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2016年2月19日星期五

Grazoprevir (MK5172) ROS, Intermediates List /EOS Med Chem, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.


Grazoprevir (MK5172)  1206524-85-7, now have 500g in stock. Assay more than 99%. HPLC, NMR, MS is ok.

Attaching ROS of Grazoprevir (MK5172), pls kindly check below.


As the fist Manu of Grazoprevir (MK5172)  1206524-85-7 , now each step of Intermediates we could produce by myself, regular production.

And we are working on the impurity of this project.

Now Intermediates list:
Grazoprevir Intermediates1206524-84-6
Grazoprevir Intermediates1206524-85-7   
Grazoprevir Intermediates1350619-77-0
Grazoprevir Intermediates1361028-94-5
Grazoprevir Intermediates1350514-68-9
Grazoprevir Intermediates1425038-19-2
Those are most need, if your need not, pls ask me.




2016 Shanghai CPHI, W5C47, Welcome!

EOS Med ChemMedchem is Big

執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
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Synonyms(1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
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Molecular StructureCAS # 1206524-85-7, MK-5172, (1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
Molecular FormulaC29H38N4O7
Molecular Weight554.63
CAS Registry Number1206524-85-7


Name(1R,2R)-2-(4-Pentyn-1-yl)cyclopropanol
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Molecular StructureCAS # 1350619-77-0, (1R,2R)-2-(4-Pentyn-1-yl)cyclopropanol
Molecular FormulaC8H12O
Molecular Weight124.18
CAS Registry Number1350619-77-0
Properties
SolubilitySoluble (15 g/L) (25 ºC), Calc.*
Density1.025±0.06 g/cm3 (20 ºC 760 Torr), Calc.*
Boiling point186.3±13.0 ºC (760 Torr), Calc.*
Flash point75.8±12.8 ºC, Calc.*
Synonyms(1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide cyclic (1→2)-ether; ; MK 5172
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Molecular StructureCAS # 1350514-68-9, Grazoprevir, (1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide cyclic (1→2)-ether, , MK 5172
Molecular FormulaC38H50N6O9S
Molecular Weight766.90
CAS Registry Number1350514-68-9