Stock 1.2kg 923950-08-7 Dulaglutide
Stock 1.2kg 923950-08-7 Dulaglutide HPLC 99.6%
Dulaglutide Stock 1.2kg, HPLC 99.6%, HNMR, MS attached.
Dulaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4. Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increases insulin secretion by pancreatic Beta cells. Simultaneously the compound reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas. GLP-1 is normally secreted by L cells of the gastrointestinal mucosa in response to a meal.
Stock 1.2kg 923950-08-7 Dulaglutide HPLC 99.6%
Dulaglutide Stock 1.2kg, HPLC 99.6%, HNMR, MS attached.
FDA New, GMP Do
Clinical Phase II, III Intermediates
GMP Custom synthesis, Full Document
R&D Center: 8000 sq, More than 100 hoods
Pilot Plant: 20000sq, 40 reactors from 5-200L
Manufacturing Site: 800000sq, 40 reactors from 100-5000L
Dulaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4. Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increases insulin secretion by pancreatic Beta cells. Simultaneously the compound reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas. GLP-1 is normally secreted by L cells of the gastrointestinal mucosa in response to a meal.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
| Molecular Weight | 59669.65 |
| Formula | C2646H4044N704O836S18 |
| CAS Number | 923950-08-7 |
| Purity | >98% |
| Solubility | |
| Storage | -80°C for long term |
References
Longer acting GLP-1 receptor agonists and the potential for improved cardiovascular outcomes: a review of current literature.
Tibble CA, et al. Expert Rev Endocrinol Metab. 2013 May;8(3):247-259. PMID: 30780817.
Tibble CA, et al. Expert Rev Endocrinol Metab. 2013 May;8(3):247-259. PMID: 30780817.
Regulation of glucose homeostasis by GLP-1.
Nadkarni P, et al. Prog Mol Biol Transl Sci. 2014;121:23-65. PMID: 24373234.
Nadkarni P, et al. Prog Mol Biol Transl Sci. 2014;121:23-65. PMID: 24373234.
