| ABT-263 (Navitoclax), 923564-51-6, Concentration 10 mM, Molecular Weight :974.61, Target:Bcl-2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, res |
| ABT-737, 852808-04-9, Concentration 11 mM, Molecular Weight :813.43, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively. |
| Linifanib (ABT-869), 796967-16-3, Concentration 12 mM, Molecular Weight :375.41, Target:CSF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively. |
| ABT-888 (Veliparib), 912444-00-9, Concentration 13 mM, Molecular Weight :244.29, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ABT-888 (Veliparib, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. |
| Axitinib, 319460-85-0, Concentration 14 mM, Molecular Weight :386.47, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. |
| Saracatinib (AZD0530), 379231-04-6, Concentration 15 mM, Molecular Weight :542.03, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Saracatinib (AZD0530) is a Src inhibitor for c-Src and v-Abl with IC50 of 2.7 nM and 30 nM, respectively. |
| FG-4592, 808118-40-3, Concentration 16 mM, Molecular Weight :352.34, Target:HIF, HPLC 99%, NMR, LCMS is ok, stock more than 5g. FG-4592 is an HIF α prolyl hydroxylase inhibitor. |
| AZD6244 (Selumetinib), 606143-52-6, Concentration 17 mM, Molecular Weight :457.68, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM. |
| BEZ235 (NVP-BEZ235), 915019-65-7, Concentration 18 mM, Molecular Weight :469.55, Target:ATM/ATR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
| BIBF1120 (Vargatef), 656247-17-5, Concentration 19 mM, Molecular Weight :539.62, Target:FGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. |
| Afatinib (BIBW2992), 439081-18-2, Concentration 20 mM, Molecular Weight :485.94, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively. |
| Bortezomib (Velcade), 179324-69-7, Concentration 21 mM, Molecular Weight :384.24, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. |
| Bosutinib (SKI-606), 380843-75-4, Concentration 22 mM, Molecular Weight :530.45, Target:Src, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively. |
| Cediranib (AZD2171), 288383-20-0, Concentration 23 mM, Molecular Weight :450.51, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. |
| Dovitinib (TKI-258), 405169-16-6, Concentration 24 mM, Molecular Weight :392.43, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively. |
| CI-1033 (Canertinib), 267243-28-7, Concentration 25 mM, Molecular Weight :485.94, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively. |
| CI-1040 (PD184352), 212631-79-3, Concentration 26 mM, Molecular Weight :478.67, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM. |
| Dasatinib (BMS-354825), 302962-49-8, Concentration 27 mM, Molecular Weight :488.01, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.5 nM and 79 nM, respectively. |
| Deforolimus (Ridaforolimus), 572924-54-0, Concentration 28 mM, Molecular Weight :990.21, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Deforolimus (Ridaforolimus, AP23573, MK-8669) is a selective mTOR inhibitor with IC50 of 0.2 nM. |
| Erlotinib HCl, 183319-69-9, Concentration 29 mM, Molecular Weight 429.9, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM. |
| Gefitinib (Iressa), 184475-35-2, Concentration 30 mM, Molecular Weight 446.9, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. |
| Imatinib Mesylate, 220127-57-1, Concentration 31 mM, Molecular Weight 589.71, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
| Lapatinib Ditosylate (Tykerb), 388082-77-7, Concentration 32 mM, Molecular Weight 925.46, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
| Lenalidomide (Revlimid), 191732-72-6, Concentration 33 mM, Molecular Weight 259.26, Target:TNF-alpha, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM. |
| Motesanib Diphosphate (AMG-706), 857876-30-3, Concentration 34 mM, Molecular Weight 569.44, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively. |
| Nilotinib (AMN-107), 641571-10-0, Concentration 35 mM, Molecular Weight 529.52, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM. |
| NVP-AEW541, 475489-16-8 , Concentration 36 mM, Molecular Weight 439.55, Target:IGF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM. |
| Pazopanib HCl, 635702-64-6, Concentration 37 mM, Molecular Weight 473.98, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. |
| PD0325901, 391210-10-9, Concentration 38 mM, Molecular Weight 482.19, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
| PI-103, 371935-74-9, Concentration 39 mM, Molecular Weight 348.36, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively. |
| Rapamycin (Sirolimus), 53123-88-9, Concentration 40 mM, Molecular Weight 914.18, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM. |
| Sorafenib (Nexavar), 475207-59-1, Concentration 41 mM, Molecular Weight 637.03, Target:PDGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
| STF-62247, 315702-99-9, Concentration 42 mM, Molecular Weight 267.35, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. STF-62247 is selectively toxic and growth inhibitory to renal cells lacking VHL |
| Sunitinib Malate (Sutent), 341031-54-7, Concentration 43 mM, Molecular Weight 532.56, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
| Tandutinib (MLN518), 387867-13-2, Concentration 44 mM, Molecular Weight 562.7, Target:FLT3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of Flt3, PDGFRβ and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.17 μM, respectively. |
| Temsirolimus (Torisel), 162635-04-3, Concentration 45 mM, Molecular Weight 1030.29, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Temsirolimus (CCI-779, Torisel) is a specific mTOR inhibitor with IC50 of 1.76 μM. |
| Trichostatin A (TSA), 58880-19-6, Concentration 46 mM, Molecular Weight 302.4, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM. |
| Vandetanib (Zactima), 443913-73-3, Concentration 47 mM, Molecular Weight 475.35, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM. |
| Vorinostat (SAHA), 149647-78-9, Concentration 48 mM, Molecular Weight 264.3, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vorinostat (suberoylanilide hydroxamic acid, SAHA, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM. |
| VX-680 (MK-0457, Tozasertib), 639089-54-6, Concentration 49 mM, Molecular Weight 464.59, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively. |
| Y-27632 2HCl, 129830-38-2, Concentration 50 mM, Molecular Weight 320.26, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM. |
| Elesclomol, 488832-69-5, Concentration 51 mM, Molecular Weight 400.5, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells.. |
| Entinostat (MS-275, SNDX-275), 209783-80-2, Concentration 52 mM, Molecular Weight 376.41, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MS-275 is an HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. |
| Enzastaurin (LY317615), 170364-57-5, Concentration 53 mM, Molecular Weight 515.61, Target:PKC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Enzastaurin (LY317615) is a potent PKC inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively. |
| BMS-599626 (AC480), 714971-09-2, Concentration 54 mM, Molecular Weight 567.01, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively. |
| Obatoclax mesylate (GX15-070), 803712-79-0, Concentration 55 mM, Molecular Weight 413.49, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM. |
| Olaparib (AZD2281), 763113-22-0, Concentration 56 mM, Molecular Weight 434.46, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively. |
| Nutlin-3, 890090-75-2, Concentration 57 mM, Molecular Weight 581.5, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM. |
| Masitinib (AB1010), 790299-79-5, Concentration 58 mM, Molecular Weight 498.64, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively. |
| GDC-0941, 957054-30-7, Concentration 59 mM, Molecular Weight 513.64, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively. |
| SL327, 305350-87-2, Concentration 60 mM, Molecular Weight 335.35, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SL327 is a selective inhibitor for MEK1 and MEK2 with IC50 of 0.18 μM and 0.22 μM, respectively. |
| SB 431542, 301836-41-9, Concentration 61 mM, Molecular Weight 384.39, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB 431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM. |
| Crizotinib (PF-02341066), 877399-52-5, Concentration 62 mM, Molecular Weight 450.34, Target:ALK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley. |
| AUY922 (NVP-AUY922), 747412-49-3, Concentration 63 mM, Molecular Weight 465.54, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively. |
| PHA-665752, 477575-56-7, Concentration 64 mM, Molecular Weight 641.61, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM. |
| HA14-1, 65673-63-4, Concentration 65 mM, Molecular Weight 409.23, Target:Bcl-2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM. |
| ZSTK474, 475110-96-4, Concentration 66 mM, Molecular Weight 417.41, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ZSTK474 is a potent pan-class I PI3K inhibitor with IC50 of 37 nM. |
| SB 216763, 280744-09-4, Concentration 67 mM, Molecular Weight 371.22, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB 216763 is a potent and selective GSK-3α inhibitor with IC50 of 34.3 nM. |
| SB 203580, 152121-47-6, Concentration 68 mM, Molecular Weight 377.43, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM. |
| SB 202190, 152121-30-7, Concentration 69 mM, Molecular Weight 331.34, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB 202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α and p38β with IC50 of 50 nM and 100 nM, respectively. |
| MK-2206 2HCl, 1032350-13-2, Concentration 70 mM, Molecular Weight 480.39, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8 nM, 12 nM and 65 nM, respectively. |
| PD153035 HCl, 183322-45-4, Concentration 71 mM, Molecular Weight 396.67, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM, respectively. |
| SU11274, 658084-23-2, Concentration 72 mM, Molecular Weight 568.09, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SU11274 is a selective Met inhibitor with IC50 of 10 nM. |
| Vismodegib (GDC-0449), 879085-55-9, Concentration 73 mM, Molecular Weight 421.3, Target:Hedgehog, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM. |
| Brivanib (BMS-540215), 649735-46-6, Concentration 74 mM, Molecular Weight 370.38, Target:FGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively. |
| Belinostat (PXD101), 414864-00-9, Concentration 75 mM, Molecular Weight 318.35, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in HeLa cell extracts. |
| Iniparib (BSI-201), 160003-66-7, Concentration 76 mM, Molecular Weight 292.03, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BSI-201 (Iniparib, SAR240550) is a PARP1 inhibitor. |
| NVP-ADW742, 475488-23-4, Concentration 77 mM, Molecular Weight 453.58, Target:IGF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM. |
| PCI-24781, 783355-60-2, Concentration 78 mM, Molecular Weight 397.42, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively. |
| Linsitinib (OSI-906), 867160-71-2, Concentration 79 mM, Molecular Weight 421.49, Target:IGF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively. |
| KU-55933, 587871-26-9, Concentration 80 mM, Molecular Weight 395.49, Target:ATM/ATR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively. |
| GSK1904529A, 1089283-49-7, Concentration 81 mM, Molecular Weight 851.96, Target:IGF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively. |
| PF-04217903, 956905-27-4, Concentration 82 mM, Molecular Weight 372.38, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM. |
| LAQ824 (NVP-LAQ824, Dacinostat), 404951-53-7, Concentration 83 mM, Molecular Weight 379.459, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LAQ824 (NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM. |
| JNJ-26481585, 875320-29-9, Concentration 84 mM, Molecular Weight 394.476, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. JNJ-26481585 (Quisinostat) is an HDAC inhibitor for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11 with IC50 of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM and 0.37 nM, respectively. |
| BTZ043 racemate, 957217-65-1, Concentration 85 mM, Molecular Weight 431.39, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis. |
| Rucaparib (AG-014699 , PF-01367338), 459868-92-9, Concentration 86 mM, Molecular Weight 421.36, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM. |
| MLN8054, 869363-13-3, Concentration 87 mM, Molecular Weight 476.86, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM. |
| Vatalanib 2HCl (PTK787), 212141-51-0, Concentration 88 mM, Molecular Weight 419.73, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively. |
| U0126-EtOH, 1173097-76-1, Concentration 89 mM, Molecular Weight 426.56, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. U0126-EtOH is a highly selective inhibitor of MEK1 and MEK2 with IC50 of 0.07 μM and 0.06 μM, respectively. |
| ZM-447439, 331771-20-1, Concentration 90 mM, Molecular Weight 513.59, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ZM-447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. |
| GDC-0879, 905281-76-7, Concentration 91 mM, Molecular Weight 334.37, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM. |
| LY294002, 154447-36-6, Concentration 92 mM, Molecular Weight 307.34, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, and also blocks autophagosome formation. |
| OSU-03012 (AR-12) , 742112-33-0, Concentration 93 mM, Molecular Weight 460.45, Target:PDK-1, HPLC 99%, NMR, LCMS is ok, stock more than 5g. OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM. |
| Danusertib (PHA-739358), 827318-97-8, Concentration 94 mM, Molecular Weight 474.55, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively. |
| TAE684 (NVP-TAE684), 761439-42-3, Concentration 95 mM, Molecular Weight 614.2, Target:ALK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM. |
| BI 2536, 755038-02-9, Concentration 96 mM, Molecular Weight 521.66, Target:PLK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BI 2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM. |
| Varespladib (LY315920), 172732-68-2, Concentration 97 mM, Molecular Weight 380.39, Target:Phospholipase (e.g. PLA), HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY315920 (Varespladib) is a potent and selective secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM. |
| Foretinib (GSK1363089, XL880), 849217-64-7, Concentration 98 mM, Molecular Weight 632.65, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively. |
| SGX-523, 1022150-57-7, Concentration 99 mM, Molecular Weight 359.41, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SGX-523 is a selective Met inhibitor with IC50 of 4 nM. |
| GSK690693, 937174-76-0, Concentration 100 mM, Molecular Weight 425.48, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
| JNJ-38877605, 943540-75-8, Concentration 101 mM, Molecular Weight 377.35, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM. |
| Odanacatib (MK 0822), 603139-19-1, Concentration 102 mM, Molecular Weight 525.56, Target:Cathepsin K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively. |
| PD 0332991 (Palbociclib) HCl, 827022-32-2, Concentration 103 mM, Molecular Weight 483.99, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD 0332991 is a highly selective inhibitor of CDK4/cyclin D1 and CDK6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively. |
| Triciribine (Triciribine phosphate), 35943-35-2, Concentration 104 mM, Molecular Weight 320.3, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively. |
| XL147, 956958-53-5, Concentration 105 mM, Molecular Weight 448.52, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. XL147 (SAR245408) is a selective and reversible class I PI3K inhibitor for wild type and mutant p110α with IC50 of 40 nM and 40 nM, respectively. |
| XL-184 (Cabozantinib), 849217-68-1, Concentration 106 mM, Molecular Weight 501.51, Target:Axl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. |
| Everolimus (RAD001), 159351-69-6, Concentration 107 mM, Molecular Weight 958.22, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
| TW-37, 877877-35-5, Concentration 108 mM, Molecular Weight 573.7, Target:Bcl-2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. |
| Mocetinostat (MGCD0103), 726169-73-9, Concentration 109 mM, Molecular Weight 396.44, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MGCD0103 (Mocetinostat) is a potent HDAC inhibitor for HDAC1, HDAC2 and HDAC3 with IC50 of 0.15 μM, 0.29 μM and 1.66 μM, respectively. |
| Abiraterone (CB-7598), 154229-19-3, Concentration 110 mM, Molecular Weight 349.51, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM. |
| SRT1720, 1001645-58-4, Concentration 111 mM, Molecular Weight 506.02, Target:Sirtuin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SRT1720 is a selective SIRT1 activator with EC1.5 of 0.16 μM. |
| YM155, 781661-94-7, Concentration 112 mM, Molecular Weight 443.29, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. YM155 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor for survivin with IC50 of 0.54 nM. |
| INO-1001, 3544-24-9, Concentration 113 mM, Molecular Weight 136.15, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. INO-1001 is a potent inhibitor of PARP with IC50 of 50 nM and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
| MLN8237 (Alisertib), 1028486-01-2, Concentration 114 mM, Molecular Weight 518.92, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM. |
| AT9283, 896466-04-9, Concentration 115 mM, Molecular Weight 381.43, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively. |
| Pemetrexed (Alimta), 150399-23-8, Concentration 116 mM, Molecular Weight 471.37, Target:DHFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pemetrexed disodium (Alimta) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| Brivanib alaninate (BMS-582664), 649735-63-7, Concentration 117 mM, Molecular Weight 441.46, Target:FGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively. |
| ADL5859 HCl, 850173-95-4, Concentration 118 mM, Molecular Weight 428.95, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM. |
| Andarine (GTX-007), 401900-40-1, Concentration 119 mM, Molecular Weight 441.36, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Andarine (GTX-007) is a selective nonsteroidal androgen receptor (AR) agonist with Ki of 4 nM. |
| 17-AAG (Tanespimycin), 75747-14-7, Concentration 120 mM, Molecular Weight 585.69, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. |
| 17-DMAG HCl (Alvespimycin), 467214-21-7, Concentration 121 mM, Molecular Weight 653.21, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM. |
| AG-490, 133550-30-8 , Concentration 122 mM, Molecular Weight 294.3, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AG-490 (Tyrphostin B42) is an inhibitor of EGFR, ErbB2 and JAK2 with IC50 of 0.1 μM, 13.5 μM, and ~10 μM, respectively. |
| Ivacaftor (VX-770), 873054-44-5, Concentration 123 mM, Molecular Weight 392.49, Target:CFTR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| SNS-032 (BMS-387032), 345627-80-7, Concentration 124 mM, Molecular Weight 380.53, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively. |
| Cyclopamine, 4449-51-8, Concentration 125 mM, Molecular Weight 411.62, Target:Hedgehog, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM. |
| Barasertib (AZD1152-HQPA), 722544-51-6, Concentration 126 mM, Molecular Weight 507.56, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM. |
| Docetaxel (Taxotere), 114977-28-5, Concentration 127 mM, Molecular Weight 807.88, Target:Microtubule Associated, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
| Gemcitabine HCl (Gemzar), 122111-03-9, Concentration 128 mM, Molecular Weight 299.66, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| Paclitaxel (Taxol), 33069-62-4, Concentration 129 mM, Molecular Weight 853.91, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Paclitaxel (Taxol, Onxol, Nov-Onxol) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. |
| PLX-4720, 918505-84-7, Concentration 130 mM, Molecular Weight 413.83, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PLX-4720 is a potent and selective inhibitor of B-RafV600E and c-Raf-1Y340D/Y341D with IC50 of 13 nM and 6.7 nM, respectively. |
| Roscovitine (Seliciclib, CYC202) , 186692-46-6 , Concentration 131 mM, Molecular Weight 354.45, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively. |
| SNS-314 Mesylate, 1146618-41-8, Concentration 132 mM, Molecular Weight 527.04, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3.4 nM, respectively. |
| NSC 74859 (S3I-201), 501919-59-1, Concentration 133 mM, Molecular Weight 365.36, Target:STAT, HPLC 99%, NMR, LCMS is ok, stock more than 5g. S3I-201 (NSC 74859) is a Stat3 inhibitor with IC50 of 86 μM. |
| Capecitabine (Xeloda), 154361-50-9, Concentration 134 mM, Molecular Weight 359.35, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. |
| MK-8245, 1030612-90-8, Concentration 135 mM, Molecular Weight 467.25, Target:Dehydrogenase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-8245 is an inhibitor of stearoyl-CoA desaturase (SCD) which targets the liver with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. |
| Ganetespib (STA-9090), 888216-25-9, Concentration 136 mM, Molecular Weight 364.4, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells. |
| TRAM-34, 289905-88-0, Concentration 137 mM, Molecular Weight 344.84, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM. |
| AT13387, 912999-49-6, Concentration 138 mM, Molecular Weight 409.52, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells. |
| E7080 (Lenvatinib), 417716-92-8, Concentration 139 mM, Molecular Weight 426.85, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. E7080 (Lenvatinib) is a multi-target inhibitor of VEGFR2 and VEGFR3 with IC50 of 4 nM and 5.2 nM, respectively. |
| ABT-751, 141430-65-1, Concentration 140 mM, Molecular Weight 371.41, Target:Microtubule Associated, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules. |
| Cisplatin, 15663-27-1, Concentration 141 mM, Molecular Weight 300.05, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cisplatin is an inorganic and water-soluble platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts. |
| CP-724714, 537705-08-1, Concentration 142 mM, Molecular Weight 469.53, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM. |
Valproic acid sodium salt (Sodium valproate), 1069-66-5, Concentration 143 mM, Molecular Weight 166.19, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinic
semialdehyde dehydrogenase. |
| TGX-221, 663619-89-4, Concentration 144 mM, Molecular Weight 364.44, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TGX-221 is a potent, selective PI3K inhibitor for p110β with IC50 of 8.5 nM. |
| WZ3146, 1214265-56-1, Concentration 145 mM, Molecular Weight 464.95, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively. |
| CYC116, 693228-63-6, Concentration 146 mM, Molecular Weight 368.46, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CYC116 is a potent inhibitor of Aurora A/B and VEGFR with Ki of 8.0 nM/9.2 nM and 44 nM, respectively. |
| JNJ 26854165 (Serdemetan), 881202-45-5, Concentration 147 mM, Molecular Weight 328.41, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. JNJ 26854165 (Serdemetan) is an orally bioavailable HDM2 (an E3 ligase) antagonist. |
| WZ4002, 1213269-23-8, Concentration 148 mM, Molecular Weight 494.18, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFRL858R and EGFRL858R/T790M with IC50 of 2 nM and 8 nM, respectively. |
| Ostarine (MK-2866), 841205-47-8, Concentration 149 mM, Molecular Weight 389.33, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ostarine (GTx-024, MK-2866, Enobosarm, S-22) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM. |
| BIIB021, 848695-25-0, Concentration 150 mM, Molecular Weight 318.76, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIIB021 is a novel inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectivley. |
| PD98059, 167869-21-8, Concentration 151 mM, Molecular Weight 267.28, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM. |
| Regorafenib (BAY 73-4506), 755037-03-7, Concentration 152 mM, Molecular Weight 482.82, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
| WZ8040, 1214265-57-2, Concentration 153 mM, Molecular Weight 481.01, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor. |
| XAV-939, 284028-89-3, Concentration 154 mM, Molecular Weight 312.31, Target:Wnt/beta-catenin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. XAV-939 is a selective Wnt β-catenin-mediated transcription inhibitor for TNKS1 and TNKS2 with IC50 of 11 nM and 4 nM, respectively. |
| ENMD-2076, 934353-76-1, Concentration 155 mM, Molecular Weight 375.47, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ENMD-2076 is a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM/15.9 nM and 58.2 nM, respectively. |
| Danoprevir, 850876-88-9, Concentration 156 mM, Molecular Weight 731.83, Target:HCV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM. |
| Ritonavir, 155213-67-5, Concentration 157 mM, Molecular Weight 720.94, Target:HIV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. |
| BIBR 1532, 321674-73-1, Concentration 158 mM, Molecular Weight 331.36, Target:Telomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIBR 1532 is a potent and selective telomerase inhibitor with IC50 of 100 nM. |
| PIK-90, 677338-12-4, Concentration 159 mM, Molecular Weight 351.36, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively. |
| Anastrozole, 120511-73-1, Concentration 160 mM, Molecular Weight 293.37, Target:Aromatase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Anastrozole inhibits the enzyme aromatase. |
| Aprepitant (MK-0869), 170729-80-3, Concentration 161 mM, Molecular Weight 534.43, Target:Substance P, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Substance P antagonists (SPA). |
| Bicalutamide (Casodex), 90357-06-5, Concentration 162 mM, Molecular Weight 430.37, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM. |
