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2016年12月7日星期三

2016 Nov, HOT SALE

Below is my company, Nov hot sale small molecule and inhibitor.

 Each one is the world best price.

 Glad to contact me.
2016 Nov, HOT SALE
NAMECASPRICENOTE
ACP 1961420477-60-6100G, CIF, USD 99.5/GEE> 99.5%, Biggest Supplier
PF-066508331817626-54-25G, CIF, USD 2100/GBiggest supplier
EAI-0451942114-09-15G, CIF, USD 280/G
FGFR4-IN-11708971-72-51G, CIF, USD 2950/G
IR-8251558079-49-45G, CIF, USD 3200/G
KPT-3301393477-72-92G, CIF, USD 1900/G
INCN0243601204669-58-810G, CIF, USD 248/G
SHP0991801747-42-12G, CIF, USD 1480/G
Alectinib1256580-46-7100G, CIF, USD 89/GBiggest supplier
Mitoquinone444890-41-95G, CIF, USD 690/G
LY28352191231929-97-710G, CIF, USD 99.5/G
TX-85-11603845-32-4Min 5G, CIF,USD 1380/GSole Supplier





GMP PRODUCE:

Alectinib;Veliparib;Acalabrutinib;Venetoclax;Sotagliflozin;Ledipasvir;LX1606;Anacetrapib;Abemaciclib 

 


2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年12月4日星期日

Alectinib

Roche's original supplier of Intermediates.

Now we could produce more than 100kg one batch.

Below is the list.

Alectinib1256580-46-7
Alectinib Intermediates1256584-78-7
Alectinib Intermediates1256584-77-6
Alectinib Intermediates1256584-75-4
Alectinib Intermediates1256584-74-3
Alectinib Intermediates1256584-73-2
Alectinib Intermediates1247119-83-0
Alectinib Intermediates1256584-72-1


Alectinib Intermediates,1256584-75-4,this is Key Intermediates, each batch we could produce more than 100kg.

Alectinib 1256580-46-7, we have 2kg in stock.




2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

Description: Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. Alectinib was approved in Dec. 2015.
Synonym: AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, Alectinib; brand name: Alecensa
IUPAC/Chemical Name: 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
SMILES Code: N#CC1=CC2=C(C=C1)C3=C(C(C)(C)C4=CC(N5CCC(N6CCOCC6)CC5)=C(CC)C=C4C3=O)N2


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2016年11月23日星期三

Selinexor (KPT-330) 1393477-72-9 biggest supplier

Until 2016, Nov, we have produced more than Selinexor (KPT-330) 1393477-72-9 1000g.

 Selinexor (KPT-330) Intermediate: 3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole, 1333154-10-1, 5kg.

 Selinexor (KPT-330) Intermediate: (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid, 1388842-44-1, 5kg

 Now we could be China first commercial supplier, produced it in China GMP, FDA plant.

 Welcome to audit.

Product Name:KPT-330
Synonyms:KPT-330;(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide;Selinexor;Selinexor (KPT-330);(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide;2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)-
CAS:1393477-72-9
MF:C17H11F6N7O
MW:443.3059592
EINECS:
Mol File:1393477-72-9.mol

Product Name:3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole
Synonyms:3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole;1H-1,2,4-Triazole, 5-[3,5-bis(trifluoromethyl)phenyl]-
CAS:1333154-10-1
MF:C10H5F6N3
MW:281.1572192
EINECS:-0
Mol File:1333154-10-1.mol

Product Name:(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
Synonyms:(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid;2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, (2Z)-
CAS:1388842-44-1
MF:C13H7F6N3O2
MW:351.2039992
EINECS:-0
Mol File:1388842-44-1.mol
1388842-44-1
FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big
2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

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How to synthesis ABT-199, Venetoclax

Venetoclax (INN, trade name Venclexta ven-KLEKS-tuh, previously known as GDC-0199, ABT-199, and RG7601) is a small molecule oral drug that treats chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality.
To synthesis the ABT 199, most customer buy like below:
 
1628047-84-6 OR 1235865-75-4 + 1628047-87-9 OR 1228780-72-0 + 1228779-96-1 to synthesis API
 

Now we could provide you all.

IMPURITY, WORKING STANDARD, DOCUMENT 

 FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big

2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

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2016年11月10日星期四

Biggest Supplier: Momelotinib（CYT-387）


Momelotinib（CYT-387）, we produce it in 2015, now each batch could produce more than 10kg.

