Biggest Manufacturer Glecaprevir (ABT-493), 1365970-03-1 and Intermediates.
Glecaprevir (ABT-493), 1365970-03-1, hplc 98.5%, stock 10kg. NMR, HPLC 99%, LCMS is ok.We are China biggest supplier.
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Glecaprevir Intermediates 1365970-48-4, hplc 98.5%, stock 100g. NMR, HPLC, LCMS is ok.
Product name: (3 3 R,3 5 S,9 1 R,9 2 R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7-dioxo-2,8,10 - trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-3 5 -carboxyl ic acid purity:98% CAS number : 1365970-48-4
Glecaprevir Intermediates 1365970-47-3, hplc 98.5%, stock 100g. NMR, HPLC, LCMS is ok.
Product name: methyl(3 3 R,3 5 S,9 1 R,9 2 R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7- dioxo -2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-3 5 -carboxylae purity:98% CAS number : 1365970-47-3
Glecaprevir Intermediates 1360828-80-3, hplc 98.5%, stock 100g. NMR, HPLC, LCMS is ok.
Product name:(1R,2R)-1-amino-2-(difluoromethyl)-N-((1-methylcyclopropyl)sulfonyl)cyclopropane-1-carboxamide hydrochloride purity:98% CAS number :1360828-80-3
Glecaprevir Intermediates 1294512-27-8, hplc 98.5%, stock 100g. NMR, HPLC, LCMS is ok.
Product name: 2-chloro-3-(1,1-difluoroallyl)quinoxaline purity:98% CAS number : 1294512-27-8
Glecaprevir Intermediates 1365970-45-1, hplc 98.5%, stock 100g. NMR, HPLC, LCMS is ok.
Product name:(S)-2-(((((1R,2R)-2-(allyloxy)cyclopentyl)oxy)carbonyl)amino)-3,3-dimethylbutanoic acid purity:98% CAS number : 1365970-45-1
Name: Glecaprevir
CAS#: 1365970-03-1
Chemical Formula: C38H46F4N6O9S
Exact Mass: 838.2983
Molecular Weight: 838.87
Elemental Analysis: C, 54.41; H, 5.53; F, 9.06; N, 10.02; O, 17.16; S, 3.82
Synonym: ABT-493; A-1282576; ABT493; A1282576; ABT 493; A 1282576
IUPAC/Chemical Name: (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxamide
InChi Key: MLSQGNCUYAMAHD-ITNVBOSISA-N
InChi Code: InChI=1S/C38H46F4N6O9S/c1-35(2,3)28-32(50)48-19-20(17-24(48)30(49)46-37(18-21(37)29(39)40)33(51)47-58(53,54)36(4)14-15-36)56-31-27(43-22-9-5-6-10-23(22)44-31)38(41,42)13-8-16-55-25-11-7-12-26(25)57-34(52)45-28/h5-6,8-10,13,20-21,24-26,28-29H,7,11-12,14-19H2,1-4H3,(H,45,52)(H,46,49)(H,47,51)/b13-8+/t20-,21+,24+,25-,26-,28-,37-/m1/s1
SMILES Code: O=C([C@H]1N(C2)C([C@H](C(C)(C)C)NC(O[C@@](CCC3)([H])[C@]3([H])OC/C=C/C(F)(F)C4=NC5=CC=CC=C5N=C4O[C@]2([H])C1)=O)=O)N[C@@]6(C(NS(=O)(C7(C)CC7)=O)=O)[C@H](C(F)F)C6
TECHNICAL DATA
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Poordad F, Felizarta F, Asatryan A, Sulkowski MS, Reindollar RW, Landis CS, Gordon SC, Flamm SL, Fried MW, Bernstein DE, Lin CW, Liu R, Lovell SS, Ng TI, Kort J, Mensa FJ. Glecaprevir and Pibrentasvir for 12 Weeks for HCV Genotype 1 Infection and Prior Direct-acting Antiviral Treatment. Hepatology. 2017 Jan 27. doi: 10.1002/hep.29081. [Epub ahead of print] PubMed PMID: 28128852.
2: Gane E, Poordad F, Wang S, Asatryan A, Kwo PY, Lalezari J, Wyles DL, Hassanein T, Aguilar H, Maliakkal B, Liu R, Lin CW, Ng TI, Kort J, Mensa FJ. High Efficacy of ABT-493 and ABT-530 Treatment in Patients With HCV Genotype 1 or 3 Infection and Compensated Cirrhosis. Gastroenterology. 2016 Oct;151(4):651-659.e1. doi: 10.1053/j.gastro.2016.07.020. PubMed PMID: 27456384.
3: Lim SG. HCV management in resource-constrained countries. Hepatol Int. 2017 Feb 21. doi: 10.1007/s12072-017-9787-0. [Epub ahead of print] Review. PubMed PMID: 28224352.
