Rucaparib, why so low /EOS Med Chem, Medicinal Chemical is Big

Rucaparib API CAS #283173-50-2

Until March 4th, we have about 100g in stock.

Half Price of market.

HPLC, NMR, MS as attachment.

This is produced in GMP plant.

We have follow Intermediates for you, pls check.

·        CAS #1082040-43-4

This is Pfizer's patent protection route, we use new route, successfully cut 30% cost. Now 10kg in hand.

CAS No.	1082040-43-4
Chemical Name:	6-Fluoro-1H-indole-4-carboxylic acid methyl ester
Synonyms:	6-Fluoro indole-4-Methylcarboxylate;Methyl 6-fluoro-1H-indole-4-carboxylate;6-Fluoro-1H-indole-4-carboxylic acid methyl ester;1H-Indole-4-carboxylic acid, 6-fluoro-, Methyl ester
CBNumber:	CB12520235
Molecular Formula:	C10H8FNO2

·        CAS # 87199-17-5

·        CAS #697739-03-0 

·        CAS #2913-97-5 

·        CAS #77123-57-0

·        CAS #63697-96-1

·        CAS #1055331-73-1

·        CAS # 1342063-52-8

·        CAS # 880160-62-3, this is KEY Intermediates, we have finished 10kg. 

Batch No.	20151202	Date Of Retest	2017.12.01
Package	5kg	Reference Standard	In-house standard
ITEMS	SPECIFICATION		RESULT
880160-62-3 Appearance	White crystal powder		Conform
880160-62-3 Identification	Infrared absorption		Conform
880160-62-3 Loss on drying	Less than 0.5%		0.31%
880160-62-3 Assay	More than 99%		99.94%
Conclusion	Complies to the in-house standard

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

L-Tyrosine Hydrazide 7662-51-3, 1kg, USD 2400/KG

L-Tyrosine Hydrazide 7662-51-3, 1kg, custom synthesis for USA lab.

1kg, USD 2400/KG.

NMR, HPLC, MS we provid. Assay more than 98%.

Now 100g in stock.

Thanks.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

Purity/Analysis Method	>98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W.	C9H13N3O2=195.22
CAS Number	7662-51-3
Related CAS Number
MDL Number	MFCD00007609

ABT-199, Venetoclax, 1257044-40-8 NMR, HPLC, LC-MS/EOS Med Chem, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.

ABT-199, Venetoclax, 1257044-40-8. Attaching NMR, HPLC, LC-MS.

Now 1000g in stock, Assay more than 99%+, ROS is OPEN.

Now we could synthesis 12 Intermediates in GMP plant.

Each Step of Intermediates, we have.

Impurity we have, thanks

Description: Venetoclax, also known as ABT-199 or GDC0199, is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. (Last Update: 2/29/2016).

Synonym: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601. Venetoclax.

IUPAC/Chemical Name: 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

SMILES Code: O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7

New chemicals 10123-62-3 & 29668-61-9

10123-62-3 & 29668-61-9 , we use both chemicals to finish a new project.

For a drug discovery project.

We could custom synthesis, 98%+ assay, NMR, HPLC, MS supply you.

Thanks.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

CAS No.:	29668-61-9
Name:	Phosphonic acid, P-(1-cyanoethyl)-, diethyl ester
Molecular Structure:
Formula:	C7H14 N O3 P
Molecular Weight:	191.1647
Synonyms:	Phosphonic acid, (1-cyanoethyl)-, diethyl ester(7CI,8CI,9CI); (1-Cyanoethyl)phosphonic acid diethylester; Diethyl 1-cyanoethanephosphonate; Diethyl 1-cyanoethylphosphonate; NSC135193
EINECS:
Density:	1.094g/cm3
Melting Point:
Boiling Point:	279.5°Cat760mmHg
Flash Point:	122.8°C

Name:

Phosphonic acid,P-(2-cyanoethyl)-, diethyl ester

Cas No.:

10123-62-3

Molecular Structure:

EINECS(EC#):

Molecular Formula:

C7H14 N O3 P

Molecular Weight:

