2017 China CPHI: E1M35
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
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| FG-4592,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 808118-40-3 | HIF | FG-4592 is an HIF α prolyl hydroxylase inhibitor. |
| BMS-599626 (AC480),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 714971-09-2, 873837-23-1 (HCl), 873837-22-0 (H2O) | EGFR, HER2 | BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively. |
| Erlotinib HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 183319-69-9, 183321-74-6 (free base), 248594-19-6 (methanesulfonate) | EGFR | Erlotinib also known as Tarceva, CP-358774, OSI-774, NSC-718781 is a HCL salt with IC50 of 2 nM for HER1/EGFR TK. |
| Gefitinib (Iressa),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 184475-35-2, 184475-55-6 (HCl) | EGFR | Gefitinib also known as ZD-1839 & Iressa is a novel potent EGFR tyrosine kinase & Akt phosphorylations inhibitor with IC50 of 37, 26 and 57 nM. |
| Neratinib (HKI-272),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 698387-09-6, 915942-22-2 (Maleic acid) | HER2, EGFR | Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively. |
| PD153035 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 183322-45-4, 153436-54-5 (free base) | EGFR | PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM). |
| Pelitinib (EKB-569),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 257933-82-7 | EGFR | Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. |
| Vandetanib (Zactima),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 443913-73-3, 338992-53-3 (TFA), 524722-52-9 (HCl) | VEGFR | Vandetanib is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. |
| WZ3146,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1214265-56-1 | EGFR | WZ3146 is an irreversiblely inhibitor against EGFR T790M. |
| WZ4002,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1213269-23-8 | EGFR | WZ4002 is an EGFR T790M inhibitor (IC50<20nM). |
| WZ8040,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1214265-57-2 | EGFR | WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM). |
| Tivozanib (AV-951),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 475108-18-0, 682745-41-1 (ClH.H2O), 682745-43-3 (HCL) | VEGFR, c-Kit, PDGFR | Tivozanib also known as AV-951 is an orally bioavailable potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively. |
| Axitinib,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 319460-85-0 | VEGFR, PDGFR, c-Kit | Axitinib blocked phosphorylation of VEGFR-2 and VEGFR-3 with average IC50s of 0.2 and 0.1 to 0.3 nM. |
| BIBF1120 (Vargatef),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 656247-17-5, 790241-30-4 (methanesulfonate), 959761-73-0 (HCl) | VEGFR, PDGFR, FGFR | Inhibitor of VEGFR, PDGFR and FGFR. all three VEGFR subtypes (IC50=13–34nmol/L) , PDGFRa and PDGFRh (IC50=59and65nmol/L) , and FGFRtypes 1, 2, and 3 (IC50=69, 37, and 108 nmol/L,respectively). |
| BMS 794833,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1174046-72-0, 1174161-83-1 (HCl) | c-Met, VEGFR | BMS-794833 is a potent ATPcompetitive Met/VEGFR-2 kinase inhibitor and it also inhibits Ron (Met family),Axl and Flt-3 with IC50 values <3 nM. |
| Dovitinib (TKI-258),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 405169-16-6, 804551-71-1 | FLT3 | Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively. |
| Cediranib (AZD2171),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 288383-20-0, 857036-77-2 (Maleic acid) | VEGFR, Flt | Cediranib (AZD2171) inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM, respectively. |
| Perifosine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 157716-52-4 | Akt | Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM. |
| CYC116,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 693228-63-6, 1067881-58-6 | Aurora Kinase, VEGFR | Aurora kinase/VEGFR2 inhibitor |
| STF-62247,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 315702-99-9 | STF-62247 is selectively toxic and growth inhibitory to renal cells lacking VHL | |
| Imatinib (Gleevec),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 152459-95-5 | PDGFR | Imatinib (STI571) is a number of tyrosine kinase enzymes specific inhibitor. |
| Imatinib Mesylate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 220127-57-1, 152459-95-5 (free base), 862366-25-4 (HCL) | PDGFR, c-Kit, Bcr-Abl | Imatinib also known as Gleevec, Glivec, CGP-57148B, STI-571 & Imatinib Mesylate is a multitargeted c-kit, PDGF-R and c-ABL inhibitor with IC50 of 3.9 and 2.9 μM for the inhibition of T-cell proliferation stimulated by DCs and PHA. |
| Ki8751,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 228559-41-9 | VEGFR, c-Kit, PDGFR | Ki8751 is a potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 0.9 nM, 40, 67, 170 nM for VEGF-2, c-Kit, PDGFRα and FGFR-2, respectively. |
| KRN 633,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 286370-15-8 | VEGFR, PDGFR | KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor with IC50 of 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. |
| Masitinib (AB1010),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 790299-79-5, 1048007-93-7 (methanesulfonate) | c-Kit, PDGFR, FGFR, FAK | Masitinib also known as Masivet, AB1010 is a tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor with IC50 of 150 ± 80, 200 ± 40 nM. |
| MGCD-265,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 875337-44-3 | c-Met, VEGFR, Tie-2 | MGCD-265 is a multi-targeted kinase inhibitor, which targets the c-MET, VEGFR1, VEGFR2, VEGFR3, Tie-2 and Ron receptor tyrosine kinases. |
| Motesanib Diphosphate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 857876-30-3, 453562-69-1 (free base), 945716-97-2 (H2O) | VEGFR, PDGFR, c-Kit | A multiple inhibitor of VEGFR1/2/3 (IC50: 2 ηM /3 ηM /6 ηM),PDGFR (84ηM), kit (8ηM), and Ret (59ηM)receptors |
| Amuvatinib (MP-470),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 850879-09-3 | c-Met, c-Kit, PDGFR, Flt, c-RET | MP470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 μM. |
| OSI-930,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 728033-96-3 | c-Kit, VEGFR | OSI-930 is an inhibitor of the receptor tyrosine kinases c-Kit (IC50:9.5nM) and VEGFR-2 (IC50:10.1nM). |
| Pazopanib HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 635702-64-6, 444731-52-6 (free base) | VEGFR, PDGFR, c-Kit | Pazopanib HCL is VEGFR inhibitor with IC50 of 10, 30 and 47 nM for VEGFR-1, -2 and -3. |
| Sorafenib (Nexavar),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 475207-59-1, 284461-73-0 (free base) | VEGFR, PDGFR, Raf | Sorafenib Tosylate is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. |
| Sunitinib Malate (Sutent),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 341031-54-7, 557795-19-4 (free base), 1126641-10-8 ( Maleic acid) | VEGFR, PDGFR, c-Kit, Flt | Sunitinib Malate (Sutent) is a multitargeted FLT3, PDGFRs, VEGFRs, and Kit kinase inhibitor with Ki of 0.009 and 0.008 µM for Flk-1 and PDGFR. |
| TSU-68,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 252916-29-3, 251356-54-4 (sodium salt) | VEGFR, PDGFR , FGFR | A novel multiple receptor tyrosine kinase inhibitor, VEGF-R1, PDGF-Rβ and FGF-R1 with IC50 values of 2.1 µM, 8 nM and 1.2 µM, respectively. |
| Vatalanib dihydrochloride (PTK787),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 212141-51-0, 212141-54-3 (free base) | VEGFR, c-Kit, Flt | Vatalanib (PTK787/ZK 222584) is a novel VEGFR and c-Kit tyrosine kinases and angiogenesis inhibitor with IC50 of 0.037, 0.077, 0.27 and 0.73 μM for KDR, Flt-1, Flk and c-Kit, respectively. |
| Foretinib (GSK1363089, XL880),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 849217-64-7, 1332889-22-1 (H2O) | c-Met, VEGFR | Foretinib (GSK1363089, XL880) is a novel MET and VEGFR2/KDR kinases inhibitor with an IC50 of 0.4 and 0.8 nM for MET and KDR, respectively. |
| Danusertib (PHA-739358),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 827318-97-8 | Aurora Kinase, FGFR, Bcr-Abl, c-RET, Src | PHA-739358 (Danusertib) is a pyrrolo-pyrazole and small molecule Aurora kinases and Bcr-Abl kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. |
| AT9283,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 896466-04-9, 896466-57-2 ((±)-Lactic acid), 896466-61-8 (HCl), 896466-55-0 (methanesulfonate) | Bcr-Abl, JAK, Aurora Kinase | AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A and B inhibitor with of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl (T3151), Jak2 and Jak3, aurora A and B, respectively. |
| Saracatinib (AZD0530),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 379231-04-6, 893428-72-3 (Fumaric acid), 893428-71-2 (3H2O) | Src, Bcr-Abl | AZD0530 (Saracatinib) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. |
| Bosutinib (SKI-606),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 380843-75-4, 918639-08-4 (H2O), 918639-09-5 (2-propanol) | Src | Bosutinib (SKI-606) is a Src family kinase inhibitor. It inhibited migration of breast cancer cell lines with IC50 values of 0.1 to 0.3 umol/L. |
| Dasatinib (BMS-354825),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 302962-49-8, 854001-07-3 (HCl) | Src, Bcr-Abl, c-Kit | Dasatinib also known as BMS-354825, Sprycel, BMS354825 is ATP-competitive, dual SRC/ABL inhibitor. BMS-354825 inhibits all members of the Src family, including c-Src, Lck, Fyn, and Yes (IC50 < 1.1nmol/L). |
| Nilotinib (AMN-107),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 641571-10-0 | Bcr-Abl | Nilotinib (AMN-107) is inhibitor of BCR-ABL with IC50 < 30nM. |
| Quercetin (Sophoretin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 117-39-5 | PI3K, PKC, Src, Sirtuin | Quercetin is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml. |
| NVP-ADW742,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 475488-23-4 | IGF-1R | IGF-1R inhibitor with an IC50 of 0.1 to 0.2 μM. |
| Quizartinib (AC220),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 950769-58-1,1132827-21-4 (2HCl), 1132827-24-7 (methanesulfonate) | Flt | AC220 is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. |
| Ponatinib (AP24534),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 943319-70-8, 1232836-25-7 (3HCl) | Bcr-Abl, VEGFR, FGFR, PDGFR, Flt | AP24534 is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN. |
| Tandutinib (MLN518),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 387867-13-2, 1227636-16-9 (3H2O) | Flt | Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of FLT3, PDGFR and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.17 μM, respectively. |
| KW 2449,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1000669-72-6 | Flt, Bcr-Abl, Aurora Kinase | KW-2449 is a multi-kinase inhibitor of FLT3 (IC50 at 6.6pM), ABL (IC50 at 14pM), ABL-T315I and Aurora kinase. |
| CI-1033 (Canertinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 267243-28-7, 289499-45-2 (2HCl) | EGFR, HER2 | CI-1033 is an orally bioavailable irreversible Pan-erbB tyrosine kinase inhibitor, targeting EGFR with IC50 of 0.8, 19 and 7 nM for EGFR, HER-2 and ErbB-4, respectively. |
| CP-724714,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 537705-08-1 | EGFR, HER2 | HER-2 tyrosine kinase inhibitor, IC50 of 15 ng/ml |
| Regorafenib (BAY 73-4506),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 755037-03-7, 835621-07-3 (HCl), 835621-08-4 (methanesulfonate) | c-Kit, Raf, VEGFR | BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
| JNJ-38877605,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 943540-75-8, 1093204-17-1 (X methanesulfonate), 1093204-20-6 (XHCl) | c-Met | JNJ-38877605 is a c-MET inhibitor with an IC50 of 4 nM. |
| PF-04217903,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 956905-27-4, 956906-93-7 (methanesulfonate), 1159490-81-9 (HCl) | c-Met | MET inhibitor with an IC50 from 3.1 nM to142 nM. |
| Crizotinib (PF-02341066),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 877399-52-5, 877399-53-6 (acetate) | c-Met, ALK | Inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). |
| Y-27632 2HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 129830-38-2, 146986-50-7 | ROCK | Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM. |
| SGX-523,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1022150-57-7, 1072116-01-8 | c-Met | SGX-523 is an exquisitely selective, ATP-competitive MET receptor tyrosine kinase inhibitor with an IC50 of 4 nM for the inhibition of HGFR. |
| SU11274,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 658084-23-2 | c-Met | SU11274 is a c-Met inhibitor (IC50 at 0.012μM). |
| TAE684 (NVP-TAE684),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 761439-42-3 | ALK | ALK inhibitor with an IC50 between 2 and 10 nM. |
| SB 525334,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 356559-20-1 | TGF-beta/Smad | SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). |
| R406,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 841290-81-1, 841290-82-2 (methanesulfonate) | Syk, Flt | R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. |
| R406(free base),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 841290-80-0 | Syk | R406 (free base) is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM. |
| XL-184 free base (Cabozantinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 849217-68-1,1140909-48-3 (L-(-)-Apple Acid) | VEGFR, c-Met, Flt, Tie-2, c-Kit | XL184 (Cabozantinib, BMS-907351) is a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. |
| BI 2536,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 755038-02-9, 876126-71-5 (H2O) | PLK | Plk1 inhibitor with an IC50 of 0.83 nM. |
| GSK461364,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 929095-18-1, 1000873-97-1 | PLK | GSK 461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM. |
| HMN-214,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 173529-46-9 | PLK | HMN-214 (a prodrug of HMN-176) is a potent PLK1 inhibitor (an average cell IC50 of 118nM). |
| ON-01910,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1225497-78-8 | PLK | ON-01910 is a non-ATP-competitive small molecule Plk1inhibitor with an IC50 of 9 nM. |
| AT7519,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 844442-38-2, 902135-91-5 (HCl), 902135-89-1 (methanesulfonate) | CDK | AT7519 is a kinase inhibitor with IC50 of 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35. |
| Elesclomol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 488832-69-5, 874477-51-7 (disodium salt) | HSP (e.g. HSP90) | Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells.. |
| BS-181 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1092443-52-1 (free base) | CDK | BS-181 is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase. |
| PD 0332991 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 827022-32-2, 571190-30-2 (free base) | CDK | CDK inhibitor with an IC50 of 0.011 μM for Cdk4 and IC50 of 0.016 μM for Cdk6. |
| PHA-793887,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 718630-59-2, 718630-60-5 (HCl) | CDK | PHA-793887 is a novel pan-cdk inhibitor, including cdk1, cdk2, cdk4, cdk5, cdk7, and cdk9 with IC50 in the 5 to 140 nM range. |
| Roscovitine (Seliciclib, CYC202),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 186692-46-6 | CDK | Roscovitine also known as CYC202 & Seliciclib. Roscovitine with purity >99% & solubility DMSO is available. |
| SNS-032 (BMS-387032),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 345627-80-7, 345627-90-9 (HCl) | CDK | SNS-032 (BMS-387032) is a potent and selective cyclin-dependent kinases (CDK) 9, 7 and 2 inhibitor with IC50 of 4, 62 and 38 nM for CDK9, CDK2/cyclin A and CDK7/Cyclin H. |
| AZD7762,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 860352-01-8, 1246094-78-9 (HCl), 1192875-06-1 (Fumaric acid) | Chk | AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. |
| Aurora A Inhibitor I,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1158838-45-9 | Aurora Kinase | Aurora A Inhibitor I is a selective Aurora A inhibitor (Aurora A: IC50 at 0.0034 μM; Aurora B: IC50 at 3.4 μM), (B / A ratio=1000). |
| Barasertib (AZD1152-HQPA),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 722544-51-6 | Aurora Kinase | AZD1152-HQPA is a highly potent and selective inhibitor of Aurora B (Ki, 0.36 nM) |
| CCT129202,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 942947-93-5 | Aurora Kinase | CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μmol/L for Aurora A, Aurora B, and Aurora C, respectively. |
| ENMD-2076,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1291074-87-7 | Flt, Aurora Kinase, VEGFR | ENMD-2076 (ENMD-981693, ENMD2076) is a antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FGFR1. |
| Hesperadin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 422513-13-1 | Aurora Kinase | Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. |
| MLN8237 (Alisertib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1028486-01-2, 1186318-95-5, 1028486-06-7 (sodium salt) | Aurora Kinase | MLN8237 (MLN-8237) is a selective Aurora kinase A inhibitor with a median IC50 of 61 nM. |
| Nutlin-3,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 890090-75-2 | Mdm2 | Nutlin-3 is a potent and selective Mdm2 antagonist with IC50 of 90 nM. |
| PHA-680632,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 398493-79-3 | Aurora Kinase | PHA-680632 is the first representative of a new class of Aurora inhibitors (Aurora A/B/C IC50 at 27,135 and 120 nM, respectively). |
| SNS-314,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1146618-41-8, 1057249-41-8 (FREE BASE) | Aurora Kinase | Inhibitor of Aurora kinases A (IC50=9.0nM),B (IC50=31nM),and C (IC50=3.4nM) |
