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2016年12月13日星期二

Below Project, we could produce

Below Project, we could produce 

2016 Mumbai CPHI, Hope to meet!
2016 Barcelona CPHI, Hope to meet!
2016 Korea(한국) CPHI, C40, Welcome!
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med ChemMedchem is Big
執大象,天下往,往而無害,安平泰
網址www.eosmedchem.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian




Abiraterone [CAS# 154229-19-3] - FOR ONCOLOGY
17-lodoandrosta-5, 16-dien-3beta-ol [CAS# 32138-69-5]
17-lodoandrosta-5, 16-dien-3beta-acetate ester [CAS# 114611-53-9]
Androsta-5, 16-diene-3, 17-diol, 3-acetate17-(trifluoromethanesulfonate), (3b)-
[CAS# 115375-60-5]

Anacetrapid Intermediates - CARDIOVASULAR
2'-fluoro-4'-methoxyacetophenone   [CAS #74457-86-6]
2-fluoro-4-methoxy-1-isopropylbenzene   [CAS #1262414-96-9]
1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene   [CAS #944317-92-4]
(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid   [CAS #875446-29-0]
(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
[CAS #875444-08-9]
2'-(chloromethyl)-4-fluoro-2-methoxy-5-(1-methylethyl)-4'-(trifluoromethyl)-1,1'-
biphenyl   [CAS #875551-28-3]
4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)-[1,1'-biphenyl]-2-methanol   
[CAS # 875548-97-3]

Besifloxacin Intermediates- OPTHALMIC
1-Cyclopropyl-6,7-difluoro-4-oxo quinoline-3-carboxylic acid [CAS # 93107-30-3]
(R)-3-Amino-Hexahydro-1H-Azepin [CAS #124932-43-0] (also known as 3R-azepan3-3-
amine)
(R)-tert-butyl azepan-3-yl-carbamate [CAS # 1354351-56-6]
8-Chloro-1-cyclopropyl-6, 7-difluoro-4-oxo-1,4-dihydroquinoline-3-caboxylic acid  
[CAS # 101987-89-7]

Bimatoprost Intermediate - OPHTALMIC
(+)(3aR,4R,5r,6aS)-hexahydro-5-hydroxy-4-((1E,3R)-hydroxy-phenyl-1-pentyl)2H-
cyclopenta(b)furan-2.one [CAS# 41639-74-1]
(+)-(3aR,4R,5r,6aS)-Hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-5-phenyl-1-pentenyl]-2H-
cyclopenta(b)furan-2-one [CAS# 41639-74-1]

Brominidine Intermediates - OPHTALMIC
5-Bromo-6-Isothiocyanate quinoxaline [CAS # 134892-46-9]
CB5083 Intermediates: - ONCOLOGY
4-Cyano-2-MethylIndole CAS no 1360883-22-1
5H-Pyrano[4,3-d]pyrimidin-4-amine CAS [1542711-55-6]

Cinacalcet [CAS# 226256-56-0] -ONCLOLOGY/KIDNEY DISEASE
3-(trifluoromethyl)cinnamic acid [CAS# 779-89-5]
3-(3-Trifluoromethylphenyl)propionic acid [CAS# 585-50-2]
3-(Trifluoromethyl)benzenepropanol [CAS# 78573-45-2]
3-(3-Trifluoromehtylphenyl)propionaldehyde [CAS# 21172-41-8]
R-(+)-alpha-(1-Naphthyl)ethylamine [CAS# 3886-70-2]

Clopidogrel Intermediate - CARDIOVASULAR
Dl-2-(2-Chlorophenyl) Glycine [CAS# 141196-64-7]
Dl-2-Chloro Mandelic Acid [CAS# 10421-85-9]
2-(2-Thienyl)Ethanol [CAS# 5402-55-1]
Methyl-(+)-A-Amino(2-Chlorophenyl)Acetate [CAS# 141109-14-0]
4-Chlorobenzenesulfonyl Chloride [CAS# 98-60-2]
L(-)-Camphorsulfonic Acid [CAS# 35963-20-3]

Duvelisib Intemediates - ONCOLOGY
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one;3-[(1S)-1-aminoethyl]-8-
chloro-2-phenyl-1(2H)-Isoquinolinone [1350643-72-9]
BOC-L-ALANINE N-METHOXY-N-METHYL AMIDE [CAS # 87694-49-3]
8-chloro-2-phenyl-3-(1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)
isoquinolin-1(2H)-one [1350643-73-0]

Dasatinib Intermediate - ONCOLOGY
Ethyl-2-aminothiazole-5-carboxylate [CAS# 32955-21-8]
2-methyl-4, 6-dichloro pyrimidine [CAS# 1780-26-3]
2-chloro-6-methylaniline [CAS# 87-63-8]
2-Amino-N-(2-chloro-6-methylphenyl) thiazole-5-carboxamide [CAS# 302964-24-5]
4, 6-Dichloro-2-methylpyrimidine [CAS# 1780-26-3]
1-Piperazine ethanol [CAS# 103-76-4]

