Is Velpatasavir a better option?

Velpatasavir, FDA approved new drug will be a big potential drug.

Original Route of Synthesis of  Velpatasavir yield is about 19%, impurity is 2%, unknown impurity is 1%.

EOS Med Chem use the new Route of Synthesis of Velpatasavir, yield improve 24%.

Reduced Velpatasavir synthesis steps, Remove unknown impurity, Remove Toxic Chemicals， Impurity is less than 1%, Assay more than 99%, Water by KF less than 0.5%.

Below is EOS Med Chem Route of Synthesis of Velpatasavir, each steps we have MSDS, COA, if you have interesting, pls contact me.

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Velpatasavir Intermediate: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbeniumhexafluorophosphate(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbeniumhexafluorophosphate1075198-30-91075198-30-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 5kg

Velpatasavir Intermediate: (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid(2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid1378388-16-91378388-16-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 2.3kg

Velpatasavir Intermediate: 1-[4-Bromo-3-(chloromethyl)phenyl] Ethanone1-[4-Bromo-3-(chloromethyl)phenyl] Ethanone1844064-90-91844064-90-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 2.5kg

Velpatasavir Intermediate: 7-Hydroxy-1-tetralone7-Hydroxy-1-tetralone22009-38-722009-38-7, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 5.3kg

Velpatasavir Intermediate: 9-Bromo-3-(2-Bromo Acetyl)-10,11-Dihydro-5H-dibenzo(c,g) Chromen-8(9H)-one9-Bromo-3-(2-Bromo Acetyl)-10,11-Dihydro-5H-dibenzo(c,g) Chromen-8(9H)-one1438383-89-11438383-89-1, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 4.1kg

Velpatasavir Intermediate: L-Proline,5-methyl-,ethylester,(5S)-,4-methylbenzenesulfonateL-Proline,5-methyl-,ethylester,(5S)-,4-methylbenzenesulfonate1844064-27-21844064-27-2, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1.9kg

Velpatasavir Intermediate: Tert-Butyl(2S,4S)-2-(4-(2-((2S,5S)-1-((methoxycarbonyl)Tert-Butyl(2S,4S)-2-(4-(2-((2S,5S)-1-((methoxycarbonyl)1378391-45-71378391-45-7, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.2kg

COA-Velpatasavir

MSDS-Velpatasavir