| VX-680 (MK-0457, Tozasertib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 639089-54-6, 639090-58-7 (sulfate) | Aurora Kinase | VX-680 is the inhibitor of Aurora-A,-B,-C kinases with apparent inhibition constant values of 0.6,18,4.6 nM respectively. |
| ZM-447439,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 331771-20-1 | Aurora Kinase | ZM-447439 is a poten, selective ATP-competitive Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM and 250 nM for Aurora B, A and C, respectively. |
| AS703026,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1236699-92-5, 1236361-78-6 (HCl) | MEK | AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor (cell IC50 ranging from 0.005 to 2 µM). |
| AZD6244 (Selumetinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 606143-52-6, 942275-12-9 (4-methylbenzenesulfonate) | MEK | AZD6244 also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. |
| AZD8330,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 869357-68-6 | MEK | AZD8330 (RRY-424704，ARRY-704) is an orally active, selective MEK inhibitor with an IC50 of 7 nM. |
| BIX 02188,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1094614-84-2 | MEK | BIX02188 is a MEK5-selective inhibitor with an IC50 of 0.8 ± 1.0 μM. |
| BIX 02189,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1094614-85-3 | MEK | BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. |
| BMS 777607,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1196681-44-3, 1025720-94-8 | c-Met | BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 μM. |
| CI-1040 (PD184352),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 212631-79-3 | MEK | MEK 1/2 inhibitor. Ki of 300nM |
| PD318088,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 391210-00-7 | MEK | PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. |
| PD0325901,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 391210-10-9, 870474-62-7 | MEK | PD0325901 is selective and non ATP-competitive mitogen activated protein kinase kinase (MEK or MAPKK) MEK inhibitor with an IC50 of 0.33 nM for inhibiton of MEK activity in mouse colon 26 cells. |
| PD98059,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 167869-21-8 | MEK | PD 98059 is an inhibitor of MEK1 and MEK2 with IC50 values of 4 µM and 50 µM. |
| U0126-EtOH,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1173097-76-1, 109511-58-2 (FREE BASE) | MEK | Inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively. |
| LY2228820,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 862507-23-1, 862505-00-8 (free base), 862507-29-7 (HCl) | p38 MAPK | LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively). |
| BIRB 796 (Doramapimod),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 285983-48-4, 1283526-53-3 (HCl) | p38 MAPK | BIRB796 Doramapimod a small molecule of p38 MAPK inhibitor with Kd of 0.1 nM is available at Selleck. |
| SB 202190,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 152121-30-7, 350228-36-3 (HCl) | p38 MAPK | P38 MAP (mitogen activated protein) Kinase inhibitor. |
| SB 203580,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 152121-47-6, 224047-03-4, 869185-85-3 (HCl) | p38 MAPK | SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). |
| VX-702,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 745833-23-2, 479543-46-9 | p38 MAPK | P38 MAPK inhibitor , IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/ml, respectively) |
| VX-745,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 209410-46-8 | p38 MAPK | VX-745 is a lead anti-inflammatory candidate, p38 MAPK inhibitor (IC50=10 nM) for the treatment of Rheumatoid arthritis (RA). |
| GDC-0879,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 905281-76-7 | Raf | GDC-0879 is an B-Raf inhibitor ( EC50 = 0.75 µM). |
| PHA-665752,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 477575-56-7, 1262750-60-6(HCl) | c-Met | PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM. |
| PLX-4720,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 918505-84-7 | Raf | PLX-4720 is a B-raf inhibitor with IC50 of 160 nM. |
| RAF265 (CHIR-265),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 927880-90-8, 1009568-00-6 (Fumaric acid) | Raf, VEGFR | RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. |
| SP600125,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 129-56-6, 67072-00-8 (potassium salt) | JNK | SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3. |
| Brivanib (BMS-540215),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 649735-46-6 | VEGFR | Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively. |
| AS-605240,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 648450-29-7 | PI3K | AS-605240 is a PI3K γ inhibitor (IC50 at 8 nM). |
| GDC-0941,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 957054-30-7, 957054-33-0 (dimethanesulfonate), 957054-54-5 (xTFA) | PI3K | Inhibitor of Class I PI3 Kinase,p110a IC50=0.003uM,U87MG IC50=0.95μM. |
| IC-87114,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 371242-69-2 | IC-87114 was the first isoform-selective PI3K inhibitor : p110δ (IC50 = 0.13 µM) vs. p110α (IC50 = 200 µM), p110β (IC50 = 16 µM) and p110γ (IC50 = 61 µM). | |
| LY294002,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 154447-36-6, 934389-88-5 (HCl) | PI3K | PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor. |
| PIK-293,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 900185-01-5 | PI3K | PIK-293 is a PI3-K inhibitor.PIK-293 inhibit the p110α, p110β, p110δ, and p110γ with IC50 of 100uM,25uM,0.24uM,and 10uM. |
| PIK-90,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 677338-12-4 | PI3K | PI3K inhibitor,IC50=11, 350, 18, and 58 for p110 α, β, γ and δ isoforms. |
| PIK-93,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 593960-11-3 | PI3K, VEGFR | PIK-93 is a PI4KIIIβinhibitor (IC50 at 19 nM). |
| TG100-115,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 677297-51-7, 677297-55-1 (2HCL) | PI3K | TG100–115 is a PI3K γ and -δ inhibitor (IC50 = 83 and 235 nM, respectively) |
| TGX-221,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 663619-89-4 | PI3K | PI3Kβ (IC50=10nM) |
| XL147,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 956958-53-5 | PI3K | XL147 is a selective inhibitor of Class I PI3K isoforms. |
| XL765,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1349796-36-6, 1123889-87-1 | PI3K, mTOR | XL765 (SAR245409) is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and δ, respectively. |
| ZSTK474,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 475110-96-4 | PI3K | ZSTK474 is an inhibitor of PI3K γ (IC50 at 6 nM). |
| AZD8055,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1009298-09-2, 1201799-04-3 (D(-)-Tartaric Acid), 1201799-05-4 (Fumaric acid) | mTOR | AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. |
| Deforolimus (Ridaforolimus),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 572924-54-0, 697252-87-2 | mTOR | Deforolimus (Ridaforolimus, AP23573 and MK-8669) is a small-molecule inhibitor of mTOR. |
| Everolimus (RAD001),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 159351-69-6, 1245613-55-1 | mTOR | Everolimus RAD001 also known as SDZ-RAD, Certican, Zortress, Afinitorm is TOR inhibitor available at Selleck with IC50 of 0.63 nM. |
| Ku-0063794,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 938440-64-3 | mTOR | Ku-0063794 is a mTOR inhibitor, IC50 ~10 nM for mTORC1 and mTORC2, respectively. |
| Rapamycin (Sirolimus),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 53123-88-9, 1179372-35-0, 1189166-54-8, 1233221-34-5, 1353039-01-6 | mTOR | Rapamycin also known as Sirolimus & Rapamune is a mTOR inhibitor. Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated pathways. |
| Temsirolimus (Torisel),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 162635-04-3, 343261-52-9, 1034922-90-1 | mTOR | Temsirolimus (CCI-779, Torisel) is a specific mTOR inhibitor with IC50 of 1.76 μM. |
| WYE-354,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1062169-56-5 | mTOR | WYE-354 is a mTOR inhibitor with an IC50 of 5 nM. |
| PCI-24781,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 783355-60-2, 783356-67-2 (HCl) | HDAC | PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively. |
| PIK-75,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 372196-77-5, 372196-67-3 (free base) | PI3K, DNA-PK | PIK-75 Hydrochloride is a hydrochloride salt form of PIK-75, which is a preferential p110α/γ forms of PI3K inhibitor with IC50 of 6, 1300, 76, 510 nM for p110α, p110β, p110γ, p110δ, respectively. |
| Linsitinib (OSI-906),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 867160-71-2 | IGF-1R | OSI-906 (Linsitinib) is a selective inhibitor of IGF-IR and IR with IC50 of 35 nM and 75 nM, respectively. |
| Indirubin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 479-41-4 | GSK-3 | Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM. |
| SB 216763,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 280744-09-4 | GSK-3 | SB 216763 inhibited human GSK-3α with IC50s of 34 nM. |
| KU-55933,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 587871-26-9 | ATM | ATM inhibitor with an IC50 of 13 nM and a Ki of 2.2 nM. |
| KU-60019,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 925701-49-1 | ATM | KU-60019 is a specific improved ATM kinase inhibitor. |
| MK-2206 dihydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1032350-13-2, 1032349-93-1 (free base), 1032349-77-1 (HCl) | Akt | MK2206 an Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3, respectively is available on Selleck. |
| GSK1904529A,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1089283-49-7 | IGF-1R | GSK1904529A is a selective inhibitor of IGF-IR and IR with IC50 of 27 nM and 25 nM, respectively. |
| AT7867,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 857531-00-1 | Akt, S6 kinase | AT7867 is a potent and oral AKT and p70 S6 kinase inhibitor with an IC50 of 17 nM. |
| BTZ043 racemate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 957217-65-1 | BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis. | |
| AZD1480,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 935666-88-9, 1260222-79-4 (TFA) | JAK | AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. |
| MLN8054,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 869363-13-3, 869366-15-4 (sodium salt) | Aurora Kinase | MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM. |
| LY2784544,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1229236-86-5, 1229236-87-6 (HCl) | JAK | LY2784544 is a small molecule selective mutant JAK2 kinase inhibitor with an IC50 of 68 nM. |
| OSU-03012,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 742112-33-0 | PDK-1 | OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 ¦ÌM |
| Enzastaurin (LY317615),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 170364-57-5, 365253-37-8 (2HCl) | PKC | Enzastaurin (LY317615) is a potent PKC beta inhibitor with an IC50 of 6 nM. |
| Varespladib (LY315920),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 172732-68-2, 172733-42-5 (sodium salt) | Phospholipase (e.g. PLA) | LY315920 (Varespladib) is a potent and selective secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM. |
| GSK690693,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 937174-76-0 | Akt | GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
| SB 431542,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 301836-41-9, 1049727-65-2 (H2O) | TGF-beta/Smad | SB-431542 is an inhibitor of activin receptor-like kinase (ALK)5 (the TGF-βtype I receptor) (IC50 = 94 nM). |
| NPI-2358 (Plinabulin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 714272-27-2, 1367709-16-7 (TFA) | VDA | NPI-2358 is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM against HT-29 cells. |
| Zibotentan (ZD4054),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 186497-07-4 | ETA Receptor | Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). |
| 2-Methoxyestradiol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 362-07-2,39-20-7 (H2SO4) | HIF | 2-methoxyestradiol (2ME2) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration. |
| GSK429286A,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 864082-47-3 | ROCK | GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor with an IC50 of 14 nM. |
| Fasudil HCl (HA-1077),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 105628-07-7,103745-39-7 (free base) | ROCK | Fasudil HCl is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM. |
| Odanacatib (MK 0822),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 603139-19-1 | Cathepsin K | Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively. |
| Doxorubicin (Adriamycin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 25316-40-9, 23214-92-8 (free base), 1246449-85-3 (4-methylbenzenesulfonate) | Topoisomerase | Doxorubicin is a topoisomerase II inhibitor with IC50 of 1 and 2 μM for the inhibition of MCF-7 and MDA-MB231. |
| Camptothecin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 7689-03-4 | Topoisomerase | Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I) with an IC50 and IC70 of 50 nM and 0. 225 μM . |
| Etoposide (VP-16) ,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 33419-42-0, 35317-32-9, 51854-34-3 | Topoisomerase | Topoisomerase II inhibitor (IC50 = 59.2 μM). |
| Irinotecan,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 97682-44-5 | Topoisomerase | Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor with an IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively. |
| Topotecan HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 119413-54-6 | Topoisomerase | Topotecan Hydrochloride (Hycamtin) is a topoisomerase I inhibitor with an IC50 of 13 and 2 nM for MCF-7 Luc cells and DU-145 Luc cells. |
| ABT-751,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 141430-65-1, 141450-48-8 (HCl) | Microtubule Associated | ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with an IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines. |
| Docetaxel (Taxotere),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 114977-28-5, 148408-66-6 (3H2O) | Microtubule Associated | Docetaxel (Taxotere) is an microtubule disassembly inhibitor with IC50 of a range of 0.31–100 ηM. |
| Epothilone A,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 152044-53-6, 1285540-20-6 (2H2O) | Microtubule Associated | Epothilone A is a new kind of microtubule function inhibitor with an IC50 of 4.4 nM for tubulin polymerization and cytotoxicity. |
| Triciribine (Triciribine phosphate),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 35943-35-2 | Akt | Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively. |
| Epothilone B (EPO906),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 152044-54-7 | Microtubule Associated | Epothilone B is a new kind of cancer drugs and microtubule function inhibitor with an IC50 of 3.5 nM. |
| Paclitaxel (Taxol),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 33069-62-4, 157069-30-2, 1203669-79-7 | Microtubule Associated | Paclitaxel also known as Taxol, Onxol, Nov-Onxol is a microtubule polymer stabilizer with an IC50 of 0.1 pM for human endothelial cells. |
| Vincristine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 2068-78-2 | Microtubule Associated | Vincristine Sulfate is a microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively. |
| Capecitabine (Xeloda),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 154361-50-9,158798-73-3, 958887-39-3 | DNA/RNA Synthesis | Capecitabine (Xeloda) is an orally-administered chemotherapeutic agent (IC50 = 0.7~5 mM) and prodrug of 5-fluorouracil which is a DNA synthesis inhibitor with an IC50 for 5.0 ± 1.8 μM. |
| Cladribine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 4291-63-8 | DNA/RNA Synthesis | Cladribine (Leustatin) is an adenosine deaminase inhibitor with an IC50 of about 0.2 μM. |
| Clofarabine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 123318-82-1 | DNA/RNA Synthesis | Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase |
| Decitabine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 2353-33-5, 879492-56-5 (HCl), 879492-57-6 (monomethanesulfonate) | DNA/RNA Synthesis | Decitabine (NSC 127716, Dacogen, DAC) is an available nucleoside-based DNA methyltransferase (DNMT) inhibitor with IC50 of 490, 400 and 100 nM for A549, LoVo and LoVo-DX cell lines. |
| Fludarabine Phosphate (Fludara),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 75607-67-9 | DNA/RNA Synthesis | Fludarabine Phosphate (Fludara, 2-F-ara-AMP, FAMP) is a nucleoside analogue and formulated as the monophosphate form of F-ara-AMP (fludarabine, IC50 < 3 μM). |
| SRT1720,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1001645-58-4, 925434-55-5 (free base), 1001908-88-8 (TFA) | Sirtuin | SRT1720 is a selective SIRT1 activator with EC1.5 of 0.16 μM. |
| Fludarabine (Fludara),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 21679-14-1 | STAT, DNA/RNA Synthesis | Fludarabine (Fludara) is a purine analog and a chemotherapy drug with IC50 < 3 μM. |
| Gemcitabine HCl (Gemzar),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 122111-03-9, 95058-81-4 (free base) | DNA/RNA Synthesis | Gemcitabine is an antimetabolites inhibiting DNA synthesis (cell IC50 of 0.06 µM). |
| Pemetrexed,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 150399-23-8, 137281-23-3 (free base) | DHFR, DNA/RNA Synthesis | Pemetrexed disodium (Alimta) is a thymidylate synthase, DHFR and glycinamide ribonucleotide formyltransferase inhibitor with an IC50 of 25, 34, 220 nM. |
| Raltitrexed (Tomudex),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 112887-68-0 | DNA/RNA Synthesis | Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. |
| BIBR1532,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 321674-73-1 | Telomerase | A selective telomerase inhibitor,IC50 of 93 nM. |
