Bedaquiline, Cas#843663-66-1,HPLC 99.49%, NMR, LCMS, MSDS, COA, MOA all we provided, More than 1kg in stock.
Name: Bedaquiline
CAS#: 843663-66-1 (free base)
Chemical Formula: C32H31BrN2O2
Exact Mass: 554.15689
Molecular Weight: 555.5
Elemental Analysis: C, 69.19; H, 5.62; Br, 14.38; N, 5.04; O, 5.76
COA, pls check:
HPLC, pls check:
HNMR. pls check:
Related CAS #: 843663-66-1 (free base) 845533-86-0 (fumarate)
Synonym: TMC207; TMC-207; TMC 207; R207910; R-207910; R 207910; Bedaquiline; Bedaquiline fumarate; trade name Sirturo,
IUPAC/Chemical Name: (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolyl)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-butan-2-ol
InChi Key: QUIJNHUBAXPXFS-XLJNKUFUSA-N
InChi Code: InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1
SMILES Code: O[C@](CCN(C)C)(C1=C2C=CC=CC2=CC=C1)[C@@H](C3=CC4=CC(Br)=CC=C4N=C3OC)C5=CC=CC=C5
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REFERENCES
1: van Heeswijk RP, Dannemann B, Hoetelmans RM. Bedaquiline: a review of human pharmacokinetics and drug-drug interactions. J Antimicrob Chemother. 2014 May 23. pii: dku171. [Epub ahead of print] Review. PubMed PMID: 24860154.
2: Kakkar AK, Dahiya N. Bedaquiline for the treatment of resistant tuberculosis: Promises and pitfalls. Tuberculosis (Edinb). 2014 Apr 18. pii: S1472-9792(14)20416-1. doi: 10.1016/j.tube.2014.04.001. [Epub ahead of print] Review. PubMed PMID: 24841672.
3: Lakshmanan M, Xavier AS. Bedaquiline - The first ATP synthase inhibitor against multi drug resistant tuberculosis. J Young Pharm. 2013 Dec;5(4):112-115. Epub 2013 Dec 30. Review. PubMed PMID: 24563587; PubMed Central PMCID: PMC3930122.
4: Palomino JC, Martin A. TMC207 becomes bedaquiline, a new anti-TB drug. Future Microbiol. 2013 Sep;8(9):1071-80. doi: 10.2217/fmb.13.85. Review. PubMed PMID: 24020736.
5: Gras J. Bedaquiline for the treatment of pulmonary, multidrug-resistant tuberculosis in adults. Drugs Today (Barc). 2013 Jun;49(6):353-61. doi: 10.1358/dot.2013.49.6.1970865. Review. PubMed PMID: 23807939.
