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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of this compound also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446.
Name: E6446 HCl
CAS#: 1345675-25-3 (HCl)
Chemical Formula: C27H37Cl2N3O3
Exact Mass:
Molecular Weight: 522.511
Elemental Analysis: C, 62.07; H, 7.14; Cl, 13.57; N, 8.04; O, 9.19
Related CAS #: 1219925-73-1 (free base) 1345675-25-3 (HCl)
Synonym: E6446 HCl; E6446; E-6446; E6446 hydrochloride
IUPAC/Chemical Name: 6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole;dihydrochloride
InChi Key: DQOUZINBHKWGGM-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H35N3O3.2ClH/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30;;/h7-12,21H,1-6,13-20H2;2*1H
SMILES Code: [H]Cl.[H]Cl.C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W,
Ataíde MA, de Oliveira RB, Golenbock DT, Gazzinelli RT. Therapeutical targeting
of nucleic acid-sensing Toll-like receptors prevents experimental cerebral
malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. doi:
10.1073/pnas.1015406108. Epub 2011 Feb 8. PubMed PMID: 21303985; PubMed Central
PMCID: PMC3048158.