| Brivanib alaninate (BMS-582664),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 649735-63-7 | VEGFR | A multiple inhibitor of VEGFR( IC50 of VEGFR-2(25 nM), VEGFR-1 (380nM), VEGFR-3 (10 nM)); FGFR (FGFR-1 (IC50=148 nM), FGFR-2 (IC50 =125 nM), and FGFR-3 (IC50 = 68 nM))tyrosine kinases |
| Cytarabine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 147-94-4, 69-74-9 (HCl) | Cytarabine (Cytosar-U) is an antimetabolic agent and a DNA polymerase with an IC50 of 16 nM for wild-type CCRF-CEM cells. | |
| Flucytosine (Ancobon),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 2022-85-7 | Flucytosine (Ancobon) is a fluorinated pyrimidine analogue and a synthetic antimycotic drug. | |
| Mizoribine (Bredinin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 50924-49-7 | DNA/RNA Synthesis | Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. |
| Belinostat (PXD101),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 414864-00-9 | HDAC | Belinostat also known as PXD101 is a HDAC inhibitor with IC50 of 27 nM. |
| CUDC-101,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1012054-59-9, 1012060-66-0 (L(+)-Tartaric Acid) | HDAC, EGFR, HER2 | Inhibitor of HDAC, EGFR, and HER2 with an IC50 of 4.4, 2.4, and 15.7 nM, respectively. |
| Droxinostat,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 99873-43-5 | HDAC | Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 (IC50 at 16.9 ,2.47 and 1.46 μM, respectively). |
| ITF2357 (Givinostat),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 732302-99-7, 497833-27-9 (free base) | HDAC | ITF2357 is a noverl HDAC inhibitor with IC50 of 10, 7.5 and 16 nM for maize HDAC preparations HD2, HD-1B and HD-1A, respectively. |
| JNJ-26481585,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 875320-29-9, 875320-30-2 (TFA), 875320-31-3 (2HCl) | HDAC | JNJ-26481585 is an orally bioavailable, second-generation, hydroxamic acid-based HDAC inhibitor with an IC50 of 2.43 nM for 5T33MMvt cells. |
| LAQ824 (NVP-LAQ824, Dacinostat),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 404951-53-7, 927176-79-2 (TFA) | HDAC | HDAC inhibitor with an IC50 of 0.032 μM. |
| Panobinostat,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 404950-80-7, 960055-57-6 (Maleic acid), 960055-60-1 (methanesulfonate) | HDAC | HDAC inhibitor, IC50 for inhibition of proliferation in MOLT-4 cells is approximately 5 μM and for Reh cells is approximately 20 μM. |
| MC1568,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 852475-26-4, 1003600-29-0 | HDAC | MC1568 is a potent selective class II (IIa) histone deacetylas (HDAC II) inhibitor (IC50 of a maize deacetylase HD2 at 22.0 µM). |
| Mocetinostat (MGCD0103),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 726169-73-9, 944537-89-7 (2BrH) | HDAC | HDAC inhibitor. HDAC 1(IC50=0.15 μM), HDAC 2(IC50=0.29 μM) and HDAC 3 (IC50=1.66 μM). |
| Entinostat (MS-275, SNDX-275),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 209783-80-2, 209784-79-2 (Maleic acid), 209784-80-5 (HCl) | HDAC | Inhibits HDAC1 (IC50=300 nM), HDAC3 (IC50=8 µM). |
| ADL5859 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 850173-95-4, 850305-06-5 (free base) | Opioid Receptor | ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM. |
| SB939 (Pracinostat),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 929016-96-6, 929016-98-8 (2HCl), 929016-97-7 (TFA) | HDAC | SB939 is a novel potent and orally active histone deacetylase inhibitor with an IC50 of 52 nM for HDAC1 and a GI50 of 0.56 µM for Colo205. |
| Andarine (GTX-007),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 401900-40-1 | Androgen Receptor | Andarine (GTX-007) is a selective nonsteroidal androgen receptor (AR) agonist with Ki of 4 nM. |
| Trichostatin A (TSA),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 58880-19-6, 204577-24-2 (sodium salt) | HDAC | Inhibitor of HDAC, HDAC inhibitory activity of TSA was similar in all cell lines with mean ± SD IC50 of 2.4 ± 0.5 nm (range, 1.5–2.9 nm) |
| Vorinostat (SAHA),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 149647-78-9 | HDAC | Vorinostat also known as SAHA, Zolinza, MK-0683 is an HDAC inhibitor. Vorinostat CAS No 149647-78-9 with purity >99% & solubility DMSO is available. |
| EX 527,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 49843-98-3 | Sirtuin | EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. |
| ABT-263 (Navitoclax),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 923564-51-6 | Bcl-2 | ABT263, Navitoclax Bcl-2 Family Inhibitor. Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w. |
| ABT-737,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 852808-04-9 | Bcl-2 | ABT-737 is a pan-Bcl-2 inhibitor. ABT737 single-agent LC90 values ranges from 100 nM for COG-LL-319. |
| Obatoclax mesylate (GX15-070),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 803712-79-0, 803712-67-6 (free base) | Bcl-2 | Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L) |
| TW-37,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 877877-35-5 | Bcl-2 | Bcl-2 protein family inhibitor,Ki value=290 nM. |
| Lenalidomide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 191732-72-6, 1243329-97-6 (HCl) | TNF-alpha | Lenalidomide also known as CC-5013 & Revlimid is TNF-alpha inhibitor. Revlimid with purity >99% & solubility DMSO is available. |
| Pomalidomide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 19171-19-8, 443912-23-0, 443919-33-3 | TNF-alpha, COX | Pomalidomide is tumor necrosis factor-α inhibitor and a new immunomodulator with an IC50 of 1 μM. |
| YM155,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 781661-94-7, 753440-91-4 (FREE BASE) | Survivin | YM155 (YM 155, YM-155) is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. |
| JNJ 26854165 (Serdemetan),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 881202-45-5, 881202-79-5 (3HCl) | p53 | JNJ-26854165 (JNJ 1, Serdemetan ) is an orally bioavailable, first-in-class small-molecule HDM2 antagonist with potential antineoplastic activity. |
| ABT-888 (Veliparib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 912444-00-9, 912445-05-7 (2HCl) | PARP | ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively. |
| MK-8245,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1030612-90-8 | Dehydrogenase | MK-8245 is an inhibitor of stearoyl-CoA desaturase (SCD) which targets the liver with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. |
| Rucaparib (AG-014699 , PF-01367338),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 459868-92-9, 283173-50-2 (free base) | PARP | AG-014699 is a PARP inhibitor (Ki, 1.4 nmol/L). |
| AG14361,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 328543-09-5 | PARP | AG14361 is a potent poly (ADP-ribose) polymerase (PARP-1) inhibitor with a GI50 of 10.9 µM. |
| Olaparib (AZD2281),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 763113-22-0, 894104-70-2, 937799-91-2, 1021843-02-6 | PARP | Olaparib, AZD2281, KU0059436, AZD-2281 or KU-0059436 is a PARP inhibitor. AZD 2281 Olaparib (CAS 763113-22-0) is available with IC50: PARP-1= 0.005 μM, PARP-2= 0.001 μM & >99% HPLC. |
| Iniparib (BSI-201),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 160003-66-7 | PARP | BSI-201 (Iniparib, BSI201) is a potent PARP1 inhibitor with strong anti-neoplastic effect. |
| INO-1001,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 3544-24-9, 220583-51-7 (TFA) | PARP | INO-1001 (NSC 36962, SR 4294, WD 97-000835) is a novel potent PARP inhibitor with an IC50 of 3 nM. |
| Ispinesib (SB-715992),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 336113-53-2, 514820-03-2 (methanesulfonate), 514820-04-3 (HCl) | Kinesin | Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. |
| SB 743921,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 940929-33-9, 618430-39-0 (free base) | Kinesin | SB743921 is a second generation, highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5). |
| Tipifarnib (Zarnestra),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 192185-72-1 | Farnesyltransferase, Ras | Tipifarnib is a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. |
| Bicalutamide (Casodex),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 90357-06-5 | Androgen Receptor, P450 | Bicalutamide (Casodex) is an active competitive non-steroidal androgen receptor antagonist. |
| Ganetespib (STA-9090),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 888216-25-9, 1143571-94-1 | HSP (e.g. HSP90) | Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells. |
| TRAM-34,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 289905-88-0 | Potassium Channel | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+channel (IKCa1, KCa3.1) with Kd of 20 nM. |
| PA-824,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 187235-37-6 | PA-824 is an anti-tuberculosis drug for tuberculosis with MIC less than 1 μg/mL. | |
| Fulvestrant (Faslodex),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 129453-61-8 | Estrogen/progestogen Receptor | Synthetic estrogen receptor antagonist (SERD) |
| AT13387,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 912999-49-6, 1019889-41-8 (HCl) | HSP (e.g. HSP90) | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells. |
| E7080 (Lenvatinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 417716-92-8, 857890-39-2 (methanesulfonate), 857890-31-4 (HCl) | VEGFR | E7080 (Lenvatinib) is a multi-target inhibitor of VEGFR2 and VEGFR3 with IC50 of 4 nM and 5.2 nM, respectively. |
| LY500307 (Erteberel),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 533884-09-2 | Estrogen/progestogen Receptor | LY500307 is a potent, selective estrogen receptor β agonist with an EC50 of 0.66 nM. |
| Anastrozole,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 120511-73-1 | Aromatase | Inhibits the enzyme aromatase |
| Exemestane,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 107868-30-4 | Aromatase | Exemestane was found to inhibit human placental aromatase with IC50 of 42 nM. |
| Ostarine (MK-2866),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 841205-47-8, 1235370-13-4 | Androgen Receptor | Ostarine (GTx-024, MK-2866, Enobosarm, S-22) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM. |
| Letrozole,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 112809-51-5 | Aromatase | Letrozole is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1–3 μg/kg p.o.). |
| Dutasteride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 164656-23-9 | 5-alpha Reductase | Dutasteride is a 5-alpha-reductase inhibitor. |
| Finasteride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 98319-26-7, 222989-99-3 (acetate) | 5-alpha Reductase | Finasteride is an inhibitor of steroid Type II 5α-reductase. |
| Maraviroc,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 376348-65-1, 674782-29-7 | CCR5 | Maraviroc is a CCR5 antagonist. Maraviroc was active (IC90) at low nanomolar concentrations against HIV-1 Ba-L. |
| Vicriviroc Malate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 541503-81-5, 541503-48-4 (HCl), 306296-47-9 (free base) | CCR5 | Vicriviroc is a CCR5 (cellular coreceptor 5) inhibitor, in vitro activity against HIV (IC90<13 nM) |
| BMS-707035,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 729607-74-3 | Integrase | BMS-707035 is an HIV-1 integrase (IN) inhibitor. |
| Elvitegravir (GS-9137),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 697761-98-1, 697762-15-5 (sodium salt) | Integrase | Elvitegravir is a human immunodeficiency virus integrase inhibitor with EC50 of 0.7, 2.8 and 1.4 for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD. |
| Raltegravir (MK-0518),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 518048-05-0, 1292804-07-9 (sodium salt) | Integrase | Raltegravir (MK-0518) is HIV integrase inhibitor with IC95 for HIV-1 in 50% normal human serum = 33 nM. |
| TAK-700 (Orteronel),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 566939-85-3 | CYP17 | TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively. |
| Bortezomib (Velcade),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 179324-69-7 | Proteasome | Bortezomib also known as Velcade, MG-341, PS-341 is proteasome Inhibitor, effectively inhibits proteasome activity (Ki-0.6 nM). |
| MLN2238,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1072833-77-2 | Proteasome | MLN-2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. |
| MLN9708,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1201902-80-8 | Proteasome | MLN9708 is an orally bioavailable second generation proteasome inhibitor with potential antineoplastic activity. |
| Ritonavir,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 155213-67-5 | HIV Protease | Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. |
| Sitagliptin phosphate monohydrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 654671-77-9, 486460-32-6 (free base), 654671-78-0 (phosphate) | DPP-4 | Sitagliptin phosphate monohydrate is a Dipeptidyl Peptidase-IV Inhibitor. |
| BMS-790052,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1214735-16-6, 1009119-64-5 | HCV Protease | BMS-790052 is a first-in-class, highly-selective oral HCV NS5A inhibitor. |
| Danoprevir,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 850876-88-9, 916881-67-9, 1001913-18-3, 1225266-12-5 | Proteasome, HCV Protease | Danoprevir is a highly potent inhibitor of the NS3/4A protease. |
| AG-1024 ,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 65678-07-1 | IGF-1R | AG-1024 (Tyrphostin) is a specific IGF-1R and IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively. |
| VX-222,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1026785-55-6 | HCV Protease | VX-222 (VCH-222) is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection. |
| Tosedostat (CHR2797),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 238750-77-1 | Aminopeptidase | Tosedostat (formerly CHR-2797) is an aminopeptidase inhibitor with IC50 of 100, 150, 220, >1000, >5000, >10000 and >30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively. |
| 17-AAG (Tanespimycin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 75747-14-7, 911710-03-7 (HCl) | HSP | 17-AAG is a less toxic analogue of the geldanamycin which binds to Hsp90 and alters its function. |
| 17-DMAG HCl (Alvespimycin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 467214-21-7, 467214-20-6 (free base) | HSP | A selective Hsp90 inhibitor with a GI50 of 53 nM. |
| BIIB021,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 848695-25-0, 848696-06-0 (XHCl), 848696-07-1 (methanesulfonate) | HSP | Inhibitor of Hsp90 (Ki=1.7nM). |
| AUY922 (NVP-AUY922),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 747412-49-3, 1051919-21-1 (methanesulfonate), 1051919-22-2 (HCl) | HSP | HSP90 inhibitor |
| NVP-BEP800,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 847559-80-2 | HSP | NVP-BEP800 is a novel, fully synthetic, oral Hsp90 inhibitor with an IC50 of 0.058 ± 0.006 μM. |
| Cyclopamine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 4449-51-8, 11051-96-0, 26108-61-2 | Hedgehog | A Smo or hedgehog signaling pathway inhibitor. |
| Vismodegib (GDC-0449),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 879085-55-9 | Hedgehog, P-gp | GDC-0449 is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. |
| XAV-939,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 284028-89-3 | Wnt/beta-catenin | XAV 939 is a small molecule and selective Wnt pathway transcription factor β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4nM for the inhibition of TNKS1 and TNKS2, respectively. |
| BMS-708163 (Avagacestat),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1146699-66-2 | Gamma-secretase | γ-secretase inhibitor (GSI) (IC50 =0.3 nM) |
| RO4929097,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 847925-91-1 | Y-Secretase | RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. |
| Semagacestat (LY450139),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 425386-60-3, 866488-53-1 | Gamma-secretase | Semagacestat (LY450139) is a γ-secretase blocker with an IC50 of 15 nM. |
| NSC 74859 (S3I-201),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 501919-59-1 | STAT | S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity |
| Cryptotanshinone,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 35825-57-1 | STAT | Cryptotanshinone is a major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. |
| MK3207 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 957116-20-0, 957118-49-9 (free base) | CGRP Receptor | MK3207 hydrochloride is a potent and orally active calcitonin gene-related peptide receptor antagonist. (Ki = 0.024 nM) |
| Dimesna,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 16208-51-8 | Dimesna is an uroprotective agent used to decrease urotoxicity. | |
| Diclofenac,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 15307-79-6 | COX | Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
| Ibuprofen (Advil),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 15687-27-1 | COX | Ibuprofen is a non-selective COX inhibitor with an IC50 of 3.3 x 10-4 M. |
| Ketoprofen (Actron),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 22071-15-4 | COX | Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. |
| Ketorolac (Toradol),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 74103-07-4 | COX | Ketorolac tromethamine is a non-selective COX inhibitor with IC50 of 31.5 µM and 60.5 µM for human recombinant COX-1 and COX-2, respectively. |
| YM201636,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 371942-69-7, 371933-96-9 (2HCl) | PI3K | YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM. |