191.19

Synonyms:

Phosphonicacid, (2-cyanoethyl)-, diethyl ester (6CI,7CI,8CI,9CI);(2-Cyanoethyl)phosphonic acid diethyl ester; 3-(Diethylphosphono)propionitrile; Diethyl (2-cyanoethyl)phosphonate; Diethyl2-cyanoethanephosphonate; NSC 43781; NSC 74863; O,O'-Diethyl(2-cyanoethyl)phosphonate; b-(Diethoxyphosphinyl)propionitrile

Chemical

Appearance:

 

mp :

 

bp :

303.5°Cat760mmHg

Flash Point:

137.3°C

Density:

1.096g/cm³

Water Solubility :

 

AZ7371 1494675-86-3 /EOS Med Chem, Medicinal Chemical is Big

AZ7371 1494675-86-3, assay more than 98%. HPLC, NMR, MS provided.

100g, USD 350/G, 200g in stock.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

New Chemicals /大象藥物化學, Medicinal Chemical is Big

EOS Med Chem have finished 5 new high cost chemical.

Each one is very hard to synthesis.

Like below:

Ethanone,1-(2-amino-3-bromo-4-methoxyphenyl)-, 923289-30-9, USD 1900/200G, assay more than 98%, HPLC, NMR, MS is ok. Delivery time 1 week.

2-isobutyraMidothiazole-4-carboxylic acid, 1082130-43-5, 10kg USD 6800/KG, assay more than 98%, HPLC, NMR, MS is ok. Delivery time 1 week.

L-Valine, N-[(cyclopentyloxy)carbonyl]-3-Methyl, 572924-00-6,  10kg USD 4800/KG, assay more than 98%, HPLC, NMR, MS is ok. Delivery time 1 week.

(1R,2S)-Methyl 1-amino-2-vinylcyclopropanecarboxylate 4-methylbenzenesulfonate  862273-27-6  10kg USD 7800/KG, assay more than 98%, HPLC, NMR, MS is ok. Delivery time 1 week.

L-Proline, N-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-4-hydroxy-, 877069-25-5, 10kg USD 3500/KG, assay more than 98%, HPLC, NMR, MS is ok. Delivery time 1 week.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE, 60025-09-4

This is my new Project 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE, 60025-09-4.

HPLC, NMR, MS, if you need, pls ask me.

Until now few suppliers could custom synthesis this compound.

We have finished 10kg order.

USD 7800/KG, 3 weeks could finish, assay more than 98%.

And we could supply you Impurity.

Thanks.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

CB-5083 | CAS#1542705-92-9 /EOS Med Chem, Medicinal Chemical is Big

CB-5083 | CAS#1542705-92-9, now 10g in stock.

USD 1650/G, assay more than 98%

Delivery soon.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

Description: CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. (Last update: 1/4/2016).

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

ABT-199, Venetoclax, 1257044-40-8 Intermediates List

ABT-199, Venetoclax, 1257044-40-8.

Now we could supply each steps of the Intermediates.

And some of them is regular producing.

Below is the list, which one you need, pls ask me.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

ABT-199, Venetoclax, 1257044-40-8 Intermediates List

1. 1228779-96-1

2. 1628047-87-9

3. 1228780-72-0

4. 1628047-84-6

5. 1603101-71-1

6. 1228837-05-5

7. 406233-31-6

8. 98549-88-3

9. 1235865-75-4

10. 1235865-77-6

(3R, 4S) - 4-aminooxan-3-ol cas 1096770-58-9, assay 98% Finished

(3R, 4S) - 4-aminooxan-3-ol cas 1096770-58-9

This is a new Intermediates, used in drug discovery, will be hot in 2017.

We help Japan pharma company, finished it.

And assay more than 98%.

1kg, USD 13500/KG, now 100g in stock.

Welcome to my booth in CPHI.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

7-azaindole-3-carboxylic acid Cas# 156270-06-3

7-azaindole-3-carboxylic acid Cas# 156270-06-3

USD 68/G for 100g, we have some in stock.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian