Name: AZD-4547
CAS#: 1035270-39-3 (1394854-62-6)
Chemical Formula: C26H33N5O3
Exact Mass: 463.25834
Molecular Weight: 463.57192
Elemental Analysis: C, 67.36; H, 7.18; N, 15.11; O, 10.35
EOS Med Chem produce AZD-4547,1035270-39-3 (1394854-62-6) in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
AZD-4547,1035270-39-3 (1394854-62-6) Intermediates, EOS Med Chem have 8; AZD-4547,1035270-39-3 (1394854-62-6) Impurity we have 10, all from GMP, FDA plant.
Now AZD-4547,1035270-39-3 (1394854-62-6) DMF document is preparing.
Until 2016, Aug, AZD-4547,1035270-39-3 (1394854-62-6) more than produced 25kg API, 120kg Intermediates
AZD4547 AZD4547 1035270-39-3
AZD4547 Intermediates Ethyl 4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzoate 234082-05-4
AZD4547 Intermediates (E)-ethyl 3-(3,5-dimethoxyphenyl)acrylate 42174-79-8
AZD4547 Intermediates 3-(3,5-dimethoxyphenyl)propanoic acid 717-94-2
AZD4547 Intermediates Ethyl 3-(3,5-dimethoxyphenyl)propanoate 54901-09-6
AZD4547 Intermediates 5-(3,5-dimethoxyphenyl)-3-oxopentanenitrile 1000895-54-4
AZD4547 Intermediates 5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-amine 1000895-53-3
GMP PRODUCE:
Alectinib;Veliparib;Acalabrutinib;Venetoclax;Sotagliflozin;Ledipasvir;LX1606;Anacetrapib;Abemaciclib
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2016 Barcelona CPHI, Hope to meet!
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Description: AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.
Synonym: AZD4547; AZD-4547; AZD 4547.
IUPAC/Chemical Name: N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide
SMILES Code: O=C(NC1=NNC(CCC2=CC(OC)=CC(OC)=C2)=C1)C3=CC=C(N4C[C@H](C)N[C@H](C)C4)C=C3
Related CAS#
Sci-Finder listed CAS#1394854-62-6 for AZD-4547
ChemIDplus listed CAS#1035270-39-3 for AZD-4547, see website: https://chem.nlm.nih.gov/chemidplus/rn/1035270-39-3
According to Sci-Finder,
Chemical name for CAS#1394854-62-6:
N-[3-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl]-4-(3,5-dimethyl-1-piperazinyl)benzamide
Chemical name for CAS#1035270-39-3:
rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
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6: Zhao R, Xie X, Shen GX. Effects of glycated low-density lipoprotein on cell viability, proliferation, and growth factors of mouse embryo fibroblasts. Can J Physiol Pharmacol. 2013 Jan;91(1):64-70. doi: 10.1139/cjpp-2012-0234. Epub 2013 Jan 21. PubMed PMID: 23369077.
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8: Chell V, Balmanno K, Little AS, Wilson M, Andrews S, Blockley L, Hampson M, Gavine PR, Cook SJ. Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance. Oncogene. 2013 Jun 20;32(25):3059-70. doi: 10.1038/onc.2012.319. Epub 2012 Aug 6. PubMed PMID: 22869148.
9: Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science. 2012 Sep 7;337(6099):1231-5. doi: 10.1126/science.1220834. Epub 2012 Jul 26. PubMed PMID: 22837387; PubMed Central PMCID: PMC3677224.
10: Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S, Rooney C, Coleman T, Baker D, Mellor MJ, Brooks AN, Klinowska T. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 2012 Apr 15;72(8):2045-56. doi: 10.1158/0008-5472.CAN-11-3034. Epub 2012 Feb 27. PubMed