| Piroxicam (Feldene),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 36322-90-4 | COX | Piroxicam (Feldene, Roxam) is a non-selective COX inhibitor with an IC50 of 6 mM. |
| Apigenin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 520-36-5 | P450 | Apigenin is a potent CYP2C9 inhibitor. |
| Valsartan (Diovan),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 137862-53-4 | RAAS | Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 µM. |
| Nebivolol (Bystolic),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 152520-56-4, 118457-14-0 (free base) | Adrenergic Receptor | Nebivolol (Bystolic) is a β1 receptor blocker with an IC50 of 4.5 µM. |
| Sotalol (Betapace),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 959-24-0 | Adrenergic Receptor | Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM. |
| LDE225 (NVP-LDE225, Erismodegib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 956697-53-3, 1270169-93-1, 1218778-76-7 (HCl) | Smoothened | LDE225 (NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. |
| Ivacaftor (VX-770),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 873054-44-5, 1134822-09-5 (benzenesulfonate), 1134822-07-3 (H2O) | CFTR | VX-770 is a CFTR potentiator with an IC50 of 43 ± 38 nM. |
| Rivaroxaban (Xarelto),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 366789-02-8, 931385-22-7 (XHCl) | Factor Xa | Rivaroxaban (Xarelto) is a FXa inhibitor, showed a similar affinity to purified human and rabbit FXa (IC50 0.7 ± 0.01 and 0.8 ± 0.01 nM). |
| Apixaban,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 503612-47-3, 898235-61-5 (H2O) | Factor Xa | Apixaban is a direct factor Xa inhibitor with an IC50 of 0.22±0.02 µM. |
| Emtricitabine (Emtriva),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 143491-57-0 | NART | Emtricitabine (Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM. |
| Stavudine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 3056-17-5, 134624-73-0 (sodium salt) | Reverse Transcriptase | Stavudine is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
| Tenofovir (Viread),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 147127-20-6, 206184-49-8 (H2O), 1236287-04-9 (Maleic acid) | Reverse Transcriptase | Tenofovir belongs to nucleotide analogue reverse transcriptase inhibitors (nRTIs). |
| MDV3100 (Enzalutamide),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 915087-33-1 | CYP17 | MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
| Amlodipine besylate (Norvasc),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 111470-99-6 | Amlodipine besylate | |
| Atropine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 5908-99-6 | Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM. | |
| Benazepril hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 86541-74-4, 86541-75-5 (free base) | RAAS | Benazepril is a medication used to treat high blood pressure. |
| BIBR 953 (Dabigatran etexilate, Pradaxa),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 211914-51-1 | Thrombin | BIBR 953 (Dabigatran) is a reversible, competitive, direct thrombin inhibitor. |
| BIBR-1048 (Dabigatran),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 211915-06-9, 872728-81-9 (methanesulfonate), 1019206-66-6 (HCl) | BIBR-1048 (Dabigatran etexilate) is an anticoagulant from the class of the direct thrombin inhibitors. | |
| Bisoprolol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 104344-23-2 | Adrenergic Receptor | A selective type β1 adrenergic receptor blocker |
| Chlorpromazine (Sonazine),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 69-09-0 | Dopamine Receptor, Potassium Channel | Chlorpromazine hydrochloride (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents. |
| Cilnidipine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 132203-70-4 | Calcium Channel | Cilnidipine is a calcium channel blocker. |
| Cilostazol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 73963-72-1 | PDE | Cilostazol is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease. |
| Clopidogrel (Plavix),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 120202-66-6, 113665-84-2 (free base) | P2 Receptor | Clopidogrel is an oral, thienopyridine class antiplatelet agent. |
| Dipyridamole (Persantine),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 58-32-2, 763-39-4 (XHCl) | Dipyridamole (Permole, Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. | |
| Doxazosin mesylate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 77883-43-3, 74191-85-8 (free base) | Adrenergic Receptor | Doxazosin mesylate (Cardura) is an alpha-1 adrenergic receptor blocker. |
| Enalapril maleate (Vasotec),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 76095-16-4 | Opioid Receptor | Enalapril maleate (Vasotec ), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. |
| Enalaprilat dihydrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 84680-54-6 | RAAS | Enalaprilat is the first dicarboxylate-containing ACE inhibitor with an IC50 of 4 nM. |
| Eplerenone,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 107724-20-9 | Eplerenone (Inspra) is an aldosterone antagonist with an IC50 of 0.36 μM. | |
| Felodipine (Plendil),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 72509-76-3 | Felodipine (Plendil, Renedil) is a calcium channel blocker with an IC50 of 3 µM and 2 x 10 µM for the formyl-Met-Leu-Phe-induced cytosolic calcium increase and H2O2 production, respectively. | |
| Irbesartan (Avapro),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | Irbesartan (Avapro) | RAAS | Irbesartan (Avapro) belongs to the class of medicines called angiotensin II inhibitor antihypertensives. |
| Manidipine (Manyper),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 89226-50-6 | Calcium Channel | Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. |
| PD173074,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 219580-11-7 | FGFR | PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM. |
| Naftopidil Dihydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 57149-08-3, 57149-07-2 (free base) | Adrenergic Receptor | Naftopidil Dihydrochloride is an antihypertensive drug. |
| Naftopidil (Flivas),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 57149-07-2 | Adrenergic Receptor | Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM. |
| Nisoldipine (Sular),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 63675-72-9 | Nisoldipine (Sular) is a calcium channel blocker. | |
| Ozagrel,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 82571-53-7 | Factor Xa | Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. |
| Perindopril Erbumine (Aceon),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 107133-36-8, 82834-16-0 (free base) | RAAS | Perindopril Erbumine (Aceon) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor. |
| Vemurafenib (PLX4032),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 918504-65-1 | Raf | PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600Ewith IC50 of 31 nM. |
| Pimobendan (Vetmedin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 74150-27-9, 77469-98-8 (HCl) | PDE | Pimobendan (Vetmedin) is a Ca(2+) sensitizer with an IC50 of 26 µM and a selective phosphodiesterase III inhibitor with an IC50 of <1 µM. |
| Ramipril (Altace),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 87333-19-5 | RAAS | Ramipril (Altace) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM. |
| Telmisartan (Micardis),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 144701-48-4 | Telmisartan (Micardis) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. | |
| Amfebutamone (Bupropion),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 31677-93-7 | Dopamine Receptor | Amfebutamone hydrochloride (Bupropion) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4µM for the reuptake of dopamine and norepinephrine, respectively. |
| Amisulpride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 71675-85-9, 81342-13-4 (HCl) | Dopamine Receptor | Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. |
| Asenapine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 65576-45-6, 135883-08-8 (Maleic acid) | Adrenergic Receptor, 5-HT Receptor | Asenapine (Saphris) is a new atypical antipsychotic used for the treatment of schizophrenia and acute mania associated with bipolar disorder . |
| BX-795,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 702675-74-9 | PDK-1 | BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively. |
| Baicalin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 21967-41-9 | Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors. | |
| Benserazide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 14919-77-8 | Dopamine Receptor | Benserazide hydrochloride (Serazide) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor. |
| Carbamazepine (Carbatrol),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 298-46-4 | Carbamazepine is a sodium channel blocker with an IC50 of 140 µM. | |
| Carbidopa,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 28860-95-9 | Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. | |
| BX-912,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 702674-56-4 | PDK-1 | BX912 is a selective potent PDK1 inhibitor with IC50 of 12 nM. |
| Chlorprothixene,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 113-59-7 | Chlorprothixene is a typical antipsychotic drug of the thioxanthene class and was the first of the series to be synthesized. | |
| Clozapine (Clozaril),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 5786-21-0 | 5-HT Receptor | Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| Donepezil HCl (Aricept),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 120011-70-3 | AChR | Donepezil hydrochloride (Aricept) is a centrally acting reversible acetylcholinesterase inhibitor with an IC50 of 12.3 nM. |
| Fluoxetine HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 59333-67-4, 56296-78-7 | 5-HT Receptor | Fluoxetine (Prozac, Sarafem) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class. |
| Granisetron HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 107007-99-8, 109889-09-0 (free base) | 5-HT Receptor | Granisetron is a serotonin 5-HT3 receptor antagonist |
| Icariin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 489-32-7 | PDE | Icariin is a flavonol and PDE5 inhibitor with IC50 of 1.0, 0.75, and 1.1 μM for PDE5A1, A2, and A3, respectively. |
| Celastrol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 34157-83-0, 956288-52-1 (sodium salt) | Celastrol, a plant-derived triterpene, has anti-inflammatory and immunosuppressive activity. | |
| Ki16425,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 355025-24-0 | LPA Receptor | Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively. |
| Pancuronium (Pavulon),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 15500-66-0 | AChR | Pancuronium (Pavulon) is a competitive acetylcholine antagonist with an IC50 of 5.5 ± 0.5 nM. |
| Pramipexole dihydrochloride monohydrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 191217-81-9 | Pramipexole dihydrochloride monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. | |
| AMG-208,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1002304-34-8 | c-Met | AMG-208 is a highly selective c-Met inhibitor with IC50 of 9.3 nM. |
| Costunolide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 553-21-9, 11028-78-7, 25333-06-6 | Telomerase | Costunolide inhibits FPTase with IC50 of 20 μM and also inhibits telomerase with IC50 of 90 μM and 65 μM in MCF-7 and MDA-MB-231 cells. |
| Tropisetron,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 105826-92-4 | Tropisetron hydrochloride is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. | |
| Flupirtine maleate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 75507-68-5, 56995-20-1 (free base), 33400-45-2 (HCl) | DNA/RNA Synthesis | Flupirtine maleate is the salt form of Flupirtine, which is a non-opioid, centrally acting analgesia, muscle relaxation and neuroprotection. |
| Venlafaxine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 99300-78-4, 93413-69-5 (free base) | 5-HT Receptor | Venlafaxine (Effexor, Efexor) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI). |
| Galanthamine HBr,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1953-04-4, 357-70-0 (free base), 5072-47-9 (HCl) | AChR | Galanthamine (Razadyne, Reminyl) is an AChE inhibitor with IC50 of 14 nM. |
| Clemastine Fumarate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 14976-57-9, 15686-51-8 (free base) | Histamine Receptor | Clemastine fumarate, a histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. |
| Diphenhydramine HCl (Benadryl),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 147-24-0 | Diphenhydramine hydrochloride (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. | |
| Tadalafil (Cialis),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 171596-29-5, 240822-07-5, 282541-36-0 | PDE | Tadalafil (Cialis) is a PDE inhibitor. |
| Amonafide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 69408-81-7, 150091-68-2 (2HCl), 135882-21-2 (methanesulfonate) | Topoisomerase | Amonafide (NSC-308847) is a selective topoisomerase II inhibitor. |
| Trilostane,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 13647-35-3, 27107-98-8, 28414-46-2 | Dehydrogenase | Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. |
| Yohimbine hydrochloride (Antagonil),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 65-19-0 | Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. | |
| Ruxolitinib (INCB018424),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 941678-49-5, 941678-50-8 (TFA), 1092939-15-5 (Maleic acid) | JAK | INCB018424 is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively. |
| Luteolin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 491-70-3 | PDE | Luteolin (Luteolol) is a PDE4 inhibitor and a general phosphodiesterase inhibitor, and an Interleukin 6 inhibitor. |
| Staurosporine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 62996-74-1 | PKC | Staurosporine (AM-2282) is a potent PKC inhibitor with IC50 of 2.7 nM. |
| S-(+)-Rolipram,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 85416-73-5 | PDE | S-(+)-Rolipram is a less active enantiomer of the PDE4 inhibitor with an EC50 of 1.0 µM. |
| Alendronate (Fosamax),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 121268-17-5 | Alendronate Sodium (Fosamax) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. | |
| Allopurinol (Zyloprim),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 315-30-0 | Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 µM. | |
| Febuxostat (Uloric),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 144060-53-7, 1140907-13-6 (sodium salt) | Febuxostat is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM. | |
| Fluvastatin sodium (Lescol),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 93957-55-2, 126872-01-3, 885513-60-0, 93957-54-1 (free base) | HMG-CoA Reductase | Fluvastatin Sodium (Lescol) is an orally active, potent and competitive HMG-CoA reductase inhibitor with an IC50 of 70 nM for vascular smooth muscle proliferation in vitro. |
| Azalomycin-B,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 37318-06-2 ,11003-23-9, 106387-86-4 | Azalomycin-B (Elaiophylin) shows antiprotozoal activity against Plasmodium falciparum K1a and Trypanosoma brucei brucei GUTat 3.1 strains with IC50 of 0.36 μM and 0.45 μM, respectively. | |
| Nizatidine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 76963-41-2 | Nizatidine (Axid) is a histamine H2-receptor antagonist with and IC50 of 6.7 nM for AChE. | |
| Ranitidine (Zantac),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 66357-59-3 | Ranitidine hydrochloride (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 µM. | |
| Vardenafil (Vivanza),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 224785-90-4, 224785-90-4 (free base) | PDE | Vardenafil (Vivanza) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
| Linezolid (Zyvox),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 165800-03-3 | Linezolid is a synthetic antibiotic used for the treatment of serious infections. | |
| Pyrimethamine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 58-14-0 | Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. | |
| Sulfanilamide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 63-74-1 | Sulfanilamide is a sulfonamide antibacterial. | |
| Terbinafine hydrochloride (Lamisil),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 78628-80-5 | Terbinafine hydrochloride (Lamisil) is a hydrochloride salt of terbinafine that is a synthetic allylamine antifungal and a squalene epoxidase inhibitor with an IC50 of 30 nM for Candida albicans. | |
| Zalcitabine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 7481-89-2 | Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). | |
| ZM 336372,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 208260-29-1 | Raf | Zm 336372 is a potent, selective c-Raf inhibitor with an IC50 of 70 nM for inhibition of human c-Raf in vitro. |
| Cilomilast (SB-207499),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 153259-65-5, 308328-52-1 (sodium salt) | PDE | Cilomilast (Ariflo, SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM). |
| Dorzolamide HCL,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 130693-82-2, 120279-96-1 (free base) | Carbonic Anhydrase | Dorzolamide (Trusopt) is a carbonic anhydrase inhibitor. |
| PH-797804,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 586379-66-0, 1073667-47-6 | p38 MAPK | PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM. |
| Tamoxifen Citrate (Nolvadex),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 54965-24-1 | Estrogen/progestogen Receptor | Tamoxifen Citrate (Nolvadex) is an estrogen receptor antagonist with an IC50 of 31 μM for the MCF-7 cells. |
