Voxilapravir, HPLC 99.5%, Intermediates list

Voxilapravir , FDA approved new drug will be a big potential drug.

Original Route of Synthesis of  Voxilapravir  yield is about 13%, impurity is 2%, unknown impurity is 1%.

EOS Med Chem use the new Route of Synthesis of Voxilapravir  yield improve 28.4%.

Reduced Voxilapravir  synthesis steps, Remove unknown impurity, Remove Toxic Chemicals， Impurity is less than 1%, Assay more than 99%, Water by KF less than 0.5%.

Below is EOS Med Chem Route of Synthesis of Voxilapravir , each steps we have MSDS, COA, if you have interesting, pls contact me.

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Voxilapravir Intermediate: (S)-1-phenylethanamine(S)-2-((((1R,2R)-2-allylcyclopropoxy)carbonyl)amino)-3,3-dimethylbutanoic acid(S)-1-phenylethanamine(S)-2-((((1R,2R)-2-allylcyclopropoxy)carbonyl)amino)-3,3-dimethylbutanoic acid1799733-54-21799733-54-2, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 6.1kg

Voxilapravir Intermediate: 1,2-Pyrrolidinedicarboxylic acid, 4-[[3-(1,1-difluoro-3-buten-1-yl)-7-methoxy-2-quinoxalinyl]oxy]- 3-ethyl-,1-(1,1-dimethylethyl)2-methyl ester, (2S,3S,4R)-1,2-Pyrrolidinedicarboxylic acid, 4-[[3-(1,1-difluoro-3-buten-1-yl)-7-methoxy-2-quinoxalinyl]oxy]- 3-ethyl-,1-(1,1-dimethylethyl)2-methyl ester, (2S,3S,4R)-1799733-69-91799733-69-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 7.5kg

Voxilapravir Intermediate: 1,2-Pyrrolidinedicarboxylic acid,3-ethyl-4-hydroxy-,1-(1,1-dimethylethyl)2-methylester,(2S,3S,4R)-1,2-Pyrrolidinedicarboxylic acid,3-ethyl-4-hydroxy-,1-(1,1-dimethylethyl)2-methylester,(2S,3S,4R)-1799733-68-81799733-68-8, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1.7kg

voxilaprevir Intermediate: (1R,2S)-1-BOC-AMINO-2-VINYLCYCLOPROPANECARBOXYLIC ACID ETHYL ESTER(1R,2S)-1-BOC-AMINO-2-VINYLCYCLOPROPANECARBOXYLIC ACID ETHYL ESTER213316-49-5213316-49-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 7.5kg

Voxilaprevir Intermediate: (33R,34S,35S,91R,92R,5S,E)-5-(tert-butyl)-34-ethyl-14, 14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2 ,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropana cyclotetradecaphane-35-carboxylic acid(33R,34S,35S,91R,92R,5S,E)-5-(tert-butyl)-34-ethyl-14, 14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2 ,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropana cyclotetradecaphane-35-carboxylic acid1535212-06-61535212-06-6, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 9.9kg

Voxilaprevir Intermediate: 3-chloro-2-(1,1-difluoroallyl)-6-methoxyquinoxaline3-chloro-2-(1,1-difluoroallyl)-6-methoxyquinoxaline1535210-94-61535210-94-6, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.1kg

voxilaprevir Intermediate: 3-chloro-2-(1,1-difluorobut-3-enyl)-6-methoxyquinoxalin3-chloro-2-(1,1-difluorobut-3-enyl)-6-methoxyquinoxalin1799733-46-21799733-46-2, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 9.6kg

Voxilaprevir Intermediate: Cyclopropanesulfonamide, 1-methyl- (9CI)Cyclopropanesulfonamide, 1-methyl- (9CI)669008-26-8669008-26-8, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1.4kg

Voxilaprevir Intermediate: di-tert-butyl(2S,3S,4R)-4-((3-(1,1-difluoroallyl)-7-methoxyquinox alin-2-yl)oxy)-3-ethylpyrrolidine-1,2-dicarboxylatedi-tert-butyl(2S,3S,4R)-4-((3-(1,1-difluoroallyl)-7-methoxyquinox alin-2-yl)oxy)-3-ethylpyrrolidine-1,2-dicarboxylate1535213-67-21535213-67-2, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 9.3kg

voxilaprevir Intermediate: L-Proline, 3-ethyl-4-hydroxy-, methyl ester, (3S,4R)-, 4-methylbenzenesulfonate (1:1)L-Proline, 3-ethyl-4-hydroxy-, methyl ester, (3S,4R)-, 4-methylbenzenesulfonate (1:1)1799733-43-91799733-43-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 6.1kg

Voxilaprevir Intermediate: tert-butyl (33R,34S,35S,91R,92R,5S)-5-(tert-butyl)-34-ethyl-14,14- difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)- quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacy clotetradecaphane-35-carboxylatetert-butyl  (33R,34S,35S,91R,92R,5S)-5-(tert-butyl)-34-ethyl-14,14- difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3- quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacy clotetradecaphane-35-carboxylate1535212-05-51535212-05-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 7.7kg

Voxilaprevir Intermediate: tert-butyl (33R,34S,35S,91R,92R,5S,E)-5-(tert-butyl)-34-ethyl-14, 14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2 ,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropana cyclotetradecaphan-12-ene-35-carboxylatetert-butyl (33R,34S,35S,91R,92R,5S,E)-5-(tert-butyl)-34-ethyl-14, 14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2 ,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropana cyclotetradecaphan-12-ene-35-carboxylate1535212-03-31535212-033, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 6.1kg

Voxilaprevir Intermediate: tert-butyl ((1R,2S)-1-(((1-Methylcyclopropyl)sulfonyl)carbaMoyl)-2-vinyl cyclopropyl)carbaMatetert-butyl ((1R,2S)-1-(((1-Methylcyclopropyl)sulfonyl)carbaMoyl)-2-vinyl cyclopropyl)carbaMate853269-57-5853269-57-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 7.6kg

Voxilaprevir Intermediate: VoxilaprevirVoxilaprevir1535212-07-71535212-07-7, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.5kg

COA-Voxilapravir 

MSDS-Voxilapravir