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1.
Elagolix Sodium （832720-36-2）, HPLC 99%, NMR, LCMS, MSDS, COA, MOA all we provided, More than 100g in stock.
Name: Elagolix sodium
CAS#: 832720-36-2 (sodium)
Chemical Formula: C32H29F5N3NaO5
Molecular Weight: 653.57
Elemental Analysis: C, 60.85; H, 4.79; F, 15.04; N, 6.65; O, 12.67
Related CAS #: 832720-36-2 (sodium)
Synonym: NBI56418 Na; NBI-56418; NBI 56418.
IUPAC/Chemical Name: Sodium (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoate
InChi Key: FLFGNMFWNBOBGE-FNNZEKJRSA-N
InChi Code: InChI=1S/C27H45N3O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(31)35-20-21-24(32)25(33)26(36-21)30-19-18-22(28)29-27(30)34/h9-10,18-19,21,24-26,32-33H,2-8,11-17,20H2,1H3,(H2,28,29,34)/b10-9+/t21-,24-,25+,26-/m1/s1
SMILES Code: O=C([O-])CCCN[C@H](C1=CC=CC=C1)CN(C(N(CC2=C(C(F)(F)F)C=CC=C2F)C(C)=C3C4=CC=CC(OC)=C4F)=O)C3=O.[Na+]
2.
Elagolix Sodium intermediate
Elagolix Sodium intermediate 5（830346-46-8），
Elagolix Sodium intermediate 6（830346-47-9），
Elagolix Sodium intermediate 7-1（1150560-54-5），
Elagolix Sodium intermediate 7-2（830346-48-0），
Elagolix Sodium intermediate 8（1150560-59-0），HPLC 99%, NMR, LCMS, MSDS, COA, MOA all we provided, More than 100g in stock.
REFERENCES
1: Ezzati M, Carr BR. Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain. Womens Health (Lond Engl). 2015 Jan;11(1):19-28. doi: 10.2217/whe.14.68. PubMed PMID: 25581052.
2: Carr B, Dmowski WP, O'Brien C, Jiang P, Burke J, Jimenez R, Garner E, Chwalisz K. Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone acetate for the treatment of endometriosis: effects on bone mineral density. Reprod Sci. 2014 Nov;21(11):1341-51. doi: 10.1177/1933719114549848. Epub 2014 Sep 23. PubMed PMID: 25249568; PubMed Central PMCID: PMC4212335.
3: Diamond MP, Carr B, Dmowski WP, Koltun W, O'Brien C, Jiang P, Burke J, Jimenez R, Garner E, Chwalisz K. Elagolix treatment for endometriosis-associated pain: results from a phase 2, randomized, double-blind, placebo-controlled study. Reprod Sci. 2014 Mar;21(3):363-71. doi: 10.1177/1933719113497292. Epub 2013 Jul 24. PubMed PMID: 23885105.
4: Deal watch: Abbott and Neurocrine to develop promising endometriosis drug. Nat Rev Drug Discov. 2010 Aug;9(8):584. doi: 10.1038/nrd3246. PubMed PMID: 20671753.
5: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Oct;31(8):541-57. PubMed PMID: 19967103.
6: Struthers RS, Nicholls AJ, Grundy J, Chen T, Jimenez R, Yen SS, Bozigian HP. Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix. J Clin Endocrinol Metab. 2009 Feb;94(2):545-51. doi: 10.1210/jc.2008-1695. Epub 2008 Nov 25. PubMed PMID: 19033369; PubMed Central PMCID: PMC2646513.
7: Chen C, Wu D, Guo Z, Xie Q, Reinhart GJ, Madan A, Wen J, Chen T, Huang CQ, Chen M, Chen Y, Tucci FC, Rowbottom M, Pontillo J, Zhu YF, Wade W, Saunders J, Bozigian H, Struthers RS. Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4 -methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem. 2008 Dec 11;51(23):7478-85. doi: 10.1021/jm8006454. PubMed PMID: 19006286.
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