| Linifanib (ABT-869),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 796967-16-3, 1145655-58-8 (HCl), 796967-17-4 (TFA) | PDGFR, VEGFR | ABT-869 (Linifanib) is a structurally novel, potent RTK and VEGF and PDGF receptor families inhibitor with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. |
| AEE788 (NVP-AEE788),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 497839-62-0 | EGFR, Flt, VEGFR, HER2 | AEE788 is a novel multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1. |
| Afatinib (BIBW2992),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 439081-18-2, 936631-70-8 (Maleic acid), 1254955-21-9 (XHCl) | EGFR, HER2 | BIBW2992 (Afatinib) is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2. |
| Lapatinib Ditosylate (Tykerb),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 388082-77-7, 231277-92-2 (free base), 1187538-35-7 (4-methylbenzenesulfonate) | EGFR, HER2 | EGFR and HER2 autophosphorylation inhibitor, against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively. |
| JNJ-7706621,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 443797-96-4 | CDK, Aurora Kinase | A Dual Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases. In vitro kinase IC50:CDK1/Cyclin B(0.009 umol/L), Aurora-A(0.011 umol/L). |
| Oligomycin A,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 579-13-5, 11030-76-5, 21307-25-5 | ATPase | Oligomycins are macrolides created by Streptomyces that can be poisonous to other organisms. |
| BEZ235 (NVP-BEZ235),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 915019-65-7, 1028385-32-1 (4-methylbenzenesulfonate) | mTOR, PI3K | Inhibitor of PI3K and mTOR.p110, IC50<6nM. |
| GSK1059615,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 958852-01-2, 1356195-42-0 (H2O . Na) | PI3K, mTOR | GSK1059615 is a pan-PI3K reversible inhibitor,IC50:PI3Kα(0.4 nM), β (0.6 nM),γ (5 nM),δ (2 nM) and mTOR(12 nM). |
| PI-103,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 371935-74-9, 371935-79-4 (HCl) | DNA-PK, PI3K, mTOR | PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively. |
| AG-490,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 133550-30-8 | JAK, EGFR | AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively. |
| Mitoxantrone Hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 70476-82-3, 65271-80-9 (free base), 70711-41-0 (diacetate) | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. | |
| Sulfamethoxazole,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 723-46-6 | Sulfamethoxazole (Gantanol) is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM. | |
| PF-04691502,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1013101-36-4 | mTOR, PI3K, Akt | PF-04691502 is a potent and selective dual PI3K/mTOR inhibitor to phosphorylation of AKT T308 and AKT S473 with IC50 of 7.5 and 3.8 nM, respectively. |
| SGI-1776 free base,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1025065-69-3, 1173928-26-1 (2H2O4S) | Pim | SGI-1776, a member of the imidazo[1,2-b]pyridazine chemical class.The IC50 of SGI-1776 for the three isoforms of the Pim kinase family, Pim-1, Pim-2, and Pim-3, were in the low nanomolar range (7 ± 1.8 nmol/L, 363 ± 27.6 nmol/L, and 69 ± 9.2 nmol/L). |
| Tofacitinib citrate (CP-690550 citrate),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 540737-29-9, 477600-75-2 (free base) | JAK | Tofacitinib (CP-690550) is a novel, small molecule potent and selective JAK-3 kinase inhibitor with an IC50 of 1 nM for inhibition of the JAK-3 activities. |
| Crenolanib (CP-868596),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 670220-88-9, 670220-93-6 (benzenesulfonate) | PDGFR | Crenolanib (CP-868569) is a highly selective and potent PDGFR-α inhibitor with IC50 of 0.9 and 1.8 nM against PDGFRα and PDGFRβ, respectively. |
| GSK1838705A,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1116235-97-2, 1116236-05-5 (H2O) | IGF-1, ALK | GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively. |
| KX2-391,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 897016-82-9, 1038395-65-1 (2HCl), 1080645-95-9 (methanesulfonate), 1201926-60-4 (Maleic acid) | Src | KX2-391 is a synthetic, orally bioavailable small molecule and non-ATP competitive Src tyrosine kinase signaling inhibitor with an IC50 of average 72 nM. |
| NVP-BSK805,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1092499-93-8 (free base) | JAK | NVP-BSK805 is a potent and selective quinoxaline JAK2 inhibitor with IC50 of 0.48, 0.56 and 0.58 nM for JAK2 JH1, FL JAK V617F and FL JAK2 wt, respectively. |
| PCI-32765 (Ibrutinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 936563-96-1 | Src | PCI-32765 is a high potent irreversible BTK inhibitor with an IC50 of 0.46 nM for the purified Btk. |
| PF-00562271 ,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 939791-38-5, 717907-75-0 (free base), 939791-39-6 (methanesulfonate) | FAK | PF-562271 is a potent ATP-competitive FAK and proline-rich tyrosine kinase (Pyk2) inhibitor with potential antineoplastic and antiangiogenic activities. |
| DCC-2036 (Rebastinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1020172-07-9, 1020172-08-0 (2HCl), 1033893-29-6 (4-methylbenzenesulfonate) | Bcr-Abl | DCC-2036 is an ABL switch control inhibitor with IC50 of 0.8 and 2 nM for u-ABL1native and p-ABL1native, respectively. |
| LDN193189,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1062368-24-4, 1062368-62-0 (HCl) | TGF-beta/Smad | LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively. |
| Adenine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 73-24-5 | DNA/RNA Synthesis | Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
| Adenine hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 2922-28-3 | DNA/RNA Synthesis | Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
| Candesartan cilexetil (Atacand),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 145040-37-5 | Candesartan cilexetil (Atacand) is a specific nonpeptide Ang II receptor (ATR) antagonist and the prodrug of candesartan which is an ATR antagonist with an IC50 of 15 µg/kg. | |
| LY2886721,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1262036-50-9, 1262036-49-6 (HCl) | LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments. | |
| Avasimibe (CI-1011),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 166518-60-1 | P450 | Avasimibe (CI-1011) is a novel orally bioavailable acyl coenzyme A:cholesterol acyltransferase inhibitor with IC50 of 2.9, 13.9, 26.5 µM for CYP2C9, CYP1A2, and CYP2C19. |
| AZD8931,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 848942-61-0, 1196531-39-1 (diFumaric acid) | EGFR, HER2 | AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively. |
| CYT997,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 917111-44-5, 917111-49-0 (2HCl), 917111-51-4 (dimethanesulfonate) | Microtubule Associated | CYT997, a small molecule inhibits the polymerization of tubulin with an IC50 of 3 μmol/L and shows an IC50 of between 1 and 100 nmol/L across a panel of cancer cell lines. |
| A-966492,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 934162-61-5 | PARP | A-966492 is a highly potent and efficacious poly(ADP-ribose) polymerase (PARP) inhibitor with a Ki and EC50 of 1 nM. |
| Aliskiren hemifumarate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 173334-58-2, 173334-57-1 (free base), 173399-03-6 (HCl) | RAAS | Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren. Aliskiren is a novel orally effective direct renin inhibitor with an IC50 of 0.72 nM against renin. |
| Raf265 derivative,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | N/A | VEGFR, Raf | Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. |
| NVP-BHG712,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 940310-85-0 | VEGFR, Src, Raf, Bcr-Abl | NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respectively. |
| OSI-420 (Desmethyl Erlotinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 183320-51-6, 183321-86-0 (free base) | EGFR | OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells. |
| R935788 (Fostamatinib disodium, R788),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1025687-58-4, 901119-35-5 (free base),1180490-89-4 (acetate) | Syk | R935788 (Fostamatinib disodium) is a selective Syk inhibitor with an IC50 of 41 nM. |
| Formestane,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 566-48-3, 127128-20-5 | Aromatase | Formestane (Lentaron(R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
| Vinflunine Tartrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1201898-17-0, 162652-95-1 (free base) | Microtubule Associated | Vinflunine Tartrate is a tartrate salt of vinflunine that is a new microtubule inhibitor agent with IC50 of 18.8 nM. |
| AZ 960,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 905586-69-8 | JAK | AZ 960 is a novel small molecule JAK2 kinase inhibitor with an IC50 and Ki of 3 mM and 0.45 nM in vitro, respectively. |
| DAPT (GSI-IX),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 208255-80-5 | Gamma-secretase, Beta Amyloid | DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 of 0.12 and 0.2 μM for total Aβ and Aβ42 levels, respectively. |
| Mubritinib (TAK 165),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 366017-09-6 | HER2 | Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. |
| Irinotecan HCl Trihydrate (Campto),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 136572-09-3 | Topoisomerase | Irinotecan hydrochloride trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively. |
| PP242,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1092351-67-1, 1173019-76-5 (H2O) | mTOR | PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. |
| Cyt387,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1056634-68-4, 1056636-08-8 (XHCl) | JAK | Cyt387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. |
| Apatinib (YN968D1),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 811803-05-1 | VEGFR | Apatinib (YN968D1) is a small-molecule selective multitargeted tyrosine kinase inhibitor with an IC50 of 2.43 nM for the inhibition of VEGFR2. |
| TAME,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 901-47-3, 1784-03-8 (HCl) | APC | TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM. |
| CAL-101 (GS-1101),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 870281-82-6 | PI3K | CAL-101 is a potent PI3K p110δ inhibitor with an IC50 of 65 nM. |
| PIK-294,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 900185-02-6 | PI3K | PIK-294 is a highly selective p110 inhibitor with an IC50 of 3 nM. |
| Thiazovivin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1226056-71-8, 1228446-06-7 (TFA) | ROCK | Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of ~0.5 μM. |
| Eltrombopag (SB-497115-GR),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 496775-61-2 | Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 μM for the inhibition of hERG K+ channel tail current. | |
| LY2157299,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 700874-72-2, 924898-09-9 (H2O) | TGF-beta/Smad | LY2157299 is a novel selective small molecule transforming growth factor beta receptor (TGF-βR) kinase inhibitor with IC50 of 86 nM and 2 nM for TβR1 and 2 nM, respectively. |
| Telatinib (BAY 57-9352),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 332012-40-5, 332013-24-8 (4-methylbenzenesulfonate), 332013-28-2 (2HCl) | VEGFR, PDGFR, c-Kit | Telatinib (BAY 57-9352) is an orally available, potent multitargeted VEGFR-2, VEGFR-3, PDGFR-β and c-Kit tyrosine kinases inhibitor with an IC50 of 19 nM for the inhibition of VEGFR-2 autophosphorylation. |
| Ketanserin (Vulketan Gel),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 74050-98-9 | 5-HT Receptor | Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. |
| Esomeprazole sodium (Nexium),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 161796-78-7, 119141-88-7 (free base) | ATPase | Esomeprazole sodium (Nexium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg. |
| BI6727 (Volasertib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 755038-65-4, 946161-17-7 (3HCl) | PLK | BI 6727 is a highly potent Polo-like kinase inhibitor with an IC50 of 0 .87 nM. |
| Fesoterodine fumarate (Toviaz),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 286930-03-8, 286930-02-7 (free base), 345663-07-2 (HCl) | AChR | Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. |
| GW 791343 hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 309712-55-8, 309712-73-0 (free base) | P2 Receptor | GW 791343 hydrochloride is a non-competitive human P2X(7) receptor inhibitor with pIC50 of about 7.1. |
| WP1130,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 856243-80-6 | DUB, Bcr-Abl | WP1130 is a novel selective small molecular deubiquitinase (DUB) inhibitor and a Bcr/Abl destruction pathway activator with an IC50 of 1.8 μM for K562 cells. |
| AR-42 (HDAC-42),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 935881-37-1 | HDAC | AR-42 is a novel HDAC inhibitor with an IC50 of 0.61 μM for acute lymphoblastic leukemia (697) cell lines. |
| CP-466722,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1080622-86-1 | ATM | CP-466722 is rapidly reversible potential ATM kinase inhibitor. |
| Abiraterone Acetate (CB7630),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 154229-18-2, 877265-41-3 (methanesulfonate), 877319-47-6 (HCl) | P450 | Abiraterone Acetate (CB 7630) is a highly active and selective 17α-hydroxylase/17,20 lyase (CYP17A1) inhibitor with an IC50 of 72 nM. |
| BKM120 (NVP-BKM120),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 944396-07-0, 1312445-63-8 (HCl), 1370351-44-2 (0.5H2O) | PI3K | BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. |
| cx-4945 (Silmitasertib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1009820-21-6, 1309357-15-0 (sodium salt) | PKC | CX-4945 (CX 4945) is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively. |
| Amantadine hydrochloride (Symmetrel),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 665-66-7 | Dopamine Receptor | Amantadine hydrochloride (Symmetrel) is used to treat or prevent infections of the respiratory tract caused by a certain virus. |
| Bupivacaine hydrochloride (Marcain),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 18010-40-7 | Bupivacaine hydrochloride (Marcain) is a more potent cAMP production inhibitor with an IC50 of 2.3 µM. | |
| Bethanechol chloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 590-63-6 | AChR | Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors. |
| Clonidine hydrochloride (Catapres),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 4205-91-8 | Adrenergic Receptor | Clonidine hydrochloride (Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. |
| Domperidone (Motilium),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 57808-66-9 | Dopamine Receptor | Domperidone (Motilium) is a dopamine blocker and an antidopaminergic reagent. |
| Fenbendazole (Panacur),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 43210-67-9 | Fenbendazole (Panacur) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC5 of about 0.01 µg/ml. | |
| Fleroxacin (Quinodis),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 79660-72-3 | Fleroxacin (Quinodis) is a new broad-spectrum fluoroquinolone. | |
| Gallamine triethiodide (Flaxedil),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 65-29-2 | AChR | Gallamine triethiodide (Flaxedil) is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 µM. |
| Gentamycin sulfate (Gentacycol),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1405-41-0 | Gentamycin (Gentacycol) is an aminoglycoside antibiotic and was isolated from Micromonospora species | |
| Hexestrol (Bibenzyl),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 84-16-2 | Estrogen/progestogen Receptor | Hexestrol (Bibenzyl) is a novel type of 17βhydroxysteroid dehydrogenase, AKR1C1and AKR1C2 potent inhibitor with IC50 of 0.8, 9.5, 2.8 µM, respectively and exhibits strong affinity for estrogen receptors. |
| Itraconazole (Sporanox),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 84625-61-6 | Itraconazole (Sporanox) is a triazole antifungal agent. | |
| Loperamide hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 34552-83-5 | Opioid Receptor | Loperamide is an opioid-receptor agonist with an ED50 of 0.15 mg/kg. |
| Manidipine dihydrochloride (CV-4093),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 89226-75-5 | Calcium Channel | Manidipine HCl (CV-4093) is a hydrochloride salt of manidipine that is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. |
| Milrinone (Primacor),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 78415-72-2 | ATPase | Milrinone (Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 µM for the inhibition of FIII PDE. |
| Moroxydine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 3160-91-6 | Moroxydine hydrochloride is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines. | |
| Neostigmine bromide (Prostigmin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 114-80-7 | AChR | Neostigmine bromide (Prostigmin) is a reversible acetylcholinesterase inhibitor. |
| Novobiocin sodium (Albamycin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1476-53-5 | Novobiocin (Albamycin) is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of of 14.87 ± 0.40 µM for hOAT1, 4.77 ± 1.12 µM for hOAT3, and 90.50 ± 7.50 µM for hOAT4 | |
| Olanzapine (Zyprexa),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 132539-06-1 | 5-HT Receptor, Dopamine Receptor | Olanzapine (Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
| Olopatadine hydrochloride (Opatanol),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 140462-76-6 | Histamine Receptor | Olopatadine hydrochloride (Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 µM for the release of histamine. |
