EOS Med Chem is the world first supplier of Upadacitinib (ABT-494) 1310726-60-3.
We start this Upadacitinib (ABT-494) 1310726-60-3 in 2015, until now, we could supply Upadacitinib (ABT-494) 1310726-60-3 and Intermediates. Produced total 20kg.
Upadacitinib (ABT-494) 1310726-60-3, Assay more than 99%, HPLC, NMR, MS is provided.
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
Keep Upadacitinib (ABT-494) 1310726-60-3 100g in stock.
Name: Upadacitinib (ABT-494)
CAS#: 1310726-60-3
Chemical Formula: C17H19F3N6O
Exact Mass: 380.1572
Molecular Weight: 380.3752
Elemental Analysis: C, 53.68; H, 5.04; F, 14.98; N, 22.09; O, 4.21
Description: Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.
Synonym: ABT-494; ABT 494; ABT494. Upadacitinib.
IUPAC/Chemical Name: (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
SMILES Code: O=C(N1C[C@@H](CC)[C@@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
1: Norman P. Selective JAK inhibitors in development for rheumatoid arthritis.
Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. doi:
10.1517/13543784.2014.918604. Epub 2014 May 12. Review. PubMed PMID: 24818516.
