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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: KIN-1148 is a IRF3 agonist. IN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.
Name: KIN-1148
CAS#: 1428729-56-9
Chemical Formula: C19H11N3OS2
Exact Mass: 361.0344
Molecular Weight: 361.437
Elemental Analysis: C, 63.14; H, 3.07; N, 11.63; O, 4.43; S, 17.74
Synonym: KIN-1148; KIN 1148; KIN1148.
IUPAC/Chemical Name: N-(benzo[1,2-d:3,4-d']bis(thiazole)-2-yl)-2-naphthamide
InChi Key: YAISOECYKYATLL-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H11N3OS2/c23-18(13-6-5-11-3-1-2-4-12(11)9-13)22-19-21-14-7-8-15-16(17(14)25-19)20-10-24-15/h1-10H,(H,21,22,23)
SMILES Code: O=C(NC1=NC2=CC=C(SC=N3)C3=C2S1)C4=CC=C5C=CC=CC5=C4
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Probst P, Grigg JB, Wang M, Muñoz E, Loo YM, Ireton RC, Gale M Jr, Iadonato
SP, Bedard KM. A small-molecule IRF3 agonist functions as an influenza vaccine
adjuvant by modulating the antiviral immune response. Vaccine. 2017 Apr
4;35(15):1964-1971. doi: 10.1016/j.vaccine.2017.01.053. Epub 2017 Mar 6. PubMed
PMID: 28279563.
