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2016年2月24日星期三

CB-5083 | CAS#1542705-92-9 /EOS Med Chem, Medicinal Chemical is Big

CB-5083 | CAS#1542705-92-9, now 10g in stock.

 USD 1650/G, assay more than 98%

 Delivery soon.

2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

Description: CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. (Last update: 1/4/2016).
Appearance:
Solid powder
Purity:
>98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:
Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
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ABT-199, Venetoclax, 1257044-40-8 Intermediates List

ABT-199, Venetoclax, 1257044-40-8.

 Now we could supply each steps of the Intermediates.

 And some of them is regular producing.

 Below is the list, which one you need, pls ask me.


2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian


ABT-199, Venetoclax, 1257044-40-8 Intermediates List
1. 1228779-96-1
2. 1628047-87-9
3. 1228780-72-0
4. 1628047-84-6
5. 1603101-71-1
6. 1228837-05-5
7. 406233-31-6
8. 98549-88-3
9. 1235865-75-4
10. 1235865-77-6





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(3R, 4S) - 4-aminooxan-3-ol cas 1096770-58-9, assay 98% Finished



(3R, 4S) - 4-aminooxan-3-ol cas 1096770-58-9

 This is a new Intermediates, used in drug discovery, will be hot in 2017.

 We help Japan pharma company, finished it.

 And assay more than 98%.

 1kg, USD 13500/KG, now 100g in stock.

 Welcome to my booth in CPHI.

2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年2月21日星期日

7-azaindole-3-carboxylic acid Cas# 156270-06-3

7-azaindole-3-carboxylic acid Cas# 156270-06-3

 USD 68/G for 100g, we have some in stock.




2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

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World biggest Manu: HATU, HBTU /EOS Med Chem, Medicinal Chemical is Big




From 2005, we start HATU, HBTU project. ROS like attachment.

2010, we are successfully be the China TOP supplier.

2011, we successfully be world biggest supplier. All products from GMP, FDA, ISO plant.

Now, India, USA, EU market, we have about 40% share of sale.

Each order, from 1g, 1kg, 10kg, 100kg, 500kg, we must provide: NMR, HPLC, MS, ROS, MOA, MSDS.

Attaching COA.

 GLENMARK, TEVA, MAYLAN, DONG-A, all use me.

 Free samples, pls contact me.






2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年2月19日星期五

Eisai pharma new project / 大象藥物化學, Medicinal Chemical is Big

Below is the project, we exported to Japan Eisai pharma.
 
1-Bromo-3-fluoro-2-nitrobenzene     886762-70-5 1.8 KG USD 1850/KG
(1S,3R,5S)-3,5-dimethylcyclohexanol  767-13-5 1.2 KG USD 2700/KG
Methyl 3-fluoro-2-nitrobenzoate 1214353-57-7 2 KG USD 3980/KG
3-Fluoro-2-nitrobenzonitrile 1000339-52-5 4 to 5 kg KG USD 2650/KG


 

2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
 


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Grazoprevir (MK5172) ROS, Intermediates List /EOS Med Chem, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

 Each day, we have new chemicals or price from my lab or plant.
Grazoprevir (MK5172)  1206524-85-7, now have 500g in stock. Assay more than 99%. HPLC, NMR, MS is ok.

 Attaching ROS of Grazoprevir (MK5172), pls kindly check below.


 As the fist Manu of Grazoprevir (MK5172)  1206524-85-7 , now each step of Intermediates we could produce by myself, regular production.

 And we are working on the impurity of this project.

 Now Intermediates list:
Grazoprevir Intermediates1206524-84-6
Grazoprevir Intermediates1206524-85-7   
Grazoprevir Intermediates1350619-77-0
Grazoprevir Intermediates1361028-94-5
Grazoprevir Intermediates1350514-68-9
Grazoprevir Intermediates1425038-19-2
Those are most need, if your need not, pls ask me.




2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian





Synonyms(1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
copyRight
Molecular StructureCAS # 1206524-85-7, MK-5172, (1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
Molecular FormulaC29H38N4O7
Molecular Weight554.63
CAS Registry Number1206524-85-7


Name(1R,2R)-2-(4-Pentyn-1-yl)cyclopropanol
copyRight
Molecular StructureCAS # 1350619-77-0, (1R,2R)-2-(4-Pentyn-1-yl)cyclopropanol
Molecular FormulaC8H12O
Molecular Weight124.18
CAS Registry Number1350619-77-0
Properties
SolubilitySoluble (15 g/L) (25 ºC), Calc.*
Density1.025±0.06 g/cm3 (20 ºC 760 Torr), Calc.*
Boiling point186.3±13.0 ºC (760 Torr), Calc.*
Flash point75.8±12.8 ºC, Calc.*
Synonyms(1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide cyclic (1→2)-ether; ; MK 5172
copyRight
Molecular StructureCAS # 1350514-68-9, Grazoprevir, (1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide cyclic (1→2)-ether, , MK 5172
Molecular FormulaC38H50N6O9S
Molecular Weight766.90
CAS Registry Number1350514-68-9
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sutezolid intermediate: CAS No.: 168828-73-7 (R)-(3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate.



sutezolid CAS Number 168828-58-8   intermediates: CAS No.: 168828-73-7   (R)-(3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate.

 Sutezolid (PNU-100480, PF-02341272) is an oxazolidinone antibiotic currently in development as a treatment for extensively drug-resistant tuberculosis.

 This is custom synthesis for Teva pharma.

 Use 3 months, we finish this project.

 Thanks.




2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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