| Fulvestrant (Faslodex), 129453-61-8, Concentration 163 mM, Molecular Weight 606.77, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.094 nM. |
| Raltitrexed (Tomudex), 112887-68-0, Concentration 164 mM, Molecular Weight 458.49, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. |
| Thalidomide, 50-35-1, Concentration 165 mM, Molecular Weight 258.23, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase， which is a CRBN-DDB1-Cul4A complex. |
| CUDC-101, 1012054-59-9, Concentration 166 mM, Molecular Weight 434.49, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively. |
| TAK-700 (Orteronel), 426219-18-3, Concentration 167 mM, Molecular Weight 307.35, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively. |
| Exemestane, 107868-30-4, Concentration 168 mM, Molecular Weight 296.4, Target:Aromatase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively. |
| Finasteride, 98319-26-7, Concentration 169 mM, Molecular Weight 372.54, Target:5-alpha Reductase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Finasteride is an inhibitor of steroid Type II 5α-reductase. |
| Irinotecan, 97682-44-5, Concentration 170 mM, Molecular Weight 586.68, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. |
| Cladribine, 4291-63-8, Concentration 171 mM, Molecular Weight 285.69, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
| Decitabine, 2353-33-5, Concentration 172 mM, Molecular Weight 228.21, Target:DNA Methyltransferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
| Dimesna, 16208-51-8, Concentration 173 mM, Molecular Weight 326.34, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dimesna is an uroprotective agent used to decrease urotoxicity. |
| Dutasteride, 164656-23-9, Concentration 174 mM, Molecular Weight 528.53, Target:5-alpha Reductase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dutasteride is a 5-alpha-reductase inhibitor |
| PIK-75, 372196-77-5, Concentration 175 mM, Molecular Weight 488.74, Target:DNA-PK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PIK-75 is a selective and competitive inhibitor of p110α with IC50 of 5.8 nM and also potently inhibits DNA-PK with IC50 of 2 nM. |
| Bisoprolol, 104344-23-2, Concentration 176 mM, Molecular Weight 441.52, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bisoprolol is a selective type β1 adrenergic receptor blocker |
| Tivozanib (AV-951), 475108-18-0, Concentration 177 mM, Molecular Weight 454.86, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively. |
| Doxorubicin (Adriamycin), 25316-40-9, Concentration 178 mM, Molecular Weight 579.98, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
| Adrucil (Fluorouracil), 51-21-8, Concentration 179 mM, Molecular Weight 130.08, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Adrucil (Fluorouracil) is an DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS). |
| Abitrexate (Methotrexate), 59-05-2, Concentration 180 mM, Molecular Weight 454.44, Target:DHFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Abitrexate (Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| Bendamustine HCL, 3543-75-7, Concentration 181 mM, Molecular Weight 394.72, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM. |
| Nelarabine (Arranon), 121032-29-9, Concentration 182 mM, Molecular Weight 297.27, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
| Bleomycin sulfate, 9041-93-4, Concentration 183 mM, Molecular Weight 1512.62, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
| Carboplatin, 41575-94-4, Concentration 184 mM, Molecular Weight 371.25, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| PFI-1, 1403764-72-6, Concentration 185 mM, Molecular Weight 347.39, Target:Epigenetic Reader Domain, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM. |
| Clafen (Cyclophosphamide), 50-18-0, Concentration 186 mM, Molecular Weight 261.09, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM. |
| Clofarabine, 123318-82-1, Concentration 187 mM, Molecular Weight 303.68, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase |
| YM201636, 371942-69-7, Concentration 188 mM, Molecular Weight 467.48, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM. |
| OSI-930, 728033-96-3, Concentration 189 mM, Molecular Weight 443.44, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. |
| Dacarbazine (DTIC-Dome), 4342-03-4, Concentration 190 mM, Molecular Weight 182.18, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers. |
| Epirubicin HCl, 56390-09-1, Concentration 191 mM, Molecular Weight 579.98, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. |
| Oxaliplatin (Eloxatin), 61825-94-3, Concentration 192 mM, Molecular Weight 397.29, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts. |
| Etoposide (VP-16), 33419-42-0, Concentration 193 mM, Molecular Weight 588.56, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
| Ku-0063794, 938440-64-3, Concentration 194 mM, Molecular Weight 465.54, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM. |
| Evista (Raloxifene HCl), 82640-04-8, Concentration 195 mM, Molecular Weight 510.04, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Raloxifene is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM. |
| Idarubicin HCl, 57852-57-0, Concentration 196 mM, Molecular Weight 533.95, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. |
| Fludarabine Phosphate (Fludara), 75607-67-9, Concentration 197 mM, Molecular Weight 365.21, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
| Topotecan HCl, 119413-54-6, Concentration 198 mM, Molecular Weight 457.91, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Topotecan (Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively. |
| 2-Methoxyestradiol, 362-07-2, Concentration 199 mM, Molecular Weight 302.41, Target:HIF, HPLC 99%, NMR, LCMS is ok, stock more than 5g. 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity. |
| AG-1024 , 65678-07-1, Concentration 200 mM, Molecular Weight 305.17, Target:IGF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AG-1024 (Tyrphostin) is a specific IGF-1R and IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively. |
| Letrozole, 112809-51-5, Concentration 201 mM, Molecular Weight 285.3, Target:Aromatase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM. |
| Temozolomide, 85622-93-1, Concentration 202 mM, Molecular Weight 194.15, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer. |
| Vincristine, 2068-78-2, Concentration 203 mM, Molecular Weight 923.04, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM. |
| Agomelatine, 138112-76-2, Concentration 204 mM, Molecular Weight 243.3, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
| Amuvatinib (MP-470), 850879-09-3, Concentration 205 mM, Molecular Weight 447.51, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively. |
| Vinblastine, 57-22-7, Concentration 206 mM, Molecular Weight 824.96, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM. |
| JNJ-7706621, 443797-96-4, Concentration 207 mM, Molecular Weight 394.36, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. JNJ-7706621 is a potent and multi-target inhibitor for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, Aurora A and Aurora B with IC50 of 9 nM, 4 nM, 3 nM, 11 nM and 15 nM, respectively. |
| MDV3100 (Enzalutamide), 915087-33-1, Concentration 208 mM, Molecular Weight 464.44, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
| Dienogest, 65928-58-7, Concentration 209 mM, Molecular Weight 311.42, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dienogest is an orally active synthetic progesterone (or progestin). |
| Rufinamide (Banzel), 106308-44-5, Concentration 210 mM, Molecular Weight 238.19, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rufinamide, a triazole derivative, is an anticonvulsant medication. |
| Posaconazole, 171228-49-2, Concentration 211 mM, Molecular Weight 700.78, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM. |
| Prasugrel (Effient), 150322-43-3, Concentration 212 mM, Molecular Weight 373.44, Target:P2 Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A novel platelet inhibitor |
| Ramelteon (TAK-375), 196597-26-9, Concentration 213 mM, Molecular Weight 259.34, Target:MT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. |
| AMG-073 HCl (Cinacalcet HCl), 364782-34-3, Concentration 214 mM, Molecular Weight 393.87, Target:CaSR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AMG-073 HCl (Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism. |
| Celecoxib, 169590-42-5, Concentration 215 mM, Molecular Weight 381.37, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM. |
| BMS-708163 (Avagacestat), 1146699-66-2, Concentration 216 mM, Molecular Weight 520.88, Target:Beta Amyloid, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively. |
| PD173074, 219580-11-7, Concentration 217 mM, Molecular Weight 523.67, Target:FGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM. |
| WYE-354, 1062169-56-5, Concentration 218 mM, Molecular Weight 495.53, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM. |
| Vemurafenib (PLX4032), 918504-65-1, Concentration 219 mM, Molecular Weight 489.92, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM. |
| IC-87114, 371242-69-2, Concentration 220 mM, Molecular Weight 397.43, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. IC-87114 is a selective inhibitor of PI3Kδ with IC50 of 0.5 μM. |
| BX-795, 702675-74-9, Concentration 221 mM, Molecular Weight 591.47, Target:IκB/IKK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively. |
| BX-912, 702674-56-4, Concentration 222 mM, Molecular Weight 471.35, Target:PDK-1, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BX912 is a selective potent PDK1 inhibitor with IC50 of 12 nM. |
| Amisulpride, 71675-85-9, Concentration 223 mM, Molecular Weight 369.48, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. |
| Aniracetam, 72432-10-1, Concentration 224 mM, Molecular Weight 219.24, Target:AMPA Receptor-kainate Receptor-NMDA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aniracetam is a nootropics and neuroprotective drug. |
| Asenapine, 85650-56-2, Concentration 225 mM, Molecular Weight 401.84, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Asenapine ihibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM. |
| Benazepril HCl, 86541-74-4, Concentration 226 mM, Molecular Weight 460.95, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Benazepril is a medication used to treat high blood pressure. |
| Biperiden HCl, 1235-82-1, Concentration 227 mM, Molecular Weight 347.92, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Biperiden is an antiparkinsonian agent of the anticholinergic type. |
| Camptothecin, 7689-03-4, Concentration 228 mM, Molecular Weight 348.35, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Camptothecin (Camptohecine, 20-(S)-Camptothecin, CPT, NSC100880) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. |
| Carmofur, 61422-45-5, Concentration 229 mM, Molecular Weight 257.26, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Carmofur (INN) is a pyrimidine analogue used as an antineoplastic agent. |
| Celastrol, 34157-83-0, Concentration 230 mM, Molecular Weight 450.61, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. |
| Cetirizine DiHCl, 83881-52-1, Concentration 231 mM, Molecular Weight 461.81, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cetirizine Dihydrochloride is an antihistamine. |
| Cilnidipine, 132203-70-4, Concentration 232 mM, Molecular Weight 492.52, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cilnidipine is a calcium channel blocker. |
| Cilostazol, 73963-72-1, Concentration 233 mM, Molecular Weight 369.46, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. |
| Epothilone A, 152044-53-6, Concentration 234 mM, Molecular Weight 493.66, Target:Microtubule Associated, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM. |
| Floxuridine (Fludara), 50-91-9, Concentration 235 mM, Molecular Weight 246.19, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Floxuridine (Fludara) is a prodrugs of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1. |
| Ftorafur, 17902-23-7, Concentration 236 mM, Molecular Weight 200.17, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ftorafur is a substance being used in the treatment of some types of cancer. |
| Ifosfamide, 3778-73-2, Concentration 237 mM, Molecular Weight 261.09, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. |
| Megestrol Acetate, 595-33-5, Concentration 238 mM, Molecular Weight 384.51, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2. |
| Mercaptopurine, 50-44-2, Concentration 239 mM, Molecular Weight 152.18, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
| Zoledronic Acid (Zoledronate), 118072-93-8, Concentration 240 mM, Molecular Weight 272.09, Target:PKC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A potent nitrogen-containing bisphosphonates.It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM. |
| Ki16425, 355025-24-0 , Concentration 241 mM, Molecular Weight 474.96, Target:LPA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively. |
| AMG-208, 1002304-34-8 , Concentration 242 mM, Molecular Weight 383.4, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AMG-208 is a highly selective c-Met inhibitor with IC50 of 9.3 nM. |
| Costunolide, 553-21-9, Concentration 243 mM, Molecular Weight 232.32, Target:Telomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Costunolide inhibits FPTase with IC50 of 20 μM and also inhibits telomerase with IC50 of 90 μM and 65 μM in MCF-7 and MDA-MB-231 cells. |
| Dexamethasone, 50-02-2, Concentration 244 mM, Molecular Weight 392.46, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dexamethasone is an anti-inflammatory and immunosuppressant. |
| Doxazosin mesylate, 77883-43-3, Concentration 245 mM, Molecular Weight 547.58, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Doxazosin mesylate is an alpha-1 adrenergic receptor blocker. |
| Ellagic acid, 476-66-4, Concentration 246 mM, Molecular Weight 302.19, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ellagic acid has antiproliferative and antioxidant property. |
| Etodolac (Lodine), 41340-25-4, Concentration 247 mM, Molecular Weight 287.35, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Etodolac (Lodine) is a COX inhibitor with an IC50 of 53.5 nM. |
| Etomidate, 33125-97-2, Concentration 248 mM, Molecular Weight 244.29, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Etomidate is a GABAA receptors agonist at GABAA receptors. |
| Flumazenil, 78755-81-4, Concentration 249 mM, Molecular Weight 303.29, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flumazenil is a benzodiazepine antagonist. |
| Fluoxetine HCl, 56296-78-7, Concentration 250 mM, Molecular Weight 345.79, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class. |
| Flupirtine maleate, 75507-68-5, Concentration 251 mM, Molecular Weight 420.39, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flupirtine maleate is the salt form of Flupirtine, which is a non-opioid, centrally acting analgesia, muscle relaxation and neuroprotection. |
| Fluvoxamine maleate, 61718-82-9, Concentration 252 mM, Molecular Weight 434.41, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI). |
| Gabapentin HCl, 60142-95-2, Concentration 253 mM, Molecular Weight 207.7, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gabapentin Hydrochloride is a GABA analogue. |
| Galanthamine HBr, 1953-04-4, Concentration 254 mM, Molecular Weight 368.27, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Galanthamine (Razadyne, Reminyl) is an AChE inhibitor with IC50 of 14 nM. |
| Genistein, 446-72-0 , Concentration 255 mM, Molecular Weight 270.24, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. |
| Glimepiride, 93479-97-1, Concentration 256 mM, Molecular Weight 490.62, Target:DPP-4, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg. |
| Granisetron HCl, 107007-99-8, Concentration 257 mM, Molecular Weight 348.87, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Granisetron HCl is a serotonin 5-HT3 receptor antagonist |
| TG100-115, 677297-51-7, Concentration 258 mM, Molecular Weight 346.34, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TG100-115 is a potent and dual selective inhibitor for PI3Kγ and PI3Kδ with IC50 of 83 nM and 235 nM, respectively. |
| Ketoconazole, 65277-42-1, Concentration 259 mM, Molecular Weight 531.43, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. |
| Lansoprazole, 103577-45-3, Concentration 260 mM, Molecular Weight 369.36, Target:Proton Pump, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. |
| Lidocaine (Alphacaine), 137-58-6, Concentration 261 mM, Molecular Weight 234.34, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. |
| Loratadine, 79794-75-5, Concentration 262 mM, Molecular Weight 382.88, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. |
| Losartan potassium, 124750-99-8, Concentration 263 mM, Molecular Weight 462.01, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. |
| GSK1059615, 958852-01-2, Concentration 264 mM, Molecular Weight 333.36, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK1059615 is a novel and dual inhibitor of PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR with IC50 of 0.4 nM, 0.6 nM, 2 nM, 5 nM and 12 nM, respectively. |
| MGCD-265, 875337-44-3, Concentration 265 mM, Molecular Weight 517.6, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2 with IC50 of 1 nM, 3 nM, 3 nM, 4 nM, 2 nM and 7 nM, respectively. |
| Rigosertib (ON-01910), 1225497-78-8, Concentration 266 mM, Molecular Weight 473.47, Target:PLK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rigosertib (Estybon, Novonex, ON-01910) is a non-ATP-competitive inhibitor of PLK1 (Polo-like kinase 1) with IC50 of 9 nM. |
| Ki8751, 228559-41-9, Concentration 267 mM, Molecular Weight 469.41, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively. |
| Epothilone B (EPO906), 152044-54-7, Concentration 268 mM, Molecular Weight 507.68, Target:Microtubule Associated, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
| BMS-707035, 729607-74-3, Concentration 269 mM, Molecular Weight 410.42, Target:Integrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. |
| Amonafide, 69408-81-7, Concentration 270 mM, Molecular Weight 283.33, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amonafide (NSC-308847) is a selective topoisomerase II inhibitor. |
| Dorzolamide HCl, 130693-82-2, Concentration 271 mM, Molecular Weight 360.9, Target:Carbonic Anhydrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dorzolamide HCl is a carbonic anhydrase inhibitor. |
| Gestodene, 60282-87-3, Concentration 272 mM, Molecular Weight 310.43, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gestodene is a progestogen hormonal contraceptive. |
| Drospirenone, 67392-87-4, Concentration 273 mM, Molecular Weight 366.49, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Drospirenone is a synthetic progestin that is an analog to spironolactone. |
| Ruxolitinib (INCB018424), 941678-49-5, Concentration 274 mM, Molecular Weight 306.37, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. INCB018424 is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively. |
| Isotretinoin, 4759-48-2, Concentration 275 mM, Molecular Weight 300.44, Target:Hydroxylase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. |
| Lopinavir (ABT-378), 192725-17-0, Concentration 276 mM, Molecular Weight 628.8, Target:HIV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM. |
| Mianserin HCl, 21535-47-7, Concentration 277 mM, Molecular Weight 300.83, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mianserin is a psychoactive agent of the tetracyclic antidepressant. |
| Minoxidil, 38304-91-5, Concentration 278 mM, Molecular Weight 209.25, Target:Lysyl Hydroxylase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. |
| Mizoribine (Bredinin), 50924-49-7, Concentration 279 mM, Molecular Weight 259.22, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. |
| Mosapride citrate, 112885-42-4, Concentration 280 mM, Molecular Weight 614.02, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. |
| Nafamostat mesylate, 82956-11-4, Concentration 281 mM, Molecular Weight 539.58, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nafamostat is an anticoagulant. |
| Naftopidil DiHCl, 57149-08-3, Concentration 282 mM, Molecular Weight 465.41, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. |
| Omeprazole (Prilosec), 73590-58-6, Concentration 283 mM, Molecular Weight 345.42, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia. |
| Ondansetron HCl (Zofran), 99614-01-4, Concentration 284 mM, Molecular Weight 329.82, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ondansetron is a serotonin 5-HT3 receptor antagonist. |
| Oxcarbazepine, 28721-07-5, Concentration 285 mM, Molecular Weight 252.27, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. |
| Pelitinib (EKB-569), 257933-82-7, Concentration 286 mM, Molecular Weight 467.92, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pelitinib (EKB-569) is a potent EGFR inhibitor with IC50 of 38.5 nM. |
| Resveratrol, 501-36-0, Concentration 287 mM, Molecular Weight 228.24, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. |
| Rocuronium bromide, 119302-91-9, Concentration 288 mM, Molecular Weight 609.68, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant. |
| Stavudine, 3056-17-5, Concentration 289 mM, Molecular Weight 224.21, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Stavudine is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
| Tenofovir Disoproxil Fumarate, 202138-50-9, Concentration 290 mM, Molecular Weight 635.51, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tenofovir disoproxil fumarate belongs to nucleotide analogue reverse transcriptase inhibitors (nRTIs). |
| Tenofovir (Viread), 147127-20-6, Concentration 291 mM, Molecular Weight 287.21, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tenofovir blocks reverse transcriptase and hepatitis B virus infections. |
| Trilostane, 13647-35-3, Concentration 292 mM, Molecular Weight 329.43, Target:Dehydrogenase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome. |
| Alfuzosin HCl (Uroxatral), 81403-68-1, Concentration 293 mM, Molecular Weight 425.91, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Alfuzosin(Uroxatral) is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). |
| AS-605240, 648450-29-7, Concentration 294 mM, Molecular Weight 257.27, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AS-605240 is a novel, potent and selective PI3Kγ inhibitor with IC50 of 8 nM. |
| Clopidogrel (Plavix), 120202-66-6, Concentration 295 mM, Molecular Weight 419.9, Target:P2 Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent. |
| Staurosporine, 62996-74-1, Concentration 296 mM, Molecular Weight 466.53, Target:PKC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Staurosporine (AM-2282) is a potent PKC inhibitor with IC50 of 2.7 nM. |
| Droxinostat, 99873-43-5, Concentration 297 mM, Molecular Weight 243.69, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Droxinostat (CMH, 5809354) is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively. |
| Ranolazine 2HCl, 95635-56-6, Concentration 298 mM, Molecular Weight 500.46, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ranolazine(Ranexa), is an antianginal medication. |
| Repaglinide, 135062-02-1, Concentration 299 mM, Molecular Weight 452.59, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Repaglinide is for the treatment of type II diabetes. |
| Rolipram, 61413-54-5, Concentration 300 mM, Molecular Weight 275.34, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rolipram is a PDE4-inhibitor and an anti-inflammatory agent. |
| Sildenafil citrate, 171599-83-0, Concentration 301 mM, Molecular Weight 666.7, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). |
| Sumatriptan succinate, 103628-48-4, Concentration 302 mM, Molecular Weight 413.49, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sumatriptan succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches. |
| Tianeptine sodium, 30123-17-2, Concentration 303 mM, Molecular Weight 458.93, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tianeptine is a selective serotonin reuptake enhancer (SSRE) compound used for treating major depressive episodes. |
| Tizanidine HCl, 64461-82-1, Concentration 304 mM, Molecular Weight 290.17, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. |
| Topiramate, 97240-79-4, Concentration 305 mM, Molecular Weight 339.36, Target:Carbonic Anhydrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Topiramate is an anticonvulsant compound. |
| Varenicline tartrate, 375815-87-5, Concentration 306 mM, Molecular Weight 361.35, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Varenicline is a prescription medication used to treat smoking addiction. |
| Venlafaxine, 99300-78-4, Concentration 307 mM, Molecular Weight 313.86, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI). |
| Voriconazole, 137234-62-9, Concentration 308 mM, Molecular Weight 349.31, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. |
| Zileuton, 111406-87-2, Concentration 309 mM, Molecular Weight 236.29, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zileuton (ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. |
| Aurora A Inhibitor I, 1158838-45-9, Concentration 310 mM, Molecular Weight 588.07, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM. |
| Ispinesib (SB-715992), 336113-53-2, Concentration 311 mM, Molecular Weight 517.06, Target:Kinesin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM. |
| Tipifarnib (Zarnestra), 192185-72-1, Concentration 312 mM, Molecular Weight 489.4, Target:Transferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tipifarnib (Zarnestra, R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. |
| PHA-680632, 398493-79-3, Concentration 313 mM, Molecular Weight 501.62, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, repectively. |
