How to produce Velpatasvir?

Velpatasvir, FDA approved new drug will be a big potential drug.

Original Route of Synthesis of  Velpatasvir yield is about 12%, impurity is 2%, unknown impurity is 1%.

EOS Med Chem use the new Route of Synthesis of Velpatasvir, yield improve 24%.

Reduced Velpatasvir synthesis steps, Remove unknown impurity, Remove Toxic Chemicals， Impurity is less than 1%, Assay more than 99%, Water by KF less than 0.5%.

Below is EOS Med Chem Route of Synthesis of Velpatasvir, each steps we have MSDS, COA, if you have interesting, pls contact me.

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Velpatasvir Intermediate: (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5- methylpyrrolidine-2-carboxylic acid(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5- methylpyrrolidine-2-carboxylic acid1335316-40-91335316-40-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.8kg

Velpatasvir Intermediate: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid334769-80-1334769-80-1, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 5kg

Velpatasvir Intermediate: (R)-2-(methoxycarbonylamino)-2-phenylacetic acid(R)-2-(methoxycarbonylamino)-2-phenylacetic acid50890-96-550890-96-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 9kg

Velpatasvir Intermediate: 3-(2-bromoacetyl)-10,11-di hydro-5H-Benzo[d]naphtho [2,3-b]pyran-8(9H)-one3-(2-bromoacetyl)-10,11-di hydro-5H-Benzo[d]naphtho [2,3-b]pyran-8(9H)-one1378390-29-41378390-29-4, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 4.8kg

Velpatasvir Intermediate: 3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one3-Chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one1378388-20-51378388-20-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8kg

Velpatasvir Intermediate: 9-Bromo-3-chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one9-Bromo-3-chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one1378388-22-71378388-22-7, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1.1kg

Velpatasvir Intermediate: Velpatasvir Co PovidoneVelpatasvir Co Povidone1844064-96-51844064-96-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.1kg

Velpatasvir Intermediate: VelpatasvirVelpatasvir1377049-84-71377049-84-7, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 9.4kg

Velpatasvir(GS5816) Intermediate: (2S,4S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate(2S,4S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate1378391-42-41378391-42-4, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.4kg

Velpatasvir(GS5816) Intermediate: 1-tert-Butyl2-[2-[9-[[[(2S,5S)-1-[(S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]carbonyl]oxy] -8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl]-2-oxoethyl](2S,4S)-4-(methoxymethyl)pyrrolidine-1,2-dicarbo xylate1-tert-Butyl2-[2-[9-[[[(2S,5S)-1-[(S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]carbonyl]oxy] -8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl]-2-oxoethyl](2S,4S)-4-(methoxymethyl)pyrrolidine-1,2-dicarbo xylate1378391-43-51378391-43-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1.1kg

Velpatasvir(GS5816) Intermediate: tert-Butyl(2S,4S)-2-[5-[2-[(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl]-1,4,5,11-tetrahydroisochrom eno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylatetert-Butyl(2S,4S)-2-[5-[2-[(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl]-1,4,5,11-tetrahydroisochrom eno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate1378391-44-61378391-44-6, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 4kg

COA-Velpatasvir

MSDS-Velpatasvir