UK 5099 CAS No. 56396-35-1 ,300g in stock
UK 5099 CAS No. 56396-35-1 COA, MSDS, HPLC MORE THAN 98%, NMR, MS is ok, stock more than 300g.
UK-5099 56396-35-1 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 ihibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.
The trypanosomal pyruvate carrier is found to be rather insensitive to inhibition by alpha-cyano-4-hydroxycinnamate (Ki=17 mM) but can be completely blocked by UK-5099 (Ki=49 microM)[2]. UK-5099 also inhibits the monocarboxylate transporter (MCT) [3]. UK5099 significantly inhibits the glucose-stimulated rise in oxygen consumption in a dose-dependent manner and at 150 μM reduced oxygen consumption below basal levels. UK5099 reduces ATP levels and increases ADP and AMP levels in 832/13 cells[4]. The UK5099 treated cells show significantly higher proportion of side population fraction and express higher levels of stemness markers Oct3/4 and Nanog. UK5099 application may be an ideal model for Warburg effect studies[5].
UK 5099 Intermediates, we have:
UK 5099 Intermediates: 32542-59-9, 1-phenyl-1H-indole-3-carbaldehyde
UK 5099 Intermediates: (E)-ethyl 2-cyano-3-(1-phenyl-1H-indol-3-yl)acrylate
UK 5099 Intermediates: 56396-35-1, (E)-2-cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid
2017 China CPHI: E1M35
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