| Cilomilast (SB-207499), 153259-65-5, Concentration 314 mM, Molecular Weight 343.42, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cilomilast (SB-207499) is a potent LPDE4 and HPDE4 inhibitor with IC50 of 100 nM and 120 nM, respectively. |
| Zibotentan (ZD4054), 186497-07-4, Concentration 315 mM, Molecular Weight 424.43, Target:Endothelin Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zibotentan (ZD4054) is a specific Endothelin A (ETA) antagonist with IC50 of 21 nM. |
| Atazanavir sulfate, 229975-97-7, Concentration 316 mM, Molecular Weight 802.93, Target:HIV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. |
| Thiazovivin, 1226056-71-8, Concentration 317 mM, Molecular Weight 311.36, Target:ROCK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of ~0.5 μM. |
| SP600125, 129-56-6, Concentration 318 mM, Molecular Weight 220.23, Target:JNK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively. |
| Ofloxacin (Floxin), 82419-36-1, Concentration 319 mM, Molecular Weight 361.37, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ofloxacin is a synthetic broad-spectrum antimicrobial agent. |
| Moxifloxacin HCl, 186826-86-8, Concentration 320 mM, Molecular Weight 437.89, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Moxifloxacin(Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent. |
| Alfacalcidol, 41294-56-8, Concentration 321 mM, Molecular Weight 400.64, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Alfacalcidol is a non-selective VDR activator medication. |
| TSU-68 (SU6668), 252916-29-3, Concentration 322 mM, Molecular Weight 310.35, Target:FGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TSU-68 (SU6668, Orantinib) is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with Ki of 2.1 μM, 1.2 μM, and 8 nM, respectively. |
| Safinamide Mesylate (FCE28073), 202825-46-5, Concentration 323 mM, Molecular Weight 398.45, Target:MAO, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Safinamide Mesylate is mesylate salt of Safinamide, which selectively and reversibly inhibits MAO-B with IC50 of 0.45 μM. |
| GSK429286A, 864082-47-3, Concentration 324 mM, Molecular Weight 432.37, Target:ROCK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. |
| AS703026 (pimasertib), 1236699-92-5, Concentration 325 mM, Molecular Weight 431.2, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AS703026 is a highly selective and potent non-competitive inhibitor of MEK1/2 with IC50 of 5-11 nM. |
| SB 525334, 356559-20-1, Concentration 326 mM, Molecular Weight 343.42, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB 525334 is a potent and selective inhibitor of TGF-β1 (ALK5) with IC50 of 14.3 nM. |
| Oligomycin A, 579-13-5, Concentration 327 mM, Molecular Weight 791.06, Target:ATPase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Oligomycin A is a specific inhibitor of complex V (ATP synthase) of the electron transport chain. |
| VX-222, 1026785-55-6, Concentration 328 mM, Molecular Weight 445.61, Target:HCV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM. |
| LY335979 (Zosuquidar 3HCl), 167465-36-3, Concentration 329 mM, Molecular Weight 636.99, Target:P-gp, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY335979 (Zosuquidar) is a potent modulator of P-glycoprotein-mediated multidrug resistance with Ki of 60 nM. |
| Daclatasvir （BMS-790052）, 1009119-64-5, Concentration 330 mM, Molecular Weight 738.88, Target:HCV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS-790052 is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM. |
| MC1568, 852475-26-4, Concentration 331 mM, Molecular Weight 314.31, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MC1568 is a selective HDAC inhibitor with IC50 of 220 nM. |
| HMN-214, 173529-46-9 , Concentration 332 mM, Molecular Weight 424.47, Target:PLK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk)1 with IC50 of 118 nM. |
| AEE788 (NVP-AEE788), 497839-62-0, Concentration 333 mM, Molecular Weight 440.58, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM and also inhibits VEGFR2 and Flt with IC50 of 77 nM and 59 nM, respectively. |
| PHA-793887, 718630-59-2, Concentration 334 mM, Molecular Weight 361.48, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively. |
| Naratriptan HCl, 143388-64-1, Concentration 335 mM, Molecular Weight 371.93, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naratriptan (Amerge) is a triptan agent that is used for the treatment of migraine headaches. |
| PIK-93, 593960-11-3, Concentration 336 mM, Molecular Weight 389.88, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PIK-93 is a novel and potent inhibitor of PI3Kγ and PI4KIIIβ with IC50 of 16 nM and 19 nM, respectively. |
| Ponatinib (AP24534), 943319-70-8, Concentration 337 mM, Molecular Weight 532.56, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
| Fludarabine (Fludara), 21679-14-1, Concentration 338 mM, Molecular Weight 285.23, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fludarabine (Fludara, F-ara-A, NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. |
| LY2228820, 862507-23-1, Concentration 339 mM, Molecular Weight 612.74, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM. |
| Pralatrexate (Folotyn), 146464-95-1, Concentration 340 mM, Molecular Weight 477.47, Target:DHFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. |
| NVP-BEP800, 847559-80-2, Concentration 341 mM, Molecular Weight 480.41, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM. |
| Mycophenolate mofetil (CellCept), 128794-94-5, Concentration 342 mM, Molecular Weight 433.49, Target:Dehydrogenase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. |
| Dyphylline (Dilor), 479-18-5, Concentration 343 mM, Molecular Weight 254.24, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dyphylline(Dilor, Lufyllin, diprophylline) is a xanthine derivative with bronchodilator and vasodilator effects. |
| Perindopril Erbumine (Aceon), 107133-36-8, Concentration 344 mM, Molecular Weight 441.6, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Perindopril Erbumine (Aceon) is a potent ACE) inhibitor with IC50 of 1.05 nM. |
| Irbesartan (Avapro), 138402-11-6, Concentration 345 mM, Molecular Weight 428.53, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Irbesartan (Avapro, SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM. |
| Tadalafil (Cialis), 171596-29-5, Concentration 346 mM, Molecular Weight 389.4, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM. |
| SB939 (Pracinostat), 929016-96-6, Concentration 347 mM, Molecular Weight 358.48, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB939 is a potent HDAC inhibitor with IC50 of 40-140 nM. |
| Ibuprofen Lysine (NeoProfen), 57469-77-9, Concentration 348 mM, Molecular Weight 352.47, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug. |
| CCT129202, 942947-93-5, Concentration 349 mM, Molecular Weight 497.02, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. |
| Tosedostat (CHR2797), 238750-77-1, Concentration 350 mM, Molecular Weight 406.47, Target:Aminopeptidase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively. |
| XL765 (SAR245409), 1349796-36-6, Concentration 351 mM, Molecular Weight 599.66, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively. |
| AT7519, 844442-38-2, Concentration 352 mM, Molecular Weight 382.24, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively. |
| MK-1775, 955365-80-7, Concentration 353 mM, Molecular Weight 500.6, Target:Wee1, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM. |
| Quizartinib (AC220), 950769-58-1, Concentration 354 mM, Molecular Weight 560.67, Target:FLT3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AC220 (Quizartinib) is a potent and selective inhibitor of Flt3ITD and Fltwt with IC50 of 1.1 nM and 4.2 nM, respectively. |
| LY2811376, 1194044-20-6, Concentration 355 mM, Molecular Weight 320.36, Target:Beta Amyloid, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2811376 is a non-peptidic BACE1 inhibitor with IC50 of 239 nM/249 nM and also decreases the Aβ secretion with EC50 of ~300 nM. |
| Hesperadin, 422513-13-1, Concentration 356 mM, Molecular Weight 516.65, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hesperadin inhibits Aurora B and T. brucei Aurora kinase-1 (TbAUK1) with IC50 of 250 nM and 40 nM, respectively. |
| BIX 02188, 1094614-84-2, Concentration 357 mM, Molecular Weight 426.51, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM. |
| BIX 02189, 1094614-85-3, Concentration 358 mM, Molecular Weight 440.54, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM. |
| AZD7762, 860352-01-8, Concentration 359 mM, Molecular Weight 362.42, Target:Chk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD7762 is a novel CHK1 and CHK2 inhibitor with IC50 of 5 nM and <10 nM, respectively. |
| R406 (free base), 841290-80-0, Concentration 360 mM, Molecular Weight 470.45, Target:Syk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. R406 (free base) is a Syk inhibitor with IC50 of 41 nM. |
| CP 673451, 343787-29-1, Concentration 361 mM, Molecular Weight 417.5, Target:PDGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM. |
| DMXAA (ASA404), 117570-53-3, Concentration 362 mM, Molecular Weight 282.29, Target:VDA, HPLC 99%, NMR, LCMS is ok, stock more than 5g. DMXAA (ASA404) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. |
| Telaprevir (VX-950), 402957-28-2, Concentration 363 mM, Molecular Weight 679.85, Target:HCV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM. |
| Saxagliptin (BMS-477118,Onglyza), 361442-04-8, Concentration 364 mM, Molecular Weight 315.41, Target:DPP-4, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. |
| EX 527, 49843-98-3, Concentration 365 mM, Molecular Weight 248.71, Target:Sirtuin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM. |
| AM-1241, 444912-48-5, Concentration 366 mM, Molecular Weight 503.33, Target:Cannabinoid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AM-1241 is a selective CB2 agonist with Ki of 3.4 nM. |
| SB-408124, 288150-92-5, Concentration 367 mM, Molecular Weight 356.37, Target:OX Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB-408124 (Tocris-1963) is a non-peptide antagonist for OX1 with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively. |
| Dapagliflozin, 461432-26-8, Concentration 368 mM, Molecular Weight 408.87, Target:SGLT, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM. |
| Nebivolol (Bystolic), 152520-56-4, Concentration 369 mM, Molecular Weight 441.9, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM. |
| Pimobendan (Vetmedin), 74150-27-9, Concentration 370 mM, Molecular Weight 334.37, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
| AZD8055, 1009298-09-2, Concentration 371 mM, Molecular Weight 465.54, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD8055 is a novel ATP-competitive inhibitor of mTOR with IC50 of 0.8 nM. |
| PHT-427, 1191951-57-1, Concentration 372 mM, Molecular Weight 409.61, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively. |
| KRN 633, 286370-15-8, Concentration 373 mM, Molecular Weight 416.86, Target:PDGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM. |
| AT7867, 857531-00-1, Concentration 374 mM, Molecular Weight 337.85, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and S6K with IC50 of 32 nM/17 n/47 nM and 85 nM, respectively. |
| BMS 777607, 1025720-94-8, Concentration 375 mM, Molecular Weight 512.89, Target:Axl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively. |
| VX-809, 936727-05-8, Concentration 376 mM, Molecular Weight 452.41, Target:CFTR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VX-809 is a CFTR modulator with EC50 of 0.1 μM. |
| Pomalidomide, 19171-19-8, Concentration 377 mM, Molecular Weight 273.24, Target:TNF-alpha, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM. |
| PD318088, 391210-00-7 , Concentration 378 mM, Molecular Weight 561.09, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. |
| KU-60019, 925701-49-1, Concentration 379 mM, Molecular Weight 547.67, Target:ATM/ATR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM. |
| BS-181 HCl, 1397219-81-6, Concentration 380 mM, Molecular Weight 416.99, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BS-181 is a highly selective CDK inhibitor for CDK7 with IC50 of 21 nM. |
| Fasudil HCl (HA-1077), 105628-07-7, Concentration 381 mM, Molecular Weight 327.83, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fasudil is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| BIRB 796 (Doramapimod), 285983-48-4, Concentration 382 mM, Molecular Weight 527.66, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM. |
| Tie2 kinase inhibitor, 948557-43-5, Concentration 383 mM, Molecular Weight 439.53, Target:Tie-2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tie2 kinase inhibitor is a potent and selective Tie2 inhibitor with IC50 of 0.25 μM. |
| Candesartan (Atacand), 139481-59-7, Concentration 384 mM, Molecular Weight 440.45, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM. |
| PD 0332991 (Palbociclib) Isethionate, 827022-33-3, Concentration 385 mM, Molecular Weight 573.66, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD 0332991 (Palbociclib) Isethionate is the isethionate of PD 0332991, a highly specific inhibitor of CDK4 and CDK6 with IC50 of 11 nM and 16 nM, respectively. |
| H 89 2HCl, 130964-39-5, Concentration 386 mM, Molecular Weight 519.28, Target:PKA, HPLC 99%, NMR, LCMS is ok, stock more than 5g. H 89 2HCl is a mutiple-targeted inhibitor for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b with IC50 of 80 nM, 120 nM, 135 nM, 270 nM, 2600 nM and 2800 nM, respectively. |
| TWS119, 601514-19-6, Concentration 387 mM, Molecular Weight 318.33, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TWS119 is a GSK-3β inhibitor with IC50 of 30 nM. |
| Ubenimex (Bestatin), 58970-76-6, Concentration 388 mM, Molecular Weight 308.37, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. |
| Apixaban, 503612-47-3, Concentration 389 mM, Molecular Weight 459.5, Target:Factor Xa, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
| Semagacestat (LY450139), 425386-60-3, Concentration 390 mM, Molecular Weight 361.44, Target:Gamma-secretase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM. |
| Olmesartan medoxomil (Benicar), 144689-63-4, Concentration 391 mM, Molecular Weight 558.59, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Olmesartan medoxomil (Benicar) is a compound which is hydrolyzed to olmesartan that is a selective AT1 subtype angiotensin II receptor antagonist. |
| Rizatriptan Benzoate (Maxalt), 145202-66-0, Concentration 392 mM, Molecular Weight 391.47, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. |
| Pyridostigmine Bromide (Mestinon), 101-26-8, Concentration 393 mM, Molecular Weight 261.12, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pyridostigmine Bromide(Mestinon) is a parasympathomimetic and a reversible cholinesterase inhibitor. |
| Cefoperazone (Cefobid), 62893-19-0, Concentration 394 mM, Molecular Weight 645.67, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM. |
| Silodosin (Rapaflo), 160970-54-7, Concentration 395 mM, Molecular Weight 495.53, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. |
| Riluzole (Rilutek), 1744-22-5, Concentration 396 mM, Molecular Weight 234.2, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Riluzole(Rilutek) is a drug used to treat amyotrophic lateral sclerosis. |
| Risperidone (Risperdal), 106266-06-2, Concentration 397 mM, Molecular Weight 410.48, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Risperidone(Risperdal) is an atypical antipsychotic used to treat schizophrenia. |
| Acetylcysteine, 616-91-1, Concentration 398 mM, Molecular Weight 163.19, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. |
| Alendronate (Fosamax), 121268-17-5, Concentration 399 mM, Molecular Weight 326.13, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Alendronate (Fosamax) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. |
| Naproxen (Aleve), 26159-34-2, Concentration 400 mM, Molecular Weight 252.24, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. |
| Nitazoxanide (Alinia, Annita), 55981-09-4, Concentration 401 mM, Molecular Weight 307.28, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM) |
| Orlistat (Alli, Xenical), 96829-58-2, Concentration 402 mM, Molecular Weight 495.73, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. |
| Allopurinol (Zyloprim), 315-30-0, Concentration 403 mM, Molecular Weight 136.11, Target:OX Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. |
| Allopurinol Sodium (Aloprim), 17795-21-0, Concentration 404 mM, Molecular Weight 159.1, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Allopurinol Sodium(Aloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. |
| Zafirlukast (Accolate), 107753-78-6, Concentration 405 mM, Molecular Weight 575.68, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zafirlukast is a leukotriene receptor antagonist (LTRA). (IC50=0.6μM, IC50=7.0 µM for CYP2C9) |
| Ibuprofen (Advil), 15687-27-1, Concentration 406 mM, Molecular Weight 206.28, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ibuprofen (Advil, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. |
| Amprenavir (Agenerase), 161814-49-9, Concentration 407 mM, Molecular Weight 505.63, Target:HIV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amprenavir is a HIV protease inhibitor with IC50 of 14.6 ng/mL in wild-type HIV isolates. |
| Methyldopa (Aldomet), 555-30-6, Concentration 408 mM, Molecular Weight 211.21, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. |
| Ketoprofen (Actron), 22071-15-4, Concentration 409 mM, Molecular Weight 254.28, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ketoprofen (Actron) is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. |
| Ketorolac (Toradol), 74103-07-4, Concentration 410 mM, Molecular Weight 376.4, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ketorolac (Ketorolac tromethamine, Toradol) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. |
| Cytarabine, 147-94-4, Concentration 411 mM, Molecular Weight 243.22, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. |
| Zolmitriptan (Zomig), 139264-17-8, Concentration 412 mM, Molecular Weight 287.36, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zolmitriptan(Zomig) is a selective serotonin receptor agonist. |
| Enalaprilat dihydrate, 84680-54-6 , Concentration 413 mM, Molecular Weight 348.4, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
| Isradipine (Dynacirc), 75695-93-1, Concentration 414 mM, Molecular Weight 371.39, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM. |
| Estrone, 53-16-7 , Concentration 415 mM, Molecular Weight 270.37, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Estrone is an estrogenic hormone. |
| Flucytosine (Ancobon), 2022-85-7, Concentration 416 mM, Molecular Weight 129.09, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flucytosine (5-Fluorocytosine, 5-FC, Ancobon) is an antifungal drug with IC50 of 0.93 μM in C. albicans. |
| Aminoglutethimide (Cytadren), 125-84-8, Concentration 417 mM, Molecular Weight 232.28, Target:Aromatase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aminoglutethimide (AMG, Cytadren) is an aromatase inhibitor with IC50 of 10 μM. |
| Aminophylline (Truphylline), 317-34-0 , Concentration 418 mM, Molecular Weight 420.43, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aminophylline(Phyllocontin, Truphylline) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist. |
| Carbamazepine (Carbatrol), 298-46-4, Concentration 419 mM, Molecular Weight 236.27, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes. |
| Torsemide (Demadex), 56211-40-6, Concentration 420 mM, Molecular Weight 348.42, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Torsemide(Demadex) is a pyridine-sulfonyl urea type loop diuretic with an IC50 of 2.7 ± 0.17 μM. |
| Didanosine (Videx), 69655-05-6, Concentration 421 mM, Molecular Weight 236.23, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Didanosine(Videx, Videx EC) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
| Divalproex sodium, 76584-70-8, Concentration 422 mM, Molecular Weight 310.41, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. |
| Emtricitabine (Emtriva), 143491-57-0 , Concentration 423 mM, Molecular Weight 247.25, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Emtricitabine (Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM. |
| Lamivudine (Epivir), 134678-17-4, Concentration 424 mM, Molecular Weight 229.26, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lamivudine(Epivir) is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM. |
| Eplerenone, 107724-20-9, Concentration 425 mM, Molecular Weight 414.49, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. |
| Piroxicam (Feldene), 36322-90-4, Concentration 426 mM, Molecular Weight 331.35, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Piroxicam (Feldene) is a non-selective COX inhibitor with an IC50 of 6 mM. |
| Gemcitabine (Gemzar), 95058-81-4 , Concentration 427 mM, Molecular Weight 263.2, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites. |
| Adefovir Dipivoxil (Preveon, Hepsera), 142340-99-6, Concentration 428 mM, Molecular Weight 501.47, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. |
| Zalcitabine, 7481-89-2, Concentration 429 mM, Molecular Weight 211.22, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
| Paliperidone (Invega), 144598-75-4, Concentration 430 mM, Molecular Weight 426.48, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Paliperidone(Invega) is an atypical antipsychotic. |
| Telmisartan (Micardis), 144701-48-4, Concentration 431 mM, Molecular Weight 514.62, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Telmisartan (Micardis) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. |
| Nevirapine (Viramune), 129618-40-2, Concentration 432 mM, Molecular Weight 266.3, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nevirapine(Viramune) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
| Esomeprazole magnesium (Nexium), 161973-10-0 , Concentration 433 mM, Molecular Weight 713.12, Target:Proton Pump, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Esomeprazole magnesium(Nexium) is a proton pump inhibitor to reduce gastric acid secretion. |
| Nimodipine (Nimotop), 66085-59-4, Concentration 434 mM, Molecular Weight 418.44, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy. |
| Nisoldipine (Sular), 63675-72-9, Concentration 435 mM, Molecular Weight 388.41, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. |
| Oxybutynin (Ditropan), 5633-20-5, Concentration 436 mM, Molecular Weight 357.49, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| Quetiapine fumarate (Seroquel), 111974-72-2, Concentration 437 mM, Molecular Weight 883.09, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Quetiapine fumarate(Seroquel) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression. |
| Chlorprothixene, 113-59-7, Concentration 438 mM, Molecular Weight 315.86, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
| Thioguanine, 154-42-7, Concentration 439 mM, Molecular Weight 167.19, Target:DNA Methyltransferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients. |
| Toremifene Citrate (Fareston, Acapodene), 89778-27-8, Concentration 440 mM, Molecular Weight 598.08, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Toremifene Citrate(Fareston, Acapodene) is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. |
| Azacitidine (Vidaza), 320-67-2, Concentration 441 mM, Molecular Weight 244.2, Target:DNA Methyltransferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. |
| Bacitracin zinc, 1405-89-6, Concentration 442 mM, Molecular Weight 1486.07, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM. |
| Simvastatin (Zocor), 79902-63-9, Concentration 443 mM, Molecular Weight 418.57, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Simvastatin (Zocor) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM . |
| Ramipril (Altace), 87333-19-5, Concentration 444 mM, Molecular Weight 416.51, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ramipril (Altace) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. |
| Ranitidine (Zantac), 66357-59-3, Concentration 445 mM, Molecular Weight 350.86, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ranitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 μM. |
| Acadesine, 2627-69-2, Concentration 446 mM, Molecular Weight 258.23, Target:AMPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Acadesine results in accumulation of ZMP, which mimics both activating effects of AMP on AMPK and AMPKK. |
| Acetylcholine chloride, 60-31-1 , Concentration 447 mM, Molecular Weight 181.66, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. |
| Nifedipine (Adalat), 21829-25-4, Concentration 448 mM, Molecular Weight 346.33, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nifedipine(Adalat), a potent vasodilator agent with calcium antagonistic action. |
| Amlodipine besylate (Norvasc), 111470-99-6, Concentration 449 mM, Molecular Weight 567.05, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amlodipine (Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM. |
| Chlorpheniramine Maleate, 113-92-8, Concentration 450 mM, Molecular Weight 390.86, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM. |
| Betaxolol HCl (Betoptic), 63659-19-8, Concentration 451 mM, Molecular Weight 343.89, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Betaxolol hydrochloride (Betoptic) is a β1 adrenergic receptor blocker with IC50 of 6 μM. |
| Proparacaine HCl, 5875-06-9, Concentration 452 mM, Molecular Weight 330.85, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. |
| Pranlukast, 103177-37-3, Concentration 453 mM, Molecular Weight 481.5, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pranlukast is a selective cysteinyl leukotriene receptor antagonist. |
| Carvedilol, 72956-09-3, Concentration 454 mM, Molecular Weight 406.47, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation. |