| Oxymetazoline hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 2315-02-8 | Adrenergic Receptor | Oxymetazoline hydrochloride is an α1 and α2 adrenergic receptor agonist. |
| Racecadotril (Acetorphan),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 81110-73-8 | Opioid Receptor | Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 µM. |
| Scopolamine hydrobromide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 114-49-8 | Scopolamine is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. | |
| AZD6482,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1173900-33-8 | PI3K | AZD6482 is an inhibitor of PI3Kβ with IC50 of 21 nM. |
| Maprotiline hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 10347-81-6 | Reuptake inhibitor | Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. |
| Naphazoline hydrochloride (Naphcon),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 550-99-2 | Adrenergic Receptor | Naphazoline hydrochloride (Naphcon) is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine. |
| Epinephrine bitartrate (Adrenalinium),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 51-42-3 | Adrenergic Receptor | Epinephrine bitartrate (D02149, Adrenalinium) is alpha- and beta-adrenergic receptor stimulator. |
| Phenytoin sodium (Dilantin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 630-93-3 | Sodium Channel | Phenytoin sodium (Dilantin) is an inactive voltage-gated sodium channel stabilizer. |
| Phenytoin (Lepitoin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 57-41-0 | Sodium Channel | Phenytoin (Lepitoin; NSC 8722; Phenytek; Phenytoine; Sodanton; Zentropi) is an inactive voltage-gated sodium channel stabilizer. |
| Alizarin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 72-48-0 | Alizarin is an organic compound and an important prominent dye. | |
| Dopamine hydrochloride (Inotropin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 62-31-7, 51-61-6 (free base) | Dopamine Receptor | Dopamine hydrochloride (Inotropin) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. |
| 7-Aminocephalosporanic acid,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 957-68-6 | 7-Aminocephalosporanic acid is a key intermediate required for the production of most of the clinically used cephalosporin derivatives. | |
| Asaraldehyde (Asaronaldehyde),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 4460-86-0 | COX | Asaraldehyde (Asaronaldehyde) is a selective COX-2 inhibitor |
| L-Ascorbyl 6-palmitate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 137-66-6 | L-Ascorbyl 6-palmitate is a synthetic lipophilic ascorbic acid derivative. | |
| Ritodrine hydrochloride (Yutopar),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 23239-51-2 | Adrenergic Receptor | Ritodrine hydrochloride (DU 21220; Miolene; NSC 291565; Pre-Par) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist. |
| Isoconazole nitrate (Travogen),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 24168-96-5 | Isoconazole nitrate (Travogen) is an azole antifungal reagent. | |
| Secnidazole (Flagentyl),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 3366-95-8 | Secnidazole (Flagentyl) is a nitroimidazole anti-infective. | |
| Acetanilide (Antifebrin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 103-84-4 | Acetanilide (Antifebrin) is an aniline derivative and has possess analgesic. | |
| Clomipramine hydrochloride (Anafranil),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 17321-77-6 | 5-HT Receptor | Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
| Phenformin hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 834-28-6 | AMPK | Phenformin hydrochloride is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. |
| Ceftiofur hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 103980-44-5 | Ceftiofur hydrochloride is a hydrochloride of ceftiofur that is a broad spectrum cephalosporin. | |
| Tiotropium Bromide hydrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 139404-48-1 | AChR | Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. |
| Trospium chloride (Sanctura),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 10405-02-4 | AChR | Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist. |
| Tolterodine tartrate (Detrol LA),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 124937-52-6 | AChR | Tolterodine tartrate (Detrol LA) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist. |
| Azelastine hydrochloride (Astelin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 79307-93-0 | Histamine Receptor | Azelastine is a potent, second-generation, selective, histamine antagonist. |
| Clarithromycin (Biaxin, Klacid),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 81103-11-9 | P450 | Clarithromycin is a macrolide antibiotic and a CYP3A4 substrate and inhibitor. |
| Rosiglitazone (Avandia),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 122320-73-4 | PPAR | Rosiglitazone (Avandia) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. |
| Safinamide Mesylate (FCE28073),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 202825-46-5, 133865-89-1 (free base) | MAO | Safinamide Mesylate is mesylate salt of Safinamide, which selectively and reversibly inhibits MAO-B with IC50 of 0.45 μM. |
| Clomifene citrate (Serophene),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 50-41-9 | Estrogen/progestogen Receptor | Clomifene citrate (Serophene) is a selective estrogen receptor modulator. |
| Isoprenaline hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 51-30-9 | Adrenergic Receptor | Isoprenaline hydrochloride is a beta-adrenergic agonist. |
| Tetracaine hydrochloride (Pontocaine),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 136-47-0 | Calcium Channel | Tetracaine hydrochloride (Pontocaine) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor. |
| Trazodone hydrochloride (Desyrel),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 25332-39-2 | 5-HT Receptor | Trazodone hydrochloride (Desyrel) is a hydrochloride salt of trazodone that is a serotonin antagonist and reuptake inhibitor with a Kd of 0.16 μM. |
| Tioxolone,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 4991-65-5 | Carbonic Anhydrase | Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. |
| Dehydroepiandrosterone (DHEA),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 53-43-0 | Androgen Receptor | Dehydroepiandrosterone (DHEA) is a 19-carbon endogenous natural steroid hormone. |
| Clorsulon,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 60200-06-8 | Clorsulon is a competitive 8-phosphoglycerate kinase and phospho-glyceromutase inhibitor. | |
| TAK-733,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1035555-63-5 | MEK | TAK-733 is highly potent and selective novel MEK allosteric site inhibitor with an IC50 of 3.2 nM. |
| MG-132,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 133407-82-6 | Proteasome | MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively. |
| GSK256066,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 801312-28-7, 801311-47-7 (XHCl), 801315-14-0 (HCl) | PDE | GSK256066 is an exceptionally high affinity and selective PDE4 inhibitor with an IC50 of 3.2 pM for PDE4B. |
| AZD5438,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 602306-29-6 | CDK | AZD5438 is a potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor with IC50 of 16, 6 and 20 nM, respectively. |
| PP-121,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1092788-83-4 | DNA-PK, mTOR, PDGF | PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 μM for p110α, p110β, p110δ, p110γ, DNA-PK, mTOR and PDGFR, respectively. |
| Omecamtiv mecarbil (CK-1827452),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 873697-71-3, 921625-14-1 | ATPase | Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 μM. |
| OSI-027,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 936890-98-1, 1187559-66-5 (sodium salt) | mTOR | OSI027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor. Rea |
| LY2603618 (IC-83),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 911222-45-2 | Chk | LY2603618 (IC-83) is a highly selective Chk 1 inhibitor with potential antitumor activity. |
| Tubastatin A hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1310693-92-5, 1252003-15-8 ,1239262-52-2 (TFA) | HDAC | Tubastatin A hydrochloride is a potent selective HDAC6 inhibitor with an IC50 of 15 nM. |
| PF-05212384 (PKI-587),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1197160-78-3 | mTOR, PI3K | PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and <0.1 μM for PI3K-α and mTOR, respectively. |
| PNU-120596,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 501925-31-1 | AChR | PNU-120596 is a potent and selective positive allosteric α7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 μM. |
| GW3965 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 405911-17-3, 405911-09-3 (free base) | Liver X Receptor | GW3965 is a synthetic selective, active non-steroidal liver X receptor (LXR) agonist with EC50 of 0.19 and 0.03 μM for hLXRα and hLXRβ, respectively. |
| URB597,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 546141-08-6 | FAAH | URB597 is a relatively selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 4.6 and 0.5 nM in brain membranes and intact neurons, respectively. |
| BMS-806 (BMS 378806),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 357263-13-9 | gp120/CD4 | BMS-806 (BMS 378806) is a small molecule gp120/CD4 inhibitor with an IC50 of median 5 nM. |
| NPS-2143 (SB262470),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 284035-33-2, 324523-20-8 (HCl) | CaSR | NPS-2143 is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively. |
| CCT128930,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 885499-61-6 | Akt | CCT128930 is a novel potent ATP-competitive, AKT inhibitor with an IC50 of 6 nM. |
| A66,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1166227-08-2 | PI3K | A66 is a highly specific and selective p110α inhibitor with IC50 of 32,30 and 43 nM for p110α, p110α/E545K, p110α/H1047R, respectively. |
| TAK-875,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1374598-80-7, 1000413-72-8 (free base) | GPR | TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with an EC50 of 0.072 μM. |
| NU7441(KU-57788),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 503468-95-9 | DNA-PK, PI3K | NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 μM for DNA-PK, mTOR and PI 3-K, respectively. |
| SNX-2112,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 908112-43-6, 945626-71-1 | HSP | SNX-2112 is a potent synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 μM for K562 cells. |
| PF-04929113 (SNX-5422),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 908115-27-5, 1173111-67-5 (methanesulfonate) | HSP | PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM. |
| GSK2126458,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1086062-66-9 | PI3K, mTOR | GSK2126458 is a highly potent PI3K and mTOR inhibitor with an app Ki of 19 pM for PI3K. |
| 5-hydroxymethyl tolterodine (PNU 200577),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 207679-81-0, 380636-50-0 (Fumaric acid) | AChR | 5-hydroxymethyl tolterodine (PNU 200577) is a potent muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively. |
| MK-0752,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 471905-41-6 | Gamma-secretase | MK-0752 is a potent gamma secretase (γ-secretase) inhibitor in clinical development with an IC50 of 5 nM for Aβ40 in human SH-SY5Y cells. |
| WYE-125132,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1144068-46-1 | mTOR | WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM. |
| ICG-001,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 780757-88-2 | Wnt/beta-catenin | ICG-001 is a selective Wnt/β-catenin signalling inhibitor with an IC50 of 3μM. |
| WAY-100635,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 162760-96-5, 146714-97-8 (3HCl), 634908-75-1 (Maleic acid 1:x) | 5-HTReceptor | WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT. |
| Clinofibrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 30299-08-2 | RAAS | Clinofibrate is a new hypelipidemic agent and a competitive hydroxymethylglutaryl coenzyme A reductase with an IC50 of 0.47 mM. |
| Ciprofibrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 52214-84-3, 128660-46-8 | PPAR | Ciprofibrate is a peroxisome proliferator-activated receptor agonist. |
| PF-3845,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1196109-52-0 | FAAH | PF-3845 is a potent, selective and irreversible fatty acid amide hydrolase (FAAH) inhibitor with a Ki of 0.23 μM. |
| S/GSK1349572 (GSK1349572),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1051375-16-6, 1051375-19-9 (sodium salt) | Integrase | S/GSK1349572 (GSK 1349572) is a novel potent integrase inhibitor with an IC50 of 2.7 nM in vitro. |
| WYE-687,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1062161-90-3, 1198178-23-2 (HCl) | mTOR | WYE-687 is a potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM. |
| LY310762,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 192927-92-7, 379215-96-0 (free base) | 5-HT Receptor | LY310762 is a potent and selective 5-HT1D serotonin receptor antagonist with an EC50 of 31 nM. |
| A-674563,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 552325-73-2 | Akt, CDK, PKA | A-674563 is a potent selective protein kinase B/Akt inhibitor with an IC50 of 14 nM. |
| AS-252424,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 900515-16-4 | PI3K | AS-252424 is a potent and selective PI3k γ inhibitor with IC50 of 33 and 935 nM for PI3Kγ and PI3Kα, respectively. |
| GSK1120212 (Trametinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 871700-17-3, 871702-06-6 (sodium salt) | MEK | GSK1120212 (Trametinib) is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 and 0.9 nM for MEK1 and MEK2. |
| BRL-15572,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 193611-72-2, 734517-40-9 (free base), 1173022-77-9 (HCl) | 5-HT Receptor | BRL-15572 is a hydrochloride salt form of BRL-15572 which is a selective serotonin receptor subtype 5-HT1D antagonist with an IC50 of 260 μM. |
| NSC-207895 (XI-006),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 58131-57-0 | p53, Mdm2, DNA/RNA Synthesis | NSC-207895 (XI-006) is a derivative of nitrobenzofuroxan and an anticancer agent with an EC50 of 1 μM. |
| Flavopiridol hydrochloride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 131740-09-5, 146426-40-6 (free base), 358739-41-0 (TFA) | CDK | Flavopiridol hydrochloride is a pan-cdk inhibitor. |
| AS-604850,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 648449-76-7 | PI3K | AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. |
| WAY-600,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1062159-35-6 | mTOR | WAY-600 is a potent ATP-competitive mTOR inhibitor with an IC50 of 9 nM. |
| ADX-47273,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 851881-60-2 | GluR | ADX-47273 is a novel, potent and selective metabotropic glutamate receptor 5 allosteric modulator with an EC50 of 170 nM in human embryonic kidney 293 cells expressing rat mGlu5. |
| BMY 7378,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 21102-95-4, 21102-94-3 (free base) | 5-HT Receptor | BMY 7378 is a 5-HT1A receptor weak partial agonist/antagonist and α1D-adrenergic receptor antagonist with Ki values of 2.8 and 0.6 μM for cloned rat rat α1A and hamster α1B receptors, respectively. |
| TG101209,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 936091-14-4 | Flt, JAK, c-RET | TG101209 is a potent and small molecule JAK2-selective kinase inhibitor with IC50 of 6, 25, 17 and 169 nM for JAK2, FLT3, RET and JAK3, respectively. |
| WAY-362450,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 629664-81-9 | FXR | WAY-362450 is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM. |
| GDC-0980 (RG7422),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1032754-93-0, 1309043-78-4, 1309384-87-9 | mTOR, PI3K | GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC50 of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively. |
| A-769662,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 844499-71-4 | AMPK | A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator with an EC50 of 0.8 μM. |
| RS-127445,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 199864-87-3, 199864-86-3 (HCl), 199864-88-5 (Maleic acid) | 5-HT Receptor | RS-127445 is a potent, selective and high affinity serotonin 5-HT2B receptor antagonist with a pIC50 of 10.4. |
| YO-01027,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 209984-56-5 | Gamma-secretase | YO-01027 is a dipeptidic gamma-secretase inhibitor with IC50 of 2.6 and 2.9 nM for the proteolysis of APPL and Notch, respectively. |
| Geldanamycin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 30562-34-6 | HSP | Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. |
| CP-91149,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 186392-40-5 | Phosphorylase | CP-91149 is a human liver glycogen phosphorylase α (HLGPα) inhibitor with an IC50 of 0.13 μM in the presence of 7.5 mM glucose |
| TAK-901,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 934541-31-8, 934542-50-4 (HCl), 1020203-96-6 (Fumaric acid), 1020203-86-4 (benzenesulfonate) | Aurora Kinase | TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. |
| AMG 900,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 945595-80-2 | Aurora Kinase | AMG 900 is a novel potent and highly selective Pan-aurora kinase inhibitor with an IC50 of median 3.5 nM. |
