Small molecule inhibitors of Clinical:
Acalabrutinib (ACP-196);CAS#1420477-60-6
ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Alofanib;RPT835;CAS#1612888-66-0
Alofanib, also known as RPT835, is a potent and selective allosteric inhibitor of FGFR2 with potential anticancer activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Altiratinib (DCC-2701);CAS#1345847-93-9, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Altiratinib (DCC-2701) is a potent inhibitor of c-MET/TIE-2/VEGFR with IC50 values of 2.7, 8.0 and 9.2 nM, respectively, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Amcasertib;CAS#1129403-56-0
Amcasertib is a potent and selective CSCPK inhibitor with potential anticancer activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Apalutamide (ARN-509) ;CAS#: 956104-40-8
Apalutamide, also known as ARN-509 and JNJ-56021927 , is an androgen receptor antagonist with potential antineoplastic activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Belizatinib;TSR011;CAS#1357920-84-3
Belizatinib, also known as TSR-011, is an orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential antineoplastic activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Bexagliflozin;CAS#1118567-05-7, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Bictegravir;GS 9883;CAS#1611493-60-7, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Brigatinib (AP26113);CAS#1197953-54-0, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Brigatinib, also known as AP-26113, is an orally active, potent and selective Dual ALK/EGFR inhibitor. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms。
Capsaicin;CAS#404-86-4, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Cenerimod;ACT-334441;CAS#1262414-04-9, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Cenerimod is a potent and orally active immunomodulator, exhibited EC50 value of 2.7 nM. Cenerimod is an agonist for the G protein-coupled receptor S1 P1/EDG1 and has a powerful and long-lasting immunomodulating effect which is achieved by reducing the number of circulating and infiltrating T- and B-lymphocytes, without affecting their maturation, memory, or expansion。
Cenobamate;YKP-3089;CAS#913088-80-9, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Cenobamate, also known as YKP-3089, is a novel new antiepileptic drug candidate, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Daprodustat;GSK1278863;CAS#960539-70-2
Daprodustat, also known as GSK1278863, is a novel HIF-prolyl hydroxylase inhibitor. Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD) inhibitors may improve ischemic conditions such as peripheral artery disease (PAD), HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Enasidenib;AG-221;CC-90007;CAS#1446502-11-9
Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2), HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Enerisant;CAS#1152747-82-4
Enerisant is a histamine H3 receptor antagonist. In H3 receptor binding assay using (R)-α-methyl[3H]histamine, Enerisant showed IC50 of 4.9 nM. Enerisant may be useful for the treatment of Alzheimer's disease, schizophrenia, etc, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Entrectinib;RXDX-101;NMS-E628;CAS#1108743-60-7
Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Erdafitinib;JNJ-42756493;CAS#1346242-81-6
Erdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Etripamil;MSP-2017;CAS#1593673-23-4
Etripamil is a calcium channel blocker. Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium (Ca2+) through calcium channels, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Evenamide;NW-3509;CAS#1092977-61-1
Evenamide is a sodium and/or calcium channel modulator. Evenamide may be potentia useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurol., cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathol. Role, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Evocalcet;MT-4580;CAS#870964-67-3
Evocalcet is a calcium-sensing receptor agonist. The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Ezutromid;BMN195;SMTC-1100;CAS#945531-77-1
Ezutromid,also known as BMN-195 and SMTC-1100, is a first orally bioavailable utrophin's translation modulator, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Fosnetupitant;CAS#1703748-89-3
Fosnetupitant is a neurokinin receptor antagonist. Neurokinin 1 (NK1) receptor antagonists (RAs) are a class of drug used to treat nausea and vomiting associated with chemotherapy. Aprepitant, casopitant, and fosaprepitant are NK1 drugs, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Merestinib (LY2801653);CAS#1206799-15-6
Merestinib, also known as LY2801653, is a n orally available, small molecule inhibitor of the proto-oncogene c-Met (mesenchymal-epithelial transition, also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Nastorazepide (Z-360);CAS#209219-38-5
Nastorazepide, also known as Z-360, is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Neladenoson bialanate;CAS#1239309-58-0, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Netarsudil;AR-11324;CAS#1254032-66-0
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Pemafibrate;K-877;CAS#848259-27-8
Pemafibrate, also known as K-877 and (R)-K 13675, is a PPAR alpha agonist. (R)-K-13675 decreases the secretion of inflammatory markers without affecting cell proliferation or tube formation, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Sacubitrilat (LBQ-657);CAS#149709-44-4
Sacubitrilat, also known as LBQ-657, is endopeptidase inhibitor. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Selonsertib (GS-4997) CAS#1448428-04-3(free base); 1448428-05-4(HCl salt)
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Sparsentan (RE-021);CAS#254740-64-2
Sparsentan, also known as RE-021, BMS346567, PS433540 and DARA-a, is a Dual angiotensin II and endothelin A receptor antagonist, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Tucatinib(ARRY380);CAS#937263-43-9
Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Vesatolimod;GS-9620;CAS#1228585-88-3
Vesatolimod, also known as GS-9620, is a potent and oral agonist of Toll-like receptor-7 developed for finite treatment of chronic hepatitis B viral (HBV) infection, with the goal of inducing a liver-targeted antiviral effect without inducing the adverse effects associated with current systemic interferon-α (IFN-α) therapies, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
Vistusertib;AZD-2014;CAS#1009298-59-2
Vistusertib, also known as AZD2014, is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity, HPLC 99%, NMR, LCMS is ok, stock more than 10g.
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