EOS Med Chem have fully-featured organizational structure, main orientation and advanced product structural design.
Product mainly involves in antiviral, cardiovascular, antidiabetic, deprementia and immune system, that more than 100 advanced intermediates of 30 projects of 5 major categories include Fostemsavir, Bictegravir, Filgotinib, Voxilaprevir, Grazoprevir, Sofosbuvir, Tenofovir, Velpatasvir, Ledipasvir, Dolutegravir, Daclatasvir, Darunavir, Atazanavir, Ertugliflozin, Sacubitril etc.
2017 China CPHI:
E1M35
EOS Med Chem, Medchem is
Big
執大象，天下往，往而無害，安平泰
労働時間: Beijing Time
4:00AM~11:00PM
辦公室: 0086-531-69905422-806(直通)
攜帶番號
& WhatsApp: +8618653174435
住所: Diaozhen Chemical Industrial
Park, Jinan City, China
Skype: willgutian
Fostemsavir intermediates
methyl 2-(7-bromo-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate 954215-11-3, Stock 20kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
1-(4-benzoylpiperazin-1-yl)-2-(7-bromo-4-methoxy-1
H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione 1449413-23-3， Stock 20kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
1-Benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazo
l-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]pipera zine 701213-36-7， Stock 25kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Di-tert-butyl chloromethylphosphonate 177348-28-6， Stock 200kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Bictegravir intermediates
(1R,3S)-3-Aminocyclopentanol 1110772-05-8， Stock 15kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
2,4,6-Trifluorobenzylamine 214759-21-4， Stock 150kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a
-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b
][1,3]oxazepine-10-carboxylic acid 1616342-45-0， Stock 18kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(2R,5S,13aR)-8-methoxy-7,9-dioxo-N-(2,4,6-trifluoro
benzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyri
do[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxa mide 1616340-94-3， Stock 15kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1S,3R)-3-AMinocyclopentanol hydrochloride 1259436-59-3， Stock 105kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1R,3S)-3-AMinocyclopentanol hydrochloride 1279032-31-3， Stock 152kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Product NaMe: (1R,3R)-3-aMinocyclopentan-1-ol hydrochloride 946826-74-0， Stock 150kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1S,3S)-3-Aminocyclopentanol 946593-67-5， Stock 525kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Dolutegravir intermediates
(3R)-3-Amino-1-butanol 61477-40-5， Stock 15kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
2,4-Difluorobenzylamine 72235-52-0， Stock 13kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarb oxylate 1357289-08-7， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Methyl
3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,
2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate 1229006-21-6， Stock 25kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(4R,12aS)-7-(benzyloxy)-4-methyl-6,8-dioxo-3,4,6,8,1,3]oxazine-9-carboxylic acid
2,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1 1339879-91-2， Stock 28kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy) 1206102-11-5， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Voxilaprevir intermediates
(S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid 1026200-27-0， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
3-chloro-2-(1,1-difluoroallyl)-6-methoxyquinoxaline 1535210-94-6， Stock 15kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
di-tert-butyl
(2S,3S,4R)-4-((3-(1,1-difluoroallyl)-7-methoxyquinox
alin-2-yl)oxy)-3-ethylpyrrolidine-1,2-dicarboxylate 1535213-67-2， Stock 26kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
tert-butyl
(33R,34S,35S,91R,92R,5S,E)-5-(tert-butyl)-34-ethyl-14,
14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2
,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropana
cyclotetradecaphan-12-ene-35-carboxylate 1535212-03-3， Stock 18kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
tert-butyl
(33R,34S,35S,91R,92R,5S)-5-(tert-butyl)-34-ethyl-14,14
-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)
-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacy
clotetradecaphane-35-carboxylate 1535212-05-5， Stock 33kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(33R,34S,35S,91R,92R,5S,E)-5-(tert-butyl)-34-ethyl-14,
14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2
,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylic acid 1535212-06-6， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1R,2R)-1-Amino-2-(difluoromethyl)-N-[(1-methylcyc
lopropyl)sulfonyl]cyclopropanecarboxamidehydrochloride (1:1) 1360828-80-3， Stock 9kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Grazoprevir intermediates
(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcycl
opropane-1-carboxamide 4-toulenesulfonate 1028252-16-5， Stock 51kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(S)-3,3-Dimethyl-2-((((1R,2R)-2-(pent-4-yn-1-yl)cyclo
propoxy)carbonyl)amino)butyric acid tert-butylaminesalt 1425038-21-6， Stock 45kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(4R)-4-[(3-Chloro-7-methoxy-2-quinoxalinyl)oxy]-L-p
roline methyl ester methanesulfonate 1425038-20-5， Stock 55kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1aR,5S,8S,10R,22aR)-18,19-Didehydro-5-(1,1-dimet
hylethyl)-1,1a,3,4,5,6,9,10,20,21,22,22a-dodecahydro-
14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[1
8,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]qui
