Glesatinib | MGCD-265 | CAS#936694-12-1 | TKI inhibitor | ,API 100g in hand, Intermediates 1kg in hand

Glesatinib | MGCD-265 | CAS#936694-12-1 | TKI inhibitor | , this will be hot project in the coming days.

EOS to be the first GMP supplier, each batch could be 1-5kg.

Assay more than 99, HPLC, NMR, MS as attachment.

Now cost only half of the market, until Jan 2016, we have sold more than 2000g, so price could be lowest.

And GMP standard.

Intermediates, we have 3.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

Description: Glesatinib, also known as MGCD-265, is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. MGCD265 binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). (last updated: 5/9/2016).

Synonym: MGCD-265; MGCD 265; MGCD265; Glesatinib; CAS#936694-12-1

IUPAC/Chemical Name: N-((3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)carbamothioyl)-2-(4-fluorophenyl)acetamide

SMILES Code: O=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=NC=C(CNCCOC)C=C4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=C(F)C=C5

CHEMICAL STRUCTURE

 

THEORETICAL ANALYSIS

Name: Glesatinib (MGCD-265) 
CAS#: 936694-12-1 
Chemical Formula: C31H27F2N5O3S2 
Exact Mass: 619.1523 
Molecular Weight: 619.7058 
Elemental Analysis: C, 60.08; H, 4.39; F, 6.13; N, 11.30; O, 7.75; S, 10.35

TECHNICAL DATA

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).