Daclatasvir Intermediate - ANTIVIRAL/ HEP C
5,5'-[1,1'-Biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole] hydrochloride (1:4)
[CAS # 1009119-83-8]

Doxercalciferol Intermediate - VITAMIN D
1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene

Erdosteine Intermediate - COPD
Dl-Homocysteine Thiolactone Hydrochloride [CAS# 6038-19-3]
N-Chloroacetyl-Dl-Homocysteine Thiolactone [CAS# 84611-23-4]
Chloroacetyl Chloride [CAS# 79-40-9]

E7386 Intermediates  - ONCOLOGY
3,7:6,10-dianhydro-8,9-O-cyclohexylidene-2,4,5-trideoxy-D-xylo-D-allo-dodeconic acid 
methyl ester [CAS #871360-12-2]
(R)-tert-butyl((4-chlorohept-6-yn-1-yl)oxy)diphenylsilane [CAS #1191268-97-9]
(2R,4R)-4-((tert-butyldimethylsilyl)oxy)-N-methoxy-N,2-dimethyloct-7-enamide
[CAS:# 914922-88-6]
3,6-anhydro-2,4,7-trideoxy-8,9-bis-O-[(1,1-dimethylethyl)dimethylsilyl]- 4-(2-methoxy-2-
oxoethyl)-5-O-methyl-D-glycero-D-gulo-nonitol [CAS # 1191256-09-3]

Erlotinib Intermediate - ONCOLOGY
4-Chloro-6,7-Bis(2methoxyethoxy)quinazolin [CAS# 183322-18-1]
3-ethynylaniline HCL [CAS# 207226-02-6]

Ertugliflozin Intermediates - DIABETES
{(2S,3S)-3,4,5-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6,8-dioxa-bicyclo
[3.2.1]oct-1-yl}-methanol [1210763-25-9]

Feropenem Intermediate - PENEM
(R)-(+)-2-Tetrahydrofuroic acid [CAS # 87392-05-0]
Ally(1’R,2’’R,5R,6S)-6(1’-tert-butyl dimethyl silyloxyethy)-2-(2’’-tetrahydrofuranyl) 
penem- 3-carboxylate [CAS # 120705-67-1]

Filgotinib Intermediate - RA
Thiomorpholine-1,1-dioxide [CAS # 39093-93-1]
N-(5-(4-(bromomethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl) clopropanecarboxamide
[CAS # 1206163-59-8]

Gatifloxacin Intermediate - OPHTHALMIC
Gati ester/Ethyl-1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-
Quinolinecarboxylate- [CAS# 112811-71-9]

Gliclazide Intermediate
3-Amino-3-Azabicyclo [3,3,0]Octane Hcl [CAS# 58108-05-7]

Glimepiride Intermediate - DIABETES
4-[2-[(3-Ethyl-4-Methyl-2-Oxo-3-.....]Benzenesulfonamide [CAS# 119018-29-0]
Trans-4-Methylcyclohexyl Amine Hcl [CAS# 2523-55-9]

Ketoprofen Intermediate - ARTHRITIS
3-(1-Cyanoethyl_Benzoic Acid [CAS# 5537-71-3]

Imatinib Intermediates - ONCOLOGY
N-(5-Amino-2-methylphenyl)-4-(3-pyridnyl)-2-pyrimidine amino [CAS# 152460-10-1]
4-((4-methylpiperazin-1-yl)benzoic acid [CAS# 106261-48-7]

Isavuconazole intermediate - ANTIFUNGUL
CAS: 241479-67-4
CAS: 368421-58-3
CAS: 241479-74-3
CAS: 1180002-01-0
CAS: 20099-89-2

Idelalisib Intermediate - ONCOLOGY
(S)-tert-Butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate
[CAS 870281-85-9]
6-Bromopurine [767-69-1]
Carbamic acid, [(1S)-1-[[(2-fluoro-6-nitrobenzoyl)phenylamino]carbonyl]propyl]-, 1,1-
dimethylethyl ester [870281-84-8]

Ivacaftor Intermediates - CYSTIC FIBROSIS
5-amino-2,4-di-tert-butylphenyl methyl carbonate(1182822-31-6) [CAS # 1182822-31-6]
2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate 
[CAS # 1246213-45-5]
2,4-Di-tert-butyl-5-nitrophenyl methyl carbonate [CAS # 873055-55-1]
2,4-Di-tert-butyl-5-nitrophenol [CAS # 873055-57-3]
5-Amino-2,4-di-tert-butylphenol [CAS # 873055-58-4]

Irbesartan Intermediate - BLOOD PRESSURE / DIABETES
2-Cyano-4'-Bromomethylbiphenyl [CAS# 114772-54-2]
2-Cyano-4'-Methylbiphenyl [CAS# 114772-53-1]
2-N-Butyl-4-Spirocyclopentane-2-Imidazole-5-One Cl [CAS# 151257-01-1]

Lapatinib Intermediates - ONCOLOGY
5-[4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde
[CAS# 231278-84-5]
2-(Methylsulfonyl)ethylamine HCl also known as 2-Aminoethylmethylsulfone HCL
[CAS# 104458-24-4]