noxaline-8-carboxylic acid methyl ester 1425038-23-8， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,
5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methox
y-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid methyl ester 1206524-84-6， Stock 15kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Velpatasvir intermediates
(2s,4s)-4-(methoxymethyl)-1,2-pyrrolidinedicarboxylic
acid 1-(1,1-dimethylethyl) ester 1378388-16-9， Stock 6kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(5s)-n-(methoxycarbonyl)-l-valyl-5-methyl-l-proline 1335316-40-9， Stock 8kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
9-Bromo-3-(2-bromoacetyl)-10,11-dihydro-5H-benzo[
d]naphtho[2,3-b]pyran-8(9H)-one 1438383-89-1， Stock 22kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(2s,4s)-2-(5-(1,11-dihydro-2-((2s,5s)-1-((2s)-2-((metho
xycarbonyl)amino)-3-methyl-1-oxobutyl)-5-methyl-2-p
yrrolidinyl)(2)benzopyrano(4',3':6,7)naphth(1,2-d)imid
azol-9-yl)-1h-imidazol-2-yl)-4-(methoxymethyl)-1-pyr
rolidinecarboxylic acid 1,1-dimethylethyl ester 1378391-45-7， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Daclatasvir intermediates
(2s,2's)-2,2'-((1,1'-biphenyl)-4,4'-diyldi-1h-imidazole-5
,2-diyl)bis-1-pyrrolidinecarboxylic acid 1,1'-bis(1,1-dimethylethyl) ester 1007882-23-6， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
5,5'-(1,1'-biphenyl)-4,4'-diylbis(2-(2s)-2-pyrrolidinyl-1
h-imidazole) hydrochloride (1:4) 1009119-83-8， Stock 251kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
tert-butyl(S)-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-
yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate 1007882-12-3， Stock 5kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Ledipasvir intermediates
(1R,3S,4S)-N-(Tert-butoxycarbonyl)-2-azabicyclo-[2.2
.1]-heptane-3-carboxylic acid 291775-59-2， Stock 26kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1R,3S,4S)-3-(6-Bromo-1H-benzimidazol-2-yl)-2-azab
icyclo[2.2.1]heptane-2-carboxylic acid
1,1-dimethylethyl este 1256387-74-2， Stock 6kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1R,3S,4S)-2-tert-butyl-3-(6-(4,4,5,5-tetraMethyl-1,3,2
-dioxaborolan-2-yl)-1H-benzo[D]imidazol-2-yl)-2-aza
bicyclo[2.2.1]heptane-2-carboxylate 1256387-87-7， Stock 36kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(6S)-5-(Tert-butoxycarbonyl)-5-azaspiro-[2.4]-heptane
-6-carboxylic acid 1129634-44-1， Stock 8kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(6S)-tert-butyl-6-(5-(7-bromo-9,9-difluoro-9H-fluoren-
2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptane-5-carboxylateoxylate 1441670-89-8， Stock 7kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(6s)-5-azaspiro(2.4)heptane-5,6-dicarboxylic acid
5-(1,1-dimethylethyl) ester potassium salt (1:1) 1441673-92-2， Stock 55kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
1-(7-bromo-9,9-difluoro-9h-fluoren-2-yl)-2-chloroetha
none 1378387-81-5， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(1r,3s,4s)-3-(6-(9,9-difluoro-7-(2-((6s)-5-((2s)-2-((met
hoxycarbonyl)amino)-3-methyl-1-oxobutyl)-5-azaspiro
(2.4)hept-6-yl)-1h-imidazol-5-yl)-9h-fluoren-2-yl)-1hbenzimidazol-
2-yl)-2-azabicyclo(2.2.1)heptane-2-carbo
xylic acid 1,1-dimethylethyl ester 1256393-27-7， Stock 8kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
2017 China CPHI:
E1M35
EOS Med Chem, Medchem is
Big
執大象，天下往，往而無害，安平泰
労働時間: Beijing Time
4:00AM~11:00PM
辦公室: 0086-531-69905422-806(直通)
攜帶番號
& WhatsApp: +8618653174435
住所: Diaozhen Chemical Industrial
Park, Jinan City, China
Skype: willgutian
Sofosbuvir intermediates
(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic
acid gamma-lacton e 3,5-dibenzoate 874638-80-9
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine 863329-66-2
(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine3',5'-dibenzoate 817204-32-3
N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphi
nyl]-L-alanine 1-methylethyl ester 1334513-02-8
Darunavir intermediates
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol 156928-09-5， Stock 11kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane 98737-29-2， Stock 7kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
tert-Butyl
[(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophen
yl)sulfonyl]amino]propyl]carbamate 191226-98-9， Stock 8kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
tert-butyl
((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-
3-hydroxy-1-phenylbutan-2-yl)carbamate 183004-94-6， Stock 9kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Atazanavir intermediates
tert-Butyl
2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate 198904-85-7， Stock 11kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
(2R,3S)-3-(tert-Butoxycarbonyl)amino-1,2-epoxy-4-ph
enylbutane 98760-08-8， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2
-hydroxy-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]me
thyl]hydrazinecarboxylic acid tert-butyl ester 198904-86-8， Stock 12kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Tenofovir and TAF intermediates
Chloromethyl isopropyl carbonate(CMIC) 35180-01-9， Stock 36kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
Diethyl [[[(4-tolyl)sulfonyl]oxy]methyl]phosphonate（DESMP） 31618-90-3， Stock 35kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid（PMPA) 147127-20-6， Stock 22kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]met
hyl]-, monophenylester 379270-35-6， Stock 21kg, HPLC 99%, NMR, LCMS, COA, MSDS, MOA is ok.
2017 China CPHI:
E1M35
EOS Med Chem, Medchem is
Big
執大象，天下往，往而無害，安平泰
労働時間: Beijing Time
4:00AM~11:00PM
辦公室: 0086-531-69905422-806(直通)
攜帶番號
& WhatsApp: +8618653174435
住所: Diaozhen Chemical Industrial
Park, Jinan City, China
Skype: willgutian
