Description: Remdesivir, also known as GS-5734, is an antiviral drug, and a novel nucleotide analog prodrug. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h. GS-5734 inhibits both epidemic and zoonotic coronaviruses. It was developed by Gilead Sciences as a treatment for filovirus infections such as Ebola virus disease and Marburg virus. Remdesivir share the same core structure with that of GS-441524. Remdesivir may consider as a prodrug of GS-441524.
Remdesivir Intermediate 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine 937046-98-5, stock 11.5kg, assay 99.2%.
Remdesivir Intermediate 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine 1770840-43-1, stock 8.5kg, assay 99.7%.
Remdesivir Intermediate (3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)dihydrofuran-2(3H)-one 55094-52-5, stock 6.5kg, assay 99.2%.
Remdesivir Intermediate L-Alanine, 2-ethylbutyl ester, hydrochloride (1:1) 946511-97-3, stock 4.5kg, assay 99.2%.
EOS Med Chem is one of TOP Remdesivir GS-5734 1809249-37-3 supplier, we have 4 different line, each Intermediates could batch size 100kg production.
Below is our 4 ROS.
Remdesivir Intermediate 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine 937046-98-5, stock 11.5kg, assay 99.2%.
Remdesivir Intermediate 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine 1770840-43-1, stock 8.5kg, assay 99.7%.
Remdesivir Intermediate (3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)dihydrofuran-2(3H)-one 55094-52-5, stock 6.5kg, assay 99.2%.
Remdesivir Intermediate L-Alanine, 2-ethylbutyl ester, hydrochloride (1:1) 946511-97-3, stock 4.5kg, assay 99.2%.
EOS執大象，天下往，往而無害，安平泰
辦公室: 0086-531-69905422
住所: Diaozhen Chemical Industrial Park, Jinan City, China
EOS Med Chem is one of TOP Remdesivir GS-5734 1809249-37-3 supplier, we have 4 different line, each Intermediates could batch size 100kg production.
Below is our 4 ROS.
EOS執大象，天下往，往而無害，安平泰
辦公室: 0086-531-69905422
住所: Diaozhen Chemical Industrial Park, Jinan City, China
Name: Remdesivir
CAS#: 1809249-37-3
Chemical Formula: C27H35N6O8P
Exact Mass: 602.2254
Molecular Weight: 602.5848
Elemental Analysis: C, 53.82; H, 5.85; N, 13.95; O, 21.24; P, 5.14
Synonym: Remdesivir; GS-5734; GS 5734; GS5734, Prodrug of GS-441524; Prodrug of GS441524; Prodrug of GS441524;
IUPAC/Chemical Name: 2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
InChi Key: RWWYLEGWBNMMLJ-YSOARWBDSA-N
InChi Code: InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1
SMILES Code: C[C@H](N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O)C(OCC(CC)CC)=O
TECHNICAL DATA
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 2934.99.90.01
ADDITIONAL INFORMATION
Remdesivir has been found to show reasonable antiviral activity against more distantly related viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, and MERS-coronavirus. GS-5734 was rapidly pushed through clinical trials due to the 2013–2016 West African Ebola virus epidemic crisis, eventually being used in at least one human patient despite its early development stage at the time. Preliminary results have been promising, and further clinical trials are planned.
REFERENCES
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