| Nanchangmycin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 65101-87-3,35865-33-9(free base) | Nanchangmycin (dianemycin) is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for for mammals and plants. | |
| LY335979 (Zosuquidar 3HCl),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 167465-36-3, 167354-41-8 (free base) | P-gp | LY335979 (Zosuquidar) is a potent modulator of P-glycoprotein-mediated multidrug resistance with Ki of 60 nM. |
| MK-1775,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 955365-80-7, 1075739-30-8 (H2O), 1075739-32-0 (XHCl) | Wee1 | MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM. |
| LY2811376,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1194044-20-6, 1194043-85-0 (2HCl) | Gamma-secretase | LY2811376 is a non-peptidic BACE1 inhibitor with IC50 of 239 nM/249 nM and also decreases the Aβ secretion with EC50 of ~300 nM. |
| CP 673451,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 343787-29-1, 343787-32-6 (4-methylbenzenesulfonate) | PDGFR | CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM. |
| DMXAA (ASA404),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 117570-53-3, 129095-08-5 (sodium salt) | VDA | DMXAA (ASA404) is a competitive inhibitor of DT-diaphorase (NAD(P)H:Quinone oxidoreductase EC 1.6.99.2) with Ki of 20 μM and IC50 of 62.5 μM, respectively. |
| Telaprevir (VX-950),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 402957-28-2, 569364-34-7 | HCV Protease | Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM. |
| AM-1241,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 444912-48-5 | Cannabinoid Receptor | AM-1241 is a selective CB2 agonist with Ki of 3.4 nM. |
| Dapagliflozin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 461432-26-8, 960404-48-2 ((2S)-1,2-propanediol, hydrate) | SGLT | Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM. |
| PHT-427,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1191951-57-1, 1178893-77-0 | Akt | PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively. |
| VX-809,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 936727-05-8, 1160221-26-0 (HCl) | CFTR | VX-809 is a CFTR modulator with EC50 of 0.1 μM. |
| Tie2 kinase inhibitor,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 948557-43-5 | Tie-2 | Tie2 kinase inhibitor is a potent and selective Tie2 inhibitor with IC50 of 0.25 μM. |
| TWS119,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 601514-19-6 | GSK-3 | TWS119 is a GSK-3β inhibitor with IC50 of 30 nM. |
| D-glutamine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 5959-95-5 | D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code. | |
| Flutamide (Eulexin),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 13311-84-7 | P450 (e.g. CYP17) | Flutamide (Eulexin) is an oral nonsteroidal antiandrogen agent primarily used to treat prostate cancer. |
| PCI-34051,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 950762-95-5, 1072027-64-5 | HDAC | PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM. |
| PF 573228,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 869288-64-2 | FAK | PF 573228 is a inhibitor of FAK with IC50 of 4 nM. |
| BMS-265246,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 582315-72-8 | CDK | BMS265246 is a potent and selective CDK inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively. |
| Cyproterone acetate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 427-51-0 | P450 (e.g. CYP17) | Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM. |
| GSK1292263,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1032823-75-8, 1032824-54-6 (HCl) | GPR | GSK-1292263 is a novel GPR119 agonist. |
| LY2608204,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1234703-40-2 | LY2608204 activates glucokinase (GK) with EC50 of 42 nM. | |
| LY2940680,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1258861-20-9, 1258861-21-0 (HCl) | Hedgehog | LY2940680 binds to the Smo receptor and potently inhibits Hh signaling. |
| PD 128907 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 112960-16-4 (HCl), 123594-64-9 | Dopamine Receptor | PD 128907 HCl is a drug used in scientific research which acts as a potent and selective agonist for the dopamine D2 and D3 receptors. |
| BGJ398 (NVP-BGJ398),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 872511-34-7, 1310746-11-2 (H2O), 1310746-12-3 (methanesulfonate), 1310746-17-8 (acetate) | FGFR | BGJ398 (NVP-BGJ398) is a potent and selective inhibitor of FGFR1, FGFR2 and FGFR3 with IC50 of 0.9 nM, 1.4 nM and 1 nM, respectively. |
| AST-1306,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1050500-29-2, 897383-62-9 (free base) | EGFR | AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively. |
| SB-505124,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 694433-59-5, 356559-13-2 (HCl) | TGF-beta/Smad | SB505124 is a selective inhibitor of ALK4 and ALK5 with IC50 of 129 nM and 47 nM, respectively. |
| SB590885,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 405554-55-4 | Raf | SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM. |
| Palomid 529,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 914913-88-5 | PI3K | Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor for VEGF-A and bFGF with IC50 of 10 nM and 30 nM, respectively. |
| 20-Hydroxyecdysone,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 5289-74-7 | 20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. | |
| Aloperine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 56293-29-9 | Aloperine is exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. | |
| Synephrine HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 5985-28-4 | Adrenergic Receptor | Synephrine HCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist. |
| Forskolin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 66575-29-9 | cAMP | Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC). |
| Equol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 531-95-3, 1112376-13-2 (H2SO4) | Estrogen/progestogen Receptor | Equol is an isoflavandiol metabolized from daidzein by bacterial flora in the intestines. |
| Daphnetin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 486-35-1 | DNA/RNA Synthesis | Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively. |
| Ribitol (Adonitol),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 488-81-3 | Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis. | |
| R788 (Fostamatinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 901119-35-5 | Syk | R788 (Fostamatinib) is a Syk inhibitor with IC50 of 41 nM. |
| A 922500,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 959122-11-3 | Transferase | A 922500 is a DGAT-1 inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively. |
| CAY10505,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1218777-13-9 | PI3K | CAY10505 is a PI3Kγ inhibitor with IC50 of 30 nM. |
| CHIR-124,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 405168-58-3 | Chk | CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. |
| CX-5461,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1138549-36-6 | DNA/RNA Synthesis | CX-5461 selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells. |
| KW-2478,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 819812-04-9, 819812-18-5 (HCl) | HSP (e.g. HSP90) | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
| PF-2545920,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1292799-56-4 | PDE | PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM. |
| Nepicastat HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 170151-24-3, 173997-05-2 (free base), 177645-08-8 ( HCl.H2O) | Hydroxylase | Nepicastat hydrochloride is a novel, potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. |
| LY2109761,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 700874-71-1 | TGF-beta/Smad | LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively. |
| JTC-801,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 244218-51-7, 244218-93-7 (free base) | Opioid Receptor | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM. |
| PF-03814735,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 942487-16-3 | Aurora Kinase | PF-03814735 is a novel, potent and reversible inhibitor of both Aurora A and Aurora B with IC50 of 0.8 nM and 5 nM, respectively. |
| Dacomitinib (PF299804,PF-00299804),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1110813-31-4, 1042385-75-0 (H2O) | EGFR | PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively. |
| AG-1478 (Tyrphostin AG-1478),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 153436-53-4, 170449-18-0 (HCl) | EGFR | AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM. |
| SB 415286,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 264218-23-7 | GSK-3 | SB 415286 is a potent GSK3α and GSK3β inhibitor with IC50 of 78 nM and ~78 nM, respectively. |
| AZ 3146,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1124329-14-1 | Kinesin | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM. |
| SCH 900776,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 891494-63-6 | Chk | SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM and also inhibits CDK2 with IC50 of 160 nM. |
| TG101348 (SAR302503),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 936091-26-8, 1374744-69-0 (2ClH.H2O) | JAK | TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM. |
| PAC-1,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 315183-21-2 | Caspase | PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM. |
| PKI-402,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1173204-81-3, 1173204-82-4 (XHCl) | PI3K | PKI-402 is a potent dual PI3K/mTOR inhibitor targeting PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR with IC50 of 2 nM, 7 nM, 16 nM, 14 nM, and 3 nM, respectively. |
| GSK1070916,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 942918-07-2 | Aurora Kinase | GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM, respectively. |
| PHA-767491,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 845714-00-3, 942425-68-5 (HCl) | CDK | PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively. |
| CCT137690,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1095382-05-0 | Aurora Kinase | CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM, respectively. |
| CHIR-98014,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 252935-94-7 | GSK-3 | CHIR-98014 is a potent and selective GSK-3 inhibitor for GSK-3ɑ and GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively. |
| AZ628,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 878739-06-1 | Raf | AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600Ewith IC50 of 29 nM and 34 nM, respectively. |
| AMG458,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 913376-83-7 | c-Met | AMG 458 is a potent c-Met inhibitor of human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM. |
| Anacetrapib (MK-0859),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 875446-37-0 | CETP | Anacetrapib (MK0859) is a potent and selective rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, respectively |
| NVP-BGT226,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1245537-68-1, 915020-55-2 (free base) | PI3K | NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
| GW788388,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 452342-67-5, 1353867-76-1 (H2O) | TGF-beta/Smad | GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM. |
| PHA-848125,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 802539-81-7, 802540-32-5 (3HCl), 1253645-38-3 (Maleic acid) | CDK | PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with IC50 of 45 nM. |
| Arry-380,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 937265-83-3 | HER2 | ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM. |
| ARQ 197 (Tivantinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 905854-02-6, 1000873-98-2, 1228508-24-4 | c-Met | ARQ-197 is a novel and selective human c-Met inhibitor with IC50 of 0.1 μM. |
| AT-406,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1071992-99-8, 1071992-57-8 (HCl) | IAP | AT-406 is a potent IAP (inhibitor of apoptosis protein) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. |
| ARRY334543,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 845272-21-1, 1146629-86-8 (di4-methylbenzenesulfonate) | EGFR | ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively. |
| Wortmannin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 19545-26-7, 1405-03-4 | PI3K | Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 0.17 μM and 3 nM, respectively. |
| PI3K/HDAC Inhibitor I,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1339928-25-4 | HDAC | PI3K/HDAC Inhibitor I is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively. |
| Canagliflozin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 842133-18-0, 928672-86-0 (0.5H2O) | SGLT | Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively. |
| NVP-BVU972,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1185763-69-2 | c-Met | NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM. |
| CH5424802,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1256580-46-7, 1256589-74-8 (HCl) | ALK | CH5424802 is a potent and selective ALK inhibitor with IC50 of 1.9 nM. |
| MK-2048,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 869901-69-9 | Integrase | MK-2048 is an potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. |
| 3-Methyladenine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 5142-23-4, 80681-18-1(HCl) | PI3K | 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively. |
| Dinaciclib (SCH727965),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 779353-01-4 | CDK | Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. |
| Dovitinib Dilactic acid (TKI258 Dilactic acid) ,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 852433-84-2, 405169-16-6 (free base) | FLT3 | Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively. |
| MK-5108 (VX-689),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1010085-13-8 | Aurora Kinase | MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM. |
| Dalcetrapib (JTT-705),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 211513-37-0 | CETP | Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM. |
| SB705498,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 501951-42-4 | TRPV | SB705498 is a TRPV1 antagonist for hTRPV1 with pIC50 and pKi of 7.1 and 7.6 in HEK293 cells. |
| MK-2461,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 917879-39-1, 1196681-15-8, 1170702-87-0 (sodium salt) | c-Met | MK-2461 is a potent inhibitor of c-Met, Ron, Flt1/3, PDGFRβ, Mer and FGFR1/2/3 with IC50 of 2.5 nM, 7 nM, 10 nM/22 nM, 22 nM, 24 nM and 65 nM/39 nM/50 nM, respectively. |
| Nocodazole,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 31430-18-9, 61167-17-7 (HCl) | Microtubule Associated | Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. |
| CPI-613,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 95809-78-2 | Dehydrogenase | CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. |
| PF-5274857,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1373615-35-0 | Smoothened | PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively. |
| GW842166X,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 666260-75-9, 956013-38-0 | Cannabinoid Receptor | GW842166X is a potent and highly selective agonist of CB2 receptor. |
| M344,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 251456-60-7 | HDAC | M344 is a potent HDAC inhibitor with IC50 of 100 nM. |
| GW4064,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 278779-30-9 | FXR | GW 4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM. |
| AZD2014,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1009298-59-2 | mTOR | AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity. |
| TAK-285,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 871026-44-7, 871027-78-0 (methanesulfonate) | EGFR | TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively. |
| A-803467,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 944261-79-4 | Sodium Channel | A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
| Laquinimod (ABR-215062),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 248281-84-7, 248282-07-7 (sodium salt) | Laquinimod (ABR-215062) is a potent immunomodulator. | |
| INCB28060,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1029712-80-8, 1029714-89-3 (XHCl), 1197376-85-4 (2HCl) | c-Met | INCB28060 is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM. |
| Tofacitinib (CP-690550, Tasocitinib),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 477600-75-2, 540737-29-9 (citrate) | JAK | CP-690550 is a novel inhibitor of JAK3 with IC50 of 1 nM. |
| Istradefylline (KW-6002),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 155270-99-8, 861889-00-1 (6H2O), 861889-02-3 (5H2O) | Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. | |
| Sotrastaurin (AEB071),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 425637-18-9, 1058706-32-3 (HCl), 1058706-35-6 (Maleic acid) | PKC | Sotrastaurin (AEB071) is a potent selective pan-PKC inhibitor and highly inhibits PKCθ with Ki of 0.22 nM. |
| Torcetrapib (CP-529414),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 262352-17-0 | CETP | Torcetrapib (CP-529414) is a CETP inhibitor with IC50 of 37 nM. |
| VU 0357121,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 433967-28-3 | GluR | VU0357121 is a novel allosteric modulator of mGlu5 with EC50 of 33 nM. |
| WP1066,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 857064-38-1 | JAK | WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells . |
| Lonafarnib (SCH66336),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 193275-84-2 | Transferase | Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. |