| Butoconazole nitrate, 64872-77-1, Concentration 455 mM, Molecular Weight 474.79, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. |
| Azithromycin (Zithromax), 83905-01-5, Concentration 456 mM, Molecular Weight 748.98, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Azithromycin (Zithromax) is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM. |
| Flubendazole (Flutelmium), 31430-15-6, Concentration 457 mM, Molecular Weight 313.28, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flubendazole (Flutelmium) is an anthelmintic agent for MDAY-D2 cells with IC50 of 3 nM. |
| Lomustine (CeeNU), 13010-47-4, Concentration 458 mM, Molecular Weight 233.7, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lomustine inhibits cancer cells by damaging the DNA and stops cells from dividing. |
| Cimetidine (Tagamet), 51481-61-9, Concentration 459 mM, Molecular Weight 252.34, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cimetidine(Tagamet), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors. |
| Clemastine Fumarate, 14976-57-9, Concentration 460 mM, Molecular Weight 459.96, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM. |
| Bifonazole, 60628-96-8, Concentration 461 mM, Molecular Weight 310.39, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bifonazole is an antifungal agent and a prostatic aromatase activity inhibitor with IC50 of 1.6 μM. |
| Metoprolol tartrate, 392-17-7, Concentration 462 mM, Molecular Weight 684.81, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Metoprolol tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL. |
| Etidronate (Didronel), 2809-21-4, Concentration 463 mM, Molecular Weight 206.03, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor with IC50 of 0.2 μM. |
| Dapoxetine HCl (Priligy), 129938-20-1, Concentration 464 mM, Molecular Weight 341.87, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor. |
| Tranexamic acid (Transamin), 1197-18-8, Concentration 465 mM, Molecular Weight 157.21, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM. |
| Roxatidine acetate HCl, 93793-83-0, Concentration 466 mM, Molecular Weight 384.9, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. |
| Felodipine (Plendil), 72509-76-3, Concentration 467 mM, Molecular Weight 384.25, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Felodipine (Plendil) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. |
| Nizatidine, 76963-41-2, Concentration 468 mM, Molecular Weight 331.46, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nizatidine is a histamine H2-receptor antagonist with and IC50 of 6.7 nM for AChE. |
| Carbidopa, 28860-95-9, Concentration 469 mM, Molecular Weight 226.23, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. |
| Valsartan (Diovan), 137862-53-4, Concentration 470 mM, Molecular Weight 435.52, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 μM |
| Tropisetron, 105826-92-4 , Concentration 471 mM, Molecular Weight 320.81, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tropisetron hydrochloride is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. |
| Diclofenac sodium, 15307-79-6, Concentration 472 mM, Molecular Weight 318.13, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
| Amlodipine (Norvasc), 88150-42-9, Concentration 473 mM, Molecular Weight 408.88, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amlodipine(Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM. |
| Flutamide (Eulexin), 13311-84-7, Concentration 474 mM, Molecular Weight 276.21, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flutamide (Eulexin) is an oral nonsteroidal antiandrogen agent primarily used to treat prostate cancer. |
| Fluvastatin sodium (Lescol), 93957-55-2, Concentration 475 mM, Molecular Weight 433.45, Target:HMG-CoA Reductase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fluvastatin sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM. |
| Tropicamide, 1508-75-4, Concentration 476 mM, Molecular Weight 284.35, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM. |
| Pregnenolone, 145-13-1, Concentration 477 mM, Molecular Weight 316.48, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 ¦ÌM and 6.0 ¦ÌM, respectively. |
| Sulfamethoxazole, 723-46-6, Concentration 478 mM, Molecular Weight 253.28, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM. |
| Irsogladine, 57381-26-7, Concentration 479 mM, Molecular Weight 256.09, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. |
| Enalapril maleate (Vasotec), 76095-16-4, Concentration 480 mM, Molecular Weight 492.52, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. |
| Metformin HCl (Glucophage), 1115-70-4, Concentration 481 mM, Molecular Weight 165.62, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Metformin hydrochloride(Glucophage) is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. |
| Tolfenamic acid, 13710-19-5, Concentration 482 mM, Molecular Weight 261.7, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tolfenamic acid is a COX-2 inhibitor with IC50 of 0.2 μM. |
| Pranoprofen, 52549-17-4, Concentration 483 mM, Molecular Weight 255.27, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM. |
| Nefiracetam (Translon), 77191-36-7, Concentration 484 mM, Molecular Weight 246.3, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nefiracetam (Translon) is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions. |
| Nicorandil (Ikorel), 65141-46-0, Concentration 485 mM, Molecular Weight 211.17, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nicorandil(Ikorel) is potassium channel activator. |
| Tamoxifen Citrate (Nolvadex), 54965-24-1, Concentration 486 mM, Molecular Weight 563.64, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. |
| Meglumine, 6284-40-8, Concentration 487 mM, Molecular Weight 195.21, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Meglumine is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL. |
| Aripiprazole (Abilify), 129722-12-9, Concentration 488 mM, Molecular Weight 448.39, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. |
| Methscopolamine (Pamine), 155-41-9, Concentration 489 mM, Molecular Weight 398.29, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Methscopolamine (Pamine) is a muscarinic acetylcholine receptor blocker. |
| Amiodarone HCl, 19774-82-4, Concentration 490 mM, Molecular Weight 681.77, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
| Adenine, 73-24-5, Concentration 491 mM, Molecular Weight 135.13, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
| Adenine sulfate, 321-30-2, Concentration 492 mM, Molecular Weight 368.33, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
| Adenine HCl, 2922-28-3 , Concentration 493 mM, Molecular Weight 171.59, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. |
| Ticlopidine HCl, 53885-35-1, Concentration 494 mM, Molecular Weight 300.25, Target:P2 Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM. |
| Lacidipine (Lacipil, Motens), 103890-78-4, Concentration 495 mM, Molecular Weight 455.54, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. |
| Procarbazine HCl (Matulane), 366-70-1, Concentration 496 mM, Molecular Weight 257.76, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. |
| Ondansetron (Zofran), 99614-02-5, Concentration 497 mM, Molecular Weight 293.36, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ondansetron (Zofran) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. |
| Sodium orthovanadate, 13721-39-6, Concentration 498 mM, Molecular Weight 183.91, Target:ATPase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM. |
| Elvitegravir (GS-9137), 697761-98-1, Concentration 499 mM, Molecular Weight 447.88, Target:Integrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Elvitegravir (EVG, JTK-303/GS-9137) is a HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. |
| Maraviroc, 376348-65-1, Concentration 500 mM, Molecular Weight 513.67, Target:CCR5, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Maraviroc (Selzentry, UK-427857, Celsentri) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively. |
| Raltegravir (MK-0518), 518048-05-0, Concentration 501 mM, Molecular Weight 444.42, Target:Integrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Raltegravir (MK-0518, Isentress) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectivly. |
| Pyrimethamine, 58-14-0, Concentration 502 mM, Molecular Weight 248.71, Target:DHFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
| Pramipexole 2HCl monohydrate , 191217-81-9, Concentration 503 mM, Molecular Weight 302.26, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. |
| PCI-34051, 950762-95-5, Concentration 504 mM, Molecular Weight 296.32, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM. |
| PF 573228, 869288-64-2, Concentration 505 mM, Molecular Weight 491.49, Target:FAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF 573228 is a inhibitor of FAK with IC50 of 4 nM. |
| BMS-265246, 582315-72-8, Concentration 506 mM, Molecular Weight 345.34, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS265246 is a potent and selective CDK inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively. |
| Suplatast tosylate, 94055-76-2, Concentration 507 mM, Molecular Weight 499.64, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Suplatast tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM. |
| ENMD-2076 L-(+)-Tartaric acid, 1291074-87-7, Concentration 508 mM, Molecular Weight 525.56, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM, 15.9 nM and 58.2 nM, respectively. |
| Formoterol hemifumarate, 43229-80-7, Concentration 509 mM, Molecular Weight 402.4, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively. |
| Ketotifen fumarate (Zaditor), 34580-14-8, Concentration 510 mM, Molecular Weight 425.5, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ketotifen fumarate (Zaditor) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer. |
| Urapidil HCl, 64887-14-5, Concentration 511 mM, Molecular Weight 423.94, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. |
| Ginkgolide A, 15291-75-5, Concentration 512 mM, Molecular Weight 408.4, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM. |
| Uridine, 58-96-8, Concentration 513 mM, Molecular Weight 244.2, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond. |
| Flunarizine 2HCl, 30484-77-6, Concentration 514 mM, Molecular Weight 477.42, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flunarizine dihydrochloride is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM. |
| Rebamipide, 90098-04-7, Concentration 515 mM, Molecular Weight 370.79, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM. |
| Epalrestat, 82159-09-9, Concentration 516 mM, Molecular Weight 319.4, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM. |
| Candesartan cilexetil (Atacand), 145040-37-5, Concentration 517 mM, Molecular Weight 610.66, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Candesartan cilexetil (Atacand) is a specific nonpeptide Ang II receptor (ATR) antagonist and the prodrug of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg |
| Phentolamine mesilate, 65-28-1, Concentration 518 mM, Molecular Weight 377.46, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Phentolamine mesilate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM. |
| Nimesulide, 51803-78-2, Concentration 519 mM, Molecular Weight 308.31, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM. |
| Cyproterone acetate, 427-51-0, Concentration 520 mM, Molecular Weight 416.94, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM. |
| Memantine HCl (Namenda), 41100-52-1, Concentration 521 mM, Molecular Weight 215.76, Target:AMPA Receptor-kainate Receptor-NMDA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Memantine hydrochloride (Namenda) is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively. |
| Cyproheptadine HCl (Periactin), 969-33-5 , Concentration 522 mM, Molecular Weight 323.86, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cyproheptadine hydrochloride (Periactin) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. |
| Doxifluridine, 3094-09-5, Concentration 523 mM, Molecular Weight 246.19, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM. |
| Pioglitazone HCl (Actos), 112529-15-4, Concentration 524 mM, Molecular Weight 392.9, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pioglitazone hydrochloride (Actos) is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. |
| Lornoxicam (Xefo), 70374-39-9, Concentration 525 mM, Molecular Weight 371.82, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lornoxicam (Xefo) is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively. |
| Strontium ranelate (Protelos), 135459-87-9, Concentration 526 mM, Molecular Weight 513.49, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Strontium ranelate (Protelos) is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM. |
| Captopril (Capoten), 62571-86-2, Concentration 527 mM, Molecular Weight 217.29, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Captopril (Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM. |
| Orphenadrine citrate (Norflex), 4682-36-4, Concentration 528 mM, Molecular Weight 461.5, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Orphenadrine citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects. |
| Gimeracil, 103766-25-2, Concentration 529 mM, Molecular Weight 145.54, Target:Dehydrogenase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair. |
| Terazosin HCl (Hytrin), 70024-40-7, Concentration 530 mM, Molecular Weight 459.92, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hytrin (terazosin) is an alpha-adrenergic blocker used to treat high blood pressure and enlarged prostate. |
| Lovastatin (Mevacor), 75330-75-5, Concentration 531 mM, Molecular Weight 404.54, Target:HMG-CoA Reductase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent). |
| Lafutidine, 118288-08-7, Concentration 532 mM, Molecular Weight 431.55, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion. |
| Moxonidine, 75438-57-2, Concentration 533 mM, Molecular Weight 241.68, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. |
| Ozagrel HCl, 78712-43-3, Concentration 534 mM, Molecular Weight 264.71, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ozagrel hydrochloride is a selective thromboxane A2 synthetase enzyme inhibitors with IC50 of 11 nM, used as antiasthmatic agent. |
| Mitiglinide calcium, 145525-41-3, Concentration 535 mM, Molecular Weight 668.88, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mitiglinide is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
| Rosiglitazone HCl, 302543-62-0, Concentration 536 mM, Molecular Weight 393.89, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
| Lisinopril (Zestril), 83915-83-7, Concentration 537 mM, Molecular Weight 405.49, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. |
| Atorvastatin calcium (Lipitor), 134523-03-8, Concentration 538 mM, Molecular Weight 1155.34, Target:HMG-CoA Reductase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Atorvastatin (Lipitor) is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. |
| Famotidine (Pepcid), 76824-35-6, Concentration 539 mM, Molecular Weight 337.45, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Famotidine is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions. |
| Moexipril HCl, 82586-52-5, Concentration 540 mM, Molecular Weight 535.03, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) with IC50 of 0.041 ¦ÌM, which is used for the treatment of hypertension and congestive heart failure. |
| Cleviprex (Clevidipine), 167221-71-8, Concentration 541 mM, Molecular Weight 456.32, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cleviprex (Clevidipine) is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure. |
| Cilazapril monohydrate (Inhibace), 92077-78-6, Concentration 542 mM, Molecular Weight 435.51, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure. |
| Adiphenine HCl, 50-42-0, Concentration 543 mM, Molecular Weight 347.88, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Adiphenine is a nicotinic receptor inhibitor with IC50 of 15 ¦ÌM, used as an antispasmodic drug. |
| Duloxetine HCl (Cymbalta), 136434-34-9 , Concentration 544 mM, Molecular Weight 333.88, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
| Trimebutine, 39133-31-8, Concentration 545 mM, Molecular Weight 387.47, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain. |
| Ivabradine HCl (Procoralan), 148849-67-6, Concentration 546 mM, Molecular Weight 505.05, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. |
| Rivastigmine tartrate (Exelon), 129101-54-8, Concentration 547 mM, Molecular Weight 400.42, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rivastigmine, a cholinesterase inhibitor with IC50 of 5.5 μM, ues as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease. |
| Dexmedetomidine HCl (Precedex), 145108-58-3, Concentration 548 mM, Molecular Weight 236.74, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dexmedetomidine is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation. |
| Betaxolol (Betoptic), 659-18-7, Concentration 549 mM, Molecular Weight 307.43, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma. |
| Detomidine HCl, 90038-01-0, Concentration 550 mM, Molecular Weight 222.71, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Detomidine produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. |
| Fosinopril sodium (Monopril), 88889-14-9, Concentration 551 mM, Molecular Weight 585.64, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fosinopril sodium (Monopril) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure. |
| Almotriptan malate (Axert), 181183-52-8, Concentration 552 mM, Molecular Weight 469.55, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Almotriptan malate (Axert) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults. |
| Ambrisentan, 177036-94-1, Concentration 553 mM, Molecular Weight 378.42, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH). |
| Bexarotene, 153559-49-0, Concentration 554 mM, Molecular Weight 348, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma. |
| Temocapril HCl, 110221-44-8, Concentration 555 mM, Molecular Weight 513.07, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension. |
| Gabexate mesylate, 56974-61-9, Concentration 556 mM, Molecular Weight 417.48, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gabexate is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation. |
| Rasagiline mesylate, 161735-79-1, Concentration 557 mM, Molecular Weight 267.34, Target:MAO, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rasagiline mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. |
| Naltrexone HCl, 16676-29-2, Concentration 558 mM, Molecular Weight 377.86, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naltrexone is an opioid receptor antagonist with IC50 of 8 nM used primarily in the management of alcohol dependence and opioid dependence. |
| Levosulpiride (Levogastrol), 23672-07-3, Concentration 559 mM, Molecular Weight 341.43, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. |
| Azasetron HCl (Y-25130), 123040-16-4, Concentration 560 mM, Molecular Weight 386.27, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. |
| Mizolastine (Mizollen), 108612-45-9, Concentration 561 mM, Molecular Weight 432.49, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. |
| Flunixin meglumin, 42461-84-7, Concentration 562 mM, Molecular Weight 491.46, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flunixin meglumine is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity. |
| Vinpocetine (Cavinton), 42971-09-5, Concentration 563 mM, Molecular Weight 350.45, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vinpocetine is a selectively inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. |
| Lapatinib, 231277-92-2, Concentration 564 mM, Molecular Weight 581.06, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
| Blonanserin (Lonasen), 132810-10-7, Concentration 565 mM, Molecular Weight 367.5, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties. |
| Cisatracurium besylate (Nimbex), 96946-42-8, Concentration 566 mM, Molecular Weight 1243.48, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cisatracurium besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission. |
| Ibutilide fumarate, 122647-32-9, Concentration 567 mM, Molecular Weight 885.23, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. |
| Naftopidil (Flivas), 57149-07-2, Concentration 568 mM, Molecular Weight 392.49, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naftopidil (Flivas) is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM. |
| S- (+)-Rolipram, 85416-73-5, Concentration 569 mM, Molecular Weight 275.34, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM. |
| Bazedoxifene HCl, 198480-56-7, Concentration 570 mM, Molecular Weight 507.06, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM. |
| Atropine, 5908-99-6, Concentration 571 mM, Molecular Weight 694.83, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM. |
| Roflumilast (Daxas), 162401-32-3, Concentration 572 mM, Molecular Weight 403.21, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM. |
| Gabapentin (Neurontin), 60142-96-3, Concentration 573 mM, Molecular Weight 171.24, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analogue. |
| AZD8330, 869357-68-6, Concentration 574 mM, Molecular Weight 461.23, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD8330 (ARRY-424704) is a MEK 1/2 inhibitor with IC50 of 7 nM. |
| GSK1292263, 1032823-75-8, Concentration 575 mM, Molecular Weight 456.56, Target:GPR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK-1292263 is a novel GPR119 agonist. |
| Neratinib (HKI-272), 698387-09-6, Concentration 576 mM, Molecular Weight 557.04, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively. |
| LDE225 (NVP-LDE225, Erismodegib), 956697-53-3, Concentration 577 mM, Molecular Weight 485.5, Target:Smoothened, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LDE225 (NVP-LDE225) is a smoothened antagonist with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
| CGS 21680 HCl, 124431-80-7, Concentration 578 mM, Molecular Weight 535.98, Target:5-alpha Reductase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CGS 21680 hydrochloride is an A2A adenosine receptor agonist with an Ki of 27 nM. |
| BIBR-1048 (Dabigatran etexilate, Pradaxa), 211915-06-9, Concentration 579 mM, Molecular Weight 627.73, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. |
| LY2608204, 1234703-40-2, Concentration 580 mM, Molecular Weight 559.81, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2608204 activates glucokinase (GK) with EC50 of 42 nM. |
| LY2886721, 1262036-50-9, Concentration 581 mM, Molecular Weight 390.41, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. |
| LY2940680, 1258861-20-9, Concentration 582 mM, Molecular Weight 512.5, Target:Hedgehog, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2940680 binds to the Smo receptor and potently inhibits Hh signaling. |
| KW 2449, 1000669-72-6, Concentration 583 mM, Molecular Weight 332.4, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. KW-2449 potently inhibits Flt3, Abl and Aurora A with IC50 of 6.6 nM, 14 nM and 48 nM, respectively. |
| Tebipenem pivoxil (L-084), 161715-24-8, Concentration 584 mM, Molecular Weight 497.63, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tebipenem pivoxil(L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 μg/ml for human CYP isoforms |
| PF-4708671, 1255517-76-0, Concentration 585 mM, Molecular Weight 390.41, Target:S6 Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM. |
| PD 128907 HCl, 112960-16-4, Concentration 586 mM, Molecular Weight 285.77, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PD 128907 HCl is a potent and selective dopamine D2/D3 receptors agonist. |
| Rosuvastatin calcium (Crestor), 147098-20-2, Concentration 587 mM, Molecular Weight 500.57, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rosuvastatin calcium is an competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM. |
| ITF2357 (Givinostat), 732302-99-7, Concentration 588 mM, Molecular Weight 475.97, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ITF2357 (Givinostat) is a potent inhibitor of HDAC with IC50 of 7.5-16 nM. |
| AG14361, 328543-09-5, Concentration 589 mM, Molecular Weight 320.39, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AG14361 is a potent inhibitor of PARP1 with Ki of < 5 nM. |
| LY2784544, 1229236-86-5, Concentration 590 mM, Molecular Weight 469.94, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2784544 is selective to V617F mutant JAK2 with IC50 of 55 nM in Ba/F3 cells. |
| MLN2238, 1072833-77-2, Concentration 591 mM, Molecular Weight 361.03, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. |
| MLN9708, 1201902-80-8, Concentration 592 mM, Molecular Weight 517.12, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MLN9708 is a selective inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM. |
| SB 743921, 940929-33-9, Concentration 593 mM, Molecular Weight 553.52, Target:Kinesin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB 743921 is a KSP inhibitor with IC50 of 0.2 nM, 0.07 nM, 1.7 nM, 0.06 nM and 14.4 nM in SKOV3, Colo205, MV522, MX1 and P388 cell lines, respectively. |
| BGJ398 (NVP-BGJ398), 872511-34-7, Concentration 594 mM, Molecular Weight 560.48, Target:FGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BGJ398 (NVP-BGJ398) is a potent and selective inhibitor of FGFR1, FGFR2 and FGFR3 with IC50 of 0.9 nM, 1.4 nM and 1 nM, respectively. |
| AST-1306, 1050500-29-2, Concentration 595 mM, Molecular Weight 621.08, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively. |
| SB-505124, 694433-59-5, Concentration 596 mM, Molecular Weight 335.4, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB505124 is a selective inhibitor of ALK4 and ALK5 with IC50 of 129 nM and 47 nM, respectively. |
| Avasimibe (CI-1011), 166518-60-1 , Concentration 597 mM, Molecular Weight 501.72, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively. |
