Rucaparib world biggest manufacturer
All from GMP plant, Document is full, COA, NMR, MSDS, HPLC, LCMS, MOA, ROS all we could supply, we keep more than 10kg in stock.
Below is Intermediates we could supply:
Rucaparib Intermediate:2913-97-5,N-(2-Oxoethyl)phthalimide, assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock
Rucaparib Intermediate: 5-Fluoro-2-methyl-3-nitrobenzoic acid methyl, 697739-03-0 assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib Intermediate: 6-Fluoro-1H-indole-4-carboxylic acid methyl ester, 1082040-43-4 assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib Intermediate: 3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester, 1408282-25-6 assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib Intermediate: 8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one, 1408282-26-7 assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib Intermediate: 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one, 283173-80-8 assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib Intermediate: 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldeyde, 283173-84-2 assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib Intermediate: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6h-pyrrolo[4,3,2-ef][2]benzazepin-6-one hydrochloride, 773059-19-1 assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib Intermediate: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one, 283173-50-2 , assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib CAS #: 283173-50-2 (free base) , assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Rucaparib CAS #: 459868-92-9 (phosphate) , assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
1859053-21-6 (Rucaparib camsylate) , assay 99.2% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok. We keep more than 5kg in stock.
Related CAS #: 283173-50-2 (free base) 459868-92-9 (phosphate) 1859053-21-6 (Rucaparib camsylate)
Rucaparib is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis.
2017 China CPHI: E1M35
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
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住所: Diaozhen Chemical Industrial Park, Jinan City, China
Skype: willgutian
QQ: 2393923585
Name: Rucaparib free base
CAS#: 283173-50-2 (free base)
Chemical Formula: C19H18FN3O
Exact Mass: 323.1434
Molecular Weight: 323.3714
Elemental Analysis: C, 70.57; H, 5.61; F, 5.88; N, 12.99; O, 4.95
Synonym: Rucaparib free base, AG-14447; AG 14447; AG14447; Rubraca.
IUPAC/Chemical Name: 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one
InChi Key: HMABYWSNWIZPAG-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
SMILES Code: O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=C2C1=CC(F)=C4
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8: Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, Sun J, Konecny GE, Coleman RL, Tinker AV, O'Malley DM, Kristeleit RS, Ma L, Bell-McGuinn KM, Brenton JD, Cragun JM, Oaknin A, Ray-Coquard I, Harrell MI, Mann E, Kaufmann SH, Floquet A, Leary A, Harding TC, Goble S, Maloney L, Isaacson J, Allen AR, Rolfe L, Yelensky R, Raponi M, McNeish IA. Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial. Lancet Oncol. 2017 Jan;18(1):75-87. doi: 10.1016/S1470-2045(16)30559-9. PubMed PMID: 27908594.
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10: Wang DD, Li C, Sun W, Zhang S, Shalinsky DR, Kern KA, Curtin NJ, Sam WJ, Kirkpatrick TR, Plummer R. PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib. Clin Pharmacol Drug Dev. 2015 Mar;4(2):89-98. doi: 10.1002/cpdd.176. PubMed PMID: 27128213.
11: Murai J, Huang SY, Renaud A, Zhang Y, Ji J, Takeda S, Morris J, Teicher B, Doroshow JH, Pommier Y. Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther. 2014 Feb;13(2):433-43. doi: 10.1158/1535-7163.MCT-13-0803. PubMed PMID: 24356813; PubMed Central PMCID: PMC3946062.
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