EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce API and Intermediates and custom synthesis.
The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.
Now my plant have 80 workers, 15 Tech person, 4 high Tech person.
And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.
Each day, we have new chemicals or price from my lab or plant.
ABT-199, Venetoclax, 1257044-40-8. Attaching NMR, HPLC, LC-MS.
Now 1000g in stock, Assay more than 99%+, ROS is OPEN.
Now we could synthesis 12 Intermediates in GMP plant.
Each Step of Intermediates, we have.
Impurity we have, thanks
Description: Venetoclax, also known as ABT-199 or GDC0199, is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. (Last Update: 2/29/2016).
Synonym: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601. Venetoclax.
IUPAC/Chemical Name: 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
SMILES Code: O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
