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2016年12月9日星期五

Omarigliptin, GMP produce

Omarigliptin and Intermediates  from GMP, FDA plant, we have 800g API in stock. Total 8 Intermediates, 10 Impurity, Working standard, produced more than 200kg. (Until Dec, 2016)

Exported to USA, Japan, India, Poland market.

Site Audit is welcome any time.
OmarigliptinMK-3102;Marizev1226781-44-7
Omarigliptin Intermediates(2S,3R,5S)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine1443380-88-8
Omarigliptin IntermediatesTert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate1280210-79-8
Omarigliptin Intermediates2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 4-methylbenzenesulfonate18193664-02-7
Omarigliptin IntermediatesTert-butyl 2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate1226781-82-3
Omarigliptin Intermediates(Z)-tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate905274-02-4
Omarigliptin IntermediatesTert-butyl 6a-hydroxy-1,2,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate1211594-55-6
Omarigliptin Intermediates2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole1226781-80-1
Omarigliptin Intermediates2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate1280210-80-1
Omarigliptin IntermediatesTert-butyl ((2R,3R)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate1456616-43-5
Omarigliptin IntermediatesTert-butyl ((2S,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate1456616-44-6
Omarigliptin Intermediates(2R,3R,5R)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine
Omarigliptin Intermediates(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine
Omarigliptin IntermediatesTert-butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate1172623-99-2
Omarigliptin Intermediates2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid61172-66-5
Omarigliptin IntermediatesTert-butyl (1-(methoxy(methyl)amino)-1-oxopent-4-yn-2-yl)carbamate172623-95-8
Omarigliptin IntermediatesTert-butyl (1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-yl)carbamate1172623-96-9
Omarigliptin Intermediates(2R,3S,5R)-2-(3-fluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine
impurity A
Omarigliptin Intermediates(2R,3S,5R)-2-(2-fluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine impurity B



GMP PRODUCE:

Alectinib;Veliparib;Acalabrutinib;Venetoclax;Sotagliflozin;Ledipasvir;LX1606;Anacetrapib;Abemaciclib 

 

2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年12月7日星期三

Sotagliflozin & Intermediates, world biggest supplier


Sotagliflozin, we are world biggest supplier in the world.

All from GMP, FDA plant.

Each batch could be more than 10-50kg. 5 key Intermeidates, Impurity, Working Standard.


SotagliflozinLP-802034;LX-4211;1018899-04-1
Sotagliflozin Intermediates((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone1103738-19-7
Sotagliflozin Intermediates(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid1103738-20-0
Sotagliflozin Intermediates(3aS,5S,6R,6aS)-5-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol114861-22-2
Sotagliflozin Intermediates(3aS,3bR,7aS,8aS)-2,2,5,5-tetramethyltetrahydro-3aH-[1,3]dioxolo[4',5':4,5]furo[3,2-d][1,3]dioxine131156-47-3

Below is some of our India customers. 

 Maylan, Glenmark, Drreddy, Sunpharma, have approved me to be suuplier of some key Intermediates.

 Site Audit approved.


GMP PRODUCE:

Alectinib;Veliparib;Acalabrutinib;Venetoclax;Sotagliflozin;Ledipasvir;LX1606;Anacetrapib;Abemaciclib 

 

2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016 Nov, HOT SALE

Below is my company, Nov hot sale small molecule and inhibitor.

 Each one is the world best price.

 Glad to contact me.
2016 Nov, HOT SALE
NAMECASPRICENOTE
ACP 1961420477-60-6100G, CIF, USD 99.5/GEE> 99.5%, Biggest Supplier
PF-066508331817626-54-25G, CIF, USD 2100/GBiggest supplier
EAI-0451942114-09-15G, CIF, USD 280/G
FGFR4-IN-11708971-72-51G, CIF, USD 2950/G
IR-8251558079-49-45G, CIF, USD 3200/G
KPT-3301393477-72-92G, CIF, USD 1900/G
INCN0243601204669-58-810G, CIF, USD 248/G
SHP0991801747-42-12G, CIF, USD 1480/G
Alectinib1256580-46-7100G, CIF, USD 89/GBiggest supplier
Mitoquinone444890-41-95G, CIF, USD 690/G
LY28352191231929-97-710G, CIF, USD 99.5/G
TX-85-11603845-32-4Min 5G, CIF,USD 1380/GSole Supplier





GMP PRODUCE:

Alectinib;Veliparib;Acalabrutinib;Venetoclax;Sotagliflozin;Ledipasvir;LX1606;Anacetrapib;Abemaciclib 

 


2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年12月4日星期日

Alectinib

Roche's original supplier of Intermediates.

Now we could produce more than 100kg one batch.

Below is the list.

Alectinib1256580-46-7
Alectinib Intermediates1256584-78-7
Alectinib Intermediates1256584-77-6
Alectinib Intermediates1256584-75-4
Alectinib Intermediates1256584-74-3
Alectinib Intermediates1256584-73-2
Alectinib Intermediates1247119-83-0
Alectinib Intermediates1256584-72-1


Alectinib Intermediates,1256584-75-4,this is Key Intermediates, each batch we could produce more than 100kg.

Alectinib 1256580-46-7, we have 2kg in stock.




2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian

Description: Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. Alectinib was approved in Dec. 2015.
Synonym: AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, Alectinib; brand name: Alecensa
IUPAC/Chemical Name: 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
SMILES Code: N#CC1=CC2=C(C=C1)C3=C(C(C)(C)C4=CC(N5CCC(N6CCOCC6)CC5)=C(CC)C=C4C3=O)N2


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