Linalidomide Intermediate - ONCOLOGY
3(1,3-dihydo-4-nitro-1-oxo-2H-isoindol-2-yl)-2,6 piperidinedione [CAS # 827026-45-9]

Lumacaftor intermediates - CYSTIC FIBROSIS
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoic acid tert-butyl ester [CAS #1083057-14-0]
tert-Butyl 3-(3-methylpyridin-2-yl)benzoate [CAS # 1083057-12-8]
3-tert-Butoxycarbonylphenylboronic acid [CAS # 220210-56-0]
1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid [CAS # 862574-88-7]

Lubiprostone Intermediate - IRRITABLE BOWEL SYNDROME
(Z)-BENZYL7-((1R,2R,3R,5S)-2-(4,4-DIFLUORO-3-HYDROXYOCTYL)-5-HYDROXY-3-
(TETRAHYDRO-2H-PYRAN-2-YLOXY)CYCLOPENTYL) HEPT-5-ENOATE
OR
16, 16-DIFLUORO-9,15-DIHYDROXY-11-[(TETRAHYDRO-2H-PYRAN-2-YL)OXY](5Z,9A,11A)-(9
CL)-PROST-5-EN-1-OIC ACID, BENZYL ESTER [CAS# 136790-77-7]

Maxacalcitol Intermediate - VITAMIN D
4-[(1S)-1-[(1S,2R,3S,5R,11R,14S,15S)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-2,15-
dimethyltetracyclo[8.7.0.0(2,7).0(11,15)]heptadeca-7,9-dien-14-yl]ethoxy]-2-methylbutan-
2-ol-

Momelotinib Intermediate - ONCOLOGY
4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoic acid [ CAS # 945749-71-3]
Aminoacetonitrile hydrochloride [CAS # 6011-14-9]

Nilotinib Intermediate - ONCOLOGY
4-methyl-3-nitrbenzoic acid [CAS# 96-98-0]
3-Fluoro-5-(trifluoromethyl) benzonitrile [CAS# 149793-69-1]
4-methyl-1H-imidazole [CAS# 822-36-6]
Diphenyl phosphoryl azide [CAS# 26386-88-9]
4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid [CAS# 641569-94-0]
3-(4-Me-1H-imidazol-1-yl)-5-(trifluoromethyl) aniline, [CAS# 641571-11-1]
Diethyl Cyano phosphonate [CAS# 2942-58-7]
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) aniline [CAS# 641571-11-1]

Prostaglandin Intermediates - SYNTHESIS
(-)-Corey Lactone Diol [CAS # 32233-40-2]
(+)-Corey Lactone Diol [CAS # 76704-05-7]
Corey Lactone Diol [CAS # 521323-11-5]
(-) Corey lactone benzoate [CAS # 39746-00-4]
(-) Corey lactone phenylbenzoate [CAS # 31752-99-5]

Pregabalin Intermediates - DIABETES / NERVE PAIN
3-Carbamoymethyl-5-methylhexanoic acid [CAS # 181289-15-6]
(R)-(-)-3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid [CAS # 181289-33-8]

Sorafinib Intermediate - ONCOLOGY
4-chloro-(2-pyridy)-N-Methyl –carboxamide (CAS# 220000-87-3)

Telmisartan Intermediate - BLOOD PRESSURE
4-Amino-3-Methylbenzoic Acid Methyl Ester [CAS# 18565-14-7]
Tert Butyl O(4-Tolyl) Benzoate Acid [CAS# 13756-42-8]
4'-Methylbiphenyl-2-Carboxylic Acid [CAS# 7148-03-0]
Dl-2-(2-Chlorophenyl)Glycine [CAS# 141196-64-7]

Travoprost Intermediate - OPHTHALMIC
1,3-Dibromo-5,5-dimethylhydantoin [CAS# 77-48-5]
(+)-(3ar,4r,5r,6as)-hexahydro-5-hydroxy-4-(1e,3r)-3-hydroxy-4-(3-trifluoromethyl)phenoxy-
1-butenyl)-2h-cyclopenta(b)-furan-2-one [CAS# 53872-60-9]
(-)-COREY LACTONE BENZOATE [CAS# 39746-00-4]

Veliparib Intermediate - ONCOLOGY
(R)-2-Methylproline  [CAS # 63399-77-9]
(S)-2-Methylproline [CAS # 42856-71-3]
1-Boc-2-methyl-D-proline  [CAS # 166170-15-6]
Cbz-2-Methyl-D-proline [ CAS # 63399-74-6]

Valpatasvir Intermediates - HEP C VIRUS
Please contact

Zileuton Intermediate - ASTHAMA
2-Acetylbenzo[b]thiophene [CAS# 22720-75-8]

OTHERS:
Ibrutinib Intermediates
Olaparib Intermediates
Ceritinib Intermediates
4R)-(+)-t-butyldimethylsiloxy-2-cyclopenten-1-one   (Cas# 61305-35-9)
1-Cyclopropyl-6,7-difluoro-4-oxo quinoline-3-carboxylic acid (CAS# 93107-30-3)
R)-3-Amino-Hexahydro-1H-Azepin (CAS# 124932-43-0)