Name: Ruxolitinib free base
CAS#: 941678-49-5 (free base)
Chemical Formula: C17H18N6
Exact Mass: 306.15929
Molecular Weight: 306.37
Elemental Analysis: C, 66.65; H, 5.92; N, 27.43
Related CAS#
941678-49-5 (Ruxolitinib free base),
1092939-17-7 (Ruxolitinib phosphate salt).
EOS Med Chem produce Ruxolitinib INCB018424 1092939-17-7 941678-49-5 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
Ruxolitinib INCB018424 1092939-17-7 941678-49-5 Intermediates, EOS Med Chem have 8; Ruxolitinib INCB018424 1092939-17-7 941678-49-5 Impurity we have 10, all from GMP, FDA plant.
Now Ruxolitinib INCB018424 1092939-17-7 941678-49-5 DMF document is preparing.
Until 2016, Aug, Ruxolitinib INCB018424 1092939-17-7 941678-49-5 more than produced 25kg API, 120kg Intermediates
Ruxolitinib Intermediates 1146629-84-6 (R)-3-cyclopentyl-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile Assay more than 98%, HPLC, NMR, MS is ok
Ruxolitinib Intermediates 1153949-38-2 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile Assay more than 98%, HPLC, NMR, MS is ok
Ruxolitinib Intermediates 3680-69-1 4-Chloropyrrolo[2,3-d]pyrimidine Assay more than 98%, HPLC, NMR, MS is ok
Ruxolitinib Intermediates 16372-08-0 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine Assay more than 98%, HPLC, NMR, MS is ok
Ruxolitinib Intermediates 269410-08-4 Pyrazole-4-boronic acid pinacol ester Assay more than 98%, HPLC, NMR, MS is ok
Ruxolitinib Intermediates 591769-05-0 3-CYCLOPENTYLACRYLONITRILE Assay more than 98%, HPLC, NMR, MS is ok
Ruxolitinib Intermediates 941685-27-4 4-(1H-PYRAZOL-4-YL)-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE Assay more than 98%, HPLC, NMR, MS is ok
Ruxolitinib Intermediates 479633-63-1 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE Assay more than 98%, HPLC, NMR, MS is ok
1: Santos FP, Verstovsek S. Efficacy of ruxolitinib for myelofibrosis. Expert Opin Pharmacother. 2014 Jul;15(10):1465-73. doi: 10.1517/14656566.2014.923404. Epub 2014 May 24. Review. PubMed PMID: 24856675.
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