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2016年3月10日星期四

New inhibitor in stock list /EOS Med Chem, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.




New inhibitor in stock list

918505-61-0PLX403298%500g
936091-26-8TG10134898%50g
872511-34-7NVPBGJ39898%1g
196868-63-0PQ40198%5g
936563-96-1PCI3276598%170g
871700-17-3GSK112021298%2g
1029044-16-3PLX339798%70g
154447-36-6LY29400298%5g
946518-60-1LY240988198%54g
587871-26-9KU5593398%0.3g
1110813-31-4PF29980498%10g
192441-08-0Lomeguaritrib98%5g
849217-68-1xl18498%10g
742112-33-0osu0301298%6g
154447-38-8ly30351198%4g
186692-46-6cyc20298%10g
1204918-72-8sb131798%10g
1093100-40-3B-Raf inhibitor 198%0.5g
404950-80-7lbh58998%0.5g
1029877-94-8syr47298%10g
1257628-77-5gzd82498%1g
1414378-14-5methyl 3-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-cyclopenta[c]thiophene-1-carboxylate98%100g
1415666-63-5(1S,2S,4S,8R)-1-(3,5-bis(trifluoromethyl)benzyl)-2-((R)-hydroxy(6-methoxyquinolin-4-yl)methyl)-8-vinyl-1-azoniabicyclo[2.2.2]octane bromide98%10g
1380087-86-4CPI-26845698%20g
1188910-76-0CEP-3249698%6g
1086062-66-9gsk212645898%6g
955977-50-1pi306598%0.2g
934162-61-5a96649298%1g
1579965-12-098%1g
1346574-57-9GSK-12698%1g


2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

2016年3月9日星期三

Biggest GMP supplier: Suvorexant (MK4305) CAS 1030377-33-3




Suvorexant (MK4305) CAS 1030377-33-3 & Intermediates 

Suvorexant, until now, we have each Intermediates about 10kg in stock, each batch is 10-100kg.

API: Suvorexant (MK4305) CAS 1030377-33-3, 5KG in stock. Attaching COA for you reference.


1001401-60-0, assay more than 98%, water less than 0.5%, single impurity less than 0.5%.
1H-1,4-Diazepine-1-carboxylic acid, hexahydro-5-Methyl-, phenylMethyl ester, (5R)-

1266975-27-2, assay more than 98%, water less than 0.5%, single impurity less than 0.5%.
(R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole

1260619-38-2assay more than 98%, water less than 0.5%, single impurity less than 0.5%.
(R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole hydrochloride

1276666-12-6assay more than 98%, water less than 0.5%, single impurity less than 0.5%.
4-((2-aMinoethyl)(5-chlorobenzo[d]oxazol-2-yl)aMino)butan-2-one (diMethanesulfonate)

API 1030377-33-3assay more than 98%, water less than 0.5%, single impurity less than 0.5%.

Each step, we have more than 10kg in stock.

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.

2016 Korea(한국) CPHI, E40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med ChemMedchem is Big
執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

2016年3月8日星期二

Snake Venom best supplier

Snake Venom is widely used in drug discovery, Oncology, Nervous Diseases, Comestic and other new field.

2010, we started to out-source Chinese best Snake Venom from China, supply to USA labs.

2015, we have cooperated with more than 20 Snake Farm, including 75 snake venom.

Including TOP 10 best venom in the world, like below.

Export Powder, Liquid to you.

If you have any interesting, pls feel free ask Price List.

Thanks.

2016 Shanghai CPHI, W5C47, Welcome!
EOS Med ChemMedchem is Big
執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

Agkistrodon acutus Guenther1: Agkistrodon acutus guenther is also named as: acutobin, Agkistrobon acutus, 100-Pacer etc.
Appearance: Triangle head, proboscis at the end of the mouth.
Living habit: Living in moutainous and highland areas, in the 300-800M rocks beside the stream or in the grass. The food of it is mainly fogs, lizard, birds and mouse.
Venom product name: defibrase etc. 
Vipera russelli2Vipera russelli (Vipera russelli Siamensis smith) is also named as Vipera berus etc.
Appearance: Triangle head, wide and round rostral side, obvious shape, big nose, squama on the back and head.
Living habit: Living in plain, highland and moutainous areas. Mainly living in wide fields.
Venom product name
Thrombin etc.
Bungarus multicinctus3: Bungarus multicinctus(Bungarus multicinctus Blyth) is also called as banded krait etc. .
Appearance: Ellipse head, bigger than neck, obtuse rostral side, small eyes
Living habit: Living in the watery areas in plain and highland, wide food range, mainly eels, loach, fish, fog, lizard, snakes and mouse.
Venom product nameneural medicines.
Bungarus fasciatus4: Bungarus fasciatus(Bungarus fasciatus Schneider) is also named as Bungarus fasciatus Banded Krait etc.
Appearance: Ellipse head, bigger than neck, black head and back.
Living habit: Living in the bushes of palin and highland in the hot and humid areas, besides the water or inside the caves.
Venom product nameneural medicines.
Naja naja atra5: Naja naja atra(Naja naja atra Chinese Cobra) is also named as cobra etc.
Appearance: Ellipse head, one small squama in the 4th or the 5th labium squama, smooth body squama.
Living habit: Living in the bushes or bamboo forest in plain, highland and mountainous areas, beside the stream or pool, rice field, near road or house. Wid efood range: fish, fogs, birds and mouse etc.
Venom product namechlocambucil etc.
Ophiophagus hannah6: Ophiophagus hannah(Ophiophagus hannah Cantor) is also named as big cobra etc.
Appearance: The appearance is nearly the same as Naja naja atra, it is the biggest viper in the world.
Living habit: Living in the bushes in the mountainous area over 1000m, the lower part can twist onto the branches, the front part suspends. It emerges beside water or bridge frusta or hides in the rock gaps or tree eyes.
Venom product name in developing. 
Agkistrdon halys7: Agkistrdon halys(Agkistrodon blomhoffii Boie) consists of Agkistrodon blomhoffii brevi caudus and Agkistrodon blomhoffii ussuriensis.
Appearance: Triangle head, obvious proboscis, big squama, sharp external flank, short and big body, short tail.
Living habit: Living in the grass of plain and highland, rice field in wild, wide food range: fish, fog, small snakes, ant, insects etc. 
Trimeresurus mucrosquamatus8: Trimeresurus mucrosquamatus(Trimeresurus mucrosquamatus Cantor) is also named as Pointed-scaled pitviper etc.
Appearance: Triangle heat, small neck, like iron, thin and long body.
Living habit: Living in the bushes in the highland and mountainous area with the altide higher than 200m, bamboo forest, near the stream or rock gaps, wide food range: fogs, lizard, birds and mouse. 
Trimeresurus stejnegeri9: Trimeresurus stejnegeri(Trimeresurus stejnegeri Schmidt)
Appearance: Triangle head, thin neck, small squama on the back and head, the first labrum squama complete separates from the nose squama, big eyes, ellipse red pupil, green body, white side line or white red side line from the neck to the tail, some big ones have not the side lines.
Living habit: living in the bushes or bamboo forest in the mountainous area.
Thailand Naja naja atra10: The shape and living habit of the Thailand Naja naja atra is nearly the same as Naja naja atra.
Appearance: Ellipse head, one small squama in the 4th or the 5th labium squama, smooth body squama.
Living habit: Living in the bushes or bamboo forest in plain, highland and mountainous areas, beside the stream or pool, rice field, near road or house. Wid efood range: fish, fogs, birds and mouse etc.

