200g : 1H-Pyrrolo[3,2-b]pyridine,7-methyl-(9CI) | 357263-42-4

1H-Pyrrolo[3,2-b]pyridine,7-methyl-(9CI) | 357263-42-4

Apr 10th, we finished 200g order. HPLC more than 98%.

We have 95%, 98%, 2 standard.

Price is different.

Next month, we will start new batch about 2kg, assay more than 98%. This chemicals will be widely used in future new drug discovery.

Takeda Pharmaceutical said, this could be synthesis some new drug.

Glad to serve you in world new drug, thanks.

Name		7-Methyl-4-azaindole
Synonyms		7-Methyl-1H-pyrrolo[3,2-b]pyridine
Molecular Structure
Molecular Formula		C8H8N2
Molecular Weight		132.16
CAS Registry Number		357263-42-4
Properties
Density		1.186
Boiling point		281 ºC
Flash point		125 ºC

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; 

eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

GMP-Moxonidine Key Intermediate 75438-54-9 / EOS Med Chem

Moxonidine Key Intermediate 75438-54-9, until Apr 2016, we have more than 3000kg production. Most custom synthesis for India, Poland market.

Use my 1000L reactor, each batch about 500kg. Usually more than 500kg in stock.

Produce a new batch need about 2 weeks.

From N-1, N-2, we could supply.

My standard, IRON, this is less than 10 ppm.

Attaching COA.

Welcome to visit my GMP plant, which have passed TEVA, GLENMARK, HIKA approved.

All my standard in the below:

ITEMS	SPECIFICATION		RESULT
Appearance	White to yellowish beige powder		White to yellowish beige powder
Identification	Positive		Complies
Loss on drying	1% max		0.5%
Water(KF)	0.5% max		0.2%
Purity(HPLC)	99% min		99.5%
Related substances	Single impurity 0.5% max		0.3%

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

Open route of synthesis Acalabrutinib (ACP-196) Intermeidtes List /EOS Med Chem, Medicinal Chemical is Big

GMP produce Acalabrutinib & Intermediate

Acalabrutinib & Intermediate, HPLC more than 98%, NMR, LCMS, stock more than 50kg.

COA, MSDS like below.

Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

Name: Acalabrutinib (ACP-196) 
CAS#: 1420477-60-6 
Chemical Formula: C26H23N7O2 
Exact Mass: 465.19132 
Molecular Weight: 465.52 
Elemental Analysis: C, 67.08; H, 4.98; N, 21.06; O, 6.87

Synonym: ACP-196; ACP196; ACP 196; Acalabrutinib
IUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N
InChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1

SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2


Acalabrutinib (ACP-196) CAS:1420477-60-6 , As the world first commercial supplier.

Now we have supply each Intermediates in the step.

OPEN of the ROS for your reference.

Pls fell free ask me any need.

Below Acalabrutinib (ACP-196) Intermeidtes List, Assay more than 98%


Acalabrutinib (ACP-196) Intermediate: 1420478-90-5,(S)-4-(8-amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Acalabrutinib (ACP-196) Intermediate: 1420478-89-2,(S)-benzyl 2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1420478-88-1, (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1420478-87-0, (S)-benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 1418307-18-2, (S)-benzyl 2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate 
Acalabrutinib (ACP-196) Intermediate: 1418307-17-1, (S)-benzyl 2-((3-chloropyrazin-2-yl)methylcarbamoyl)pyrrolidine-1-carboxylate
Acalabrutinib (ACP-196) Intermediate: 771581-15-8,  2-Aminomethyl-3-chloropyrazine
Acalabrutinib (ACP-196) Intermediate: 55557-52-3, 3-Chloropyrazine-2-carbonitrile

Acalabrutinib (ACP-196) Intermediate: 1383385-64-5, No Name


Acalabrutinib (ACP-196) Intermediate: 180516-87-4, 4-Carboxylphenylboronic acid pinacol ester

2017 China CPHI: E1M35

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

労働時間: Beijing Time 4:00AM~11:00PM

郵箱: info@eosmedchem.com ; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp & Wechat: +8618653174435

住所: Diaozhen Chemical Industrial Park, Jinan City, China

Skype: willgutian

QQ: 2393923585

2-Azaadamantane HCl [3015-17-6] EOS Med Chem, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

Product Name: 2-AzaadaMantane hydrochloride

Synonyms: 2-AzaadaMantane hydrochloride

CAS: 3015-17-6

MF: C9H16ClN

MW: 173.68304

We finish it in 2015 Sep, now we have 100g in stock, assay more than 96%

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

1-(4,5-dichloro-1H-indol-3-yl)-ethanone [1482735-76-1] / 大象藥物化學, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.

1-(4,5-dichloro-1H-indol-3-yl)-ethanone  [1482735-76-1] , as the China sole supplier, we could finish it assay more than 98%, HPLC, NMR, MS is ok.

Thanks.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

Icatibant Intermediates List

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

Sl.No	Name	Structure	CAS No
1	Fmoc-Arg(Pbf)-OH		154445-77-9
2	Fmoc-Oic-OH		130309-37-4
3	Fmoc-D-Tic-OH		130309-33-0
4	Fmoc-Ser(tBu)-OH		71989-33-8
5	Fmoc-Thi-OH		130309-35-2
6	Fmoc-Gly-OH		29022-11-5
7	Fmoc-Hyp(tBu)-OH		122996-47-8
8	Fmoc-Pro-OH		71989-31-6
9	Fmoc-D-Arg(Pbf)-OH		187618-60-6