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Niraparib（1038915-60-4 ）, HPLC 99.2%, HNMR, C13-NMR, LCMS, MSDS, COA, MOA all we provided, More than 100g in stock.
Name: Niraparib free base
CAS#: 1038915-60-4 (free base)
Chemical Formula: C19H20N4O
Exact Mass: 320.1637
Molecular Weight: 320.396
Elemental Analysis: C, 71.23; H, 6.29; N, 17.49; O, 4.99
Appearance: Light yellow solid powder
Related CAS: 1038915-60-4 (free base), 1038915-64-8 (HCl), 1038915-73-9 (tosylate), 1613220-15-7 (tosylate hydrate)
Synonym: MK-4827; MK 4827; MK4827; Niraparib. Niraparib free base.
IUPAC/Chemical Name: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
InChi Key: PCHKPVIQAHNQLW-CQSZACIVSA-N
InChi Code: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
SMILES Code: O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N
Niraparib HCL（1038915-64-8 ）, HPLC 99.2%, HNMR, C13-NMR, LCMS, MSDS, COA, MOA all we provided, More than 100g in stock.
Name: Niraparib HCl
CAS#: 1038915-64-8 (HCl)
Chemical Formula: C19H21ClN4O
Exact Mass: 356.1404
Molecular Weight: 356.854
Elemental Analysis: C, 63.95; H, 5.93; Cl, 9.93; N, 15.70; O, 4.48
Appearance: Light yellow solid powder
Niraparib Tosylate（1038915-73-9）, HPLC 99.2%, HNMR, C13-NMR, LCMS, MSDS, COA, MOA all we provided, More than 100g in stock.
Name: Niraparib Tosylate
CAS#: 1038915-73-9 (tosylate)
Chemical Formula: C26H28N4O4S
Exact Mass:
Molecular Weight: 492.59
Elemental Analysis: C, 63.40; H, 5.73; N, 11.37; O, 12.99; S, 6.51
Appearance: Light yellow solid powder
1.
Niraparib Intermeidates: 19733-56-3; 1171197-20-8; 677304-69-7; 1476776-76-7; 138229-59-1
Niraparib intermediate, 4-piperidin-3-ylaniline, CAS NO.:19733-56-3, HPLC 99%, HNMR, LCMS, MSDS, COA, MOA all we provided, More than 10KG in stock.
Niraparib intermediate, (S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate, CAS:1171197-20-8, HPLC 99%, HNMR, LCMS, MSDS, COA, MOA all we provided, More than 10KG in stock.
Niraparib intermediate, 1H-Indazole-7-carboxylic acid, CAS:677304-69-7, HPLC 99%, HNMR, LCMS, MSDS, COA, MOA all we provided, More than 10KG in stock.
Niraparib intermediate, N-tert-butyl-1H-indazole-7-carboxamide, CAS:1476776-76-7, HPLC 99%, HNMR, LCMS, MSDS, COA, MOA all we provided, More than 10KG in stock.
Niraparib intermediate, Methyl 3-formyl-2-nitrobenzoate, CAS: 138229-59-1, HPLC 99%, HNMR, LCMS, MSDS, COA, MOA all we provided, More than 10KG in stock.
TECHNICAL DATA
Appearance: Light yellow solid powder
Purity: >98%
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
REFERENCES
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14: Genther Williams SM, Kuznicki AM, Andrade P, Dolinski BM, Elbi C, O'Hagan RC, Toniatti C. Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status. Cancer Cell Int. 2015 Feb 4;15(1):14. doi: 10.1186/s12935-015-0162-8. eCollection 2015. PubMed PMID: 25685067; PubMed Central PMCID: PMC4326439.
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18: Reinbolt RE, Hays JL. The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies. Front Oncol. 2013 Oct 1;3:237. doi: 10.3389/fonc.2013.00237. Review. PubMed PMID: 24098868; PubMed Central PMCID: PMC3787651.
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