2016年3月4日星期五

3-Fluoro-4-pyridineboronic acid pinacol ester [458532-88-2]

EOS Med Chem, now have a GMP plant in Taizhou city. Regular produce some Intermediates and custom synthesis.

The plant have approved by TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others.

Now my plant have 40 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.


We use the new route, successfully control the cost of 3-Fluoro-4-pyridineboronic acid pinacol ester [458532-88-2]. HPLC, NMR, MS we could supply.

Now my price is the half of the market.

Any interesting, pls ask me.


2016 Shanghai CPHI, W5C47, Welcome!

EOS Med ChemMedchem is Big
執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

Rucaparib, why so low /EOS Med Chem, Medicinal Chemical is Big


Rucaparib API CAS #283173-50-2

Until March 4th, we have about 100g in stock.


Half Price of market.


HPLC, NMR, MS as attachment.


This is produced in GMP plant.


We have follow Intermediates for you, pls check.



·        CAS #1082040-43-4

This is Pfizer's patent protection route, we use new route, successfully cut 30% cost. Now 10kg in hand.


CAS No.1082040-43-4
Chemical Name:6-Fluoro-1H-indole-4-carboxylic acid methyl ester
Synonyms:6-Fluoro indole-4-Methylcarboxylate;Methyl 6-fluoro-1H-indole-4-carboxylate;6-Fluoro-1H-indole-4-carboxylic acid methyl ester;1H-Indole-4-carboxylic acid, 6-fluoro-, Methyl ester
CBNumber:CB12520235
Molecular Formula:C10H8FNO2

·        CAS # 87199-17-5
·        CAS #697739-03-0 
·        CAS #2913-97-5 
·        CAS #77123-57-0
·        CAS #63697-96-1
·        CAS #1055331-73-1
·        CAS # 1342063-52-8
·        CAS # 880160-62-3, this is KEY Intermediates, we have finished 10kg. 

Batch No.
20151202
Date Of Retest
2017.12.01
Package
5kg
Reference Standard
In-house standard
ITEMS
SPECIFICATION
RESULT
880160-62-3 Appearance
White crystal powder
Conform
880160-62-3 Identification
Infrared absorption
Conform
880160-62-3 Loss on drying
Less than 0.5%
0.31%
880160-62-3 Assay
More than 99%
99.94%
Conclusion
Complies to the in-house standard


2016 Shanghai CPHI, W5C47, Welcome!

EOS Med ChemMedchem is Big

執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

2016年3月2日星期三

L-Tyrosine Hydrazide 7662-51-3, 1kg, USD 2400/KG

L-Tyrosine Hydrazide 7662-51-3, 1kg, custom synthesis for USA lab.

1kg, USD 2400/KG.

NMR, HPLC, MS we provid. Assay more than 98%.

Now 100g in stock.

Thanks.



2016 Shanghai CPHI, W5C47, Welcome!
EOS Med ChemMedchem is Big
執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian


Purity/Analysis Method>98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W.C9H13N3O2=195.22
CAS Number7662-51-3
Related CAS Number
MDL NumberMFCD00007609


2016年2月29日星期一

ABT-199, Venetoclax, 1257044-40-8 NMR, HPLC, LC-MS/EOS Med Chem, Medicinal Chemical is Big



EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.


ABT-199, Venetoclax, 1257044-40-8. Attaching NMR, HPLC, LC-MS.

Now 1000g in stock, Assay more than 99%+, ROS is OPEN.

Now we could synthesis 12 Intermediates in GMP plant.

Each Step of Intermediates, we have.

Impurity we have, thanks






Description: Venetoclax, also known as ABT-199 or GDC0199, is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. (Last Update: 2/29/2016).
Synonym: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601. Venetoclax.
IUPAC/Chemical Name: 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
SMILES Code: O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7