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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.
Name: ISCK03
CAS#: 945526-43-2
Chemical Formula: C19H21N3O2S
Exact Mass: 355.1354
Molecular Weight: 355.456
Elemental Analysis: C, 64.20; H, 5.96; N, 11.82; O, 9.00; S, 9.02
Synonym: ISCK03, ISCK-03, ISCK 03.
IUPAC/Chemical Name: [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
InChi Key: YKRCYYGZFGRSAX-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-6-17(7-5-15)22(25(23)24)18-10-8-16(9-11-18)21-13-12-20-14-21/h4-14,25H,1-3H3
SMILES Code: O=S(N(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(N3C=CN=C3)C=C2)=O
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Na YJ, Baek HS, Ahn SM, Shin HJ, Chang IS, Hwang JS.
[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits
SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin
production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep
1;74(5):780-6. Epub 2007 Jun 14. PubMed PMID: 17658483.
2: Kamlah F, Hänze J, Arenz A, Seay U, Hasan D, Juricko J, Bischoff B, Gottschald
OR, Fournier C, Taucher-Scholz G, Scholz M, Seeger W, Engenhart-Cabillic R, Rose
F. Comparison of the effects of carbon ion and photon irradiation on the
angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol
Phys. 2011 Aug 1;80(5):1541-9. doi: 10.1016/j.ijrobp.2011.03.033. Epub 2011 May
27. PubMed PMID: 21621345.
3: Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, Yamazaki T. Long
noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation
of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7.
PubMed PMID: 25928165; PubMed Central PMCID: PMC4423487.