| AZD8931, 848942-61-0, Concentration 598 mM, Molecular Weight 473.93, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, respectively. |
| GSK461364, 929095-18-1, Concentration 599 mM, Molecular Weight 543.6, Target:PLK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK461364 inhibits purified Plk1 with Ki of 2 nM. |
| R406, 841290-81-1, Concentration 600 mM, Molecular Weight 628.63, Target:FLT3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3. |
| SGI-1776 free base, 1025065-69-3, Concentration 601 mM, Molecular Weight 405.42, Target:Pim, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SGI-1776 is a novel ATP competitive inhibitor to Pim1, Pim2 and Pim3 with IC50 of 7 nM, 363 nM and 69 nM, respectively. |
| Aliskiren hemifumarate, 173334-58-2, Concentration 602 mM, Molecular Weight 609.83, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM. |
| BMS 794833, 1174046-72-0, Concentration 603 mM, Molecular Weight 468.84, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS794833 is a potent ATP competitive inhibitor of Met and VEGFR2 with IC50 of 1.7 nM and 15 nM, respectively. |
| NVP-BHG712, 940310-85-0, Concentration 604 mM, Molecular Weight 503.48, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-BHG712 is a specific inhibitor of c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM and also inhibits EphB4 and VEGFR2 with ED50 of 25 nM and 4.2 μM, respectively. |
| OSI-420, 183320-51-6, Concentration 605 mM, Molecular Weight 415.87, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. OSI-420 is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for inhibition of human EGFR and EGFR autophosphorylation with IC50 of 2 nM and 20 nM, respectively. |
| R935788 (Fostamatinib disodium, R788 disodium), 1025687-58-4, Concentration 606 mM, Molecular Weight 624.42, Target:Syk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM. |
| PIK-293, 900185-01-5 , Concentration 607 mM, Molecular Weight 397.43, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PIK-293 is a PI3-K inhibitor for p110α, p110β, p110δ and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM and 10 μM, respectively. |
| Formestane, 566-48-3, Concentration 608 mM, Molecular Weight 302.41, Target:Aromatase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Formestane(Lentaron(R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
| Vinflunine Tartrate, 1201898-17-0, Concentration 609 mM, Molecular Weight 967.02, Target:Microtubule Associated, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. |
| AZ 960, 905586-69-8, Concentration 610 mM, Molecular Weight 354.36, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, respectively. |
| DAPT (GSI-IX), 208255-80-5, Concentration 611 mM, Molecular Weight 432.46, Target:Beta Amyloid, HPLC 99%, NMR, LCMS is ok, stock more than 5g. DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. |
| Mubritinib (TAK 165), 366017-09-6, Concentration 612 mM, Molecular Weight 468.47, Target:HER2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mubritinib (TAK 165) is a potent inhibitor of ErbB2 with IC50 of 6 nM. |
| Irinotecan HCl Trihydrate (Campto), 136572-09-3, Concentration 613 mM, Molecular Weight 677.18, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
| PP242, 1092351-67-1, Concentration 614 mM, Molecular Weight 308.34, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PP242 is a selective mTOR inhibitor with IC50 of 8 nM. |
| Cyt387, 1056634-68-4, Concentration 615 mM, Molecular Weight 414.46, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively. |
| SB590885, 405554-55-4 , Concentration 616 mM, Molecular Weight 453.54, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM. |
| Apatinib (YN968D1), 811803-05-1, Concentration 617 mM, Molecular Weight 493.58, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM. |
| TAME, 901-47-3, Concentration 618 mM, Molecular Weight 342.41, Target:APC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor and also inhibits an E3 ubiquitin ligase called "anaphase-promoting complex/cyclosome (APC/C)". |
| CAL-101 (GS-1101), 870281-82-6, Concentration 619 mM, Molecular Weight 415.42, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CAL-101 is a selective PI3K class I inhibitor of p110δ with IC50 of 2.5 nM. |
| PIK-294, 900185-02-6, Concentration 620 mM, Molecular Weight 489.53, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PIK-294 is a highly potent and selective p110δ inhibitor with IC50 of 10 nM. |
| Eltrombopag (SB-497115-GR), 496775-61-2, Concentration 621 mM, Molecular Weight 442.47, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 μM for the inhibition of hERG K+ channel tail current. |
| LY2157299, 700874-72-2, Concentration 622 mM, Molecular Weight 369.42, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. |
| Telatinib (BAY 57-9352), 332012-40-5, Concentration 623 mM, Molecular Weight 409.83, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRβ with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. |
| Ketanserin (Vulketan Gel), 74050-98-9, Concentration 624 mM, Molecular Weight 395.43, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. |
| Esomeprazole sodium (Nexium), 161796-78-7, Concentration 625 mM, Molecular Weight 367.4, Target:ATPase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Esomeprazole sodium (Nexium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg. |
| BI6727 (Volasertib), 755038-65-4, Concentration 626 mM, Molecular Weight 618.81, Target:PLK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BI6727 (Volasertib) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM. |
| Palomid 529, 914913-88-5, Concentration 627 mM, Molecular Weight 406.43, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor for VEGF-A and bFGF with IC50 of 10 nM and 30 nM, respectively. |
| Fesoterodine fumarate (Toviaz), 286930-03-8, Concentration 628 mM, Molecular Weight 527.65, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. |
| WP1130, 856243-80-6, Concentration 629 mM, Molecular Weight 384.27, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WP1130 (degrasyn) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM. |
| AR-42 (HDAC-42), 935881-37-1, Concentration 630 mM, Molecular Weight 312.36, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AR-42 (HDAC-42, OSU-HDAC42) is a pan-HDAC inhibitor with IC50 30 nM. |
| CP-466722, 1080622-86-1, Concentration 631 mM, Molecular Weight 349.35, Target:ATM/ATR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CP-466722 is an potent and reversible ATM inhibitor. |
| Abiraterone Acetate (CB7630), 154229-18-2, Concentration 632 mM, Molecular Weight 391.55, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Abiraterone acetate (CB7630, CB 7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM. |
| BKM120 (NVP-BKM120), 944396-07-0, Concentration 633 mM, Molecular Weight 410.39, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BKM120 is a selective PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50 of 52-99 nM, 166 nM, 116 nM and 262 nM, respectively. |
| CX-4945 (Silmitasertib), 1009820-21-6, Concentration 634 mM, Molecular Weight 349.77, Target:PKC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CX-4945 is a potent and selective inhibitor of CK2α and CK2α' with IC50 of 1 nM. |
| (-)-Huperzine A, 102518-79-6, Concentration 635 mM, Molecular Weight 242.32, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM. |
| 4-Methylumbelliferone (4-MU), 90-33-5, Concentration 636 mM, Molecular Weight 176.17, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. |
| Aloe-emodin, 481-72-1, Concentration 637 mM, Molecular Weight 270.24, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. |
| Apigenin, 520-36-5, Concentration 638 mM, Molecular Weight 270.24, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Apigenin is a potent P450 inhibitor for CYP2C9 with IC50 of 23 pM |
| Arbutin (Uva, p-Arbutin), 497-76-7, Concentration 639 mM, Molecular Weight 272.25, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Arbutin(Uvasol, p-Arbutin) is a tyrosinase inhibitor with an IC50 of 1.09 mM. |
| Artesunate, 88495-63-0, Concentration 640 mM, Molecular Weight 384.42, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. |
| Asiatic acid, 464-92-6, Concentration 641 mM, Molecular Weight 488.7, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. |
| Baicalein, 491-67-8, Concentration 642 mM, Molecular Weight 270.24, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. |
| Baicalin, 21967-41-9, Concentration 643 mM, Molecular Weight 446.36, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors. |
| Cryptotanshinone, 35825-57-1, Concentration 644 mM, Molecular Weight 296.36, Target:STAT, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM. |
| Cytisine (Baphitoxine, Sophorine), 485-35-8, Concentration 645 mM, Molecular Weight 190.24, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cytisine is a nicotinic acetylcholine receptor agonist. |
| Hesperetin, 520-33-2, Concentration 646 mM, Molecular Weight 302.27, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hesperetin is a bioflavonoid and, to be more specific, a flavanone. |
| Honokiol, 35354-74-6, Concentration 647 mM, Molecular Weight 266.334, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway. |
| Icariin, 489-32-7, Concentration 648 mM, Molecular Weight 676.66, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Icariin is a flavonol and PDE5 inhibitor with IC50 of 1.0, 0.75, and 1.1 μM for PDE5A1, A2, and A3, respectively. |
| Luteolin, 491-70-3 , Concentration 649 mM, Molecular Weight 286.24, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Luteolin is a PDE4 inhibitor and a general phosphodiesterase inhibitor, and an Interleukin 6 inhibitor. |
| Matrine ((+)-Matrine), 519-02-8 , Concentration 650 mM, Molecular Weight 248.36, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. |
| Neohesperidin, 13241-33-3 , Concentration 651 mM, Molecular Weight 610.56, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. |
| Parthenolide ((-)-Parthenolide), 20554-84-1, Concentration 652 mM, Molecular Weight 248.32, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew(Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions. |
| Puerarin (Kakonein), 3681-99-0, Concentration 653 mM, Molecular Weight 432.38, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Puerarin (Kakonein) is a 5-HT2C receptor and benzodiazepine site antagonist. |
| Salinomycin (Procoxacin), 53003-10-4, Concentration 654 mM, Molecular Weight 751, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aminoglutethimide (Cytadren) is an anti-steroid drug which inhibits aromatase. |
| Synephrine (Oxedrine), 94-07-5, Concentration 655 mM, Molecular Weight 167.21, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Synephrine (Oxedrine) is a compound commonly used for weight loss. |
| 5-hydroxytryptophan (5-HTP), 56-69-9, Concentration 656 mM, Molecular Weight 220.22, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. 5-Hydroxytryptophan(5-HTP) is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of Vitamin B6. |
| Aloin (Barbaloin), 1415-73-2 , Concentration 657 mM, Molecular Weight 418.39, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aloin(Barbaloin) is a potent tyrosinase inhibitor with an IC50 of 97 μM for HeLaS3 cells |
| Dioscin (Collettiside III), 19057-60-4 , Concentration 658 mM, Molecular Weight 869.04, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dioscin(Collettiside III) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. |
| Indirubin, 479-41-4 , Concentration 659 mM, Molecular Weight 262.26, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM. |
| Quercetin (Sophoretin), 117-39-5, Concentration 660 mM, Molecular Weight 302.24, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml. |
| Naringenin, 480-41-1, Concentration 661 mM, Molecular Weight 272.25, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. |
| Salidroside (Rhodioloside), 10338-51-9, Concentration 662 mM, Molecular Weight 300.3, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Salidroside (Rhodioloside; Rhodosin) is a glucoside compound with an IC50 of 4.99 ± 0.23 μg/mL for the proliferation of SACC-2 cells. |
| Sodium Danshensu, 67920-52-9, Concentration 663 mM, Molecular Weight 220.15, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. |
| Tetrandrine (Fanchinine), 518-34-3, Concentration 664 mM, Molecular Weight 622.75, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23± 25.77 μM. |
| Chrysophanic acid (Chrysophanol), 481-74-3, Concentration 665 mM, Molecular Weight 254.24, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor. |
| Astragaloside A, 83207-58-3, Concentration 666 mM, Molecular Weight 784.97, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Astragaloside A is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis. |
| 20-Hydroxyecdysone, 5289-74-7, Concentration 667 mM, Molecular Weight 480.63, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. 20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. |
| 10-Hydroxycamptothecin, 19685-09-7, Concentration 668 mM, Molecular Weight 364.35, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. 10-Hydroxycamptothecin (10-HCPT, 10-hydroxy-CPT, OHCPT, NSC107124) is a DNA topoisomerase I inhibitor with potent anti-tumor activity. |
| Apocynin (Acetovanillone), 498-02-2, Concentration 669 mM, Molecular Weight 166.17, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Apocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. |
| Rotundine, 483-14-7, Concentration 670 mM, Molecular Weight 355.43, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
| Synephrine HCl, 5985-28-4, Concentration 671 mM, Molecular Weight 203.67, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Synephrine HCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist. |
| Tolbutamide, 64-77-7, Concentration 672 mM, Molecular Weight 270.35, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM. |
| Forskolin, 66575-29-9, Concentration 673 mM, Molecular Weight 410.5, Target:cAMP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC). |
| Equol, 531-95-3, Concentration 674 mM, Molecular Weight 242.27, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Equol is an isoflavandiol metabolized from daidzein by bacterial flora in the intestines. |
| Amantadine HCl (Symmetrel), 665-66-7, Concentration 675 mM, Molecular Weight 187.7, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amantadine hydrochloride(Symmetrel) is used to treat or prevent infections of the respiratory tract caused by a certain virus. |
| Amfebutamone (Bupropion), 31677-93-7, Concentration 676 mM, Molecular Weight 276.2, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amfebutamone (Bupropion) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectively |
| Benserazide, 14919-77-8, Concentration 677 mM, Molecular Weight 293.7, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor. |
| Bupivacaine HCl (Marcain), 18010-40-7, Concentration 678 mM, Molecular Weight 324.89, Target:cAMP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bupivacaine hydrochloride(Marcain) is a more potent cAMP production inhibitor with an IC50 of 2.3 μM |
| Bethanechol chloride, 590-63-6, Concentration 679 mM, Molecular Weight 196.68, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors. |
| Chlorpromazine (Sonazine), 69-09-0, Concentration 680 mM, Molecular Weight 355.33, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currents |
| Clonidine HCl (Catapres), 4205-91-8, Concentration 681 mM, Molecular Weight 266.5, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clonidine hydrochloride(Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. |
| Clozapine (Clozaril), 5786-21-0, Concentration 682 mM, Molecular Weight 326.82, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| Pramipexole (Mirapex), 104632-26-0, Concentration 683 mM, Molecular Weight 211.33, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pramipexole (Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. |
| Domperidone (Motilium), 57808-66-9, Concentration 684 mM, Molecular Weight 425.91, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. |
| Donepezil HCl (Aricept), 120011-70-3, Concentration 685 mM, Molecular Weight 416, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
| Estriol, 50-27-1, Concentration 686 mM, Molecular Weight 288.39, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. |
| Fluocinolone acetonide (Flucort-N), 67-73-2, Concentration 687 mM, Molecular Weight 452.4999, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fluocinolone(Flucort-N) acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor. |
| Gallamine triethiodide (Flaxedil), 65-29-2, Concentration 688 mM, Molecular Weight 891.53, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gallamine triethiodide(Flaxedil) is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM. |
| Hexestrol (Bibenzyl), 84-16-2, Concentration 689 mM, Molecular Weight 270.37, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. |
| Imatinib (Gleevec), 152459-95-5, Concentration 690 mM, Molecular Weight 493.6, Target:PDGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
| Loperamide HCl, 34552-83-5, Concentration 691 mM, Molecular Weight 513.5, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Loperamide is an opioid-receptor agonist with an ED50 of 0.15 mg/kg. |
| Manidipine (Manyper), 89226-50-6, Concentration 692 mM, Molecular Weight 610.7, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. |
| Manidipine 2HCl (CV-4093), 89226-75-5, Concentration 693 mM, Molecular Weight 683.62, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Manidipine HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. |
| Milrinone (Primacor), 78415-72-2, Concentration 694 mM, Molecular Weight 211.22, Target:ATPase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE |
| Mitoxantrone HCl, 70476-82-3, Concentration 695 mM, Molecular Weight 517.4, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mitoxantrone HCl is a classic folic acid antagonist. |
| Nateglinide (Starlix), 105816-04-4, Concentration 696 mM, Molecular Weight 317.42, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nateglinide(Starlix) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. |
| Neostigmine bromide (Prostigmin), 114-80-7, Concentration 697 mM, Molecular Weight 303.2, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor. |
| Nitrendipine, 39562-70-4, Concentration 698 mM, Molecular Weight 360.3699, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM. |
| Olanzapine (Zyprexa), 132539-06-1, Concentration 699 mM, Molecular Weight 312.43975, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Olanzapine(Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
| Olopatadine HCl (Opatanol), 140462-76-6, Concentration 700 mM, Molecular Weight 373.87, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Olopatadine hydrochloride(Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine |
| Oxymetazoline HCl, 2315-02-8, Concentration 701 mM, Molecular Weight 296.84, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Oxymetazoline hydrochloride is an α1 and α2 adrenergic receptor agonist. |
| Ozagrel, 82571-53-7, Concentration 702 mM, Molecular Weight 228.25, Target:Factor Xa, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. |
| Pancuronium (Pavulon), 15500-66-0, Concentration 703 mM, Molecular Weight 732.67, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pancuronium (Pavulon) is a competitive acetylcholine antagonist with an IC50 of 5.5 ¡À 0.5 nM |
| Phenoxybenzamine HCl, 63-92-3, Concentration 704 mM, Molecular Weight 340.3, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. |
| Propafenone (Rytmonorm) HCl, 34183-22-7, Concentration 705 mM, Molecular Weight 377.9, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Propafenone(Rytmonorm) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. |
| Racecadotril (Acetorphan), 81110-73-8, Concentration 706 mM, Molecular Weight 385.48, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM |
| Rosiglitazone maleate, 155141-29-0, Concentration 707 mM, Molecular Weight 473.5, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rosiglitazone maleate (Avandia) is an anti-diabetic agent in the thiazolidinedione class of agents. |
| Salbutamol sulfate (Albuterol), 51022-70-9, Concentration 708 mM, Molecular Weight 337.39, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Salbutamol (Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. |
| Scopolamine HBr, 114-49-8, Concentration 709 mM, Molecular Weight 384.26, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ¡À 4.3 nM |
| Sotalol (Betapace), 959-24-0, Concentration 710 mM, Molecular Weight 308.82, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM |
| Sulfadoxine (Sulphadoxine), 2447-57-6, Concentration 711 mM, Molecular Weight 310.33378, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax |
| Tenoxicam (Mobiflex), 59804-37-4, Concentration 712 mM, Molecular Weight 337.37832, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tenoxicam(Mobiflex) is a good HO. radicals scavenger with an IC50 of 56.7 μM |
| Vardenafil Hydrochloride Trihydrate (Vivanza), 224785-90-4, Concentration 713 mM, Molecular Weight 579.11, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vardenafil Hydrochloride Trihydrate (Vivanza) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
| Xylazine HCl, 23076-35-9, Concentration 714 mM, Molecular Weight 256.79, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Xylazine HCl is α2 class of adrenergic receptor agonist. |
| Maprotiline HCl, 10347-81-6, Concentration 715 mM, Molecular Weight 313.86, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. |
| Naphazoline HCl (Naphcon), 550-99-2, Concentration 716 mM, Molecular Weight 246.74, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naphazoline hydrochloride (Naphcon) is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine. |
| Epinephrine bitartrate (Adrenalinium), 51-42-3, Concentration 717 mM, Molecular Weight 333.29, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Epinephrine bitartrate (D02149, Adrenalinium) is alpha- and beta-adrenergic receptor stimulator. |
| L-Adrenaline (Epinephrine), 51-43-4, Concentration 718 mM, Molecular Weight 183.2, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. L-Adrenaline (Epinephrine) belongs to a group of the compounds known as catecholamines. |
| DL-Adrenaline, 329-65-7, Concentration 719 mM, Molecular Weight 183.2, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands. |
| Phenytoin sodium (Dilantin), 630-93-3, Concentration 720 mM, Molecular Weight 274.25, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Phenytoin sodium (Dilantin) is an inactive voltage-gated sodium channel stabilizer. |
| Phenytoin (Lepitoin), 57-41-0, Concentration 721 mM, Molecular Weight 252.27, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Phenytoin (Lepitoin; NSC 8722; Phenytek; Phenytoine; Sodanton; Zentropi) is an inactive voltage-gated sodium channel stabilizer. |
| Alizarin, 72-48-0, Concentration 722 mM, Molecular Weight 240.21, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively. |
| Dopamine HCl (Inotropin), 62-31-7, Concentration 723 mM, Molecular Weight 189.64, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dopamine hydrochloride (Inotropin) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. |
| Asaraldehyde (Asaronaldehyde), 4460-86-0 , Concentration 724 mM, Molecular Weight 196.2, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Asaraldehyde (Asaronaldehyde) is natural COX-2 inhibitor. |
| Ritodrine HCl (Yutopar), 23239-51-2, Concentration 725 mM, Molecular Weight 323.81, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ritodrine hydrochloride (DU 21220; Miolene; NSC 291565; Pre-Par) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist. |
| Clomipramine HCl (Anafranil), 17321-77-6, Concentration 726 mM, Molecular Weight 351.31, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
| Phenformin HCl, 834-28-6, Concentration 727 mM, Molecular Weight 241.72, Target:AMPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Phenformin hydrochloride is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. |
| Scopine, 498-45-3, Concentration 728 mM, Molecular Weight 155.19, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. |
| Tiotropium Bromide hydrate, 139404-48-1, Concentration 729 mM, Molecular Weight 490.43, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. |
| Scopine HCl, 85700-55-6, Concentration 730 mM, Molecular Weight 191.66, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Scopine HCl is the hydrochloride of Scopine, which is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. |
| Trospium chloride (Sanctura), 10405-02-4, Concentration 731 mM, Molecular Weight 427.96, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist. |
| Tolterodine tartrate (Detrol LA), 124937-52-6, Concentration 732 mM, Molecular Weight 475.57, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tolterodine tartrate (Detrol LA) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist. |
| Azelastine HCl (Astelin), 79307-93-0, Concentration 733 mM, Molecular Weight 418.36, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist. |
| Daphnetin, 486-35-1, Concentration 734 mM, Molecular Weight 178.14, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively. |
| Clarithromycin (Biaxin, Klacid), 81103-11-9, Concentration 735 mM, Molecular Weight 747.95, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clarithromycin (Biaxin, Klacid) is a macrolide antibiotic and a CYP3A4 substrate and inhibitor. |
| Rosiglitazone (Avandia), 122320-73-4, Concentration 736 mM, Molecular Weight 357.43, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rosiglitazone (Avandia) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. |
| Amiloride HCl dihydrate, 17440-83-4, Concentration 737 mM, Molecular Weight 302.12, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker. |
