Efficacy and Safety of Vibegron

Vibegron, FDA approved new drug will be a big potential drug.

Original Route of Synthesis of  Vibegron yield is about 12%, impurity is 2%, unknown impurity is 1%.

EOS Med Chem use the new Route of Synthesis of Vibegron, yield improve 25%.

Reduced Vibegron synthesis steps, Remove unknown impurity, Remove Toxic Chemicals， Impurity is less than 1%, Assay more than 99%, Water by KF less than 0.5%.

Below is EOS Med Chem Route of Synthesis of Vibegron, each steps we have MSDS, COA, if you have interesting, pls contact me.

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Vibegron Intermediate: (1R,2R)-2-amino-6-(4-nitrophenyl)-1-phenylhex-5-yn-1-ol(1R,2R)-2-amino-6-(4-nitrophenyl)-1-phenylhex-5-yn-1-ol1628898-52-11628898-52-1, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 7kg

Vibegron Intermediate: (S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid(S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid1369766-03-91369766-03-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 3.2kg

Vibegron Intermediate: sodium (S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylatesodium (S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate1421271-22-31421271-22-3, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1kg

Vibegron Intermediate: tert-butyl ((1R,2R)-1-hydroxy-1-phenylhex-5-yn-2-yl)carbamatetert-butyl ((1R,2R)-1-hydroxy-1-phenylhex-5-yn-2-yl)carbamate1437235-52-31437235-52-3, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 4.8kg

Vibegron Intermediate: VibegronVibegron308242-62-8308242-62-8, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 9.7kg

COA-Vibegron

MSDS-Vibegron