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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: TMP195 is a potent and selective class IIa HDAC inhibitor with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.
Name: TMP195
CAS#: 1314891-22-9
Chemical Formula: C23H19F3N4O3
Exact Mass: 456.1409
Molecular Weight: 456.4252
Elemental Analysis: C, 60.53; H, 4.20; F, 12.49; N, 12.28; O, 10.52
Synonym: TMP195; TMP-195; TMP 195.
IUPAC/Chemical Name: N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
InChi Key: QTCSXAUJBQZZSN-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31)
SMILES Code: O=C(NCC(C1=COC(C2=CC=CC=C2)=N1)(C)C)C3=CC=CC(C4=NOC(C(F)(F)F)=N4)=C3
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Cassetta L, Pollard JW. Repolarizing macrophages improves breast cancer
therapy. Cell Res. 2017 Apr 21. doi: 10.1038/cr.2017.63. [Epub ahead of print]
PubMed PMID: 28429765.
2: Targeting Class IIa HDACs May Suppress Breast Tumors and Metastases. Cancer
Discov. 2017 Mar 17. doi: 10.1158/2159-8290.CD-RW2017-053. [Epub ahead of print]
PubMed PMID: 28314719.
3: Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S,
Johnson SF, Carrasco RD, Lazo S, Bronson RT, Davis SP, Lobera M, Nolan MA, Letai
A. Class IIa HDAC inhibition reduces breast tumours and metastases through
anti-tumour macrophages. Nature. 2017 Mar 16;543(7645):428-432. doi:
10.1038/nature21409. Epub 2017 Mar 8. PubMed PMID: 28273064.
