ONO4059-Analog, custom synthesis 140g

USA Trade company buy 300g from my side in 2016, March.

Now nothing in stock, Key Intermediates we have 2, total 1kg.

Assay more than 99%, HPLC, NMR, MS is ok

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

Description: ONO4059-Analog, CAS#1351635-67-0, is a potent and selective BTK inhibitor, and is a structural analogue of ONO-4059. ONO4059 is currently under clinical trials. Note: ONO4059 HCl has CAS#1439901-97-9; ONO4059 free base has CAS#1351636-18-4. (Last updated: 5/19/2016).

Synonym: ONO4059-Analog; ONO 4059-Analog; ONO-4059-Analog; GS 4059-Analog; GS-4059-Analog; GS4059-Analog.

IUPAC/Chemical Name: (S)-9-(1-acryloylpiperidin-3-yl)-6-amino-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one

SMILES Code: O=C1N(C2=CC=C(C=C2)OC3=CC=CC=C3)C4=C(N)N=CN=C4N1[C@@H]5CN(C(C=C)=O)CCC5

CHEMICAL STRUCTURE

 

THEORETICAL ANALYSIS

Name: ONO4059-Analog 
CAS#: 1351635-67-0 
Chemical Formula: C25H24N6O3 
Exact Mass: 456.19099 
Molecular Weight: 456.51 
Elemental Analysis: C, 65.78; H, 5.30; N, 18.41; O, 10.51

TECHNICAL DATA

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months). 

ON-123300 CAS 1357470-29-1, produced 350g, 200g in hand

ON-123300 CAS  1357470-29-1

Supply USA, Inhibitor Trade company. 

Until 2016. March 12, we have 200g in stock, Intermediates have 1 key Intermediates.

Pilot production is going.

Description: ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as β-type platelet-derived growth factor receptor (PDGFRβ). ON123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 μmol/L. ON123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo. ON123300 might be an effective agent in MCL, including ibrutinib-resistant forms of the disease. (Last updated: 5/9/2016).

Synonym: ON-123300; ON 123300; ON123300.

IUPAC/Chemical Name: 8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile

SMILES Code: N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O

CHEMICAL STRUCTURE

 

THEORETICAL ANALYSIS

Name: ON-123300 
CAS#: 1357470-29-1 
Chemical Formula: C24H27N7O 
Exact Mass: 429.22771 
Molecular Weight: 429.0 
Elemental Analysis: C, 67.11; H, 6.34; N, 22.83; O, 3.72

Solid powde

r

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Olmutinib (HM71224) Finish 300g

Olmutinib (HM71224) 1353550-13-6 (free base); 1842366-97-5 (HCl), we have produced 300g for USA market.

Until now, Intermediates we are commercial production, soon, all cost will cut 50%.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

CHEMICAL STRUCTURE

 

THEORETICAL ANALYSIS

Name: Olmutinib (HM71224) 
CAS#: 1353550-13-6 (free base); 1842366-97-5 (HCl). 
Chemical Formula: C26H26N6O2S 
Exact Mass: 486.18379 
Molecular Weight: 486.59 
Elemental Analysis: C, 64.18; H, 5.39; N, 17.27; O, 6.58; S, 6.59

GSK-114 CAS#: 1301761-96-5 (free base); 1301760-19-9 (2HCl).

2016 , Apr 15th, we start to custom synthesis GSK-114 CAS#: 1301761-96-5 (free base); 1301760-19-9 (2HCl).

Now we have finished 90%, assay more than 99%+, HPLC, NMR, MS is ok.

This batch is 120g.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

CHEMICAL STRUCTURE

 

THEORETICAL ANALYSIS

Name: GSK-114 

CAS#: 1301761-96-5 (free base); 1301760-19-9 (2HCl). 

Chemical Formula: C19H23N5O4S 

Exact Mass: 417.1471 

Molecular Weight: 417.484 

Elemental Analysis: C, 54.66; H, 5.55; N, 16.78; O, 15.33; S, 7.68

TECHNICAL DATA

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Glesatinib | MGCD-265 | CAS#936694-12-1 | TKI inhibitor | ,API 100g in hand, Intermediates 1kg in hand

Glesatinib | MGCD-265 | CAS#936694-12-1 | TKI inhibitor | , this will be hot project in the coming days.

EOS to be the first GMP supplier, each batch could be 1-5kg.

Assay more than 99, HPLC, NMR, MS as attachment.

Now cost only half of the market, until Jan 2016, we have sold more than 2000g, so price could be lowest.

And GMP standard.

Intermediates, we have 3.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

Description: Glesatinib, also known as MGCD-265, is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. MGCD265 binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). (last updated: 5/9/2016).

