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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: Endoxifen E-isomer is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).
Name: Endoxifen E-isomer HCl
CAS#: 1197194-61-8 (HCl)
Chemical Formula: C25H28ClNO2
Exact Mass:
Molecular Weight: 409.954
Elemental Analysis: C, 73.25; H, 6.88; Cl, 8.65; N, 3.42; O, 7.81
Related CAS #: 114828-90-9 (free base) 1197194-61-8 (HCl)
Synonym: Endoxifen E-isomer HCl;
IUPAC/Chemical Name: 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;hydrochloride
InChi Key: RPFIMPDXTABYCN-QREUMGABSA-N
InChi Code: InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24+;
SMILES Code: OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Ford BM, Franks LN, Radominska-Pandya A, Prather PL. Tamoxifen Isomers and
Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors:
Potential Scaffold for Drug Development. PLoS One. 2016 Dec 9;11(12):e0167240.
doi: 10.1371/journal.pone.0167240. eCollection 2016. PubMed PMID: 27936172;
PubMed Central PMCID: PMC5147891.
2: Elkins P, Coleman D, Burgess J, Gardner M, Hines J, Scott B, Kroenke M, Larson
J, Lightner M, Turner G, White J, Liu P. Characterization of the
isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution
LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.
doi: 10.1016/j.jpba.2013.07.010. Epub 2013 Jul 24. PubMed PMID: 24055701; PubMed
Central PMCID: PMC4057282.
3: Fauq AH, Maharvi GM, Sinha D. A convenient synthesis of
(Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen). Bioorg Med Chem Lett. 2010 May
15;20(10):3036-8. doi: 10.1016/j.bmcl.2010.03.117. Epub 2010 Apr 3. PubMed PMID:
20400308.