| AZD4547,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1035270-39-3 | FGFR | AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively. |
| BAY80-6946,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1032568-63-0 | PI3K | |
| Galeterone (TOK-001),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 851983-85-2, 1239339-16-2 (methanesulfonate), 1239339-18-4 (sulfate), 1239339-17-3 (HCl) | Androgen Receptor | Galeterone (TOK-001, VN/124-1) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively. |
| Sirtinol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 410536-97-9 | Sirtuin | Sirtinol is a specific SIRT1 and SIRT2 inhibtor with IC50 of 131 μM and 38 μM, respectively. |
| LY364947,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 396129-53-6 | TGF-beta/Smad | LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM. |
| CEP33779,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1257704-57-6 | JAK | CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM. |
| Dabrafenib (GSK2118436),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1195765-45-7, 1195768-06-9 (methanesulfonic acid) | Raf | Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600Eand c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively. |
| GDC-0068,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1001264-89-6 | Akt | GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. |
| MPEP,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 96206-92-7, 219911-35-0 (HCl) | GluR | MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM. |
| INK 128,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1224844-38-5 | mTOR | INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM. |
| Ciproxifan,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 184025-19-2, 184025018-1(free base) | Histamine Receptor | Ciproxifan is a highly potent and selective H3-receptor antagonist with IC50 of 9.2 nM. |
| BYL719,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1217486-61-7 | PI3K | BYL719 strongly and selectively inhibits the PI3Kα. |
| Tyrphostin AG 879 (AG 879),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 148741-30-4 | HER2 | AG879 inhibits both ErbB2 and Flk-1 with IC50 of 1 μM. |
| Torin 2,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1223001-51-1 | mTOR | Torin2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM. |
| CI994 (Tacedinaline),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 112522-64-2, 1299346-14-7 (HCl), 1353653-79-8 (TFA) | HDAC | CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM. |
| AM251,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 183232-66-8, 1061340-04-2 (TFA) | Cannabinoid Receptor | AM251 is a cannabinoid 1 receptor antagonist with IC50 of 8.9 μM. |
| NVP-TAE226,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 761437-28-9 | FAK | NVP-TAE226, a potent dual FAK/IGF-IR, inhibiting FAK and IGF-IR with IC50 of 5.5 nM and 0.14 μM, respectively. |
| RG108,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 48208-26-0 | Transferase | RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM. |
| Tideglusib,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 865854-05-3 | GSK-3 | Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM. |
| TPCA-1,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 507475-17-4 | IKK | TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| ML133 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1222781-70-5, 185669-79-8 (free base) | Potassium Channel | ML133 is a potent potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5). |
| Desmethyl Erlotinib (CP-473420),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 183321-86-0, 183320-51-6 (HCl) | EGFR | Desmethyl Erlotinib (CP-473420) is a free base of OSI-420, which is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for human EGFR with IC50 of 2 nM. |
| Torin 1,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1222998-36-8 | mTOR | Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM. |
| JNJ 1661010,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 681136-29-8 | FAAH | JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human). |
| Epiandrosterone (3β-androsterone),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 481-29-8 | Estrogen/progestogen Receptor | |
| ARN-509,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 956104-40-8 | Adrenergic Receptor | ARN-509 is a selective androgen receptor inhibitor with IC50 of 16 nM. |
| R428,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1037624-75-1 | R428 is an inhibitor of Axl with IC50 of 14 nM. | |
| SAR131675,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | VEGFR | SAR131675 is a VEGFR-3 inhibitor with IC50 of 20 nM. | |
| BI-D1870,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 501437-28-1 | S6 Kinase | BI-D1870 is an ATP-competitive inhibitor of ribosomal S6 for RSK1, RSK2, RSK3 and RSK4 with IC50 of 31 nM, 24 nM, 18 nM and 15 nM, respectively. |
| Semaxanib (SU5416),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 194413-58-6 | VEGFR | Adrenalone is an adrenergic agonist. |
| Cathepsin Inhibitor 1,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 225120-65-0 | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. | |
| SB-269970 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 261901-57-9, 201038-74-6 (free base) | 5-HT Receptor | SB-269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3. |
| Baricitinib (LY3009104),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1187594-09-7, 1187594-10-0 (TFA) | JAK | Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively. |
| BRL 54443,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 57477-39-1, 57477-41-5 (HBr), 1197333-54-2 (Maleic acid) | 5-HT Receptor | BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively. |
| Carfilzomib (PR-171),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 868540-17-4, 1140908-84-4 (TFA), 1140908-85-5 (methanesulfonate) | Proteasome | Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM. |
| BML-190,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 2854-32-2 | Cannabinoid Receptor | BML-190 is a selective CB2 inverse agonist with Ki of 435 nM. |
| MRS 2578,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 711019-86-2 | P2 Receptor | MRS2578 is a potent P2Y6 receptor with IC50 of 37 nM. |
| SB 271046,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 209481-20-9 | 5-HT Receptor | SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9. |
| Dizocilpine (MK 801),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 77086-21-6 | GluR | Dizocilpine is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. |
| StemRegenin 1,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1227633-49-9 | StemRegenin 1 is an AhR inhibitor with IC50 of 127 nM. | |
| Golvatinib (E7050),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 928037-13-2 , 1007601-96-8 (L(+)-Tartaric Acid), 1007601-91-3 (Fumaric acid) | c-Met | E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively. |
| IEM 1754 dihydrobroMide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 162831-31-4, 697221-65-1 (free base) | GluR | IEM 1754 dihydrobroMide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
| CTEP,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 871362-31-1 | GluR | CTEP is a selective allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM. |
| VU 0364770,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 61350-00-3 | GluR | VU 0364770 is a selective positive allosteric mGlu4 with EC50 of 1.1 μM. |
| ML130,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 799264-47-4 | NOD1 | ML130 is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM. |
| IMD 0354,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 978-62-1, 634914-41-3 (sodium salt ) | IKK | IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NFκβ pathway. |
| VUF 10166,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 155584-74-0, 55686-37-8 (HCl) | 5-HT Receptor | VUF10166 is a novel, potent and competitive antagonist to 5-HT3A with Ki of 0.04 nM. |
| U-104,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 178606-66-1 | Carbonic Anhydrase | U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with IC50 of 45.1 nM and 4.5 nM, respectively. |
| WHI-P154,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 211555-04-3, 296234-84-9 (HCl) | JAK | WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM. |
| Alogliptin (SYR-322),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 850649-61-5, 850649-62-6 (benzoate) | DPP-4 | Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of < 10 nM. |
| TG 100713,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 925705-73-3 | PI3K | TG 100713 is a PI3K inhibitor for PI3Kg, PI3Kd, PI3Ka and PI3Kb with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively. |
| T0070907,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 313516-66-4, 372095-17-5 (HCl) | PPAR | T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM. |
| Camostat Mesilate (FOY-305),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 59721-29-8 | HCV Protease | Camostat is a trypsin-like protease inhibitor, inhibiting matriptase and human neutrophil elastase with IC50 of 0.5 μM and 0.2 μM, respectively. |
| Prucalopride,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 179474-81-8, 179474-80-7 (HCl) | 5-HT Receptor | Prucalopride is a potent 5-HT4 receptor antagonist with IC50 of 2.5 nM. |
| (-)-MK 801 Maleate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 121917-57-5 | GluR | MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. |
| L-NAME HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 51298-62-5, 50903-99-6 (free base) | L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. | |
| IKK-16,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 873225-46-8 | IKK | IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
| A 205804,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 251992-66-2 | A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. | |
| PF-562271,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 717907-75-0 | FAK | PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
| GW441756,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 504433-23-2 | ||
| VU 0361737,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 1161205-04-4 | GluR | |
| NU7026,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 154447-35-5 | DNA-PK | NU7026 is a DNA-PK inhibitor with IC50 of 0.23 μM. |
| SB-742457,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 607742-69-8 | 5-HT Receptor | SB-742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63. |
| Tyrphostin 9 (SF 6847),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 10537-47-0 | EGFR | SF 6847 is an inhibitor of EGFR with IC50 of 460 μM. |
| ZM 323881 HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 193000-39-4 | VEGFR | ZM-323881 is a potent and selective inhibitor of VEGFR2 with IC50 < 2 nM. |
| ZM 306416,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 690206-97-4 | VEGFR | ZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively. |
| CCG 50014,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 883050-24-6 | CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM. | |
| S-Ruxolitinib,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 941685-37-6 | JAK | S-Ruxolitinib is a JAK family inhibitor for JAK1 and JAK2 with IC50 of 3.3 nM and 2.8 nM, respectively. |
| Lumiracoxib (COX-189),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 220991-20-8 | COX | Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with Ki of 0.06 μM. |
| PF 477736,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 952021-60-2 | Chk | PF 477736 is a ChK inhibitor against ChK1, ChK2, VEGFR2, Yes and Fms with IC50 of 0.49 nM, 47 nM, 8 nM, 14 nM and 10 nM, respectively. |
| JNJ-7777120,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 459168-41-3 | Histamine Receptor | JNJ-7777120 is a potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM. |
| Ki16198,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 355025-13-7 | LPA Receptor | |
| Pirfenidone,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 53179-13-8 | TGF-beta/Smad | Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. |
| Tempol (4-Hydroxy-TEMPO),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 2226-96-2 | ||
| Go 6983,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 133053-19-7 | PKC | Go 6983 is a pan PKC inhibitor against PKCα, PKCβ, PKCγ, PKCδ, PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively. |
| WZ 811,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 55778-02-4 | CXCR | WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM. |
| Dapivirine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 244767-67-7 | Reverse Transcriptase | Dapivirine is an nonnucleoside reverse transcriptase inhibitor for HIV reverse transcriptase with IC50 of 24 nM. |
| GW9662,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 22978-25-2 | PPAR | GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively. |
| ML-161,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 423735-93-7 | ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM. | |
| HC-030031,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 349085-38-7 | HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. | |
| IOX2,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 931398-72-0 | HIF | IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM. |
| Mozavaptan,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 137975-06-5, 138470-70-9 (HCl) | ||
| Icotinib,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 610798-31-7 | EGFR | |
| Salubrinal,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 405060-95-9 | Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM. | |
| CHIR-99021 (CT99021) HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 252917-06-9 (free base) | GSK-3 | CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. |
| TDZD-8,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 327036-89-5 | GSK-3 | |
| TAK 715,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 303162-79-0 | p38 MAPK | |
| Piceatannol,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 10083-24-6, 21100-92-5 | Syk | Piceatannol is a selective Syk inhibitor with IC50 of ~10 μM. |
| Sitaxentan sodium (TBC-11251),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 210421-74-2, 184036-34-8 (free base) | Endothelin Receptor | Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively. |
| Purmorphamine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 483367-10-8 | Smoothened | Purmorphamine directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with Smo antagonist and also is a inducer of osteoblast differentiation with EC50 of 1μM. |
| Bosentan Hydrate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 157212-55-0, 147536-97-8 (free base), 150726-52-6 (sodium salt ) | Endothelin Receptor | Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
| Rupatadine Fumarate,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 182349-12-8 | Histamine Receptor | Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 and 102 nM, respectively. |
| Ambroxol HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 23828-92-4 | Sodium Channel | Ambroxol HCl is a potent inhibitor of the neuronal Na+channels with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, respectively. |
| Piracetam,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 7491-74-9 | Piracetam is a cyclic derivative of the neurotransmitter ?-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders. | |
| Fingolimod (FTY720),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 162359-56-0, 162359-55-9 (free base), 1227170-83-3 (acetate) | S1P Receptor | FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM. |
| LY2140023 (LY404039),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 635318-55-7, 956385-05-0 (H2O),635318-26-2 (HCl) | GluR | LY404039 is a potent agonist of recombinant human mGlu2, mGlu3 receptors and rat neurons expressing native mGlu2/3 receptors with Ki of 149 nM, 92 nM and 88 nM, respectively. |
| NXY-059 (Cerovive),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 168021-79-2, 252027-72-8, 168021-77-0 (free base) | NXY-059 (Cerovive) is a novel nitrone, shows efficacious neuroprotective effects. | |
| PTC124 (Ataluren),assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 775304-57-9, 1015238-98-8 (H2O), 775304-59-1 (sodium salt) | CFTR | PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM. |
| Cyclocytidine HCl,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 10212-25-6 | ||
| Astragaloside A,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 83207-58-3 | TGF-beta/Smad | Astragaloside A is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis. |
| Ipriflavone,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 35212-22-7 | Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption. | |
| 10-Hydroxycamptothecin,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 19685-09-7 | Topoisomerase | 10-Hydroxycamptothecin (10-HCPT, 10-hydroxy-CPT, OHCPT, NSC107124) is a DNA topoisomerase I inhibitor with potent anti-tumor activity. |
| Hypoxanthine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 68-94-0 | Hypoxanthine is a naturally occurring purine derivative. | |
| Rotundine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 483-14-7 | Calcium Channel | Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
| Inosine,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 58-63-9 | Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond. | |
| Triptolide,assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. | 38748-32-2 |
