
Exact Mass:	142.06300
Molecular Weight:	142.15200
PSA:	46.53000
LogP:	0.23890

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Custom synthesis new compound: 39161-84-7 , 4-MERCAPTOPHENYLACETIC ACID

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.

New 39161-84-7 , 4-MERCAPTOPHENYLACETIC ACID

Now we regular production. 1-10kg in stock.

World biggest supplier of 39161-84-7 , 4-MERCAPTOPHENYLACETIC ACID

Product Name:	4-MERCAPTOPHENYLACETIC ACID
Synonyms:	4-MERCAPTOBENZENEACETATE;4-MERCAPTOPHENYLACETIC ACID;4-Mercaptophenylacetic acid 97%
CAS:	39161-84-7
MF:	C8H8O2S
MW:	168.21
EINECS:
Product Categories:	Aromatic Phenylacetic Acids and Derivatives;Intermediates;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans
Mol File:	39161-84-7.mol