 Intermediates, we have produced more than 30kg.

 All from GMP, FDA plant.

 Welcome to visit me.

 Thanks.
FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big
 

2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
Momelotinib（CYT-387）1056634-68-4200g in shand
Momelotinib Intermediates499195-60-730kg in hand
Momelotinib Intermediates1056634-62-812kg in hand
Momelotinib Intermediates945749-71-35kg in hand
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Sole supplier: CAS:1817626-54-2 (Synonyms PF06650833;PF 06650833)

CAS:1817626-54-2 
 (Synonyms  PF06650833;PF 06650833)

We are the China sole supplier now.

We have more than 12g in hand (2016.11.10)

Assay more than 99%.

If you want to see: HNMR, HPLC, MS, pls contact me.



FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big
 
2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年10月28日星期五

Best GMP : Brilanestrant | GDC-0810 | ARN-810 | CAS#1365888-06-7

FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big
 
2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

Name: GDC-0810 (ARN-810) 
CAS#: 1365888-06-7 
Chemical Formula: C26H20ClFN2O2 
Exact Mass: 446.11973 
Molecular Weight: 446.9064 
Elemental Analysis: C, 69.88; H, 4.51; Cl, 7.93; F, 4.25; N, 6.27; O, 7.16

Now we have produced 500g. And all Intermediates we have.

Description: Brilanestrant, also known as GDC-0810, ARN-810 and RG6046, an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. GDC-0810 functions by binding to the estrogen receptor, inducing a conformational change resulting in the degradation of the receptor. GDC-0810 or ARN-810 demonstrates robust activity in models of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer. 
Synonym: GDC0810; GDC 0810; GDC-0810; ARN810; ARN 810; ARN-810; RG6046; RG-6046; RG 6046; Brilanestrant
IUPAC/Chemical Name: (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid
SMILES Code: O=C(O)/C=C/C1=CC=C(C=C1)/C(C2=CC3=C(NN=C3)C=C2)=C(CC)\C4=CC=C(C=C4Cl)F


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FDA approved 2014-2016 New API and Intermediates, Custom synthesis, I am Big
 
2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian



2016 Oct New API and Intermediates
Below API and Intermediates, all from GMP system plant, audit is
ok




NAME STRUC CAS
LY2835219 Intermediates1 1118-69-0
LY2835219 Intermediates2 1231930-33-8
LY2835219 Intermediates3 1231930-37-2
LY2835219 Intermediates4 1231930-42-9
LY2835219 Intermediates5 1180132-17-5
LY2835219 1231929-97-7
LY2835219 1231930-82-7
AZD3759 Intermediates1 230955-75-6
AZD3759 Intermediates2 740081-22-5
AZD3759 Intermediates3 612501-52-7

AZD3759 Intermediates4 /
AZD3759 Intermediates5 /
AZD3759 1626387-80-1
CO1686 Intermediates1 68621-88-5
CO1686 Intermediates2 1021426-42-5
CO1686 Intermediates3 1374507-23-9
CO1686 Intermediates4 /
CO1686 1374640-70-6
LEE011 Intermediates1 1374639-77-6
LEE011 Intermediates2 1211443-58-1
LEE011 Intermediates3 1211443-61-6

LEE011 Intermediates4 1374639-78-7
LEE011 1211441-98-3
LEE011 1211443-80-9
Tipiracil Intermediates1 18592-13-7
Tipiracil Intermediates2 73742-45-7
Tipiracil 183204-72-0
HM61713 Intermediates1 16234-14-3
HM61713 Intermediates2 1353553-07-7
HM61713 Intermediates3 /
HM61713 Intermediates4 /
HM61713 1802181-20-9
AZD9291 Intermediates1 1032452-86-0

AZD9291 Intermediates2 1421372-94-2
AZD9291 Intermediates3 1421372-67-9
AZD9291 Intermediates4 1421372-66-8
AZD9291 Intermediates5 1421373-65-0
AP26113 Intermediates1 1089279-91-3
AP26113 Intermediates2 761440-75-9
AP26113 1197958-12-5
AP26113 /
E7050 Intermediates1 53617-36-0
E7050 Intermediates2 864245-57-8
E7050 928037-13-2


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