Ruxolitinib phosphate(1092939-17-7), HPLC99%, NMR, LCMS, COA ROS is ok, stock more than 1kg.
World biggest GMP manu, first time open synthesis route.
Name: Ruxolitinib phosphate
CAS: 1092939-17-7 (phosphate)
Chemical Formula: C17H21N6O4P
Exact Mass: 404.13619
Molecular Weight: 404.37
Ruxolitinib free base, 941678-49-5 (free base), HPLC99%, NMR, LCMS, COA ROS is ok, stock more than 1kg.
Name: Ruxolitinib free base
CAS: 941678-49-5 (free base)
Chemical Formula: C17H18N6
Exact Mass: 306.15929
Molecular Weight: 306.37
Elemental Analysis: C, 66.65; H, 5.92; N, 27.43
Ruxolitinib intermediate,1236033-04-7, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,1146629-84-6, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,1153949-38-2, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,941685-27-4, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,941685-26-3, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,16372-08-0, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,479633-63-1, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,591769-05-0, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
Ruxolitinib intermediate,3680-69-1, HPLC99%, NMR, LCMS, COA is ok, stock more than 1KG.
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REFERENCES
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2: Molica M, Serrao A, Saracino R, Zacheo I, Stingone C, Alimena G, Breccia M. Disappearance of fibrosis in secondary myelofibrosis after ruxolitinib treatment: new endpoint to achieve? Ann Hematol. 2014 Nov;93(11):1951-2. doi: 10.1007/s00277-014-2096-y. Epub 2014 May 7. Review. PubMed PMID: 24801017.
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4: Swaim SJ. Ruxolitinib for the treatment of primary myelofibrosis. Am J Health Syst Pharm. 2014 Mar 15;71(6):453-62. doi: 10.2146/ajhp120602. Review. PubMed PMID: 24589536.
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8: Wade R, Rose M, Neilson AR, Stirk L, Rodriguez-Lopez R, Bowen D, Craig D, Woolacott N. Ruxolitinib for the treatment of myelofibrosis: a NICE single technology appraisal. Pharmacoeconomics. 2013 Oct;31(10):841-52. doi: 10.1007/s40273-013-0083-0. Review. PubMed PMID: 23996108.
9: Lemal R, Robin M, Ravinet A, Cacheux V, Guièze R, Bay JO. [Ruxolitinib prescription in myelofibrosis]. Bull Cancer. 2013 Sep;100(9):897-902. doi: 10.1684/bdc.2013.1792. Review. French. PubMed PMID: 23985569.
10: Kremyanskaya M, Atallah EL, Hoffman R, Mascarenhas JO. Clarifying the use of ruxolitinib in patients with myelofibrosis. Oncology (Williston Park). 2013 Jul;27(7):706-14. Review. Erratum in: Oncology (Williston Park). 2013 Aug;27(8):737. PubMed PMID: 23977767.
11: Mascarenhas J, Hoffman R. A comprehensive review and analysis of the effect of ruxolitinib therapy on the survival of patients with myelofibrosis. Blood. 2013 Jun 13;121(24):4832-7. doi: 10.1182/blood-2013-02-482232. Epub 2013 Apr 9. Review. PubMed PMID: 23570800.
12: Verstovsek S. Ruxolitinib: an oral Janus kinase 1 and Janus kinase 2 inhibitor in the management of myelofibrosis. Postgrad Med. 2013 Jan;125(1):128-35. doi: 10.3810/pgm.2013.01.2628. Review. PubMed PMID: 23391678.
13: Ganetsky A. Ruxolitinib: a new treatment option for myelofibrosis. Pharmacotherapy. 2013 Jan;33(1):84-92. doi: 10.1002/phar.1165. Review. PubMed PMID: 23307549.
14: Vaddi K, Sarlis NJ, Gupta V. Ruxolitinib, an oral JAK1 and JAK2 inhibitor, in myelofibrosis. Expert Opin Pharmacother. 2012 Nov;13(16):2397-407. doi: 10.1517/14656566.2012.732998. Epub 2012 Oct 10. Review. PubMed PMID: 23051187.
15: Mascarenhas J, Mughal TI, Verstovsek S. Biology and clinical management of myeloproliferative neoplasms and development of the JAK inhibitor ruxolitinib. Curr Med Chem. 2012;19(26):4399-413. Review. PubMed PMID: 22830345; PubMed Central PMCID: PMC3480698.
16: Ruxolitinib (Jakafi) for myelofibrosis. Med Lett Drugs Ther. 2012 Apr 2;54(1387):27-8. Review. PubMed PMID: 22469651.
17: Ostojic A, Vrhovac R, Verstovsek S. Ruxolitinib for the treatment of myelofibrosis. Drugs Today (Barc). 2011 Nov;47(11):817-27. doi: 10.1358/dot.2011.47.11.1708829. Review. PubMed PMID: 22146225.
18: Naqvi K, Verstovsek S, Kantarjian H, Ravandi F. A potential role of ruxolitinib in leukemia. Expert Opin Investig Drugs. 2011 Aug;20(8):1159-66. doi: 10.1517/13543784.2011.589383. Epub 2011 Jun 3. Review. PubMed PMID: 21635221; PubMed Central PMCID: PMC4143907
