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Avibactam sodium, CAS# 1192491-61-4 (sodium):
HPLC99.2%, LCMS, NMR, ROS, MOA, COA is ok, stock more than 5G.
Name: Avibactam sodium
CAS#: 1192491-61-4 (sodium)
Chemical Formula: C7H10N3NaO6S
Molecular Weight: 287.22
Elemental Analysis: C, 29.27; H, 3.51; N, 14.63; Na, 8.00; O, 33.42; S, 11.16
Related CAS #: 1192491-61-4 (sodium); 1192500-31-4 (free acid)
Synonym: NXL104; Avibactam;
IUPAC/Chemical Name: sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
InChi Key: RTCIKUMODPANKX-JBUOLDKXSA-M
InChi Code: InChI=1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15;/h4-5H,1-3H2,(H2,8,11)(H,13,14,15);/q;+1/p-1/t4-,5+;/m1./s1
SMILES Code: O=C1N(OS(=O)(O[Na])=O)[C@H]2CN1[C@H](C(N)=O)CC2
TECHNICAL DATA
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Safety Data Sheet (MSDS): View Material Safety Data Sheet (MSDS)
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
REFERENCES
1: Krishnan NP, Nguyen NQ, Papp-Wallace KM, Bonomo RA, van den Akker F. Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study. PLoS One. 2015 Sep 4;10(9):e0136813. doi: 10.1371/journal.pone.0136813. eCollection 2015. PubMed PMID: 26340563.
2: Zasowski EJ, Rybak JM, Rybak MJ. The β-Lactams Strike Back: Ceftazidime-Avibactam. Pharmacotherapy. 2015 Aug;35(8):755-70. doi: 10.1002/phar.1622. PubMed PMID: 26289307; PubMed Central PMCID: PMC4545577.
3: Humphries RM, Yang S, Hemarajata P, Ward KW, Hindler JA, Miller SA, Gregson A. First report of ceftazidime-avibactam resistance in a KPC-3 expressing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2015 Jul 20. pii: AAC.01165-15. [Epub ahead of print] PubMed PMID: 26195508.
4: Shields RK, Clancy CJ, Hao B, Chen L, Press EG, Iovine NM, Kreiswirth BN, Nguyen MH. Effects of Klebsiella pneumoniae Carbapenemase Subtypes, Extended-Spectrum β-Lactamases, and Porin Mutations on the In Vitro Activity of Ceftazidime-Avibactam against Carbapenem-Resistant K. pneumoniae. Antimicrob Agents Chemother. 2015 Sep;59(9):5793-7. doi: 10.1128/AAC.00548-15. Epub 2015 Jul 13. PubMed PMID: 26169413.
5: Sillén H, Mitchell R, Sleigh R, Mainwaring G, Catton K, Houghton R, Glendining K. Determination of avibactam and ceftazidime in human plasma samples by LC-MS. Bioanalysis. 2015 Jul;7(12):1423-34. doi: 10.4155/bio.15.76. PubMed PMID: 26168250.
6: Caravaca-Fontán F, Jiménez-Álvaro S, Marcén-Letosa R, Fernández-Rodríguez A, Rodríguez-Navarro CQ. Ceftazidime-avibactam in urinary tract infections due to carbapenemase-producing Klebsiella in kidney transplantation. Nefrologia. 2015 Jul 22. pii: S0211-6995(15)00070-3. doi: 10.1016/j.nefro.2015.01.001. [Epub ahead of print] English, Spanish. PubMed PMID: 26306955.
