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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: ALG1001 is an angiogenesis inhibitors and Integrin alpha 5 beta 1 modulator. ALG1001 targets integrin alpha2beta1, alphaV-beta 3, alphaV-beta 5. ALG1001 is being developed by Allegro Ophthalmics. ALG1001 has been shown to be effective at regressing and inhibiting new blood vessel formation, as well as reducing vascular leakage to maintain and restore vision.
Name: ALG1001
CAS#: 1307293-62-4
Chemical Formula: C22H39N9O11S
Exact Mass: 637.249
Molecular Weight: 637.666
Elemental Analysis: C, 41.44; H, 6.16; N, 19.77; O, 27.60; S, 5.03
Synonym: ALG1001; ALG-1001; ALG 1001; Luminate; H-Gly-Arg-Gly-（L-Ala（SO3））-Thr-Pro-OH.
IUPAC/Chemical Name: L-Proline, glycyl-L-arginylglycyl-3-sulfo-L-alanyl-L-threonyl-
InChi Key: MYZAXBZLEILEBR-RVFOSREFSA-N
InChi Code: InChI=1S/C22H39N9O11S/c1-11(32)17(20(37)31-7-3-5-14(31)21(38)39)30-19(36)13(10-43(40,41)42)29-16(34)9-27-18(35)12(28-15(33)8-23)4-2-6-26-22(24)25/h11-14,17,32H,2-10,23H2,1H3,(H,27,35)(H,28,33)(H,29,34)(H,30,36)(H,38,39)(H4,24,25,26)(H,40,41,42)/t11-,12+,13+,14+,17+/m1/s1
SMILES Code: O=C(O)[C@H]1N(C([C@H]([C@H](O)C)NC([C@H](CS(=O)(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC(CN)=O)=O)=O)=O)=O)CCC1
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1. Mackel, Michael John; Park, John Y.; Karageozian, Hampar L.; Karageozian, Vicken H. Integrin receptor antagonists and their methods of use. U.S. Pat. Appl. Publ. (2013), US 20130129621 A1 20130523.
2. Mackel, Michael John; Park, John Y.; Karageozian, Hampar L.; Karageozian, Vicken H. Integrin receptor antagonists and their methods of use. PCT Int. Appl. (2012), WO 2012154894 A2 20121115.
3. Mackel, Michael John; Park, John Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites. PCT Int. Appl. (2011), WO 2011060104 A2 20110519.