Synonym: MGCD-265; MGCD 265; MGCD265; Glesatinib; CAS#936694-12-1

IUPAC/Chemical Name: N-((3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)carbamothioyl)-2-(4-fluorophenyl)acetamide

SMILES Code: O=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=NC=C(CNCCOC)C=C4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=C(F)C=C5

CHEMICAL STRUCTURE

 

THEORETICAL ANALYSIS

Name: Glesatinib (MGCD-265) 
CAS#: 936694-12-1 
Chemical Formula: C31H27F2N5O3S2 
Exact Mass: 619.1523 
Molecular Weight: 619.7058 
Elemental Analysis: C, 60.08; H, 4.39; F, 6.13; N, 11.30; O, 7.75; S, 10.35

TECHNICAL DATA

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

60410-16-4, Why we so cheap?

We use the new route, finish 60410-16-4, save 30% cost in the price.

NMR, HPLC as attachment.

Until 2016 May, we have 3kg in hand, any interesting, pl ask me.

Med-chemicals, I am big

Web: www.eosmedchem.com

Email: info@eosmedchem.com; 

eosmedchem@gmail.com

Office line: 0086-531-69905422

CAS No.	60410-16-4
Chemical Name:	(1R,3S)-4-CYCLOPENTENE-1,3-DIOL 1-ACETATE
Synonyms:	(1R,4S)-4-hydroxycyclopent-2-enylacetate;(1S,4R)-CIS-4-ACETOXY-2-CYCLOPENTEN-1-OL;(1R,3S)-4-CYCLOPENTENE-1,3-DIOL 1-ACETATE;(1R,4S)-4-hydroxycyclopent-2-en-1-yl acetate;(1R,4S)-CIS-4-HYDROXY-2-CYCLOPENTENYL ACETATE;(1S,4R)-cis-4-Acetoxy-2-cyclopenten-1-ol >=99%;(1R,3S)-(+)-CIS-4-CYCLOPENTENE-1,3-DIOL 1-ACETATE;ACETIC ACID (1R,4S)-4-HYDROXY-CYCLOPENT-2-ENYL ESTER;(1R,3S)-(+)-CIS-4-CYCLOPENTEN-1,3-DIOL-1 -ACETAT 99+%;(1R,3S)-(+)-4-Cyclopentene-1,3-diol 1-acetate,99%,stabilzed
CBNumber:	CB3434428
Molecular Formula:	C7H10O3
Formula Weight:	142.15

May 24, New compounds

Below is new Compounds we have finished.

Any interesting, welcome to my booth to have a meet.

2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰

網址: www.eosmedchem.com 

郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 

辦公室: 0086-531-69905422-806(直通)

攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian

1	4-Chloro-1H-pyrrolo[2,3-b]pyridine	55052-28-3	690/100g	1150/250g	1850/kg	Stock
2	4-​Chloro-​1-​(phenylsulfonyl)​-1H-​Pyrrolo[2,​3-​b]​pyridine	744209-63-0	780/100g	1150/250g	2700/kg	4 Weeks
3	4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine	1245645-97-9	3050/100g	3850/250g	7700/kg	5 weeks
4	4-​Chloro-​5-​nitro-​1-​(phenylsulfonyl)​-1H-​pyrrolo[2,​3-​b]​pyridine	1245649-52-8	3050/100g	3850/250g	7700/kg	5 Weeks
5	5-​Nitro-1H-​Pyrrolo[2,​3-​b]​pyridine-​4-​carbonitrile	1401447-80-0	3050/100g	3850/250g	7700/kg	5 Weeks
6	3-Pyrrolidinecarboxylic acid	59378-87-9	1050/100g	1350/250g	3700/kg	6 Weeks
7	1-​(Phenylmethyl)​-3-​pyrrolidinecarboxyli​c acid	5731-18-0	1260/100g	1460/250g	1850/kg	3 Weeks
8	1-​Acetyl-3-​Pyrrolidinecarboxyli​c acid	712270-40-1	1550/100g	2550/250g	4150/kg	5-6 Weeks
9	1-​Benzoyl-3-​Pyrrolidinecarboxyli​c acid	113558-92-2	1180/100g	1850/250g	3030/kg	5-6 Weeks
10	5-Oxo-3-pyrrolidinecarboxylic acid	7268-43-1	1180/100g	1850/250g	3030/kg	5-6 Weeks
11	5-Oxo-1-benzylpyrrolidine-3-carboxylic acid	5733-86-8	780/100g	1180/250g	1850/kg	5-6 Weeks
12	3-Nitromethyl-1-phenylmethylpyrrolidine	1369148-11-7	1550/100g	2050/250g	4350/kg	5-6 Weeks
13	1-​Pyrrolidinecarboxyli​c acid, 3-​(nitromethyl)​-​, 1,​1-​dimethylethyl ester	1369237-63-7	2180/100g	2700/250g	4700/kg	5-6 Weeks
14	1-​Pyrrolidinecarboxyli​c acid, 4-​(nitromethyl)​-​2-​oxo-​, 1,​1-​dimethylethyl ester	1026779-31-6	1550/100g	2050/250g	4350/kg	5-6 Weeks
15	1-​(Phenylmethyl)​-2-​Pyrrolidinone	5291-77-0	550/100g	620/250g	690/kg	Stock