| Clomifene citrate (Serophene), 50-41-9, Concentration 738 mM, Molecular Weight 598.08, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clomifene citrate (Serophene) is a selective estrogen receptor modulator. |
| Hydralazine HCl, 304-20-1, Concentration 739 mM, Molecular Weight 196.64, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. |
| Isoprenaline HCl, 51-30-9, Concentration 740 mM, Molecular Weight 247.72, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Isoprenaline is a non-selective β-adrenoceptor, inhibits the 3H-inositol phosphate accumulation with IC50 of 0.08 μM. |
| Medroxyprogesterone acetate, 71-58-9, Concentration 741 mM, Molecular Weight 386.52, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist. |
| Phenylephrine HCl, 61-76-7, Concentration 742 mM, Molecular Weight 203.67, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Phenylephrine hydrochloride is a selective α1-adrenergic receptor agonist. |
| Tetracaine HCl (Pontocaine), 136-47-0, Concentration 743 mM, Molecular Weight 300.82, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tetracaine hydrochloride (Pontocaine) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor. |
| Phenacetin, 62-44-2, Concentration 744 mM, Molecular Weight 179.22, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Phenacetin is a non-opioid analgesic without anti-inflammatory properties. |
| Zidovudine (Retrovir), 30516-87-1, Concentration 745 mM, Molecular Weight 267.24, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zidovudine (Retrovir) is a reverse transcriptase inhibitor. |
| Quinapril HCl (Accupril), 82586-55-8, Concentration 746 mM, Molecular Weight 474.98, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Quinapril hydrochloride (Accupril) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM. |
| Trazodone HCl (Desyrel), 25332-39-2, Concentration 747 mM, Molecular Weight 408.32, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Trazodone is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders. |
| Brompheniramine, 980-71-2, Concentration 748 mM, Molecular Weight 435.31, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Brompheniramine is a histamine H1 receptors antagonist. |
| Pioglitazone (Actos), 111025-46-8, Concentration 749 mM, Molecular Weight 356.44, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator. |
| Tolvaptan (OPC-41061), 150683-30-0, Concentration 750 mM, Molecular Weight 448.94, Target:Vasopressin Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tolvaptan (OPC-41061) is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28¦ÌM for the inhibition of AVP-induced platelet aggregation. |
| Gliclazide (Diamicron), 21187-98-4, Concentration 751 mM, Molecular Weight 323.41, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gliclazide (Diamicron) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 ¡À 30 nM |
| Acemetacin (Emflex), 53164-05-9, Concentration 752 mM, Molecular Weight 415.82, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Acemetacin (Emflex) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor. |
| Tioxolone, 4991-65-5, Concentration 753 mM, Molecular Weight 168.17, Target:Carbonic Anhydrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. |
| Dehydroepiandrosterone (DHEA), 53-43-0, Concentration 754 mM, Molecular Weight 288.43, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone. |
| Mifepristone (Mifeprex), 84371-65-3, Concentration 755 mM, Molecular Weight 429.59, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mifepristone (Mifeprex, RU-486, RU-38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. |
| Lonidamine, 50264-69-2, Concentration 756 mM, Molecular Weight 321.16, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lonidamine is an orally administered small molecule hexokinase inactivator with an IC50 of 0.85 mM. |
| Ethisterone, 434-03-7, Concentration 757 mM, Molecular Weight 312.45, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ethisterone is a progestogen hormone being considered to treat prostate cancer. |
| Arecoline, 300-08-3 , Concentration 758 mM, Molecular Weight 236.11, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Arecoline is a muscarinic acetylcholine receptor agonist. |
| Noradrenaline bitartrate monohydrate (Levophed), 108341-18-0, Concentration 759 mM, Molecular Weight 337.28, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator. |
| TAK-733, 1035555-63-5, Concentration 760 mM, Molecular Weight 504.23, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAK-733 is a potent, selective, non ATP-competitive MEK inhibitor with IC50 of 3.2 nM. |
| LDN193189, 1062368-24-4, Concentration 761 mM, Molecular Weight 406.48, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. |
| GSK256066, 801312-28-7, Concentration 762 mM, Molecular Weight 518.58, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK256066 is a selective PDE4B inhibitor with IC50 of 3.2 pM. |
| AZD5438, 602306-29-6 , Concentration 763 mM, Molecular Weight 371.46, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD5438 is a potent inhibitor of CDK1, CDK2 and CDK9 with IC50 of 16 nM, 6 nM, and 20 nM, respectively. |
| PP-121, 1092788-83-4, Concentration 764 mM, Molecular Weight 319.36, Target:DNA-PK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PP-121 is a multi-target inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, respectively, and also inhibits DNA-PK with IC50 of 60 nM. |
| OSI-027, 936890-98-1, Concentration 765 mM, Molecular Weight 406.44, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
| R788 (Fostamatinib), 901119-35-5, Concentration 766 mM, Molecular Weight 580.46, Target:Syk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. R788 (Fostamatinib) is a Syk inhibitor with IC50 of 41 nM. |
| LY2603618 (IC-83), 911222-45-2, Concentration 767 mM, Molecular Weight 436.3, Target:Chk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2603618 (IC-83) is a selective Chk1 inhibitor with potential anti-tumor activity. |
| Tubastatin A HCl, 1310693-92-5, Concentration 768 mM, Molecular Weight 371.86, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tubastatin A is a potent HDAC6 inhibitor with IC50 of 15 nM. |
| PF-05212384 (PKI-587), 1197160-78-3, Concentration 769 mM, Molecular Weight 615.73, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PKI-587 is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM, respectively. |
| PNU-120596, 501925-31-1, Concentration 770 mM, Molecular Weight 311.72, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM in α7*-expressing SH-EP1 cells. |
| GW3965 HCl, 405911-17-3, Concentration 771 mM, Molecular Weight 618.51, Target:Liver X Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW3965 is a potent, selective LXR agonist, which exhibits its potency in the LXRα/SRC1 LiSA and LXRα-GAL4 with EC50 of 125 nM and 190 nM, respectively. |
| URB597, 546141-08-6 , Concentration 772 mM, Molecular Weight 338.4, Target:FAAH, HPLC 99%, NMR, LCMS is ok, stock more than 5g. URB597 (KDS-4103) is a potent FAAH inhibitor with IC50 of 4.6 nM. |
| BMS-806 (BMS 378806), 357263-13-9 , Concentration 773 mM, Molecular Weight 406.43, Target:gp120/CD4, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMS-806 (BMS 378806) selectively inhibitis the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus. |
| DCC-2036 (Rebastinib), 1020172-07-9, Concentration 774 mM, Molecular Weight 553.59, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. DCC-2036 is a conformational control inhibitor of Abl1 and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, respectively. |
| CCT128930, 885499-61-6, Concentration 775 mM, Molecular Weight 341.84, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM. |
| A66, 1166227-08-2 , Concentration 776 mM, Molecular Weight 393.53, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A66 is a potent and specific p110α inhibitor with IC50 of 32 nM. |
| TAK-875, 1374598-80-7, Concentration 777 mM, Molecular Weight 533.63, Target:GPR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAK-875 is a selective GPR40 agonist with EC50 of 14 nM. |
| NU7441 (KU-57788), 503468-95-9 , Concentration 778 mM, Molecular Weight 413.49, Target:DNA-PK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM. |
| SNX-2112, 908112-43-6, Concentration 779 mM, Molecular Weight 464.48, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, respectively. |
| PF-04929113 (SNX-5422), 908115-27-5, Concentration 780 mM, Molecular Weight 521.53, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and also inhibits Her-2 degradation with IC50 of 37 nM. |
| GSK2126458, 1086062-66-9 , Concentration 781 mM, Molecular Weight 505.5, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with Ki of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively. |
| 5-hydroxymethyl tolterodine (PNU 200577), 207679-81-0, Concentration 782 mM, Molecular Weight 341.49, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. 5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM. |
| MK-0752, 471905-41-6 , Concentration 783 mM, Molecular Weight 442.9, Target:Beta Amyloid, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM in human SH-SY5Y cells. |
| WYE-125132, 1144068-46-1, Concentration 784 mM, Molecular Weight 519.6, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WYE-125132 is a highly potent, ATP-competitive and specific mTOR inhibitor with IC50 of 0.19 nM. |
| WAY-100635 HCl, 146714-97-8, Concentration 785 mM, Molecular Weight 531.95, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WAY 100635 is a potent and selective 5-HT agonist with IC50 of 0.95 nM. |
| Clinofibrate, 30299-08-2, Concentration 786 mM, Molecular Weight 468.58, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM. |
| Ciprofibrate, 52214-84-3, Concentration 787 mM, Molecular Weight 289.15, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ciprofibrate is a peroxisome proliferator-activated receptor agonist. |
| PF-3845, 1196109-52-0, Concentration 788 mM, Molecular Weight 456.46, Target:FAAH, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM. |
| S/GSK1349572 (GSK1349572), 1051375-16-6, Concentration 789 mM, Molecular Weight 419.38, Target:Integrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM. |
| WYE-687, 1062161-90-3, Concentration 790 mM, Molecular Weight 528.61, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM. |
| LY310762, 192927-92-7, Concentration 791 mM, Molecular Weight 430.94, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY310762 is a 5-HT1D antagonist with Ki of ~0.2 μM. |
| A-674563, 552325-73-2, Concentration 792 mM, Molecular Weight 358.44, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A-674563 inhibits Akt1, PKA and CDK2 with Ki of 11 nM, 16 nM and 46 nM, respectively. |
| AS-252424, 900515-16-4, Concentration 793 mM, Molecular Weight 305.28, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM. |
| PF-00562271, 939791-38-5, Concentration 794 mM, Molecular Weight 665.66, Target:FAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
| GSK1120212 (Trametinib), 871700-17-3, Concentration 795 mM, Molecular Weight 615.39, Target:MEK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively. |
| A 922500, 959122-11-3, Concentration 796 mM, Molecular Weight 428.48, Target:Transferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A 922500 is a DGAT-1 inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively. |
| BRL-15572, 193611-72-2, Concentration 797 mM, Molecular Weight 479.87, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BRL-15572 is a 5-HT1D antagonist with pKi of 7.9. |
| NSC-207895 (XI-006), 58131-57-0, Concentration 798 mM, Molecular Weight 279.25, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NSC-207895 suppresses MDMX with IC50 of 2.5 ¦ÌM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulate MDM2, an E3 ligase |
| Flavopiridol (Alvocidib) HCl, 131740-09-5, Concentration 799 mM, Molecular Weight 438.3, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM. |
| PCI-32765 (Ibrutinib), 936563-96-1, Concentration 800 mM, Molecular Weight 440.5, Target:BTK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM. |
| AS-604850, 648449-76-7 , Concentration 801 mM, Molecular Weight 285.22, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM. |
| CAY10505, 1218777-13-9 , Concentration 802 mM, Molecular Weight 289.28, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CAY10505 is a PI3Kγ inhibitor with IC50 of 30 nM. |
| CHIR-124, 405168-58-3, Concentration 803 mM, Molecular Weight 419.91, Target:Chk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. |
| CX-5461, 1138549-36-6, Concentration 804 mM, Molecular Weight 513.61, Target:DNA/RNA Synthesis, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CX-5461 selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells. |
| KW-2478, 819812-04-9, Concentration 805 mM, Molecular Weight 574.66, Target:HSP (e.g. HSP90), HPLC 99%, NMR, LCMS is ok, stock more than 5g. KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
| NVP-BSK805 2HCl, 1092499-93-8 (free base), Concentration 806 mM, Molecular Weight 563.47, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM. |
| R547, 741713-40-6, Concentration 807 mM, Molecular Weight 441.45, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively. |
| WAY-600, 1062159-35-6 , Concentration 808 mM, Molecular Weight 494.59, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM. |
| ADX-47273, 851881-60-2, Concentration 809 mM, Molecular Weight 369.36, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ADX47273 is a potent and specific mGlu5 antagonist with IC50 of 0.17μM. |
| BMY 7378, 21102-95-4, Concentration 810 mM, Molecular Weight 458.42, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BMY 7378 is a multiple inhibitors of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively. |
| TG101209, 936091-14-4, Concentration 811 mM, Molecular Weight 509.67, Target:c-RET, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TG101209 is a potent inhibitor of JAK2, Flt3 and RET with IC50 of 6 nM, 25 nM and 17 nM, respectively. |
| WAY-362450, 629664-81-9, Concentration 812 mM, Molecular Weight 438.47, Target:FXR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WAY-362450 is a potent, selective FXR agonist with EC50 of 4 nM. |
| GDC-0980 (RG7422), 1032754-93-0, Concentration 813 mM, Molecular Weight 498.6, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GDC-0980 (RG7422) is a potent, selective inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 5 nM, 27 nM, 7 nM, and 14 nM, and also a mTOR inhibitor with Ki of 17 nM. |
| A-769662, 844499-71-4, Concentration 814 mM, Molecular Weight 360.39, Target:AMPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM and inhibits fatty acid synthesis with IC50 of 3.2 μM. |
| RS-127445, 199864-87-3, Concentration 815 mM, Molecular Weight 281.33, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. RS-127445 is a selective 5-HT2B antagonist with pKi of 9.5 and pIC50 of 10.4. |
| CH5132799, 1007207-67-1, Concentration 816 mM, Molecular Weight 377.42, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CH5132799 exhibits a strong inhibitory activity especially against PI3Kα with IC50 of 14 nM and also inhibits mTOR with IC50 of 1.6 µM. |
| KX2-391, 897016-82-9, Concentration 817 mM, Molecular Weight 431.53, Target:Src, HPLC 99%, NMR, LCMS is ok, stock more than 5g. KX2-391 (KX01) is a highly selective non ATP-competitive Src inhibitor with GI50 of 9-60 nM in cancer cell lines . |
| GSK1838705A, 1116235-97-2, Concentration 818 mM, Molecular Weight 532.57, Target:ALK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK1838705A is a potent inhibitor of IGF-1R, IR and ALK with IC50 of 2.0 nM, 1.6 nM and 0.5 nM, respectively |
| LY2109761, 700874-71-1 , Concentration 819 mM, Molecular Weight 441.52, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively. |
| YO-01027, 209984-56-5, Concentration 820 mM, Molecular Weight 463.48, Target:Gamma-secretase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch, respectively. |
| Geldanamycin, 30562-34-6, Concentration 821 mM, Molecular Weight 560.64, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM. |
| LY411575, 209984-57-6, Concentration 822 mM, Molecular Weight 479.48, Target:Gamma-secretase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM and 0.082 nM for membrane- and cell-based γ-secretase. |
| CP-91149, 186392-40-5, Concentration 823 mM, Molecular Weight 399.87, Target:Phosphorylase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM. |
| TAK-901, 934541-31-8, Concentration 824 mM, Molecular Weight 504.64, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAK-901 is a novel inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM, respectively. |
| AMG 900, 945595-80-2, Concentration 825 mM, Molecular Weight 503.58, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AMG 900 is a potent and highly selective pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 5 nM, 4 nM and 1 nM, respectively. |
| ZM 336372, 208260-29-1, Concentration 826 mM, Molecular Weight 389.45, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM. |
| Nilvadipine (ARC029), 75530-68-6, Concentration 827 mM, Molecular Weight 385.37, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nilvadipine (ARC029) is a potent calcium channel blocker with an IC50 of 0.03 nM. |
| JTC-801, 244218-51-7, Concentration 828 mM, Molecular Weight 447.96, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM. |
| PF-03814735, 942487-16-3, Concentration 829 mM, Molecular Weight 474.48, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-03814735 is a novel, potent and reversible inhibitor of both Aurora A and Aurora B with IC50 of 0.8 nM and 5 nM, respectively. |
| PH-797804, 586379-66-0, Concentration 830 mM, Molecular Weight 477.3, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM. |
| Dacomitinib (PF299804,PF-00299804), 1110813-31-4, Concentration 831 mM, Molecular Weight 469.94, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively. |
| AG-1478 (Tyrphostin AG-1478), 153436-53-4, Concentration 832 mM, Molecular Weight 315.75, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM. |
| SB 415286, 264218-23-7, Concentration 833 mM, Molecular Weight 359.72, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB 415286 is a potent GSK3α and GSK3β inhibitor with IC50 of 78 nM and ~78 nM, respectively. |
| Crenolanib (CP-868596), 670220-88-9, Concentration 834 mM, Molecular Weight 443.54, Target:PDGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Crenolanib (CP-868596) is a potent and selective inihibitor of PDGFRα with IC50 of 10 nM in PDGFRα over-expressed CHO cells. |
| AZ 3146, 1124329-14-1, Concentration 835 mM, Molecular Weight 452.55, Target:Kinesin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM. |
| TG101348 (SAR302503), 936091-26-8, Concentration 836 mM, Molecular Weight 524.68, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM. |
| PAC-1, 315183-21-2, Concentration 837 mM, Molecular Weight 392.49, Target:Caspase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM. |
| PKI-402, 1173204-81-3, Concentration 838 mM, Molecular Weight 570.65, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PKI-402 is a potent dual PI3K/mTOR inhibitor targeting PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR with IC50 of 2 nM, 7 nM, 16 nM, 14 nM, and 3 nM, respectively. |
| GSK1070916, 942918-07-2, Concentration 839 mM, Molecular Weight 507.63, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM, respectively. |
| PHA-767491, 845714-00-3, Concentration 840 mM, Molecular Weight 213.24, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively. |
| PF-04691502, 1013101-36-4 , Concentration 841 mM, Molecular Weight 425.48, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-04691502 is an ATP-competitive, selective inhibitor of PI3K(α/β/δ/γ)/mTOR with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, also inhibits Akt phosphorylation on T308/S473 with IC50 of 7.5 nM/3.8 nM. |
| CCT137690, 1095382-05-0, Concentration 842 mM, Molecular Weight 551.48, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM, respectively. |
| CHIR-98014, 252935-94-7, Concentration 843 mM, Molecular Weight 486.31, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CHIR-98014 is a potent and selective GSK-3 inhibitor for GSK-3ɑ and GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively. |
| AZ628, 878739-06-1, Concentration 844 mM, Molecular Weight 451.52, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively. |
| AMG458, 913376-83-7 , Concentration 845 mM, Molecular Weight 539.58, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AMG 458 is a potent c-Met inhibitor of human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM. |
| Anacetrapib (MK-0859), 875446-37-0, Concentration 846 mM, Molecular Weight 637.51, Target:CETP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Anacetrapib (MK0859) is a potent and selective rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, respectively |
| NVP-BGT226, 1245537-68-1, Concentration 847 mM, Molecular Weight 650.6, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
| GW788388, 452342-67-5, Concentration 848 mM, Molecular Weight 425.48, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM. |
| Milciclib (PHA-848125), 802539-81-7, Concentration 849 mM, Molecular Weight 460.57, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with IC50 of 45 nM. |
| Arry-380, 937265-83-3, Concentration 850 mM, Molecular Weight 569.63, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM. |
| AT-406, 1071992-99-8, Concentration 851 mM, Molecular Weight 561.71, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. AT-406 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. |
| ARRY334543, 845272-21-1, Concentration 852 mM, Molecular Weight 466.94, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively. |
| Wortmannin, 19545-26-7, Concentration 853 mM, Molecular Weight 428.43, Target:ATM/ATR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM |
| PI3K/HDAC Inhibitor I, 1339928-25-4, Concentration 854 mM, Molecular Weight 508.55, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PI3K/HDAC Inhibitor I is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively. |
| Canagliflozin, 842133-18-0, Concentration 855 mM, Molecular Weight 444.52, Target:SGLT, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively. |
| NVP-BVU972, 1185763-69-2, Concentration 856 mM, Molecular Weight 340.38, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM. |
| CH5424802, 1256580-46-7, Concentration 857 mM, Molecular Weight 482.62, Target:ALK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CH5424802 is a potent and selective ALK inhibitor with IC50 of 1.9 nM. |
| MK-2048, 869901-69-9, Concentration 858 mM, Molecular Weight 461.87, Target:Integrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-2048 is an potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. |
| 3-Methyladenine, 5142-23-4, Concentration 859 mM, Molecular Weight 149.15, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM and also blocks autophagosome formation. |
| Dinaciclib (SCH727965), 779353-01-4, Concentration 860 mM, Molecular Weight 396.49, Target:CDK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. |
| Dovitinib Dilactic acid (TKI258 Dilactic acid) , 852433-84-2, Concentration 861 mM, Molecular Weight 572.59, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively. |
| MK-5108 (VX-689), 1010085-13-8, Concentration 862 mM, Molecular Weight 461.94, Target:Aurora Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM. |
| Dalcetrapib (JTT-705), 211513-37-0, Concentration 863 mM, Molecular Weight 389.59, Target:CETP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM. |
| SB705498, 501951-42-4, Concentration 864 mM, Molecular Weight 429.23, Target:TRPV, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB705498 is a TRPV1 antagonist for hTRPV1 with pIC50 and pKi of 7.1 and 7.6 in HEK293 cells. |
| MK-2461, 917879-39-1, Concentration 865 mM, Molecular Weight 495.55, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-2461 is a potent inhibitor of c-Met, Ron, Flt1/3, PDGFRβ, Mer and FGFR1/2/3 with IC50 of 2.5 nM, 7 nM, 10 nM/22 nM, 22 nM, 24 nM and 65 nM/39 nM/50 nM, respectively. |
| Nocodazole, 31430-18-9, Concentration 866 mM, Molecular Weight 301.32, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. |
| CPI-613, 95809-78-2, Concentration 867 mM, Molecular Weight 388.59, Target:Dehydrogenase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. |
| PF-5274857, 1373615-35-0, Concentration 868 mM, Molecular Weight 436.96, Target:Smoothened, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively. |
| GW842166X, 666260-75-9, Concentration 869 mM, Molecular Weight 449.25, Target:Cannabinoid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW842166X is a potent and highly selective agonist of CB2 receptor. |
| M344, 251456-60-7 , Concentration 870 mM, Molecular Weight 307.39, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. M344 is a potent HDAC inhibitor with IC50 of 100 nM. |
| RITA (NSC 652287), 213261-59-7, Concentration 871 mM, Molecular Weight 292.37, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells, and also inhibits MDM2-p53 interaction by targeting to p53. |
| GW4064, 278779-30-9, Concentration 872 mM, Molecular Weight 542.84, Target:FXR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW 4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM. |
| AZD2014, 1009298-59-2, Concentration 873 mM, Molecular Weight 462.54, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity. |
| TAK-285, 871026-44-7, Concentration 874 mM, Molecular Weight 547.96, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively. |
| A-803467, 944261-79-4, Concentration 875 mM, Molecular Weight 357.79, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
| INCB28060, 1029712-80-8, Concentration 876 mM, Molecular Weight 412.42, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. INCB28060 is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM. |
