Description: Mirogabalin, also known as DS-5565, is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia. Mirogabalin was estimated to be 17-fold more potent than pregabalin. Mirogabalin is being developed by Daiichi Sankyo and related to drugs such as gabapentin and pregabalin. Similarly to these drugs, mirogabalin binds to the α2δ calcium channels (1 and 2), but with significantly higher potency than pregabalin. It has shown promising results in Phase II clinical trials for the treatment of diabetic peripheral neuropathic pain, and is currently in Phase III trials.
Name: Mirogabalin besylate
CAS#: 1138245-21-2 (besylate)
Chemical Formula: C18H25NO5S
Exact Mass:
Molecular Weight: 367.46
Elemental Analysis: C, 58.84; H, 6.86; N, 3.81; O, 21.77; S, 8.72
CAS#: 1138245-21-2 (besylate)
Chemical Formula: C18H25NO5S
Exact Mass:
Molecular Weight: 367.46
Elemental Analysis: C, 58.84; H, 6.86; N, 3.81; O, 21.77; S, 8.72
Synonym: DS-5565; DS 5565; DS5565; A-2000700; Mirogabalin; Mirogabalin besylate.
IUPAC/Chemical Name: 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)
InChi Key: OKJXJRVWXYRSAN-TXULWXBWSA-N
InChi Code: InChI=1S/C12H19NO2.C6H6O3S/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8;7-10(8,9)6-4-2-1-3-5-6/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15);1-5H,(H,7,8,9)/t9-,10-,12-;/m1./s1
SMILES Code: O=C(O)C[C@]1(CN)[C@]2([H])C=C(CC)C[C@]2([H])C1.O=S(C3=CC=CC=C3)(O)=O
| Mirogabalin 1138245-13-2 | 1G, CIF, USD 2200/G, IN STOCK |
| Mirogabalin 1138245-13-2 | 5G, CIF, USD 1580/G, IN STOCK |
| Mirogabalin 1138245-13-2 | 10G, CIF, USD 1280/G, IN STOCK |
| Mirogabalin Intermediate 1235479-61-4 | 10G, CIF, USD 6980/10G, 3-4 WEEKS |
