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2018年11月18日星期日

Efficacy and Safety of WYE-125132

WYE-125132 , FDA approved new drug will be a big potential drug.

 Original Route of Synthesis of  WYE-125132  yield is about 12%, impurity is 2%, unknown impurity is 1%.

 EOS Med Chem use the new Route of Synthesis of WYE-125132 , yield improve 24.8%.

 Reduced WYE-125132 synthesis steps, Remove unknown impurity, Remove Toxic Chemicals， Impurity is less than 1%, Assay more than 99%, Water by KF less than 0.5%.

 Below is EOS Med Chem Route of Synthesis of WYE-125132 , each steps we have MSDS, COA, if you have interesting, pls contact me.

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WYE-125132 Intermediate: 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea1144068-46-11144068-46-1, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.2kg
WYE-125132 Intermediate: 1,4-dioxaspiro[4.5]decan-8-ylhydrazine1,4-dioxaspiro[4.5]decan-8-ylhydrazine1144080-29-41144080-29-4, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1.4kg
WYE-125132 Intermediate: 4,6-dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidine4,6-dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidine1144080-31-81144080-31-8, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.6kg
WYE-125132 Intermediate: 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine42754-96-142754-96-1, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 9.8kg
WYE-125132 Intermediate: 8-oxa-3-azabicyclo[3.2.1]octane8-oxa-3-azabicyclo[3.2.1]octane280-13-7280-13-7, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 6kg
WYE-125132 Intermediate: ethyl 5-(hydroxymethyl)isoxazole-3-carboxylateethyl 5-(hydroxymethyl)isoxazole-3-carboxylate123770-62-7123770-62-7, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.1kg


COA-WYE-125132 


MSDS-WYE-125132 


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