| Tofacitinib (CP-690550, Tasocitinib), 477600-75-2, Concentration 877 mM, Molecular Weight 312.37, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CP-690550 is a novel inhibitor of JAK3 with IC50 of 1 nM. |
| Istradefylline (KW-6002), 155270-99-8, Concentration 878 mM, Molecular Weight 384.43, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. |
| Sotrastaurin (AEB071), 425637-18-9, Concentration 879 mM, Molecular Weight 438.48, Target:PKC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sotrastaurin (AEB071) is a potent selective pan-PKC inhibitor and highly inhibits PKCθ with Ki of 0.22 nM. |
| Torcetrapib (CP-529414), 262352-17-0, Concentration 880 mM, Molecular Weight 600.47, Target:CETP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Torcetrapib (CP-529414) is a CETP inhibitor with IC50 of 37 nM. |
| VU 0357121, 433967-28-3, Concentration 881 mM, Molecular Weight 305.32, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VU0357121 is a novel allosteric modulator of mGlu5 with EC50 of 33 nM. |
| WP1066, 857064-38-1, Concentration 882 mM, Molecular Weight 356.22, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells . |
| Lonafarnib (SCH66336), 193275-84-2, Concentration 883 mM, Molecular Weight 638.82, Target:Transferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. |
| APO866 (FK866), 658084-64-1, Concentration 884 mM, Molecular Weight 391.51, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. APO866 effectively inhibits NAMPT with IC50 of 0.09 nM. |
| AZD4547, 1035270-39-3, Concentration 885 mM, Molecular Weight 463.57, Target:FGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively. |
| BAY80-6946, 1032568-63-0, Concentration 886 mM, Molecular Weight 480.52, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BAY 80-6946 is a potent and highly selective reversible PI3K inhibitor for PI3Kα and PI3Kβ with IC50 of 0.469 nM and 3.72 nM, respectively. |
| Galeterone (TOK-001), 851983-85-2, Concentration 887 mM, Molecular Weight 388.55, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Galeterone (TOK-001, VN/124-1) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively. |
| Sirtinol, 410536-97-9, Concentration 888 mM, Molecular Weight 394.47, Target:Sirtuin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sirtinol is a specific SIRT1 and SIRT2 inhibtor with IC50 of 131 μM and 38 μM, respectively. |
| LY364947, 396129-53-6, Concentration 889 mM, Molecular Weight 272.3, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM. |
| CEP33779, 1257704-57-6, Concentration 890 mM, Molecular Weight 462.57, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM. |
| Dabrafenib (GSK2118436), 1195765-45-7, Concentration 891 mM, Molecular Weight 519.56, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively. |
| GDC-0068, 1001264-89-6, Concentration 892 mM, Molecular Weight 458, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. |
| MPEP, 96206-92-7, Concentration 893 mM, Molecular Weight 193.24, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM. |
| INK 128 (MLN0128), 1224844-38-5, Concentration 894 mM, Molecular Weight 309.33, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM. |
| AT101, 90141-22-3, Concentration 895 mM, Molecular Weight 578.61, Target:Bcl-2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members. |
| Ciproxifan, 184025-19-2, Concentration 896 mM, Molecular Weight 386.4, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ciproxifan is a highly potent and selective H3-receptor antagonist with IC50 of 9.2 nM. |
| BYL719, 1217486-61-7, Concentration 897 mM, Molecular Weight 441.47, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BYL719 strongly and selectively inhibits PI3Kα. |
| Tyrphostin AG 879 (AG 879), 148741-30-4, Concentration 898 mM, Molecular Weight 316.46, Target:HER2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AG879 inhibits both ErbB2 and Flk-1 with IC50 of 1 μM. |
| Torin 2, 1223001-51-1, Concentration 899 mM, Molecular Weight 432.4, Target:ATM/ATR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively. |
| CI994 (Tacedinaline), 112522-64-2, Concentration 900 mM, Molecular Weight 269.3, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM. |
| AM251, 183232-66-8, Concentration 901 mM, Molecular Weight 555.24, Target:Cannabinoid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AM251 is a cannabinoid 1 receptor antagonist with IC50 of 8.9 μM. |
| NVP-TAE226, 761437-28-9, Concentration 902 mM, Molecular Weight 468.94, Target:FAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NVP-TAE226, a potent dual FAK/IGF-1R, inhibiting FAK and IGF-1R with IC50 of 5.5 nM and 0.14 μM, respectively. |
| RG108, 48208-26-0, Concentration 903 mM, Molecular Weight 334.33, Target:DNA Methyltransferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM. |
| Tideglusib, 865854-05-3 , Concentration 904 mM, Molecular Weight 334.39, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM. |
| TPCA-1, 507475-17-4, Concentration 905 mM, Molecular Weight 279.29, Target:IκB/IKK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| ML133 HCl, 1222781-70-5, Concentration 906 mM, Molecular Weight 313.82, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ML133 is a potent potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5). |
| Desmethyl Erlotinib (CP-473420), 183321-86-0, Concentration 907 mM, Molecular Weight 379.41, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Desmethyl Erlotinib (CP-473420) is a free base of OSI-420, which is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for human EGFR with IC50 of 2 nM. |
| Torin 1, 1222998-36-8, Concentration 908 mM, Molecular Weight 607.62, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM. |
| JNJ 1661010, 681136-29-8, Concentration 909 mM, Molecular Weight 365.45, Target:FAAH, HPLC 99%, NMR, LCMS is ok, stock more than 5g. JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human). |
| Epiandrosterone (3β-androsterone), 481-29-8, Concentration 910 mM, Molecular Weight 290.44, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Epiandrosterone (3β-androsterone) is a steroid hormone with weak androgenic activity which acts as a L-type Ca2+ channel antagonist. |
| ARN-509, 956104-40-8, Concentration 911 mM, Molecular Weight 477.43, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ARN-509 is a selective androgen receptor inhibitor with IC50 of 16 nM. |
| SAR131675, , Concentration 912 mM, Molecular Weight 358.39, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SAR131675 is a VEGFR-3 inhibitor with IC50 of 20 nM. |
| BI-D1870, 501437-28-1, Concentration 913 mM, Molecular Weight 391.42, Target:S6 Kinase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BI-D1870 is an ATP-competitive inhibitor of ribosomal S6 for RSK1, RSK2, RSK3 and RSK4 with IC50 of 31 nM, 24 nM, 18 nM and 15 nM, respectively. |
| Semaxanib (SU5416), 194413-58-6, Concentration 914 mM, Molecular Weight 238.28, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Semaxanib (SU5416) is a potent and selective VEGFR (Flk-1/KDR) inhibitor with IC50 of 1.04 μM. |
| Cathepsin Inhibitor 1, 225120-65-0, Concentration 915 mM, Molecular Weight 401.89, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
| SB-269970 HCl, 261901-57-9, Concentration 916 mM, Molecular Weight 388.95, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB-269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3. |
| Baricitinib (LY3009104, INCB28050), 1187594-09-7, Concentration 917 mM, Molecular Weight 371.42, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively. |
| BRL 54443, 57477-39-1, Concentration 918 mM, Molecular Weight 230.31, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively. |
| Carfilzomib (PR-171), 868540-17-4, Concentration 919 mM, Molecular Weight 719.91, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM. |
| BML-190, 2854-32-2, Concentration 920 mM, Molecular Weight 426.89, Target:Cannabinoid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BML-190 is a selective CB2 inverse agonist with Ki of 435 nM. |
| MRS 2578, 711019-86-2, Concentration 921 mM, Molecular Weight 472.67, Target:P2 Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MRS2578 is a potent P2Y6 receptor with IC50 of 37 nM. |
| SB 271046, 209481-20-9, Concentration 922 mM, Molecular Weight 451.99, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9. |
| Dizocilpine (MK 801), 77086-21-6, Concentration 923 mM, Molecular Weight 221.3, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dizocilpine is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. |
| StemRegenin 1, 1227633-49-9, Concentration 924 mM, Molecular Weight 429.54, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. StemRegenin 1 is an AhR inhibitor with IC50 of 127 nM. |
| Golvatinib (E7050), 928037-13-2, Concentration 925 mM, Molecular Weight 633.69, Target:c-Met, HPLC 99%, NMR, LCMS is ok, stock more than 5g. E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively. |
| IEM 1754 dihydrobroMide, 162831-31-4, Concentration 926 mM, Molecular Weight 412.25, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. IEM 1754 dihydrobroMide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
| CTEP, 871362-31-1, Concentration 927 mM, Molecular Weight 391.77, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CTEP is a selective allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM. |
| VU 0364770, 61350-00-3, Concentration 928 mM, Molecular Weight 232.67, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VU 0364770 is a selective positive allosteric mGlu4 with EC50 of 1.1 μM. |
| ML130, 799264-47-4, Concentration 929 mM, Molecular Weight 287.34, Target:NOD1, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ML130 is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM. |
| IMD 0354, 978-62-1, Concentration 930 mM, Molecular Weight 383.67, Target:IκB/IKK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NFκβ pathway. |
| VUF 10166, 155584-74-0, Concentration 931 mM, Molecular Weight 262.74, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VUF10166 is a novel, potent and competitive antagonist to 5-HT3A with Ki of 0.04 nM. |
| U-104, 178606-66-1, Concentration 932 mM, Molecular Weight 309.32, Target:Carbonic Anhydrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with IC50 of 45.1 nM and 4.5 nM, respectively. |
| WHI-P154, 211555-04-3, Concentration 933 mM, Molecular Weight 376.2, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM. |
| Alogliptin (SYR-322), 850649-61-5, Concentration 934 mM, Molecular Weight 339.39, Target:DPP-4, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of < 10 nM. |
| TG 100713, 925705-73-3, Concentration 935 mM, Molecular Weight 254.25, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TG 100713 is a PI3K inhibitor for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively. |
| T0070907, 313516-66-4, Concentration 936 mM, Molecular Weight 277.66, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM. |
| GW5074, 220904-83-6, Concentration 937 mM, Molecular Weight 520.94, Target:Raf, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM. |
| Camostat Mesilate (FOY-305), 59721-29-8, Concentration 938 mM, Molecular Weight 494.52, Target:HCV Protease, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Camostat is a trypsin-like protease inhibitor, inhibiting matriptase and human neutrophil elastase with IC50 of 0.5 μM and 0.2 μM, respectively. |
| Prucalopride, 179474-81-8, Concentration 939 mM, Molecular Weight 367.87, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Prucalopride is a selective, high affinity 5-HT receptor agonistfor 5-HT4a and 5-HT4b with Ki of 2.5 nM and 8 nM, respectively. |
| (-)-MK 801 Maleate, 121917-57-5, Concentration 940 mM, Molecular Weight 337.37, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. |
| L-NAME HCl, 51298-62-5, Concentration 941 mM, Molecular Weight 269.69, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. |
| IKK-16, 873225-46-8, Concentration 942 mM, Molecular Weight 483.63, Target:IκB/IKK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
| A 205804, 251992-66-2, Concentration 943 mM, Molecular Weight 300.4, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. |
| PF-562271, 717907-75-0, Concentration 944 mM, Molecular Weight 507.49, Target:FAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
| GW441756, 504433-23-2, Concentration 945 mM, Molecular Weight 275.3, Target:Trk receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW 441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM. |
| VU 0361737, 1161205-04-4, Concentration 946 mM, Molecular Weight 262.69, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VU 0361737 is a selective positive allosteric modulator for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively. |
| SB-742457, 607742-69-8, Concentration 947 mM, Molecular Weight 353.44, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SB-742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63. |
| Tyrphostin 9 (SF 6847), 10537-47-0, Concentration 948 mM, Molecular Weight 282.38, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SF 6847 is an inhibitor of EGFR with IC50 of 460 μM. |
| ZM 323881 HCl, 193000-39-4, Concentration 949 mM, Molecular Weight 411.86, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ZM-323881 is a potent and selective inhibitor of VEGFR2 with IC50 < 2 nM. |
| ZM 306416, 690206-97-4, Concentration 950 mM, Molecular Weight 333.74, Target:VEGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively. |
| GNF-2, 778270-11-4, Concentration 951 mM, Molecular Weight 374.32, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, inhibiting the proliferation of the Bcr-Abl-expressing cells with IC50 of 138 nM. |
| Cobicistat (GS-9350), 1004316-88-4, Concentration 952 mM, Molecular Weight 776.02, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| CCG 50014, 883050-24-6, Concentration 953 mM, Molecular Weight 316.35, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM. |
| S-Ruxolitinib, 941685-37-6, Concentration 954 mM, Molecular Weight 306.37, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. S-Ruxolitinib is a JAK family inhibitor for JAK1 and JAK2 with IC50 of 3.3 nM and 2.8 nM, respectively. |
| Lumiracoxib (COX-189), 220991-20-8, Concentration 955 mM, Molecular Weight 293.72, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with Ki of 0.06 μM. |
| PF 477736, 952021-60-2, Concentration 956 mM, Molecular Weight 419.48, Target:Chk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF 477736 is a ChK inhibitor against ChK1, ChK2, VEGFR2, Yes and Fms with IC50 of 0.49 nM, 47 nM, 8 nM, 14 nM and 10 nM, respectively. |
| JNJ-7777120, 459168-41-3, Concentration 957 mM, Molecular Weight 277.75, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. JNJ-7777120 is a potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM. |
| Ki16198, 355025-13-7, Concentration 958 mM, Molecular Weight 488.98, Target:LPA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively. |
| Pirfenidone, 53179-13-8, Concentration 959 mM, Molecular Weight 185.22, Target:TGF-beta/Smad, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. |
| Go 6983, 133053-19-7, Concentration 960 mM, Molecular Weight 442.51, Target:PKC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Go 6983 is a pan PKC inhibitor against PKCα, PKCβ, PKCγ, PKCδ, PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively. |
| WZ 811, 55778-02-4, Concentration 961 mM, Molecular Weight 290.36, Target:CXCR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM. |
| BAY 11-7082 (BAY 11-7821), 19542-67-7, Concentration 962 mM, Molecular Weight 207.25, Target:E2 conjugating, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bay 11-7082 inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM and inactivates the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13, UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex). |
| Dapivirine, 244767-67-7, Concentration 963 mM, Molecular Weight 329.4, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dapivirine is an nonnucleoside reverse transcriptase inhibitor for HIV reverse transcriptase with IC50 of 24 nM. |
| GW9662, 22978-25-2, Concentration 964 mM, Molecular Weight 276.68, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively. |
| HC-030031, 349085-38-7, Concentration 965 mM, Molecular Weight 355.39, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
| IOX2, 931398-72-0, Concentration 966 mM, Molecular Weight 352.34, Target:HIF, HPLC 99%, NMR, LCMS is ok, stock more than 5g. IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM. |
| Mozavaptan, 137975-06-5, Concentration 967 mM, Molecular Weight 427.54, Target:Vasopressin Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively. |
| PF-4981517, 1390637-82-7, Concentration 968 mM, Molecular Weight 456.59, Target:P450 (e.g. CYP17), HPLC 99%, NMR, LCMS is ok, stock more than 5g. PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM. |
| Icotinib, 610798-31-7, Concentration 969 mM, Molecular Weight 391.42, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with IC50 of 5 nM. |
| Salubrinal, 405060-95-9, Concentration 970 mM, Molecular Weight 479.81, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM. |
| CHIR-99021 (CT99021) HCl, 252917-06-9 (free base), Concentration 971 mM, Molecular Weight 501.8, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. |
| Evacetrapib (LY2484595), 1186486-62-3, Concentration 972 mM, Molecular Weight 638.65, Target:CETP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY2484595 is a potent and selective inhibitor of CETP with IC50 of 5.5 nM. |
| TDZD-8, 327036-89-5 , Concentration 973 mM, Molecular Weight 222.26, Target:GSK-3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM. |
| Apoptosis Activator 2, 79183-19-0, Concentration 974 mM, Molecular Weight 306.14, Target:Caspase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. |
| TAK 715, 303162-79-0, Concentration 975 mM, Molecular Weight 399.51, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAK 715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM. |
| Pifithrin-α, 63208-82-2, Concentration 976 mM, Molecular Weight 367.3, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. |
| Rivaroxaban (Xarelto), 366789-02-8, Concentration 977 mM, Molecular Weight 435.88, Target:Factor Xa, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rivaroxaban (Xarelto, BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM, respectively. |
| Paroxetine HCl, 78246-49-8, Concentration 978 mM, Molecular Weight 365.83, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Paroxetine is an antidepressant drug of the SSRI type. |
| Zaltoprofen, 74711-43-6, Concentration 979 mM, Molecular Weight 298.36, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis. |
| Pazopanib, 444731-52-6, Concentration 980 mM, Molecular Weight 437.52, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. |
| Plerixafor 8HCl (AMD3100 8HCl), 155148-31-5, Concentration 981 mM, Molecular Weight 794.47, Target:CXCR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Plerixafor 8HCl (DB06809, Mozobil, AMD3100) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| Aspirin (Acetylsalicylic acid), 50-78-2, Concentration 982 mM, Molecular Weight 180.16, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. |
| Niflumic acid, 4394-00-7, Concentration 983 mM, Molecular Weight 282.22, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain. |
| Ciclopirox ethanolamine, 41621-49-2, Concentration 984 mM, Molecular Weight 268.35, Target:ATPase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator. |
| Rimonabant (SR141716), 168273-06-1, Concentration 985 mM, Molecular Weight 463.79, Target:Cannabinoid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. |
| Bufexamac, 2438-72-4, Concentration 986 mM, Molecular Weight 223.27, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM. |
| Lamotrigine, 84057-84-1, Concentration 987 mM, Molecular Weight 256.09, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, respectively. |
| PMSF (Phenylmethylsulfonyl Fluoride), 329-98-6, Concentration 988 mM, Molecular Weight 174.19, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PMSF (Phenylmethyl sulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor. |
| Piceatannol, 10083-24-6, Concentration 989 mM, Molecular Weight 244.24, Target:Syk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Piceatannol is a selective Syk inhibitor with IC50 of ~10 μM. |
| Niclosamide (Niclocide), 50-65-7, Concentration 990 mM, Molecular Weight 327.12, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Niclosamide can inhibit DNA replication and inhibit STAT with IC50 of 0.7 μM. |
| Linagliptin (BI-1356), 668270-12-0, Concentration 991 mM, Molecular Weight 472.54, Target:DPP-4, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. |
| Bindarit , 130641-38-2, Concentration 992 mM, Molecular Weight 324.37, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. |
| Vildagliptin (LAF-237), 274901-16-5, Concentration 993 mM, Molecular Weight 303.4, Target:DPP-4, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM. |
| Sitaxentan sodium (TBC-11251), 210421-74-2, Concentration 994 mM, Molecular Weight 476.89, Target:Endothelin Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively. |
| Daunorubicin HCl (Daunomycin HCl), 23541-50-6, Concentration 995 mM, Molecular Weight 563.98, Target:Telomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. |
| Pravastatin sodium, 81131-70-6, Concentration 996 mM, Molecular Weight 446.51, Target:HMG-CoA Reductase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| Bepotastine Besilate, 190786-44-8, Concentration 997 mM, Molecular Weight 547.06, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7. |
| Fosaprepitant dimeglumine, 265121-04-8, Concentration 998 mM, Molecular Weight 1004.83, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist. |
| Rofecoxib (Vioxx), 162011-90-7, Concentration 999 mM, Molecular Weight 314.36, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM. |
| Lurasidone HCl, 367514-88-3, Concentration 1000 mM, Molecular Weight 529.14, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. |
| Azilsartan (TAK-536), 147403-03-0, Concentration 1001 mM, Molecular Weight 456.45, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM. |
| Otilonium Bromide, 26095-59-0, Concentration 1002 mM, Molecular Weight 563.57, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Otilonium bromide is an antimuscarinic. |
| Solifenacin succinate, 242478-38-2, Concentration 1003 mM, Molecular Weight 480.55, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class. |
| Palonosetron HCl, 135729-62-3, Concentration 1004 mM, Molecular Weight 332.87, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
| Bosentan Hydrate, 157212-55-0, Concentration 1005 mM, Molecular Weight 569.63, Target:Endothelin Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
| Rupatadine Fumarate, 182349-12-8, Concentration 1006 mM, Molecular Weight 532.03, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 and 102 nM, respectively. |
| Azelnidipine, 123524-52-7, Concentration 1007 mM, Molecular Weight 582.65, Target:Calcium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Azelnidipine is a dihydropyridine calcium channel blocker. |
| Miltefosine (Hexadecylphosphocholine), 58066-85-6, Concentration 1008 mM, Molecular Weight 407.57, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa. |
| Azilsartan Medoxomil (TAK-491), 863031-21-4, Concentration 1009 mM, Molecular Weight 568.53, Target:RAAS, HPLC 99%, NMR, LCMS is ok, stock more than 5g. |
| Medetomidine HCl, 86347-15-1, Concentration 1010 mM, Molecular Weight 236.74, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. |
| Ambroxol HCl, 23828-92-4, Concentration 1011 mM, Molecular Weight 414.56, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ambroxol HCl is a potent inhibitor of the neuronal Na+ channels with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, respectively. |
| Amikacin sulfate, 39831-55-5, Concentration 1012 mM, Molecular Weight 781.76, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amikacin sulfate binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis. |
| Naloxone HCl, 357-08-4, Concentration 1013 mM, Molecular Weight 363.84, Target:Opioid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose. |
| Piracetam, 7491-74-9, Concentration 1014 mM, Molecular Weight 142.16, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Piracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders. |
| (R)-baclofen, 69308-37-8, Concentration 1015 mM, Molecular Weight 213.66, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. (R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity. |
| Dexmedetomidine, 113775-47-6, Concentration 1016 mM, Molecular Weight 200.28, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dexmedetomidine is a sedative medication used by intensive care units and anesthetists. |
| Etravirine (TMC125), 269055-15-4, Concentration 1017 mM, Molecular Weight 435.28, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
| Ulipristal, 126784-99-4, Concentration 1018 mM, Molecular Weight 475.62, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure. |
| Indacaterol Maleate, 753498-25-8, Concentration 1019 mM, Molecular Weight 508.56, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36. |
| Oxybutynin chloride, 1508-65-2, Concentration 1020 mM, Molecular Weight 393.95, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| Milnacipran HCl, 101152-94-7, Concentration 1021 mM, Molecular Weight 246.35, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
| Darifenacin HBr, 133099-07-7, Concentration 1022 mM, Molecular Weight 507.46, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9. |
| Tripelennamine HCl, 154-69-8, Concentration 1023 mM, Molecular Weight 291.82, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tripelennamine is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM. |
