GMP produce Acalabrutinib & Intermediate
Acalabrutinib & Intermediate, HPLC more than 98%, NMR, LCMS, stock more than 50kg.
COA, MSDS like below.
Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Name: Acalabrutinib (ACP-196)
CAS#: 1420477-60-6
Chemical Formula: C26H23N7O2
Exact Mass: 465.19132
Molecular Weight: 465.52
Elemental Analysis: C, 67.08; H, 4.98; N, 21.06; O, 6.87
Synonym: ACP-196; ACP196; ACP 196; Acalabrutinib
IUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N
InChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
Acalabrutinib (ACP-196) CAS:1420477-60-6 , As the world first commercial supplier.
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Below Acalabrutinib (ACP-196) Intermeidtes List, Assay more than 98%
Acalabrutinib (ACP-196) Intermediate: 1420478-90-5,(S)-4-(8-amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Acalabrutinib (ACP-196) Intermediate: 1420478-89-2,(S)-benzyl 2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1420478-88-1, (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1420478-87-0, (S)-benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1418307-18-2, (S)-benzyl 2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1418307-17-1, (S)-benzyl 2-((3-chloropyrazin-2-yl)methylcarbamoyl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 771581-15-8, 2-Aminomethyl-3-chloropyrazine
Acalabrutinib (ACP-196) Intermediate: 55557-52-3, 3-Chloropyrazine-2-carbonitrile
Acalabrutinib (ACP-196) Intermediate: 1383385-64-5, No Name
Acalabrutinib (ACP-196) Intermediate: 180516-87-4, 4-Carboxylphenylboronic acid pinacol ester
2017 China CPHI: E1M35
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