EOS Med Chem produce Lumacaftor VX-809 936727-05-8 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok

EOS Med Chem produce Lumacaftor VX-809 936727-05-8 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-8 Intermediates, EOS Med Chem have 8; Lumacaftor VX-809 936727-05-8 Impurity we have 10, all from GMP, FDA plant.

Now Lumacaftor VX-809 936727-05-8 DMF document is preparing.

Until 2016, Aug, Lumacaftor VX-809 936727-05-8 more than produced 25kg API, 120kg Intermediates

Lumacaftor VX-809 936727-05-8   VX 809 936727-05-8, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-9 Intermediate 1- (2,2-Difluoro-benzo [1,3] dioxol-5-yl) -cyclopropanecarboxylicacid 862574-88-7, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-10 Intermediate 6-Chloro-5-Methyl-pyridin-2-ylaMine 442129-37-5, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-11 Intermediate 3- (6-Amino-3-methyl-pyridin-2-yl) -benzoicacidtert-butylester 1083057-14-0, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-12 Intermediate 3-Carboxyphenylboronic acid pinacol ester 269409-73-6, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-13 Intermediate 1- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarbonitrile 862574-87-6, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-14 Intermediate 2- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) acetonitrile 68119-31-3, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Lumacaftor VX-809 936727-05-15 Intermediate 3-tert-Butoxycarbonylphenylboronic acid 220210-56-0, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

Name: Lumacaftor

CAS#: 936727-05-8

Chemical Formula: C24H18F2N2O5

Exact Mass: 452.11838

Molecular Weight: 452.41

Elemental Analysis: C, 63.72; H, 4.01; F, 8.40; N, 6.19; O, 17.68

Description: Lumacaftor, also known as VX-809, is a potent CFTR corrector, many be useful for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation. Cystic fibrosis (CF) is a genetic disorder that causes multiorgan morbidity and premature death, most commonly from pulmonary dysfunction.

Synonym: VX-809; VX809; VX 809; Lumacaftor

IUPAC/Chemical Name: 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid

SMILES Code: O=C(O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)=CC=C2C)=C1

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