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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. In functional assays, YM-90709 inhibited IL-5-prolonged eosinophil survival with an IC50 value of 0.45 microM and did not affect the GM-CSF-prolonged eosinophil survival. Furthermore, YM-90709 inhibited the IL-5-induced but not GM-CSF-induced tyrosine phosphorylation of Janus kinase 2 (JAK2) in eosinophilic HL-60 clone 15 cells.
Name: YM-90709
CAS#: 163769-88-8
Chemical Formula: C22H21N3O2
Exact Mass: 359.1634
Molecular Weight: 359.429
Elemental Analysis: C, 73.52; H, 5.89; N, 11.69; O, 8.90
Synonym: YM-90709; YM 90709; YM90709.
IUPAC/Chemical Name: 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline
InChi Key: HIXSPVQXXDULHS-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
SMILES Code: CC(CC1=CC(OC)=C(OC)C=C12)(C)N3C2=CC4=NC5=CC=CC=C5N=C43
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Morokata T, Suzuki K, Ida K, Yamada T. Effect of a novel interleukin-5
receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into
the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5. Epub 2004 Nov 28.
PubMed PMID: 15790522.
2: Morokata T, Suzuki K, Ida K, Tsuchiyama H, Ishikawa J, Yamada T. Effect of a
novel interleukin-5 receptor antagonist, YM-90709
(2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline),
on antigen-induced airway inflammation in BN rats. Int Immunopharmacol. 2004
Jul;4(7):873-83. PubMed PMID: 15182727.
3: Morokata T, Ida K, Yamada T. Characterization of YM-90709 as a novel
antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.
Int Immunopharmacol. 2002 Nov;2(12):1693-702. PubMed PMID: 12469943.