| Entacapone, 130929-57-6, Concentration 1024 mM, Molecular Weight 305.29, Target:Histone Methyltransferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. |
| Estradiol valerate, 979-32-8, Concentration 1025 mM, Molecular Weight 356.5, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies. |
| Gliquidone, 33342-05-1, Concentration 1026 mM, Molecular Weight 527.63, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Ethynodiol diacetate, 297-76-7, Concentration 1027 mM, Molecular Weight 384.51, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills. |
| Benztropine mesylate, 132-17-2, Concentration 1028 mM, Molecular Weight 403.53, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. |
| Abacavir sulfate, 188062-50-2, Concentration 1029 mM, Molecular Weight 335.35, Target:Reverse Transcriptase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
| Altrenogest, 850-52-2, Concentration 1030 mM, Molecular Weight 310.43, Target:Estrogen/progestogen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Altrenogest is a progestogen structurally related to veterinary steroid trenbolone. |
| Anagrelide HCl , 58579-51-4, Concentration 1031 mM, Molecular Weight 292.55, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Anagrelide is a drug used for the treatment of essential thrombocytosis. |
| Atomoxetine HCl, 82248-59-7, Concentration 1032 mM, Molecular Weight 291.82, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. |
| Betahistine 2HCl, 5579-84-0, Concentration 1033 mM, Molecular Weight 209.12, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Betahistine is a histamine H3 receptors inhibitor with IC50 of 1.9 μM. |
| Brinzolamide, 138890-62-7, Concentration 1034 mM, Molecular Weight 383.51, Target:Carbonic Anhydrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM. |
| Flumequine, 42835-25-6, Concentration 1035 mM, Molecular Weight 261.25, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. |
| Amitriptyline HCl , 549-18-8, Concentration 1036 mM, Molecular Weight 313.86, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively. |
| Adrenalone HCl, 62-13-5, Concentration 1037 mM, Molecular Weight 217.65, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors. |
| Azatadine dimaleate, 3978-86-7, Concentration 1038 mM, Molecular Weight 522.55, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively. |
| Ropinirole HCl, 91374-20-8, Concentration 1039 mM, Molecular Weight 296.84, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ropinirole a selective dopamine D2 receptors inhibitor with IC50 of 29 nM. |
| Reboxetine mesylate, 98769-84-7, Concentration 1040 mM, Molecular Weight 409.5, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Reboxetine is a norepinephrine reuptake inhibitor with Ki of 8.2 nM. |
| Triflusal, 322-79-2, Concentration 1041 mM, Molecular Weight 248.16, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. |
| Trifluoperazine 2HCl, 440-17-5, Concentration 1042 mM, Molecular Weight 480.42, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. |
| Catharanthine, 2468-21-5, Concentration 1043 mM, Molecular Weight 336.43, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 ¦ÌM |
| Meptazinol HCl, 59263-76-2, Concentration 1044 mM, Molecular Weight 269.81, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. |
| Fexofenadine HCl, 153439-40-8, Concentration 1045 mM, Molecular Weight 538.12, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Fexofenadine inhibits histamine H1 receptor with IC50 of 246 nM. |
| Moclobemide, 71320-77-9, Concentration 1046 mM, Molecular Weight 268.74, Target:MAO, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Moclobemide is MAO-A (5-HT) inhibitor with IC50 of 6.1 μM. |
| Betulinic acid, 472-15-1, Concentration 1047 mM, Molecular Weight 456.7, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties. |
| Pergolide mesylate, 66104-23-2, Concentration 1048 mM, Molecular Weight 410.59, Target:Dopamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist. |
| Cabozantinib malate , 1140909-48-3, Concentration 1049 mM, Molecular Weight 635.59, Target:Axl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. |
| Sitagliptin phosphate monohydrate, 654671-77-9, Concentration 1050 mM, Molecular Weight 523.32, Target:DPP-4, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sitagliptin phosphate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts. |
| Ethambutol HCl, 1070-11-7, Concentration 1051 mM, Molecular Weight 277.23, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. |
| Doxycycline HCl, 10592-13-9, Concentration 1052 mM, Molecular Weight 480.9, Target:MMP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Doxycycline HCL is a tetracycline antibiotic that commonly used to treat a variety of infections and MMP inhibitor. |
| Clinafloxacin (PD127391), 105956-97-6, Concentration 1053 mM, Molecular Weight 365.79, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Clinafloxacin (PD127391) is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. |
| Pentamidine HCl, 50357-45-4, Concentration 1054 mM, Molecular Weight 413.34, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pentamidine is an inhibitor of <i>PRL Phosphatases</i> and also inhibits synthesis of DNA, RNA and protein. |
| Pemirolast (BMY 26517) potassium, 100299-08-9, Concentration 1055 mM, Molecular Weight 266.3, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. |
| Mirabegron (YM178), 223673-61-8, Concentration 1056 mM, Molecular Weight 396.51, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM. |
| Acebutolol HCl, 34381-68-5, Concentration 1057 mM, Molecular Weight 372.89, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias. |
| Ampiroxicam, 99464-64-9, Concentration 1058 mM, Molecular Weight 447.46, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. |
| Desloratadine, 100643-71-8, Concentration 1059 mM, Molecular Weight 310.82, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM. |
| Sodium Monofluorophosphate , 10163-15-2, Concentration 1060 mM, Molecular Weight 143.95, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM. |
| Hyoscyamine (Daturine), 101-31-5, Concentration 1061 mM, Molecular Weight 289.37, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM. |
| Ouabain, 11018-89-6, Concentration 1062 mM, Molecular Weight 728.77, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ouabain is a selective Na+, K+-ATPase inhibitor, binds to α2 subunit and α3 subunit with Ki of 41 nM and 15 nM, respectively. |
| Allylthiourea, 109-57-9, Concentration 1063 mM, Molecular Weight 116.18, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation. |
| Avanafil, 330784-47-9, Concentration 1064 mM, Molecular Weight 483.95, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM. |
| Tolcapone, 134308-13-7, Concentration 1065 mM, Molecular Weight 273.24, Target:Transferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM. |
| Probenecid (Benemid), 57-66-9, Concentration 1066 mM, Molecular Weight 285.36, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. |
| Procaine (Novocaine) HCl, 51-05-8, Concentration 1067 mM, Molecular Weight 272.77, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Procaine (Novocaine) HCl is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM. |
| Homatropine Methylbromide, 80-49-9, Concentration 1068 mM, Molecular Weight 370.28, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. |
| Homatropine Bromide, 51-56-9, Concentration 1069 mM, Molecular Weight 356.25, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. |
| Hydroxyzine 2HCl, 2192-20-3, Concentration 1070 mM, Molecular Weight 447.83, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM. |
| Flavoxate HCl, 3717-88-2, Concentration 1071 mM, Molecular Weight 427.92, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM. |
| Dexamethasone Sodium Phosphate, 2392-39-4, Concentration 1072 mM, Molecular Weight 516.4, Target:IL Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dexamethasone is an interleukin receptor inhibitor and also suppresses COX-2. |
| Aclidinium Bromide, 320345-99-1, Concentration 1073 mM, Molecular Weight 564.55, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively. |
| Bismuth Subsalicylate, 14882-18-9, Concentration 1074 mM, Molecular Weight 362.09, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2. |
| Diphemanil Methylsulfate, 62-97-5, Concentration 1075 mM, Molecular Weight 389.51, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR). |
| Vitamin D2 (Ergocalciferol), 50-14-6, Concentration 1076 mM, Molecular Weight 396.65, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vitamin D2 is a selective inhibitors of mammalian DNA polymerase A (pol A) with IC50 of 123 mM. |
| Doxapram HCl, 7081-53-0, Concentration 1077 mM, Molecular Weight 432.98, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| Dibucaine (Cinchocaine) HCl, 61-12-1, Concentration 1078 mM, Molecular Weight 379.92, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dibucaine (Cinchocaine) HCl is a local anesthetics. |
| Methazolamide, 554-57-4, Concentration 1079 mM, Molecular Weight 236.27, Target:Carbonic Anhydrase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. |
| Tetrahydrozoline HCl, 522-48-5, Concentration 1080 mM, Molecular Weight 236.74, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity. |
| Valdecoxib, 181695-72-7, Concentration 1081 mM, Molecular Weight 314.36, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM. |
| Nabumetone, 42924-53-8, Concentration 1082 mM, Molecular Weight 228.29, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. |
| Sertraline HCl, 79559-97-0, Concentration 1083 mM, Molecular Weight 342.69, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sertraline HCl is a 5-HT antagonist with Ki of 13 nM. |
| Spironolactone, 52-01-7, Concentration 1084 mM, Molecular Weight 416.57, Target:Androgen Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM. |
| Ropivacaine HCl, 98717-15-8, Concentration 1085 mM, Molecular Weight 310.86, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. |
| Erythromycin Ethylsuccinate, 1264-62-6, Concentration 1086 mM, Molecular Weight 862.05, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by <i>Streptomyces erythreus</i>, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis. |
| Vitamin D3 (Cholecalciferol), 67-97-0, Concentration 1087 mM, Molecular Weight 384.64, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Vitamin D3 (Cholecalciferol) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM. |
| Escitalopram Oxalate, 219861-08-2, Concentration 1088 mM, Molecular Weight 414.43, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
| Guanabenz (WY-8678) Acetate, 23256-50-0, Concentration 1089 mM, Molecular Weight 291.13, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Guanabenz (WY-8678) Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively. |
| Dequalinium Chloride, 522-51-0, Concentration 1090 mM, Molecular Weight 527.57, Target:PKC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. |
| Hexamethonium Bromide, 55-97-0, Concentration 1091 mM, Molecular Weight 362.19, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia. |
| Decamethonium Bromide, 541-22-0, Concentration 1092 mM, Molecular Weight 418.29, Target:AChR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent. |
| Sodium 4-Aminosalicylate, 6018-19-5, Concentration 1093 mM, Molecular Weight 211.15, Target:NF-κB, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-?oB inhibition and free radical scavenging. |
| Sodium Nitrite, 7632-00-0, Concentration 1094 mM, Molecular Weight 69, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM. |
| Zinc Pyrithione, 13463-41-7, Concentration 1095 mM, Molecular Weight 317.7, Target:Proton Pump, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. |
| Propranolol HCl, 318-98-9, Concentration 1096 mM, Molecular Weight 295.8, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM. |
| Mefenamic Acid, 61-68-7, Concentration 1097 mM, Molecular Weight 241.29, Target:COX, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Mefenamic acid is a competitive inhibitor of COX-1 and COX-2. |
| Ticagrelor, 274693-27-5, Concentration 1098 mM, Molecular Weight 522.57, Target:P2 Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively. |
| Triamterene, 396-01-0, Concentration 1099 mM, Molecular Weight 253.26, Target:Sodium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM. |
| Sulfacetamide Sodium, 127-56-0, Concentration 1100 mM, Molecular Weight 236.22, Target:Autophagy, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sulfacetamide Sodium is an anti-biotic. |
| Lorcaserin HCl, 846589-98-8, Concentration 1101 mM, Molecular Weight 232.15, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lorcaserin HCl is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| Estradiol Benzoate, 50-50-0, Concentration 1102 mM, Molecular Weight 376.49, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM. |
| Desvenlafaxine Succinate, 386750-22-7, Concentration 1103 mM, Molecular Weight 381.46, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
| Desvenlafaxine, 93413-62-8, Concentration 1104 mM, Molecular Weight 263.38, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. |
| Histamine 2HCl, 56-92-8, Concentration 1105 mM, Molecular Weight 184.07, Target:Histamine Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2. |
| Pefloxacin Mesylate Dihydrate, 149676-40-4, Concentration 1106 mM, Molecular Weight 465.49, Target:Topoisomerase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication. |
| Timolol Maleate, 26921-17-5, Concentration 1107 mM, Molecular Weight 432.49, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM. |
| Sodium Phenylbutyrate, 1716-12-7, Concentration 1108 mM, Molecular Weight 186.18, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Sodium Phenylbutyrate is a transcriptional regulators that act by altering chromatin structure via the modulation of HDAC activity. |
| Terbutaline Sulfate, 23031-32-5 , Concentration 1109 mM, Molecular Weight 548.65, Target:Adrenergic Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM. |
| Deoxyarbutin, 53936-56-4, Concentration 1110 mM, Molecular Weight 194.23, Target:, HPLC 99%, NMR, LCMS is ok, stock more than 5g. DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM. |
| Tofacitinib citrate (CP-690550 citrate), 540737-29-9, Concentration 1111 mM, Molecular Weight 504.49, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tofacitinib citrate (CP-690550) is a potent JAK3 inhibitor with IC50 of 1 nM. |
| Fingolimod (FTY720), 162359-56-0, Concentration 1112 mM, Molecular Weight 343.9, Target:Bcr-Abl, HPLC 99%, NMR, LCMS is ok, stock more than 5g. FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM. |
| LY2140023 (LY404039), 635318-55-7, Concentration 1113 mM, Molecular Weight 235.22, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. LY404039 is a potent agonist of recombinant human mGlu2, mGlu3 receptors and rat neurons expressing native mGlu2/3 receptors with Ki of 149 nM, 92 nM and 88 nM, respectively. |
| PTC124 (Ataluren), 775304-57-9, Concentration 1114 mM, Molecular Weight 284.24, Target:CFTR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM. |
| VX-702, 745833-23-2, Concentration 1115 mM, Molecular Weight 404.3, Target:p38 MAPK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM. |
| PP2, 172889-27-9, Concentration 1116 mM, Molecular Weight 301.77, Target:Src, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PP2 is Src kinase inhibitor, potently inhibits GST-Src activity with IC50 of 100 nM. |
| Stattic, 19983-44-9, Concentration 1117 mM, Molecular Weight 211.19, Target:STAT, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Stattic inhibits STAT3 with IC50 of 5.1 μM. |
| Embelin, 550-24-3, Concentration 1118 mM, Molecular Weight 294.39, Target:IAP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Embelin, from the Japanese Ardisia herb, is a fairly potent, nonpeptidic, cell-permeable inhibitor of XIAP and efficiently overcomes the protective effect of XIAP XLALP to apoptosis. |
| IPI-145 (INK1197), 1201438-56-3, Concentration 1119 mM, Molecular Weight 416.86, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. IPI-145 (INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM. |
| AZD2461, 1174043-16-3, Concentration 1120 mM, Molecular Weight 395.43, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD2461 is a poor P-glycoprotein substrate with lower affinity for Pgp than does olaparib. |
| PD168393, 194423-15-9, Concentration 1121 mM, Molecular Weight 369.22, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. |
| Brefeldin A , 20350-15-6, Concentration 1122 mM, Molecular Weight 280.36, Target:ATPase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. |
| Oprozomib (ONX 0912), 935888-69-0, Concentration 1123 mM, Molecular Weight 532.61, Target:Proteasome, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. |
| VX-661, 1152311-62-0, Concentration 1124 mM, Molecular Weight 520.5, Target:CFTR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. |
| GSK J4 HCl, 1373423-53-0(free base), Concentration 1125 mM, Molecular Weight 453.96, Target:Histone demethylases, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3/UTX with IC50 of 60 nM. |
| (+)-Bicuculline, 485-49-4, Concentration 1126 mM, Molecular Weight 367.35, Target:GABA Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM. |
| NMDA (N-Methyl-D-aspartic acid), 6384-92-5, Concentration 1127 mM, Molecular Weight 147.13, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of L-glutamate. |
| Cilengitide (EMD 121974, NSC 707544), 188968-51-6, Concentration 1128 mM, Molecular Weight 588.66, Target:Integrin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively. |
| KY02111, 1118807-13-8, Concentration 1129 mM, Molecular Weight 376.86, Target:Wnt/beta-catenin, HPLC 99%, NMR, LCMS is ok, stock more than 5g. KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling. |
| (−)-Blebbistatin, 856925-71-8, Concentration 1130 mM, Molecular Weight 292.33, Target:ATPase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases with IC50 from 0.5-5 μM. |
| Zebularine, 3690-10-6, Concentration 1131 mM, Molecular Weight 228.2, Target:DNA Methyltransferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Zebularine is an inhibitor of cytidine deaminase and also inhibit DNA methylation. |
| AMG-517, 659730-32-2, Concentration 1132 mM, Molecular Weight 430.4, Target:TRPV, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AMG 517 is a potent and selective transient receptor potential vanilloid-1 (TRPV1) antagonist with IC50 of <10 nM. |
| Tenovin-1, 380315-80-0, Concentration 1133 mM, Molecular Weight 369.48, Target:E3 Ligase , HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tenovin-1 protects against MDM2-mediated p53 degradation, which invloves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. |
| Rocilinostat (ACY-1215), 1316214-52-4, Concentration 1134 mM, Molecular Weight 433.5, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM. |
| GSK2636771, 1372540-25-4, Concentration 1135 mM, Molecular Weight 433.42, Target:PI3K, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor. |
| PQ 401, 196868-63-0, Concentration 1136 mM, Molecular Weight 341.79, Target:IGF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PQ 401 is an IGF-1R inhibitor with IC50 of <1 μM. |
| ZM 39923 HCl, 1021868-92-7, Concentration 1137 mM, Molecular Weight 367.91, Target:JAK, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ZM39923 is an JAK inhibitor for JAK1, JAK3, EFGR and TGM2 with IC50 of 4.4 μM, 7.1 μM, 5.6 μM and 10 nM, respectively. |
| SMI-4a, 438190-29-5, Concentration 1138 mM, Molecular Weight 273.23, Target:Pim, HPLC 99%, NMR, LCMS is ok, stock more than 5g. SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM. |
| BIX01294, 1392399-03-9, Concentration 1139 mM, Molecular Weight 600.02, Target:Histone Methyltransferase, HPLC 99%, NMR, LCMS is ok, stock more than 5g. BIX01294 is an inhitor of G9a histone methyltransferase with IC50 of 2.7 μM. |
| VE-821, 1232410-49-9, Concentration 1140 mM, Molecular Weight 368.41, Target:ATM/ATR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively. |
| AG 18 (Tyrphostin 23), 118409-57-7, Concentration 1141 mM, Molecular Weight 186.17, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AG 18 inhibits EGFR with IC50 of 35 μM. |
| PRX-08066, 866206-55-5, Concentration 1142 mM, Molecular Weight 517.96, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. PRX-08066 is a selective 5-HT2B antagonist with IC50 of 3.4 nM. |
| Otenabant (CP-945598) HCl , 686347-12-6, Concentration 1143 mM, Molecular Weight 546.88, Target:Cannabinoid Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CP-945598 HCl is a potent and selective cannabinoid type 1 receptor antagonist with Ki of 0.7 nM. |
| GW9508, 885101-89-3, Concentration 1144 mM, Molecular Weight 347.41, Target:GPR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32. |
| CEP-32496, 1188910-76-0, Concentration 1145 mM, Molecular Weight 517.46, Target:CSF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. CEP-32496 is a RAF inhibitor for BRAF(V600E), BRAF(WT), c-Raf, Abl-1 and CSF-1R with IC50 of 14 nM, 36 nM, 39 nM, 3 nM and 9 nM, respectively. |
| TAK-438, 1260141-27-2, Concentration 1146 mM, Molecular Weight 461.46, Target:Potassium Channel, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TAK-438 is a novel potassium-competitive acid blocker (P-CAB) type antisecretory agent that reversibly inhibits gastric H+, K+-ATPase with IC50 of 19 nM at pH 6.5. |
| AZD5363, 1143532-39-1, Concentration 1147 mM, Molecular Weight 428.92, Target:Akt, HPLC 99%, NMR, LCMS is ok, stock more than 5g. AZD5363 is a potent Akt inhibitor for Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively. |
| GW0742, 317318-84-6, Concentration 1148 mM, Molecular Weight 471.49, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW0742 is a potent and highly selective PPARβ/δ agonist, binding to hPPARδ with IC50 of 1 nM. |
| Vortioxetine (Lu AA21004) hydrobromide, 960203-27-4, Concentration 1149 mM, Molecular Weight 379.36, Target:5-HT Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Lu-AA21004 is an oral multimodal serotonergic agent, inhibits 5-HT(1A), 5-HT(1B), 5-HT(3A), 5-HT(7) and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. |
| Empagliflozin (BI10773), 864070-44-0, Concentration 1150 mM, Molecular Weight 450.91, Target:SGLT, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Empagliflozin (BI-10773) is a potent and selective SGLT2 inhibitor with IC50 of 3.1 nM. |
| TCS 359, 301305-73-7, Concentration 1151 mM, Molecular Weight 360.43, Target:FLT3, HPLC 99%, NMR, LCMS is ok, stock more than 5g. TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM. |
| Tyrphostin AG 1296 (AG 1296), 146535-11-7, Concentration 1152 mM, Molecular Weight 266.29, Target:c-Kit, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tyrphostin AG 1296 (AG 1296) is an inhibitor of PDGFR, FGFR and c-Kit with IC50 of < 1 μM, 12.3 μM and 1.8 μM, respectively. |
| GSK3787, 188591-46-0, Concentration 1153 mM, Molecular Weight 392.78, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GSK3787 is as a potent and selective antagonist of PPARδ with pIC50 of 6.6. |
| Tariquidar, 206873-63-4, Concentration 1154 mM, Molecular Weight 646.73, Target:P-gp, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM. |
| WY 14643 (Pirinixic Acid), 50892-23-4, Concentration 1155 mM, Molecular Weight 323.8, Target:PPAR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with ED50 of 1.5 μM. |
| Plerixafor (AMD3100), 110078-46-1, Concentration 1156 mM, Molecular Weight 502.78, Target:CXCR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| NSC 23766, 1177865-17-6, Concentration 1157 mM, Molecular Weight 530.96, Target:Rac, HPLC 99%, NMR, LCMS is ok, stock more than 5g. NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of about 50 μM. |
| PRT062607 (P505-15, PRT2607, BIIB057) HCl, 1370261-97-4,1370261-96-3(free base), Concentration 1158 mM, Molecular Weight 429.91, Target:Syk, HPLC 99%, NMR, LCMS is ok, stock more than 5g. |
| Apremilast (CC-10004), 608141-41-9, Concentration 1159 mM, Molecular Weight 460.5, Target:PDE, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Apremilast (CC-10004) is a potent PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively. |
| VU 0364439, 1246086-78-1, Concentration 1160 mM, Molecular Weight 422.29, Target:GluR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. |
| Butein, 487-52-5, Concentration 1161 mM, Molecular Weight 272.25, Target:EGFR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Butein, a plant polyphenol isolated from <i>Rhus verniciflua</i>, inhibits EGFR tyrosine phosphorylation with IC50 of 8 μM. |
| Necrostatin-1, 4311-88-0, Concentration 1162 mM, Molecular Weight 259.33, Target:TNF-alpha, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
| UPF 1069, 1048371-03-4, Concentration 1163 mM, Molecular Weight 279.29, Target:PARP, HPLC 99%, NMR, LCMS is ok, stock more than 5g. UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. |
| GDC-0349, 1207360-89-1, Concentration 1164 mM, Molecular Weight 452.55, Target:mTOR, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GDC-0349, is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM. |
| GW2580, 870483-87-7, Concentration 1165 mM, Molecular Weight 366.41, Target:CSF-1R, HPLC 99%, NMR, LCMS is ok, stock more than 5g. GW2580 is a selective inhibitor of human c-FMS with IC50 of 30 nM. |
| Scriptaid , 287383-59-9, Concentration 1166 mM, Molecular Weight 326.35, Target:HDAC, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Scriptaid is an inhibitor of histone deacetylase. |
| ABT-199 (GDC-0199 ), 1257044-40-8, Concentration 1167 mM, Molecular Weight 868.44, Target:Bcl-2, HPLC 99%, NMR, LCMS is ok, stock more than 5g. ABT-199 is a Bcl-2-selective inhibitor with Ki of < 0.010 nM. |
| Macitentan, 441798-33-0, Concentration 1168 mM, Molecular Weight 588.27, Target:Endothelin Receptor, HPLC 99%, NMR, LCMS is ok, stock more than 5g. Macitentana (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM. |
